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Patent # Description
2017/0028083 Methods and Compositions for RNA-Directed Repression of Transcription Using CRISPR-Associated Genes
The present invention is directed to methods and compositions for targeted gene silencing that provide the ability to not only repress expression but to...
2017/0028082 ADENO-ASSOCIATED VIRUS (AAV) CLADES, SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREFOR
Sequences of novel adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such...
2017/0028081 Immunoconjugates with an Intracellularly-Cleavable Linkage
The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an...
2017/0028080 Targeted Drug Conjugates
A targeted therapeutic agent comprising a compound of formula: B-L-D wherein: B is a non-internalizing binding moiety specific for a cancer associated protein; D...
2017/0028079 Compounds and Compositions for Treating HER2 Positive Tumors
Provided are compounds for targeted immunotherapy. The compounds are useful in the treatment of HER2 positive tumors/cancers. Also provided are compositions...
2017/0028078 SUSTAINED-RELEASE DRUG FORMULATIONS FOR GLAUCOMA
A polymer-drug conjugate includes a crosslinked polymer network comprising a biocompatible polymer and a multivalent covalent crosslinker, wherein the...
2017/0028077 PROTEASE INHIBITORS HAVING ENHANCED FEATURES
Provided herein (among other things) are protease inhibitor compounds having enhanced features, along with methods for administering such compounds. For...
2017/0028076 BILIRUBIN NANOPARTICLE, USE THEREOF, AND PREPARATION METHOD THEREFOR
The present invention provides a bilirubin nanoparticle formed by the self-assembly of bilirubin and a composite comprising a hydrophilic polymer, a use...
2017/0028075 INJECTABLE DENDRIMER HYDROGEL NANOPARTICLES
Injectable hydrogels in the form of crosslinked nano beads or particle in the size range 5 nm to 10 .mu.m, comprising PAMAM dendrimer with asymmetrical...
2017/0028074 MultiLigand Agent for Drug Delivery
Described herein is a compound having the structure of formula I, II, or III, ##STR00001## wherein R comprises a double stranded RNA molecule, and L.sub.1,...
2017/0028073 POLYAMINE-DIHYDROXYBENZOIC ACID CONJUGATE HYDROGELS AS IRON CHELATORS
Compositions and methods for making a composition comprising a polymer and one or more chelators covalently coupled to polymer, wherein the one or more...
2017/0028072 POLYAMINE-DIHYDROXYBENZOIC ACID CONJUGATE HYDROGELS AS IRON CHELATORS
Compositions and methods for making a composition comprising a polymer and one or more chelators covalently coupled to polymer, wherein the one or more...
2017/0028071 Methods for Improved Delivery of Aminothiols, Dimers of Aminothiols, and Heterodimers Composed of Aminothiols
The disclosure relates to methods of improving safety, efficacy, or both, of pharmaceutically active aminothiol compounds by delivering them in a ...
2017/0028070 PINCERS COMPRISING ANTIBODY AND APTAMER CONJUGATED VIA A LINKER WHICH BINDS TO THE SAME TARGET MATERIAL AND USE...
The present invention relates to a pincer for binding to a target material, wherein an antibody or a fragment thereof binding to a first target site of the...
2017/0028069 COMPOSITION COMPRISING AN ORGANIC LIQUID DILUENT AND A CELLULOSE ETHER OF VERY LOW VISCOSITY
A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPas, measured as a...
2017/0028068 PHARMACEUTICAL COMPOSITION WITH IMPROVED STORAGE STABILITY AND METHOD FOR PREPARING THE SAME
A pharmaceutical composition containing a specific related compound within a specified limit and a method for preparing the same are provided.
2017/0028067 PHARMACEUTICAL COMPOSITION WITH IMPROVED STORAGE STABILITY AND METHOD FOR PREPARING THE SAME
A pharmaceutical composition containing a specific related compound in an amount within a specified limit and a method for preparing the same are provided.
2017/0028066 PHARMACEUTICAL COMPOSITION WITH IMPROVED STORAGE STABILITY AND METHOD FOR PREPARING THE SAME
A pharmaceutical composition containing a specific related compound in an amount within a specified limit and a method for preparing the same are provided.
2017/0028065 ANTICANCER AGENT AND SIDE-EFFECT-ALLEVIATING AGENT
The purpose of the present invention is to provide an anticancer agent for potentiating an antitumor effect, alleviating side effects, and further extending...
2017/0028064 COMPOSITE POLYDOTS AND APPLICATIONS THEREOF
The present invention relates to nanoparticle compositions and, in particular, to composite polymeric nanoparticle compositions. A composite nanoparticle...
2017/0028063 Stable Protein Formulations Comprising a Molar Excess of Sorbitol
A stable pharmaceutical formulation comprising a protein of interest, sorbitol and polyethylene glycol (PEG). The sorbitol and protein is present in a molar...
2017/0028062 STABLE FORMULATIONS FOR ANTI-CD19 ANTIBODIES AND ANTIBODY-DRUG CONJUGATES
This disclosure provides optimized formulations for CD19 antibodies and antibody-drug conjugates (ADCs)
2017/0028061 COMPOSITIONS AND METHODS FOR INDUCTION OF TH17 CELLS
Strains of human-derived bacteria have been obtained from complex fecal samples and shown to induce accumulation of Th17 cells in the intestine and promote...
2017/0028060 COMPOSITIONS OF VACCINES AND ADJUVANTS AND METHODS FOR THE TREATMENT OF URINARY TRACT INFECTIONS
This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about...
2017/0028059 VACCINE COMPOSITION COMPRISING COMPLEXED IMMUNOSTIMULATORY NUCLEIC ACIDS AND ANTIGENS PACKAGED WITH...
The present invention is directed to a composition or vaccine composition comprising a) an adjuvant component comprising or consisting of at least one...
2017/0028058 HERPES SIMPLEX VIRUS VACCINES
The present invention is directed to Herpes simplex-2 viruses that may be used in vaccines to immunize patients against genital herpes.
2017/0028057 KOI HERPESVIRUS VACCINE
The present invention relates to a recombinant Koi herpesvirus (KHV), methods for the production of such KHV, cells comprising such KHV and the use of such KHV...
2017/0028056 Altering the Immundominance Hierarchy Using a DNA Vaccine Expressing Conserved Regions
The invention provides methods and compositions for eliciting broad immune responses. The methods employ nucleic acid vaccines that encodes highly conserved...
2017/0028055 AVIAN REOVIRUS VACCINES
The present invention relates to novel strains of avian reovirus that were isolated from clinical cases of viral arthritis/tenosynovitis in chickens in the...
2017/0028054 VACCINE COMPOSITION
An intraorally administrable vaccine composition useful to be a preventive or therapeutic agent for infectious diseases, and effectively induces a systemic...
2017/0028053 Peptide Sequences and Compositions
Provided is a polypeptide having no more than 100 amino acids, which polypeptide comprises one or more sequences having at least 60% homology with any of SEQ...
2017/0028052 GENERATION OF HPV-SPECIFIC T-CELLS
Embodiments of the disclosure concern methods and compositions for immunotherapy for human papillomavirus infection and diseases associated therewith. In...
2017/0028051 RNA INTERFERENCE FUNCTIONS AS AN ANTIVIRAL IMMUNITY IN MAMMALS
The disclosure provides recombinant viral vectors and attenuated viruses and viral vaccines comprising a virus lacking a functional viral RNA suppressor of...
2017/0028050 NOVEL IMMUNOGENS AND METHODS FOR DISCOVERY AND SCREENING THEREOF
The present application is generally directed to methods for identifying immunogens from organisms and pathogens, and in particular for identifying immunogens...
2017/0028049 SPECIFIC AND UNIQUE T CELL RESPONSES AND MOLECULAR SIGNATURES FOR THE TREATMENT AND DIAGNOSIS OF MYCOBACTERIUM...
The invention relates to novel targets for immune response modulation, treatment of tuberculosis infection and epitopes of Mycobacterium tuberculosis, or...
2017/0028048 METHODS FOR PRODUCING AN IMMUNE RESPONSE TO TUBERCULOSIS
Methods for producing an immune response to Mycobacterium tuberculosis (Mtb) are disclosed herein. In several examples, the immune response is a protective...
2017/0028047 A CHECKPOINT INHIBITOR AND A WHOLE CELL MYCOBACTERIUM FOR USE IN CANCER THERAPY
An immunomodulator is for use in the treatment, reduction, inhibition or control of a neoplastic disease in a patient intended to undergo checkpoint inhibition...
2017/0028046 VACCINE AGAINST COLIBACILLOSIS
The present invention provides an agent for controlling colibacillosis including a fusion protein comprising a subunit of Shiga toxin and a subunit of...
2017/0028045 METHODS FOR CONSTRUCTING ANTIBIOTIC RESISTANCE FREE VACCINES
The present invention provides Listeria vaccine strains that express a heterologous antigen and a metabolic enzyme, and methods of generating same.
2017/0028044 Compositions And Methods For Viral Cancer Neoepitopes
Methods and compositions for preparation and use of recombinant viruses or other recombinant expression systems are presented in which neoepitopes are first...
2017/0028043 Iterative Discovery Of Neoepitopes And Adaptive Immunotherapy And Methods Therefor
Contemplated cancer treatments comprise recursive analysis of patient-, cancer-, and location-specific neoepitopes from various biopsy sites of a patient after...
2017/0028042 T Cell Expansion
A method of treating a cancer in a subject is disclosed, comprising: (1) isolating T cells from a subject; generating or expanding a population of T cells...
2017/0028041 HLA-A2 TUMOR ASSOCIATED ANTIGEN PEPTIDES AND COMPOSITIONS
A peptide or composition comprising at least one HLA-A2 epitope or analog from CEA, HER2/neu, MAGE2, MAGE3, or p53.
2017/0028039 DNA VACCINES AND METHODS FOR THE PREVENTION OF TRANSPLANTATION REJECTION
Methods for preventing, delaying the onset of, or treating rejection of an allograft using a DNA vaccine, where the vaccine can comprise a polynucleotide...
2017/0028038 COMPOSITIONS AND METHODS OF USING CHONDROITINASE ABCI MUTANTS
The present disclosure relates to protein and nucleic acid mutants of chondroitinase ABCI. Such nucleic acid mutants encode for chondroitinase ABCI mutant...
2017/0028037 REDUCED-PRESSURE TREATMENT SYSTEMS AND METHODS EMPLOYING DEBRIDEMENT MECHANISMS
Reduced-pressure treatment systems and methods are disclosed that employ debridement mechanisms to remove unwanted tissue. In one instance, a reduced-pressure...
2017/0028036 TREATMENT OF HYPERBILIRUBINEMIA
The invention relates to a nucleic acid sequence useful in the treatment of hyperbilirubinemia, in particular in the treatment of Crigler-Najjar syndrome. More...
2017/0028035 Peptide Having Fibrosis Inhibitory Activity and Composition Containing Same
The present invention relates to a composition for inhibiting fibrosis and more specifically, to a composition for inhibiting fibrosis, wherein the composition...
2017/0028034 MUTANT HUNTINGTIN-MEDIATED PROTEIN DYSFUNCTION
The present invention relates to methods of inhibiting neurodegeneration in a subject suffering from or genetically at risk and/or destined to develop...
2017/0028033 ECZEMA TREATMENT
A method of a composition including lactoferrin and/or immunoglobulin for minimizing the severity of one or more symptoms associated with eczema.
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