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Patent # Description
2017/0044555 RECOMBINANT RNA PARTICLES AND METHODS OF PRODUCING PROTEINS
The present invention provides compositions and methods for the production and delivery of recombinant double-stranded RNA molecules (dsRNA) encoding...
2017/0044553 MICROORGANISMS PRODUCING L-AMINO ACIDS AND PROCESS FOR PRODUCING L-AMINO ACIDS USING THE SAME
Disclosed are a recombinant microorganism having enhanced L-amino acid producibility, wherein the recombinant microorganism is transformed to have an...
2017/0044552 Methods for Recombinant Production of Saffron Compounds
Recombinant microorganisms and methods for producing saffron compounds including hydroxy-.beta.-cylcocitral and picrocrocin are disclosed herein. Methods...
2017/0044551 HIGH YIELD ROUTE FOR THE PRODUCTION OF COMPOUNDS FROM RENEWABLE SOURCES
Provided herein are methods, compositions, and non-naturally occurring microbial organism for preparing compounds such as 1-butanol, butyric acid, succinic...
2017/0044550 Polycomb-associated Non-Coding RNAs
This invention relates to long non-coding RNAs (lncRNAs), libraries of those lncRNAs that bind chromatin modifiers, such as Polycomb Repressive Complex 2,...
2017/0044549 SIRNA IN TANDEM EXPRESSION AND USES THEREOF IN TREATING CHRONIC LYMPHOCYTIC LEUKEMIA
Provided is an siRNA in tandem expression and uses thereof in treating chronic lymphocytic leukemia, and particularly, provided are a method of a tandem...
2017/0044548 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER
Some embodiments of the present invention relate to agents and compositions for treating cancer. More embodiments include agents and compositions for...
2017/0044547 PLANT sRNA EXTRACT FOR USE AS AN IMMUNOSUPPRESSIVE AGENT
The present invention relates to a plant sRNA extract for use as an immunosuppressive agent.
2017/0044546 FUNCTIONAL LIGANDS TO TARGET MOLECULES AND METHODS
The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for...
2017/0044545 APTAMER FOR BONDING TO AUTOTAXIN AND INHIBITING BIOLOGICAL ACTIVITY OF AUTOTAXIN, AND USE FOR SAME
The present invention provides an aptamer binding to an autotaxin, which contains a nucleotide sequence represented by the formula: TABLE-US-00001 (SEQ ID...
2017/0044544 OLIGONUCLEOTIDE SPECIFIC UPTAKE OF NANOCONJUGATES
Disclosed are nanoparticles functionalized with an oligonucleotide and a domain, wherein the domain increases cellular uptake of the nanoparticles. The domain...
2017/0044543 COMPOSITIONS AND METHODS TO PROMOTE ERYTHROPOIESIS
Described herein are compositions and methods for enhancing erythropoiesis in an individual in need thereof. Specifically agents that decrease the expression...
2017/0044542 PLANT sRNA EXTRACT OR PLANT miRNA FOR USE AS AN IMMUNOSUPPRESSIVE AGENT
The present invention relates to a plant sRNA extract for use as an immunosuppressive agent and to plant miRNA for use as an immunosuppressive agent.
2017/0044541 miRNAs Enhancing Cell Productivity
The invention relates to a nucleic acid construct comprising at least two different regions, wherein the regions are selected of a first region encoding for at...
2017/0044540 SARNA COMPOSITIONS AND METHODS OF USE
The invention relates to a saRNAs useful in upregulating the expression of a target gene and therapeutic compositions comprising the saRNA. Methods of using...
2017/0044539 OLIGOMERIC COMPOUNDS COMPRISING ALPHA-BETA-CONSTRAINED NUCLEIC ACID
The present disclosure provides oligomeric compounds comprising at least one .alpha.-.beta.-constrained nucleic acid as provided herein. More particularly, the...
2017/0044538 Compositions and Methods for Modulation of SMN2 Splicing in a Subject
Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject.
2017/0044537 CRISPR-BASED COMPOSITIONS AND METHODS OF USE
This invention pertains to modified compositions for use in CRISPR systems, and their methods of use. In particular, length-modified and chemically-modified...
2017/0044536 CRISPR-BASED COMPOSITIONS AND METHODS OF USE
This invention pertains to modified compositions for use in CRISPR systems, and their methods of use. In particular, length-modified and chemically-modified...
2017/0044535 CRISPR-BASED COMPOSITIONS AND METHODS OF USE
This invention pertains to modified compositions for use in CRISPR systems, and their methods of use. In particular, length-modified and chemically-modified...
2017/0044534 METHODS AND MEANS FOR EFFICIENT SKIPPING OF AT LEAST ONE OF THE FOLLOWING EXONS OF THE HUMAN DUCHENNE MUSCULAR...
The invention relates a method wherein a molecule is used for inducing and/or promoting skipping of at least one of exon 43, exon 46, exons 50-53 of the DMD...
2017/0044533 METHODS FOR THE TREATMENT OF LEBER CONGENITAL AMAUROSIS
The present invention relates to a method for treating a Leber congenital amaurosis in a patient harbouring the mutation c.2991+1655 A>G in the CEP290 gene,...
2017/0044532 Methods for Producing Enteroendocrine Cells That Make and Secrete Insulin
Methods are described for producing enteroendocrine cells that make and secrete insulin in a mammal by blocking the expression or biological activity of one or...
2017/0044531 Transposon Activation During Aging and Neuronal Decline
The present invention relates to transposon activation and mobilization, particularly in the brain, during normal aging; reporter systems to detect such...
2017/0044530 tRNA DERIVED SMALL RNAs (tsRNAs) INVOLVED IN CELL VIABILITY
The present invention features compositions and methods relating to tRNA-derived small RNAs (tsRNAs). Provided herein are oligonucleotide compositions that are...
2017/0044529 Methods and Compositions to Modulate RNA Processing
The present disclosure provides methods and compositions to selectively modulate RNA processing. The methods and compositions selectively enhance or repress...
2017/0044528 CROSSLINKED NUCLEOSIDE AND NUCLEOTIDE
Disclosed are bridged nucleosides and nucleotides. The nucleosides of the present invention have a 2',4'-bridged structure and are represented by formula I...
2017/0044527 Novel 2'/3'/5'-(R/S)-Serinyl Functionalized Oligonucleotides
The present invention provides novel chiral serinyl functionalized tethered oligunucleotides i.e. R/S serinyl functionalized tethered oligonucleotides and the...
2017/0044526 LINKAGE MODIFIED OLIGOMERIC COMPOUNDS
The present invention provides oligomeric compounds comprising at least one neutral methoxypropyl phosphonate modified internucleoside linkage. Such oligomeric...
2017/0044525 MULTIPLEXED SINGLE CELL GENE EXPRESSION ANALYSIS USING TEMPLATE SWITCH AND TAGMENTATION
Presented herein are methods and compositions for multiplexed single cell gene expression analysis. Some methods and compositions include the use of droplets...
2017/0044524 METHODS FOR GENERATING POLYMER ARRAYS
The present disclosure provides a polymer array comprising a plurality of polymers, each of which is immobilized at a distinct locations and differs from...
2017/0044523 METHOD FOR RECOVERING TWO OR MORE GENES, OR GENE PRODUCTS, ENCODING AN IMMUNORECEPTOR
The present invention is related to a method for recovering two or more genes, or gene products, or cDNAs, encoding for an immunoreceptor having two or more...
2017/0044522 MIRAC PROTEINS
This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are...
2017/0044521 BIOMASS EXTRACTS AND METHODS THEREOF
The invention provides novel and improved methods that allow effective capture of valuable active ingredients in biomass (e.g., DDGS) at cost-effective...
2017/0044520 EVOLUTION OF SITE-SPECIFIC RECOMBINASES
Some aspects of the present disclosure provide methods for evolving recombinases to recognize target sequences that differ from the canonical recognition...
2017/0044519 A NOVEL AFFINITY MATRIX AND DEVICES FOR ISOLATION AND PURIFICATION OF RNA AND DNA FOR POINT OF CARE MOLECULAR...
The present disclosure relates to nucleic acid extraction and purification methods and devices to accomplish the same. The present disclosure proposes a novel...
2017/0044518 RAPID SOLID PHASE EXTRACTION DEVICE AND METHODS
A method and system for solid phase extraction of a compound of interest from a sample matrix using a syringe having a barrel and a plunger, a sorbent for use...
2017/0044517 ACOUSTOPHORETIC SEPARATION TECHNOLOGY USING MULTI-DIMENSIONAL STANDING WAVES
A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the...
2017/0044516 BIOCHEMISTRY REACTIVE MATERIAL AND DEVICE FOR ELIMINATING ELECTRONEGATIVE LOW-DENSITY LIPOPROTEIN (LDL) AND...
The present disclosure provides a biochemistry reactive material, including a substrate and an enzyme composition immobilized on the substrate. The enzyme...
2017/0044515 ASX-SPECIFIC PROTEIN LIGASE
The present invention is directed to enzymes having Asx-specific ligase and cyclase activity and to nucleic acids encoding those as well as methods of the...
2017/0044514 ENGINEERED PRIMATE L-METHIONINASE FOR THERAPEUTIC PURPOSES
Methods and compositions relating to the engineering of an improved protein with methionine-.gamma.-lyase enzyme activity are described. For example, in...
2017/0044513 PROTEIN DEAMIDASE
A novel protein deamidase having an activity of directly acting on a side chain amide group of an asparagine residue in a protein to form a side chain carboxyl...
2017/0044512 Chimeric Clotting Factors
Chimeric clotting factors which localize the therapeutic to sites of coagulation (e.g., by being targeted to platelets or being activatable at sites of...
2017/0044511 PULLULANASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
The present invention relates to pullulanase variants having increased thermoactivity and comprising substitutions of the parent pullulanase at one or more...
2017/0044510 COLD-ACTIVE ALPHA-AMYLASE
There is provided a novel cold-active alpha-amylase identified by a functional metagenomic approach expressed in E. coli and purified to homogeneity....
2017/0044509 AMYLASE VARIANTS
The present invention pertains to the field of amylases, particularly alpha-amylases, and compositions comprising such amylases. Also described are means and...
2017/0044508 COMPOSITIONS AND METHODS OF ENGINEERED CRISPR-CAS9 SYSTEMS USING SPLIT-NEXUS CAS9-ASSOCIATED POLYNUCLEOTIDES
The present specification discloses engineered Type II CRISPR-Cas9 systems comprising split-nexus Cas9-associated polynucleotides (sn-casPNs), including...
2017/0044507 MODIFIED RNASE H ENZYMES AND THEIR USES
The invention provides a provides improvements to assays that employ RNase H cleavage for biological applications related to nucleic acid amplification and...
2017/0044506 cDNA SYNTHESIS USING A REVERSIBLY INACTIVATED REVERSE TRANSCRIPTASE
The present invention provides compositions and methods for a reverse transcription reaction using a reversibly inactivated reverse transcriptase enzyme. The...
2017/0044505 MUTATED LUX OPERON SEQUENCES
The present disclosure relates to mutated genes of the LUX operon and their use in producing autoluminescent plants and bacteria exhibiting improved light output.
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