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Patent # Description
2017/0044250 Antibodies, Uses & Methods
The present invention relates to anti-human OX40L antibodies, new medical uses and methods.
2017/0044249 MULTIPLE-VARIABLE DOSE REGIMEN FOR TREATING TNFalpha-RELATED DISORDERS
Multiple-variable dose methods for treating TNF.alpha.-related disorders, including Crohn's disease and psoriasis, comprising administering TNF.alpha....
2017/0044248 METHODS OF ALTERING BONE GROWTH BY ADMINISTRATION OF SOST OR WISE ANTAGONIST OR AGONIST
The present invention provides a method of promoting local bone growth by administering a therapeutic amount of a Sost antagonist to a mammalian patient in...
2017/0044247 HEAVY CHAIN ONLY ANTIBODIES TO PDGF
Disclosed herein are monospecific HCAb antibodies with antigen-binding specificity to PDGF and bispecific antibodies with antigen-binding specificities to...
2017/0044246 FC-REGION VARIANTS WITH IMPROVED PROTEIN A-BINDING
Herein is reported a polypeptide comprising a first polypeptide and a second polypeptide each comprising in N-terminal to C-terminal direction at least a...
2017/0044245 ANTIBODY PREPARATION METHOD, AND ANTIBODY AND ANTIBODY LIBRARY THUS PREPARED
Provided is a method for preparing antibodies against a protein of interest, through which highly specific antibodies against all proteins can be effectively...
2017/0044244 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS BY INTRANASAL ADMINISTRATION OF IMMUNOGLOBULIN G
The present invention provides, among other aspects, methods and compositions for treating a central nervous system (CNS) disorder by delivering a...
2017/0044243 METHODS OF TREATING CHRONIC PAIN
The invention relates to an anti-CGRP antibody for use in the prevention and/or treatment of chronic pain and/or symptoms of chronic pain, and to a method of...
2017/0044242 LUNG-TARGETING NANOBODIES AGAINST PULMONARY SURFACTANT PROTEIN A AND THEIR PREPARATION
The present invention relates to pharmaceutical and medical technologies, and more particularly to novel nanobodies against pulmonary surfactant protein A...
2017/0044241 Single Chain Intrabodies that Alter Huntingtin Mutant Degradation
Compositions and methods of use are provided for intrabodies that bind and alter the effects of poly-glutamate protein aggregation in poly-glutamate associated...
2017/0044240 CCR5 DISRUPTION OF CELLS EXPRESSING ANTI-HIV CHIMERIC ANTIGEN RECEPTOR (CAR) DERIVED FROM BROADLY NEUTRALIZING...
The present application generally relates to methods of genetically modifying a T-cell comprising a chimeric antigen receptor wherein the T-cell lacks a...
2017/0044239 PHAGE-DISPLAYED ANTIBODY LIBRARIES AND USES THEREOF
Disclosed herein are phage-displayed single-chain variable fragment (scFv) libraries, which comprised a plurality of scFvs with a specific sequence in each...
2017/0044238 ENGINEERING OF IMMUNOGLOBULIN DOMAINS
The present invention provides a single domain antibody (sdAb) scaffold comprising one or more than one non-canonical disulfide bond in the framework region...
2017/0044237 ANTIBODIES AND PROCESSES FOR PREPARING THE SAME
Provided herein are various processes for the improved production of antibody producing organisms, antibody producing tissues, antibody producing cells and...
2017/0044236 Integrin Antagonists
Provided herein are integrin antagonists and methods of using the same. For example, one or more of the compounds or polypeptides provided herein can be used...
2017/0044235 BIOMOLECULE-RELEASING CELL AND SELECTION THEREOF BY MEANS OF A SURFACE PROTEIN
The invention relates, firstly, to a biomolecule-releasing cell characterised by a surface protein with an extracellularly exposed ligation peptide sequence...
2017/0044234 POLYPEPTIDES AND USES THEREOF FOR REDUCING CD95-MEDIATED CELL MOTILITY
The present invention relates to polypeptides and uses thereof for reducing CD95-meditated cell motility. In particular, the present invention relates to a...
2017/0044233 REPERTOIRE OF ALLO-RESTRICTED PEPTIDE-SPECIFIC T CELL RECEPTOR SEQUENCES AND USE THEREOF
The present invention is directed to a kit-of-parts or composition containing nucleic acid sequences coding for high-avidity, allo-restricted TCR, wherein the...
2017/0044232 MUTANT SMOOTHENED AND METHODS OF USING THE SAME
The emergence of mutations in tyrosine kinases following treatment of cancer patients with molecular-targeted therapy represents a major mechanism of acquired...
2017/0044231 NOVEL THIOAMIDE-MODIFIED PEPTIDES AND USES THEREOF
The invention includes a thioamide-modified peptide, wherein the thioamide modification increases the in vivo half-life of the peptide. The invention further...
2017/0044230 LONG-ACTING STABLE PEPTIDE GHRELIN ANALOGS FOR THE TREATMENT OF CACHEXIA
The present invention provides long-acting stable peptide ghrelin analogs of general formulae TABLE-US-00001 (I) ...
2017/0044229 Superagonists, Partial Agonists and Antagonists of Interleukin-2
Novel human interleukin-2 (IL-2) muteins or variants thereof are provided. In particular, provided are IL-2 muteins that have an increased binding capacity for...
2017/0044228 Ligands Modified by Circular Permutation as Agonists and Antagonists
The present invention provides fusion polypeptides comprising polypeptide ligands that are modified by circular permutation and fused to at least one...
2017/0044227 Interleukin 15 as Selectable Marker for Gene Transfer in Lymphocytes
The present invention relates to the use of interleukin-15 (IL-15) as selectable marker for gene transfer, preferably of at least one gene of therapeutic...
2017/0044226 FUSION PROTEINS, POLYNUCLEOTIDES, EXPRESSION VECTORS, AND THEIR USES
Provided are fusion proteins, polynucleotides and expression vectors with therapeutic utility in the prevention and/or treatment of cancer, as well as medical...
2017/0044225 AMYLOID Precursor Protein (APP) Based .beta.-Secretase Inhibitor Peptides, and Methods of Use
The present invention provides fusion peptides, compositions, methods and kits for treating, reducing the risk of, lessening the severity of, preventing, or...
2017/0044224 A PROTEIN SECRETORY FACTOR WITH HIGH SECRETORY EFFICIENCY AND AN EXPRESSION VECTOR COMPRISING THE SAME
The present invention relates to a novel protein secretion factor, a vector including a nucleic acid sequence encoding the protein secretion factor, and a...
2017/0044223 Human Sperm Fibrous Sheath (FS) Proteins: New Target Antigens For Use In Therapeutic Cancer Vaccines And...
Cancer vaccines were demonstrated to be promising strategies for cancer treatment; however these strategies are limited by the paucity of target antigens that...
2017/0044222 Anti-Microbial Coatings and Devices
Compositions and methods for coating medical devices are provided. A coating composition may comprise a tether covalently attached to an anti-microbial...
2017/0044221 TRANSCRIPTION FACTOR GENES AND PROTEINS FROM HELIANTHUS ANNUUS, AND TRANSGENIC PLANTS INCLUDING THE SAME
A polynucleotide having at least 80% sequence identity with the fill-length nucleotide sequence of SEQ ID NO: 1 and substantially identical polynucleotides; an...
2017/0044220 EXPRESSION OF TRIPLE-HELICAL COLLAGEN-LIKE PRODUCTS IN E.COLI
Recombinant bacterial triple-helical collagen-like proteins comprising two or more repetitive sequences of Gly-Xaa-Yaa yielding high-stability polymeric...
2017/0044219 RED-SHIFTED OPSIN MOLECULES AND USES THEREOF
Compositions and methods for altering cell activity and function by expressing a light-activated ion pump polypeptide in a cell and contacting the cell with...
2017/0044218 Use of a HIV derived accessory protein for the reactivation of latent HIV
The present invention concerns the use of a protein comprising at least a HIV-derived accessory protein tat (trans-activator of transcription) or any...
2017/0044217 PROPHYLACTIC VACCINE AGAINST EGG DROP SYNDROME (EDS)
The present invention is intended to provide an egg drop syndrome (EDS) vaccine that is capable of effectively preventing EDS and can be stably supplied. The...
2017/0044216 COMPOSITIONS AND METHODS TO INCREASE PRODUCTION
Disclosed herein are methods for increasing protein yield and cellular productivity. Chemical agents facilitate host cell production of biological molecules to...
2017/0044215 TAT PROTEIN AND PREPARATION METHOD AND USE THEREOF
Disclosed is a Tat protein, the amino acid sequence of which is shown as SEQ NO: 1, SEQ NO: 2, SEQ NO: 3 and SEQ NO: 4. The Tat protein of the present...
2017/0044214 SELECTIVE DELIVERY MOLECULES AND METHODS OF USE
Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells...
2017/0044213 METHOD FOR IDENTIFYING NOVEL MINOR HISTOCOMPATIBILITY ANTIGENS
A novel method for human minor histocompatibility antigen (MiHA) discovery, novel MiHAs identified using this method, as well as uses of the novel MiHAs, are...
2017/0044212 COMPOUND FOR TREATING SEQUELAE OF ISCHEMIC CEREBRAL STROKE
The present invention provides a compound (I) for treating sequelae of ischemic cerebral stroke: ...
2017/0044211 Wash solution comprising arginine for the affinity chromatography step in antibody purification
The invention provides a washing method for affinity chromatography in which a wash solution comprising arginine, or an arginine derivative, and a nonbuffering...
2017/0044210 METHODS FOR THE PURIFICATION OF PROTEINS USING CAPRYLIC ACID
A protein purification process with virus inactivation or removal uses caprylic acid (octanoic acid) at acidic pH. The method comprises caprylic acid treatment...
2017/0044209 METHOD FOR REDUCING THE DNA CONTENT OF A FERMENTATION BROTH
A method for reducing the level of DNA in a fermentation broth is disclosed where the method includes a heating step where the broth is heated to a temperature...
2017/0044208 SELECTIVE GLUCOCORTICOID RECEPTOR LIGANDS
Described herein are certain steroid derivative compounds, for example of formula (I): wherein X.sup.1, X.sup.2, X.sup.3 L, and Ar are as defined herein,...
2017/0044207 PROCEDURE FOR THE PREPARATION OF ABIRATERONE ACETATE AND INTERMEDIATES THEREOF
Disclosed is a process for the preparation of abiraterone and abiraterone acetate with high yields and purity. A key element of the method is the isolation of...
2017/0044206 CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
A class of polycyclic compounds of general formula (I), of general formula (I'), or of general formula (I''), wherein Base.sup.1, Base.sup.2, Y, Y.sup.a,...
2017/0044205 3'-SUBSTITUTED METHYL OR ALKYNYL NUCLEOSIDES NUCLEOTIDES FOR THE TREATMENT OF HCV
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments,...
2017/0044204 METHOD FOR THE SYNTHESIS OF CLOFARABINE
The present invention relates to a method for the high yield production of the anticancer nucleoside clofarabine, the method comprising the preparation of...
2017/0044203 PURINE DERIVATIVES AS CD73 INHIBITORS FOR THE TREATMENT OF CANCER
Provided are novel compounds, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are inhibitors of CD73 and are useful...
2017/0044202 PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF
The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and...
2017/0044201 PROCESS FOR EXTRACTION OF SAPONINS FROM AGRICULTURAL PRODUCTS
A process for the extraction and concentration of saponins from agricultural feedstocks. An agricultural feedstock can undergo a first preparation step...
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