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Patent # Description
2017/0044149 PHARMACEUTICAL SALTS OF AN OREXIN RECEPTOR ANTAGONIST
The invention is directed to pharmaceutically acceptable salts of suvorexant, which is an antagonist of orexin receptors. The pharmaceutically acceptable salts...
2017/0044148 GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are...
2017/0044147 GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are...
2017/0044146 GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are...
2017/0044145 MORPHOLIN-PYRIDINE DERIVATIVES
The present invention relates to compounds of formula of formula I wherein X, R, L, Ar, R.sup.1 and n are as described herein, compositions containing...
2017/0044144 SELECTIVE HDAC1 AND HDAC2 INHIBITORS
Provided herein are compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or...
2017/0044143 ISOINDOLINE-1-ONE DERIVATIVES AS CHOLINERGIC MUSCARINIC M1 RECEPTOR POSITIVE ALLOESTERIC MODULATOR ACTIVITY FOR...
The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the...
2017/0044142 NOVEL COMPLEXES FOR THE SEPARATION OF CATIONS
Complexes including a solid support and a material with a matrix structure containing domains complexing rare earth or strategic metals, preparation process...
2017/0044141 ALKYNE-, AZIDE- AND TRIAZOLE-CONTAINING FLAVONOIDS AS MODULATORS FOR MULTIDRUG RESISTANCE IN CANCERS
A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (Az...
2017/0044140 BRIDGED RING COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
Provided herein is a bridged bring compound of formula (I) or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically...
2017/0044139 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described...
2017/0044138 CGRP RECEPTOR ANTAGONISTS
The present invention provides a compound of Formula II: ##STR00001## or a pharmaceutically acceptable salt thereof.
2017/0044137 Omeprazole sodium semihydrate and preparation method thereof
It discloses Omeprazole Sodium semihydrate and preparation method thereof, wherein every mole of Omeprazole Sodium semihydrate contains 0.5 mole of water, and...
2017/0044136 Pyridinoylpiperidines As 5-HT1F Agonists
The present invention relates to compounds of formula I: ##STR00001## or pharmaceutically acceptable acid addition salts thereof, where; R.sup.1 is...
2017/0044135 PROCESS FOR PREPARING 3-[(4S)-8-BROMO-1-METHYL-6-(2-PYRIDINYL)-4H-IMIDAZO[1,2-A][1,4]BENZODIAZE- ...
The invention concerns a new process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiaze- pine-4-yl]-propionic acid methyl...
2017/0044134 PROCESS FOR THE PREPARATION OF 3-(3-CHLORO-1H-PYRAZOL-1-YL)PYRIDINE
3-(3-chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-dihydrochloride with a dialkyl maleate to provide an alkyl...
2017/0044133 NOVEL 2-AMINO-PYRIDINE AND 2-AMINO-PYRIMIDINE DERIVATIVES AND MEDICINAL USE THEREOF
Provided is a compound superior in an autotaxin inhibitory action and the like, effective as a prophylactic or therapeutic drug for diseases involving ATX. The...
2017/0044132 HETEROCYCLIC COMPOUND
The present invention provides a heterocyclic compound having a CDK8 and/or CDK19 inhibitory effect. The present invention provides a compound represented by...
2017/0044131 TRIAZOLE AGONISTS OF THE APJ RECEPTOR
Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the...
2017/0044130 AGONISTS THAT ENHANCE BINDING OF INTEGRIN-EXPRESSING CELLS TO INTEGRIN RECEPTORS
A method of enhancing binding of cells to an integrin-binding ligand comprises treating integrin-expressing cells in vitro with an agonist of integrin, wherein...
2017/0044129 METHOD FOR PREPARING CANAGLIFLOZIN INTERMEDIATE 2-(2-METHYL-5-BROMOBENZYL)-5-(4-FLUOROPHENYL)THIOPHENE
Provide in the present invention is a method for preparing canagliflozin intermediate 2-(2-methyl-5-bromobenzyl)-5-(4-fluorobenzene)thiophene. The method...
2017/0044128 Carbonated Estolides And Methods Of Making And Using The Same
Disclosed herein are the conversion of estolide compounds having unsaturated fatty acid groups into estolides containing cyclic carbonate moieties and methods...
2017/0044127 ICARIIN DERIVATIVES
Disclosed are derivatives of icariin. Disclosed are compounds having Formula I-VIII as defined herein. Methods of using these compounds for the treatment of...
2017/0044126 PROCESS FOR MAKING BERAPROST
A method is described for making single isomers of synthetic beraprost diol, a key intermediate for making 314-d isomer of beraprost. The method requires fewer...
2017/0044125 Catalytic Converter Arrangement with Optimized Surface for Producing Phthalic Anhydride
A catalytic converter arrangement for producing phthalic anhydride by means of a gas phase oxidation of aromatic hydrocarbons, comprising a reactor with a gas...
2017/0044124 BIOREFINING COMPOUNDS AND ORGANOCATALYTIC UPGRADING METHODS
The invention provides new methods for the direct umpolung self-condensation of 5-hydroxymethylfurfural (HMF) by organocatalysis, thereby upgrading the readily...
2017/0044123 SYNTHESIS OF R-GLUCOSIDES, SUGAR ALCOHOLS, REDUCED SUGAR ALCOHOLS, AND FURAN DERIVATIVES OF REDUCED SUGAR ALCOHOLS
Disclosed herein are methods for synthesizing 1,2,5,6-hexanetetrol (HTO), 1,6 hexanediol (HDO) and other reduced polyols from C5 and C6 sugar alcohols or R...
2017/0044122 Oxaspiro[2.5]Octane Derivatives and Analogs
The invention provides oxaspiro[2.5]octane derivatives and analogs, methods for preparation thereof, intermediates thereto, pharmaceutical compositions, and...
2017/0044121 TETRA-O-SUBSTITUTED BUTANE-BRIDGE MODIFIED NDGA DERIVATIVES, THEIR SYNTHESIS AND PHARMAECUTICAL USE
The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and...
2017/0044120 ORGANO-1-OXA-4-AZONIUM CYCLOHEXANE COMPOUNDS
Novel 1-oxa-4-azonium cyclohexane salts are described. These compounds can be used as structure directing agents, and they overcome many of the typical...
2017/0044118 SALT COMPOUND
A salt compound, and methods for mitigating neurodegeneration, effecting, neuroprotection and/or effecting cognition enhancement in a subject using the salt...
2017/0044117 SEMICARBAZIDE-SENSITIVE AMINE OXIDASE INHIBITORS FOR USE AS ANALGESICS IN TRAUMATIC NEUROPATHY AND NEUROGENIC...
The invention relates to a compound having SSAO/VAP-1 inhibitor activity for use in the treatment of hyperalgesia and allodynia implicated in traumatic...
2017/0044116 PROCESS FOR THE PREPARATION OF SUBSTITUTED CYCLOSERINES
The present invention relates to processes for the preparation of substituted cycloserine compounds of formula (I) wherein R.sup.1 is C.sub.1-C.sub.8alkyl,...
2017/0044115 NOVEL DISUBSTITUTED 1, 2, 4-TRIAZINE COMPOUND
This invention provides a novel disubstituted 1,2,4-triazine compound or a pharmaceutically acceptable salt thereof, which has an aldosterone synthetase...
2017/0044114 Diaminotriazine compounds and their use as herbicides
The present invention relates to diaminotriazine compounds and to their use as herbicides. It also relates to agrochemical compositions for crop protection and...
2017/0044113 NOVEL ALKYLATED DIPHENYLAMINE DERIVATIVES OF TRIAZOLE AND LUBRICATING COMPOSITIONS CONTAINING THE SAME
Novel compounds are described, being alkylated diphenylamine derivatives of triazole, wherein the alkyl group on at least one of the phenyl groups is C8 or...
2017/0044112 HYDROPHOBICALLY TAGGED JANUS KINASE INHIBITORS AND USES THEREOF
The present invention provides Janus kinase inhibitors, such as compounds of Formula (I) and Formula (II) wherein R.sup.Y1 and R.sup.Y2 comprise a tagged...
2017/0044111 JANUS KINASE INHIBITORS AND USES THEREOF
The present invention provides kinase inhibitors, such as compounds of Formula (I) and Formula (II). The compounds may covalently or non-covalently bind a...
2017/0044110 Pyrimidine Compounds and Use as Anti-Cervical Cancer Thereof
Provided is use of a pyrimidine compound or a pharmaceutically acceptable salt thereof in preparation of an anti-cervical cancer medicament. Research of the...
2017/0044109 SULFONYL HYDRAZIDE COMPOUNDS AND A REGIO-SELECTIVE PROCESS TO PREPARE 4-AROYL PYRAZOLE DERIVATIVES
Disclosed are compounds of Formula I, including all stereoisomers, (N-oxides), and salts thereof, wherein A and R are as defined in the disclosure. ...
2017/0044108 S-Crystal Form of Ivabradine Hydrochloride, and Preparation Method and Pharmaceutical Composition Thereof
Disclosed are a new S crystal form of ivabradine hydrochloride, and preparation method and pharmaceutical composition thereof. The S crystal form of ivabradine...
2017/0044107 Inhibitors of JMJD2C as Anticancer Agents
The present disclosure provides compounds, pharmaceutical compositions and related methods for the treatment of cancer, e.g., castration-resistant prostate...
2017/0044106 Crystalline Solid Forms of N--N'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, Processes for Making, and...
The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl- )...
2017/0044105 PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS
4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and...
2017/0044104 NEW PESTICIDAL COMPOUNDS AND USES
The invention relates to the use of known and novel phenalkyl carboxamide derivatives of the formula (I) ##STR00001## wherein the structural elements have the...
2017/0044103 ANTI-VASCULATURE AND ANTI-TUBULIN COMBRETASTATIN ANALOGS FOR TREATMENT OF CANCER
Combretastatins analog compounds and their pharmaceutically acceptable salts are presented, as well as pharmaceutical compositions comprising the...
2017/0044102 New Method for Preparing Isofagomine and Its Derivatives
A method for preparing isofagomine, its derivatives, intermediates and salts thereof using novel processes to make isofagomine from D-(-)-arabinose and...
2017/0044101 SALTS OF AN LSD1 INHIBITOR
The present disclosure relates to tosylate salts 1-{[4-(methoxymethyl)-4-({[(1R,2S)-2-phenylcyclopropyl]amino}methyl)piper- ...
2017/0044100 INHIBITORS OF DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS
The present invention provides novel indoleamide compounds for treating tuberculosis, including drug-resistant M-tuberculosis, compositions comprising the...
2017/0044099 COVALENTLY PATTERNED GRAPHENE SURFACES BY A FORCE ACCELERATED CYCLOADDITION REACTION
The present invention relates generally to molecular printing techniques for use in sensors, assays, and integrated optics and electronics. Specifically, the...
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