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Patent # Description
2017/0050984 HISTONE DEACETYLASE INHIBITORS
This invention relates to generally inhibiting histone deacetylase ("HDAC") enzymes (e.g., HDAC1, HDAC2, and HDAC3).
2017/0050983 METHOD FOR PRODUCING INHIBITOR OF ACTIVATED BLOOD COAGULATION FACTOR X (FXA)
An object of the present invention is to provide a novel method for producing a compound, a salt thereof, or a hydrate of the compound or the salt, which is an...
2017/0050982 NEW CRYSTALLINE FORM OF CEFAMANDOLE SODIUM COMPOUND, FORMULATION AND PREPARATION METHOD THEREOF
A novel crystalline form is defined by diffraction angle 2.theta..degree. of X-ray powder diffraction pattern and characteristic peak of differential scanning...
2017/0050981 MARINOPYRROLE DERIVATIVES AND METHODS OF MAKING AND USING SAME
Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents...
2017/0050980 OXADIAZINE COMPOUNDS AND METHODS OF USE THEREOF
The present disclosure relates to oxadiazine compounds, pharmaceutical compositions comprising an effective amount of an oxadiazine compound and methods for...
2017/0050979 SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASES POLYPEPTIDES
This document relates to inhibitors of G protein coupled receptor 6 kinase (GRK6) polypeptides as well as methods and materials for using such inhibitors to...
2017/0050978 Monocyclic, Thieno, Pyrido, and Pyrrolo Pyrimidine Compounds and Methods of Use and Manufacture of the Same
The present invention provides a compound of Formula I: ##STR00001## wherein R is H, a methyl group, an ethyl group, a n-propyl group, an iso-propyl group, or a...
2017/0050977 METHOD FOR SYNTHESIZING MILBEMYCIN OXIME
The present invention provides a method for synthesizing Milbemycin oxime. The method comprises the following steps. (1) Oxidizing reaction: oxidizing...
2017/0050976 TETRANDRINE FAMILY PHARMACEUTICAL FORMULATIONS AND METHOD
Drug formulations, methods and their use in treatment of diseases using formulations of pure di-acid salts of tetrandrine family members, especially...
2017/0050975 TETRANDRINE FAMILY PHARMACEUTICAL FORMULATIONS AND METHOD
Drug formulations, methods and their use in treatment of diseases using formulations of pure di-acid salts of tetrandrine family members, especially...
2017/0050974 HETEROCYCLIC COMPOUND
The present invention relates to compound (I) or a salt thereof which has a ROR.gamma.t inhibitory action. ##STR00001## wherein each symbol is as defined in the...
2017/0050973 TETRAHYDROOXEPINOPYRIDINE COMPOUND
[Problem] Provided is a compound having a positive allosteric modulating activity (PAM activity) on an .alpha.7 nicotinic acetylcholine receptor (.alpha.7 nACh...
2017/0050972 PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their...
2017/0050971 PYRROLOBENZODIAZEPINE COMPOUNDS
The invention relates to pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) of formula (I) and in particular to PBD dimers linked through the C1 position, and PBD...
2017/0050970 INHIBITORS OF BRUTON'S TYROSINE KINASE
Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition,...
2017/0050969 NOVEL CRYSTAL OF DORIPENEM, AND PREPARATION METHOD THEREFOR
This invention relates to a novel doripenem crystal, a solvate thereof, and a preparation method thereof and, more specifically, to a novel doripenem anhydride...
2017/0050968 BROMODOMAIN INHIBITOR
The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and...
2017/0050967 GANCICLOVIR DERIVATIVES FOR MODULATING INNATE AND ADAPTIVE IMMUNITY AND FOR USE IN IMMUNOTHERAPY
Compositions and methods for modulating innate and adaptive immunity and for use in immunotherapy are disclosed. In particular, the invention relates to novel...
2017/0050966 INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL
The present invention relates to compounds of the Formula (I), or a pharmaceutically acceptable salt, pharmaceutical preparation, or pharmaceutical composition...
2017/0050965 New Compounds
The invention relates to a compound of formula (I) wherein the variables have the meaning as indicated in the claims; in free form and in salt form; and...
2017/0050964 LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS
The present application describes lactam-containing compounds and derivatives thereof of Formula I: P.sub.4--P-M-M.sub.4 I or pharmaceutically acceptable salt...
2017/0050963 MICROBICIDALLY ACTIVE IMIDAZOPYRIDINE DERIVATIVES
The present invention provides compounds of formula (I) ##STR00001## wherein Y.sup.1, Y.sup.2, Y.sup.3, G, V.sup.1, V.sup.2, V.sup.3 and V.sup.4 are as defined...
2017/0050962 IMIDAZO[1,2-A]PYRIDINES AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE FOR TREATING CARDIOVASCULAR DISEASES
The present application relates to novel heterocyclyl- and heteroaryl-substituted imidazo[1,2-a]pyridines, to processes for preparation thereof, to the use...
2017/0050961 IMIDAZO[1,2-A]PYRIDINES AS SOLUBLE GUANYLATE CYCLASE STIMULATORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES
The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or...
2017/0050960 NEW BICYCLIC DERIVATIVES
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, Y, A, W, R.sup.2, m, n, p and q are as described herein, ...
2017/0050959 HETEROARYL-SUBSTITUTED 1,3-DIHYDROINDOL-2-ONE DERIVATIVES AND MEDICAMENTS CONTAINING THEM
The present invention relates to novel 1,3-dihydroindol-2-one (oxindole) derivatives of the formula (I) ##STR00001## in which A, R.sup.3, R.sup.4, R.sup.5,...
2017/0050958 Cycloalkyl-Linked Diheterocycle Derivatives
The present invention relates to compounds of formula (I) ##STR00001## or pharmaceutically acceptable salts thereof, wherein A, L, D, R.sup.1-R.sup.15, w, x,...
2017/0050957 4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-(HETEROCYCLIC)PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS ...
4-Amino-6-(heterocyclic)picolinic acids and their derivatives; 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their derivatives; and methods of using...
2017/0050956 PIPERAZINE DERIVATIVES FOR TREATING DISORDERS
Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of...
2017/0050955 OXAZOLIDINE-BASED COMPOUND AND SELECTIVE ANDROGEN RECEPTOR AGONIST COMPRISING SAME
Provided are novel selective androgen receptor agonists, a preparation method thereof, and a pharmaceutical composition including the same at a ...
2017/0050954 Diaminotriazine Compounds as Herbicides
The present invention relates to diaminotriazine compounds and to their use as herbicides. The present invention also relates to agrochemical compositions for...
2017/0050953 PYRIDAZINONE HERBICIDES
Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, ##STR00001## wherein X is O, S or NR.sup.5; or X is...
2017/0050952 NOVEL ANNELATED BENZAMIDES
The present invention relates to compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, and Z.sup.- have one of the meanings as indicated in the...
2017/0050951 TRIAMINOPYRIMIDINE COMPOUNDS USEFUL FOR PREVENTING OR TREATING MALARIA
The present invention relates to triaminopyrimidines and to pharmaceutically acceptable salts thereof, to their use in the treatment and/or prevention of...
2017/0050950 AROMATIC HETEROCYCLIC COMPOUND
The compound represented by the general formula: wherein ring A is benzene which may be substituted and the like; ring B is benzene which may be substituted...
2017/0050949 URACIL DERIVATIVES AS AXL AND C-MET KINASE INHIBITORS
The present application provides compounds of Formula I ##STR00001## or salt forms thereof, wherein R.sub.a, R.sub.b, R.sub.c, R.sub.d, D, W, R.sub.1a, R.sub.1b,...
2017/0050948 Process for the Synthesis of Dabigatran Etexilate and Its Intermediates
The present invention describes an improved process for the preparation of Dabigatran Etexilate (Formula-VII) or it's pharmaceutically acceptable salt for the...
2017/0050947 MELDRUM'S ACID, BARBITURIC ACID AND PYRAZOLONE DERIVATIVES SUBSTITUTED WITH HYDROXYLAMINE AS HNO DONORS
The disclosed subject matter provides certain N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds,...
2017/0050946 ANTIMICROBIALS FROM AN EPIGENETICS BASED FUNGAL METABOLITE SCREENING PROGRAM
Novel antimicrobial compounds and associated methods of development are presented herein.
2017/0050945 COMPOSITIONS AND METHODS FOR THE TREATMENT OF SARCOIDOSIS
Compounds, methods, compositions and kits for treating a patient with pulmonary sarcoidosis are provided. The compositions are formulated for delivery to a...
2017/0050944 SYNTHESIS OF FDCA AND FDCA PRECURSORS FROM GLUCONIC ACID DERIVATIVES
The present invention provides methods of method of synthesizing 2,5-furan dicarboxylic acid (FDCA) and FDCA precursor molecules. The methods involve...
2017/0050943 METHOD FOR PRODUCING FURFURAL, AND METHOD FOR PRODUCING FURAN
A problem is to provide an industrially advantageous method in which in purifying a furfural composition, the formation of a solid matter which have been...
2017/0050942 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS
The present invention relates to 3-cycloalkylaminopyrrolidine derivatives of the formula I: ##STR00001## (wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5,...
2017/0050941 NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS
Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in...
2017/0050940 SURFACE-MODIFYING AGENT AND ARTICLE USING SAME
Provided are a surface-modifying agent that enables production of a coating film that preserves transparency of a substrate while displaying high water...
2017/0050939 SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES
This document relates to inhibitors of G protein coupled receptor 6 kinase (GRK6) polypeptides as well as methods and materials for using such inhibitors to...
2017/0050938 SUBSTITUTED QUINOXALINES AS B-RAF KINASE INHIBITORS
Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
2017/0050937 COMPOUNDS AND THERAPEUTICAL USE THEREOF
Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are...
2017/0050936 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
Chemical entities that are effective as kinase inhibitors, pharmaceutical compositions and methods of treatment are disclosed. The chemical entities disclosed...
2017/0050935 HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF E1 ACTIVATING ENZYMES
This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the...
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