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TRANSLOCATION OF NON-NATURAL CHEMICAL ENTITIES THROUGH ANTHRAX PROTECTIVE
Disclosed is a new approach for delivering compounds and drugs to the cytosol of living cells through the use of engineered protein transporters. The...
METHODS FOR MAINTAINING PEGYLATION OF POLYPEPTIDES
Described herein are methods for maintaining PEGylation and inhibiting dePEGylation of polypeptides, such as fibronectin-based scaffold proteins, during storage.
POLYALKYLENE POLYMER COMPOUNDS AND USES THEREOF
The invention relates to novel polyalkylene glycol compounds and methods of using them. In particular, compounds comprising a novel polyethylene glycol...
COMPLEXING AGENTS FOR COMPOSITIONS CONTAINING INCLUSION COMPLEXES
The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent....
Polythioaminals and Uses Thereof
Polythioaminal polymers are made from hexahydrotriazine precursors and dithiol precursors. The precursors are blended together and subjected to mild heating to...
BIS-POLYMER LIPID-PEPTIDE CONJUGATES AND NANOPARTICLES THEREOF
The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer...
CATIONIC POLYSACCHARIDES FOR DELIVERY OF PHOSPHOINOSITIDES TO CELLS FOR
The present invention provides a complex comprising at least one phosphoinositide and at least one positively charged modified polysaccharide, pharmaceutical...
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a...
INFLUENZA ANTIGEN DELIVERY VECTORS AND CONSTRUCTS
The present invention relates to fluorocarbon vectors for the delivery of influenza antigens to immunoresponsive target cells. It further relates to...
Provided are conjugates between p97 (melanotransferrin) and polynucleotides such as small interfering RNA (siRNA) molecules, and related compositions and...
HYDROGELS OF METHACRYLIC HYALURONIC ACID DERIVATIVES FOR ORAL ENZYME
THERAPY IN CELIAC DISEASE
The present invention relates to a composition comprising hydrogels from functionalized hyaluronic acid derivatives, said hydrogels loaded with exogenous...
A stable pharmaceutical formulation is provided that comprises a biologically active protein and an excipient selected from carnitine, creatine or creatinine.
LYOPHILIZED PREPARATION OF CYTOTOXIC DIPEPTIDES
The present invention is directed to novel lyophilized pharmaceutical preparations comprising a cytotoxic dipeptides such as melphalan flufenamide and one or...
CAROTENOID PARTICLES AND USES THEREOF
This invention relates to the incorporation of bioactive cargo molecules into particles with carotenoids, such as lycopene. The incorporation of a cargo...
PROCESS FOR PRODUCING OF INORGANIC PARTICULATE MATERIAL
The present invention is directed to a process for producing inorganic particulate material, the material obtainable by such process, a modified release...
5-AMINOLEVULINIC ACID CONJUGATED QUANTUM DOT NANOPARTICLE
A 5-aminolevulinic acid conjugated quantum dot nanoparticle is useful for treating cancer by administering the 5-aminolevulinic acid conjugated quantum dot...
BIOCERAMIC COMPOSITIONS AND BIOMODULATORY USES THEREOF
The subject matter described herein is directed to articles, compositions, systems, and methods of using and preparing bioceramic compositions and to the...
Method for treating infectious diseases using emissive energy
The present invention relates to the treatment of infectious diseases, specifically by extracorporeally eradicating the pathogen. This invention comprises...
HIGH CONCENTRATION ANTIBODY AND PROTEIN FORMULATIONS
The present application relates to highly concentrated antibody and protein formulations with reduced viscosity that are stable, relatively isotonic and are of...
METHODS OF PERMITTING A SUBJECT TO RECEIVE MULTIPLE DOSES OF RECOMBINANT
Provided herein are compositions, kits and methods related to permitting a human or non-human primate subject to receive multiple doses of recombinant...
METHODS FOR REDUCING OR ELIMINATING THE NEED FOR LIPOPROTEIN APHERESIS IN
PATIENTS WITH HYPERLIPIDEMIA BY...
The present invention provides methods for reducing or eliminating a patient's need for lipoprotein apheresis therapy. The methods of the present invention...
COMBINATION THERAPY OF ANTI-MIF ANTIBODIES AND CHEMOTHERAPEUTICS
The present invention pertains to anti-MIF antibodies, in particular their use in combination with cancer therapeutics, i.e. chemotherapeutics, in the...
USE OF ANTI-CCR5 ANTIBODIES IN GRAFT VERSUS HOST DISEASE
This composition and method provides for a method for reducing GVHD in a human subject which comprises administering to the subject at a predefined interval...
SYNTHETIC HAPTEN CARRIER COMPOSITIONS AND METHODS
The present disclosure relates to peptide monomers comprising an amphipathic ?-helical peptide, and optionally, at least one T cell epitope peptide; and to...
LIPID VESICLE COMPOSITIONS AND METHODS OF USE
The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use...
EPITOPES CROSS-REACTIVE BETWEEN HSV-1, HSV-2 AND VZV AND METHODS FOR USING
The invention provides epitopes of HSV and VZV that are cross-reactive and are useful for the prevention and treatment of alphaherpesvirus infection. T-cells...
Infectious laryngotracheitis virus (ILTV) vaccine using recombinant
newcastle disease virus vector
In this study, for the first time, protective efficacy of gD against ILTV challenge was evaluated. Immunization with recombinant Newcastle disease virus...
The invention relates to an expression system comprising polynucleotides encoding proteins, wherein the expression system comprises a first polynucleotide...
TREATMENT OF PRDC IN PIGS
The present invention relates to the use of an immunogenic composition comprising a porcine circovirus type 2 (PCV2) antigen for the prevention and treatment,...
WEST NILE VIRUS VACCINE
The invention provides for immunogenic compositions against West Nile Virus. The immunogenic compositions, in alternate embodiments, also include other equine...
TREATMENT OF PIGS WITH PCV2 ANTIGEN
The present invention relates to a method for the treatment or prophylaxis of a PCV2 infection or for reduction of clinical symptoms caused by or associated...
USE OF A PCV2 IMMUNOGENIC COMPOSITION FOR LESSENING CLINICAL SYMPTOMS IN
The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several...
COMPOSITIONS, METHODS AND USES FOR DENGUE VIRUS SEROTYPE-4 CONSTRUCTS
Embodiments herein report compositions, methods and uses for dengue-4 (DENV-4) virus constructs. Some embodiments concern a composition that includes, but is...
Vaccine Candidates Against Johne's Disease
A composition and method for immunizing a mammal infected with Mycobacterium are disclosed. The genes gcpE, pstA, kdpC, papA2, impA, umaA1, fabG2_2, aceAB,...
LIVE SALMONELLA VACCINE AND METHODS TO PREVENT FOWL TYPHOID
We constructed S. Gallinarum strains deleted for the global regulatory gene fur (FIG. 1) and evaluated their virulence and protective efficacy in Rhode Island...
VACCINES BASED ON HEPATITIS B CORE ANTIGENS
The invention provides a protein comprising hepatitis B core antigen (HBcAg) with a sugar attached to an e1 loop. The protein may comprise a first and a second...
Antigen Peptide Derived From the Sequence of Epidermal Growth Factor
Receptor Having T790M Point Mutation
The present application relates to an antigen peptide derived from the sequence of epidermal growth factor receptor having T790M point mutation and a...
Compositions and Methods for Identifying and Targeting Cancer Cells of
Alimentary Canal Origin
Screening and diagnostic reagents, kits and methods for primary and/or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of...
INDOLEAMINE 2,3-DIOXYGENASE BASED IMMUNOTHERAPY
The present invention relates to the field of prophylaxis and therapy of cancer. In particular there is provided a protein Indoleamine 2,3-dioxygenase (IDO) or...
COMPOSITIONS COMPRISING ANGIOGENIC FACTORS AND METHODS OF USE THEREOF
The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor...
Cell Membrane Translocation of Regulated Snare Inhibitors, Compositions
Therefor, and Methods for Treatment of...
Compositions and methods of modulating cellular function and treatment of disease in mammals comprising locally administering a regulated SNARE inhibitor and a...
PROTEOLYTIC EXTRACT FROM BROMELAIN FOR THE TREATMENT OF CONNECTIVE TISSUE
The present invention relates to a proteolytic extract obtained from bromelain for the treatment of connective tissue diseases. In particular, the present...
NOROVIRUS DEACTIVATOR AND METHOD FOR PRODUCING SAME, METHOD FOR
DEACTIVATING NOROVIRUS, METHOD FOR PRODUCING...
Provided is a norovirus deactivator, including a lysozyme component that includes at least one kind selected from lysozyme and/or a salt thereof, and a...
METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING VASO-OCCLUSIVE CRISIS
The present invention relates to methods and pharmaceutical compositions for treating vaso-occlusive crises. In particular, the present invention relates to a...
Enhancing Health in Mammals Using Telomerase Reverse Transcriptase Gene
Methods of treating an age-related disorder in a subject are provided. Aspects of the methods include administering to the subject a nucleic acid vector...
AGENT, PRODUCT AND USE
The present invention relates to a composition for modulating tumor cell dissemination, in particular metastatic cancer cells. In particular, the invention...
FACTOR VIII SEQUENCES
There is provided a nucleic acid molecule comprising a nucleotide sequence encoding for a functional factor VIII protein, wherein the portion of the nucleotide...
STABLE FORMULATIONS FOR PARENTERAL INJECTION OF PEPTIDE DRUGS
Stable formulations for parenteral injection of peptide drugs and methods of using such stable formulations are provided. In particular, the present invention...
PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING CORNEAL WOUND
COMPRISING THYMOSIN BETA 4 AND CITRIC ACID
The present invention relates to a composition for the treatment or prevention of a corneal injury, which comprises thymosin .beta.4, and citric acid or its...
SDF-1 DELIVERY FOR TREATING ADVANCED ISCHEMIC CARDIOMYOPATHY
Provided herein are methods of treating a cardiomyopathy in a subject by administering directly to, or expressing locally in, a weakened, ischemic, and/or...