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Patent # Description
2017/0049754 PHARMACEUTICAL COMPOSITIONS COMPRISING 40 - O - ( 2 - HYDROXY) ETHYL - RAPAMYCIN
The invention relates to extended release pharmaceutical formulations in form of multiparticulates comprising 40-O-(2-hydroxy)ethyl-rapamycin, to dosage forms...
2017/0049753 METHODS AND COMPOSITIONS FOR INCREASING FERTILITY AND/OR INHIBITING PREGNANCY FAILURE AND RESTORING GLUCOSE...
Methods and compositions for enhancing fertility and/or inhibiting pregnancy failure, restoring glucose tolerance and/or preventing glucose intolerance and/or...
2017/0049752 METHODS FOR DOSING AN ORALLY ACTIVE 1,2,4-OXADIAZOLE FOR NONSENSE MUTATION SUPPRESSION THERAPY
The present invention relates to specific doses of and dosing regimens for using a 1,2,4-oxadiazole benzoic acid compound in treating or preventing diseases...
2017/0049751 OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF
A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the...
2017/0049750 Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic Agents
The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and...
2017/0049749 METHODS FOR TREATING BURNS USING ALLANTOIN
Embodiments of the present invention relate generally to compositions comprising an effective amount of allantoin that can be used to treat skin burns. The...
2017/0049748 METHODS AND COMPOSITIONS FOR ENHANCED TRANSUNGUAL DELIVERY OF AR-12
Methods and compositions for enhancing transungual delivery of AR-12 comprising administering AR-12 and permeation enhancers are provided.
2017/0049747 METHODS TO MOBILIZE PROGENITOR/STEM CELLS
Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred...
2017/0049746 USES OF BUTYLIDENEPHTHALIDE
A method for preventing, mitigating and/or inhibiting the growth, migration, invasion and/or metastasis of cancer stem cell (CSC) is provided. The method...
2017/0049745 METHODS AND COMPOSITIONS FOR TARGETING CANCER STEM CELLS
Aspects of the disclosure relate to methods that involve activating the Protein Kinase A (PKA) pathway to induce cancer stem cells (CSCs) to undergo a...
2017/0049744 PREVENTION OR TREATMENT AGENT FOR CEREBRAL AMYLOID BETA STORAGE DISEASES
Provided is a prevention or treatment agent for cerebral amyloid beta storage diseases, that contains a substance capable of suppressing the progression,...
2017/0049743 Methods Of Using Low-Dose Doxepin For The Improvement Of Sleep
Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g.,...
2017/0049742 Method for treating a glycoprotein-related disease
A method for treating a glycoprotein-related disease is disclosed, which comprises: administering a first effective amount of phenol red and a second effective...
2017/0049741 Formulations for Cathepsin K Inhibitors
The instant invention relates to pharmaceutical compositions containing cathespin K inhibitors. Also disclosed are processes for making said pharmaceutical...
2017/0049740 USE OF HISTONE DEACETYLASE INHIBITORS FOR THE CARE OF PHILADELPHIA-NEGATIVE MYELOPROLIFERATIVE SYNDROMES
The use of substances capable of inhibiting one or more enzymes of the histone deacetylase family (histone deacetylase inhibitors) for the therapeutic...
2017/0049739 PROSTACYCLIN COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked...
2017/0049738 INHIBITORS FOR TREATING DISEASES CHARACTERIZED BY ATRIAL ENLARGEMENT OR REMODELING
The present invention relates to the NEP inhibitor pro-drug N-(3-carboxy-1-oxopropyl)-(4S)-p-phenylphenylmethyl)-4-amino-(2R)-methylb- utanoic acid ethyl ester,...
2017/0049737 (2R)-2-PROPYLOCTANOIC ACID FOR FUNCTIONAL BRAIN DISEASE
An agent for preventing or treating a functional brain disease and/or inhibiting symptom development of the functional brain disease includes ...
2017/0049736 CREATINE ORAL SUPPLEMENTATION USING CREATINE HYDROCHLORIDE SALT
The present invention is directed to an oral supplement including creatine hydrochloride, which has an aqueous solubility that is at least 15 times greater...
2017/0049735 BROMFENAC BIOAVAILABILITY
Formulations and methods that provided enhanced bromfenac penetration into ocular tissue when topically administered, compared to the currently available...
2017/0049734 QUANTITATIVE PERI-ORBITAL APPLICATION OF OPHTHALMOLOGY DRUGS
The present invention is directed methods of lowering intraocular pressure in a patient suffering from elevated intraocular pressure or glaucoma and treating...
2017/0049733 METHODS FOR INHIBITING EXPRESSION OF ASC, EXPRESSION OF NLRP3, AND/OR FORMATION OF NLRP3 INFLAMMASOME COMPLEX...
Methods and compositions for inhibiting expression of ASC, expression of NLRP3, and/or formation of NLRP3 inflammasome complex by using diacerein or its...
2017/0049732 ADMINISTRATION OF 6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHOIC ACID FOR THE TREATMENT OF DERMATOLOGICAL...
Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by...
2017/0049731 METHOD OF ADMINISTRATION OF GAMMA HYDROXYBUTYRATE WITH MONOCARBOXYLATE TRANSPORTERS
One embodiment of the present invention is to improve the safety and efficacy of the administration of GHB or a salt thereof to a patient. It has been...
2017/0049730 COMPOSITION FOR PROMOTING REMYELINATION IN NERVE CELLS COMPRISING 2,5-DIHYDROXYBENZENESULFONIC ACID AND USE THEREOF
A method of preventing or treating a disease associated with demyelination of a nerve cell in a mammal, a method of promoting remyelination or suppressing...
2017/0049729 PHARMACEUTICAL FORMULATION FOR REDUCING FREQUENCY OF URINATION AND METHOD OF USE THEREOF
Methods and compositions for reducing frequency of urination are disclosed. The methods comprise administering to a subject having a condition that resulting...
2017/0049728 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE
The invention relates to therapeutic compositions for the treatment of dry eye, more specifically to compositions comprising a TRPM8 receptor agonist ligand....
2017/0049727 Use of N-Acetylcysteine Amide in the Treatment of Acquired Immune Deficiency Syndrome and HIV Infection
This disclosure describes methods of use for N-acetylcysteine amide for the treatment of HIV infection and AIDS.
2017/0049726 METFORMIN IN TREATMENT OF NEUROBLASTOMA
Use of metformin in inhibition of growth and/or viability of human neuroblastoma cells is described. Use of metformin in inhibition of growth and/or viability...
2017/0049725 COMBINATION CANCER TREATMENT
Described herein is TRAIL receptor targeting therapy in combination with metformin for treatment of cancer in humans. Using TRAIL receptor targeting therapy...
2017/0049724 EXTENDED-RELEASE DOSAGE FORM
Provided are pharmaceutical formulations comprising sustained release particles each having an inner core bead comprising an active pharmaceutical ingredient...
2017/0049723 ISOLATED COMPOUNDS FROM TURMERIC OIL AND METHODS OF USE
Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided....
2017/0049722 ALKOXY COMPOUNDS FOR DISEASE TREATMENT
The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and...
2017/0049721 EPINEPHRINE-BASED OPHTHALMIC COMPOSITIONS FOR INTRAOCULAR ADMINISTRATION AND METHODS FOR FABRICATING THEREOF
Pharmaceutical compositions for intraocular injection are described, the compositions comprise therapeutically effective quantity of lyophilized ...
2017/0049720 PROCESS FOR PRODUCING A STABLE LOW CONCENTRATION, INJECTABLE SOLUTION OF NORADRENALINE
In a first aspect, the present invention relates to a process for producing a stable, injectable solution with low content of noradrenaline, which includes...
2017/0049719 METHOD FOR TREATING OR PREVENTING DRY EYE DISORDERS USING ALKYLAMINO-POLYHYDROXYALKANES
Method for the treatment or prophylaxis of dry eye disorders by the administration of alkylamino-polyhydroxyalkanes and compositions thereof.
2017/0049718 DRUG FOR TREATMENT OF TINNITUS PATIENTS
A drug for treatment of patients having tinnitus associated with age-related hearing loss, comprising neramexane or a pharmaceutically acceptable salt thereof.
2017/0049717 DRUG FOR TREATMENT OF TINNITUS PATIENTS
A drug for treatment of patients having tinnitus associated with sudden hearing loss, comprising neramexane or a pharmaceutically acceptable salt thereof,...
2017/0049716 NITISINONE DOSING REGIMENS FOR THE TREATMENT OF ALKAPTONURIA
The invention relates to nitisinone (2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione) for use in the treatment of alkaptonuria, wherein nitisinone...
2017/0049714 TRANSDERMAL AND/OR TOPICAL DELIVERY SYSTEM COMPRISING CLOBAZAM
A Transdermal Drug Delivery System (TDDS) of the reservoir or plaster type for administrating clobazam for the treatment of various types of anxiety and...
2017/0049713 TRANSDERMAL DELIVERY SYSTEM COMPRISING BUPRENORPHINE
The invention relates to transdermal therapeutic system for the transdermal administration of buprenorphine, comprising a buprenorphine-containing...
2017/0049712 TOPICAL FILM DELIVERY SYSTEM
The described invention provides a topical bioadhesive film-forming pharmaceutical composition formulated for application directly to skin or to a substrate....
2017/0049711 METHODS OF TREATMENT OF PANCREATIC CANCER
The present invention provides methods and compositions for treating pancreatic cancer in an individual who has been previously treated for pancreatic cancer...
2017/0049710 NOVEL FORMULATIONS AND METHODS
Nanoparticles comprising VIP and their use in treating, e.g., pulmonary hypertension. Such nanoparticles provide improved delivery of VIP and allow for acute...
2017/0049709 THERAPEUTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT AND METHODS OF MAKING AND USING SAME
The present disclosure generally relates to nanoparticles comprising an endo-lysosomal escape agent, a nucleic acid, and a polymer. Other aspects include...
2017/0049708 METHODS FOR DELIVERING INSULIN PREPARATIONS INTO A LUMEN OF THE INTESTINAL TRACT USING A SWALLOWABLE DRUG...
Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many...
2017/0049707 MANUFACTURING METHOD FOR SOFTGEL CAPSULE CONTAINING SOLID AND LIQUID FORMULATIONS AS CORE INGREDIENT
The present invention relates to a manufacturing method for softgel capsule containing solid and liquid formulations as core ingredient, wherein at least one...
2017/0049706 PROCESS FOR THE PRODUCTION OF AN ABUSE-PROOFED DOSAGE FORM
The present invention relates to a process for the production of abuse-proofed, thermoformed dosage forms containing, apart from one or more active ingredients...
2017/0049705 MONOLITHIC TABLETS BASED ON CARBOXYL POLYMERIC COMPLEXES FOR CONTROLLED DRUG RELEASE
The present document describes a dosage form for delivery of an active ingredient comprising: a first carboxylated polymer having carboxyl groups, having a...
2017/0049704 PHARMACEUTICAL COMPOSITIONS FOR TREATING OR PREVENTING PAIN
Methods and compositions are provided which comprise effective amounts of one or more analgesics, such as hydrocodone or acetaminophen, and an antiemetic, such...
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