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PHARMACEUTICAL COMPOSITIONS COMPRISING 40 - O - ( 2 - HYDROXY) ETHYL -
The invention relates to extended release pharmaceutical formulations in form of multiparticulates comprising 40-O-(2-hydroxy)ethyl-rapamycin, to dosage forms...
METHODS AND COMPOSITIONS FOR INCREASING FERTILITY AND/OR INHIBITING
PREGNANCY FAILURE AND RESTORING GLUCOSE...
Methods and compositions for enhancing fertility and/or inhibiting pregnancy failure, restoring glucose tolerance and/or preventing glucose intolerance and/or...
METHODS FOR DOSING AN ORALLY ACTIVE 1,2,4-OXADIAZOLE FOR NONSENSE MUTATION
The present invention relates to specific doses of and dosing regimens for using a 1,2,4-oxadiazole benzoic acid compound in treating or preventing diseases...
OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF
A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the...
Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic
The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and...
METHODS FOR TREATING BURNS USING ALLANTOIN
Embodiments of the present invention relate generally to compositions comprising an effective amount of allantoin that can be used to treat skin burns. The...
METHODS AND COMPOSITIONS FOR ENHANCED TRANSUNGUAL DELIVERY OF AR-12
Methods and compositions for enhancing transungual delivery of AR-12 comprising administering AR-12 and permeation enhancers are provided.
METHODS TO MOBILIZE PROGENITOR/STEM CELLS
Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred...
USES OF BUTYLIDENEPHTHALIDE
A method for preventing, mitigating and/or inhibiting the growth, migration, invasion and/or metastasis of cancer stem cell (CSC) is provided. The method...
METHODS AND COMPOSITIONS FOR TARGETING CANCER STEM CELLS
Aspects of the disclosure relate to methods that involve activating the Protein Kinase A (PKA) pathway to induce cancer stem cells (CSCs) to undergo a...
PREVENTION OR TREATMENT AGENT FOR CEREBRAL AMYLOID BETA STORAGE DISEASES
Provided is a prevention or treatment agent for cerebral amyloid beta storage diseases, that contains a substance capable of suppressing the progression,...
Methods Of Using Low-Dose Doxepin For The Improvement Of Sleep
Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g.,...
Method for treating a glycoprotein-related disease
A method for treating a glycoprotein-related disease is disclosed, which comprises: administering a first effective amount of phenol red and a second effective...
Formulations for Cathepsin K Inhibitors
The instant invention relates to pharmaceutical compositions containing cathespin K inhibitors. Also disclosed are processes for making said pharmaceutical...
USE OF HISTONE DEACETYLASE INHIBITORS FOR THE CARE OF
PHILADELPHIA-NEGATIVE MYELOPROLIFERATIVE SYNDROMES
The use of substances capable of inhibiting one or more enzymes of the histone deacetylase family (histone deacetylase inhibitors) for the therapeutic...
PROSTACYCLIN COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked...
INHIBITORS FOR TREATING DISEASES CHARACTERIZED BY ATRIAL ENLARGEMENT OR
The present invention relates to the NEP inhibitor pro-drug N-(3-carboxy-1-oxopropyl)-(4S)-p-phenylphenylmethyl)-4-amino-(2R)-methylb- utanoic acid ethyl ester,...
(2R)-2-PROPYLOCTANOIC ACID FOR FUNCTIONAL BRAIN DISEASE
An agent for preventing or treating a functional brain disease and/or inhibiting symptom development of the functional brain disease includes ...
CREATINE ORAL SUPPLEMENTATION USING CREATINE HYDROCHLORIDE SALT
The present invention is directed to an oral supplement including creatine hydrochloride, which has an aqueous solubility that is at least 15 times greater...
Formulations and methods that provided enhanced bromfenac penetration into ocular tissue when topically administered, compared to the currently available...
QUANTITATIVE PERI-ORBITAL APPLICATION OF OPHTHALMOLOGY DRUGS
The present invention is directed methods of lowering intraocular pressure in a patient suffering from elevated intraocular pressure or glaucoma and treating...
METHODS FOR INHIBITING EXPRESSION OF ASC, EXPRESSION OF NLRP3, AND/OR
FORMATION OF NLRP3 INFLAMMASOME COMPLEX...
Methods and compositions for inhibiting expression of ASC, expression of NLRP3, and/or formation of NLRP3 inflammasome complex by using diacerein or its...
ADMINISTRATION OF 6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHOIC ACID FOR
THE TREATMENT OF DERMATOLOGICAL...
Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by...
METHOD OF ADMINISTRATION OF GAMMA HYDROXYBUTYRATE WITH MONOCARBOXYLATE
One embodiment of the present invention is to improve the safety and efficacy of the administration of GHB or a salt thereof to a patient. It has been...
COMPOSITION FOR PROMOTING REMYELINATION IN NERVE CELLS COMPRISING
2,5-DIHYDROXYBENZENESULFONIC ACID AND USE THEREOF
A method of preventing or treating a disease associated with demyelination of a nerve cell in a mammal, a method of promoting remyelination or suppressing...
PHARMACEUTICAL FORMULATION FOR REDUCING FREQUENCY OF URINATION AND METHOD
OF USE THEREOF
Methods and compositions for reducing frequency of urination are disclosed. The methods comprise administering to a subject having a condition that resulting...
PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE
The invention relates to therapeutic compositions for the treatment of dry eye, more specifically to compositions comprising a TRPM8 receptor agonist ligand....
Use of N-Acetylcysteine Amide in the Treatment of Acquired Immune
Deficiency Syndrome and HIV Infection
This disclosure describes methods of use for N-acetylcysteine amide for the treatment of HIV infection and AIDS.
METFORMIN IN TREATMENT OF NEUROBLASTOMA
Use of metformin in inhibition of growth and/or viability of human neuroblastoma cells is described. Use of metformin in inhibition of growth and/or viability...
COMBINATION CANCER TREATMENT
Described herein is TRAIL receptor targeting therapy in combination with metformin for treatment of cancer in humans. Using TRAIL receptor targeting therapy...
EXTENDED-RELEASE DOSAGE FORM
Provided are pharmaceutical formulations comprising sustained release particles each having an inner core bead comprising an active pharmaceutical ingredient...
ISOLATED COMPOUNDS FROM TURMERIC OIL AND METHODS OF USE
Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided....
ALKOXY COMPOUNDS FOR DISEASE TREATMENT
The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and...
EPINEPHRINE-BASED OPHTHALMIC COMPOSITIONS FOR INTRAOCULAR ADMINISTRATION
AND METHODS FOR FABRICATING THEREOF
Pharmaceutical compositions for intraocular injection are described, the compositions comprise therapeutically effective quantity of lyophilized ...
PROCESS FOR PRODUCING A STABLE LOW CONCENTRATION, INJECTABLE SOLUTION OF
In a first aspect, the present invention relates to a process for producing a stable, injectable solution with low content of noradrenaline, which includes...
METHOD FOR TREATING OR PREVENTING DRY EYE DISORDERS USING
Method for the treatment or prophylaxis of dry eye disorders by the administration of alkylamino-polyhydroxyalkanes and compositions thereof.
DRUG FOR TREATMENT OF TINNITUS PATIENTS
A drug for treatment of patients having tinnitus associated with age-related hearing loss, comprising neramexane or a pharmaceutically acceptable salt thereof.
DRUG FOR TREATMENT OF TINNITUS PATIENTS
A drug for treatment of patients having tinnitus associated with sudden hearing loss, comprising neramexane or a pharmaceutically acceptable salt thereof,...
NITISINONE DOSING REGIMENS FOR THE TREATMENT OF ALKAPTONURIA
The invention relates to nitisinone (2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione) for use in the treatment of alkaptonuria, wherein nitisinone...
TRANSDERMAL AND/OR TOPICAL DELIVERY SYSTEM COMPRISING CLOBAZAM
A Transdermal Drug Delivery System (TDDS) of the reservoir or plaster type for administrating clobazam for the treatment of various types of anxiety and...
TRANSDERMAL DELIVERY SYSTEM COMPRISING BUPRENORPHINE
The invention relates to transdermal therapeutic system for the transdermal administration of buprenorphine, comprising a buprenorphine-containing...
TOPICAL FILM DELIVERY SYSTEM
The described invention provides a topical bioadhesive film-forming pharmaceutical composition formulated for application directly to skin or to a substrate....
METHODS OF TREATMENT OF PANCREATIC CANCER
The present invention provides methods and compositions for treating pancreatic cancer in an individual who has been previously treated for pancreatic cancer...
NOVEL FORMULATIONS AND METHODS
Nanoparticles comprising VIP and their use in treating, e.g., pulmonary hypertension. Such nanoparticles provide improved delivery of VIP and allow for acute...
THERAPEUTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT AND METHODS OF
MAKING AND USING SAME
The present disclosure generally relates to nanoparticles comprising an endo-lysosomal escape agent, a nucleic acid, and a polymer. Other aspects include...
METHODS FOR DELIVERING INSULIN PREPARATIONS INTO A LUMEN OF THE INTESTINAL
TRACT USING A SWALLOWABLE DRUG...
Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many...
MANUFACTURING METHOD FOR SOFTGEL CAPSULE CONTAINING SOLID AND LIQUID
FORMULATIONS AS CORE INGREDIENT
The present invention relates to a manufacturing method for softgel capsule containing solid and liquid formulations as core ingredient, wherein at least one...
PROCESS FOR THE PRODUCTION OF AN ABUSE-PROOFED DOSAGE FORM
The present invention relates to a process for the production of abuse-proofed, thermoformed dosage forms containing, apart from one or more active ingredients...
MONOLITHIC TABLETS BASED ON CARBOXYL POLYMERIC COMPLEXES FOR CONTROLLED
The present document describes a dosage form for delivery of an active ingredient comprising: a first carboxylated polymer having carboxyl groups, having a...
PHARMACEUTICAL COMPOSITIONS FOR TREATING OR PREVENTING PAIN
Methods and compositions are provided which comprise effective amounts of one or more analgesics, such as hydrocodone or acetaminophen, and an antiemetic, such...