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Patent # Description
2017/0096452 Novel Tumor-Targeting Compounds
The invention relates to a novel compounds targeting human cancer cells, a method for synthesis of such compounds, and use of such compounds in treating cancer.
2017/0096451 INHIBITION OF GLIADIN PEPTIDES
Novel compounds and methods for the inhibition of biological barrier permeability and for the inhibition of peptide translocation across biological barriers...
2017/0096450 Dipeptide Comprising a Non-Proteogenic Amino Acid
Described is a dipeptide comprising a non-proteogenic amino acid, methods of making such and methods of using said dipeptide in a process of making a...
2017/0096449 Compositions and Methods Relating to Ionic Salts of Peptides
The present invention relates to compounds of Formula I, compositions containing same, and methods of use.
2017/0096448 SYSTEMS AND METHODS FOR EXCHANGE OF BUFFER SOLUTIONS
Systems and methods for exchanging buffer solutions are disclosed. In accordance with some embodiments, the methods and systems for buffer exchange may be...
2017/0096447 CONTROL APPARATUS FOR DISPENSING SMALL PRECISE AMOUNTS OF LIQUID REAGENTS
A precision volumetric liquid dispensing instrument is disclosed that includes two pressure sensors and a fluid passageway with a defined volume portion in...
2017/0096446 Extended Triterpene Derivatives
The present invention concerns novel pharmaceutically active triterpene derivatives, pharmaceutical compositions containing the same, their use as medicaments,...
2017/0096445 PROCESS FOR THE PREPARATION OF MACROLIDE ANTIBACTERIAL AGENTS
Described herein are processes for the preparation of compounds of formula (I): and pharmaceutically acceptable salts, solvates, and hydrates thereof.
2017/0096444 MINIMAL SAPONIN ANALOGUES, SYNTHESIS AND USE THEREOF
Truncated triterpene saponin analogues containing a trisaccharide or tetrasaccharide ester are disclosed. Also disclosed are pharmaceutical compositions...
2017/0096443 PLATINUM(IV) COMPOUNDS AND METHODS OF MAKING AND USING SAME
Reactions of 1,3-dipole-functional (e.g., azide-functional) platinum(IV) compounds with cyclic alkynes under conditions effective for a cycloaddition reaction...
2017/0096442 Crystalline Forms of Fosnetupitant
The present invention provides crystalline forms of the chloride monohydrochloride salt of fosnetupitant, methods of making the crystalline forms, and...
2017/0096441 PHOSPHONATES WITH REDUCED TOXICITY FOR TREATMENT OF VIRAL INFECTIONS
There are provided, inter alia, acyclic nucleoside phosphonate compounds having reduced toxicity and enhanced antiviral activity, and pharmaceutically accepted...
2017/0096440 NOVEL ACTIVATORS OF GLUCOKINASE
The present invention provides for novel compounds of Formulas I and II and pharmaceutically acceptable salts and co-crystals thereof which have glucokinsae...
2017/0096439 INCLUSION COMPOUND OF 3',5'-CYCLICDIADENYLIC ACID, AND METHOD FOR PRODUCING SAME
Though 3',5'-cyclic diadenylic acid was conventionally provided only as a freeze-dried product, a solid material other than a freeze-dried product and a...
2017/0096438 Method for the Preparation of Functionalized Cyclosiloxanes
The present invention relates to a method for preparing functionalized cyclosiloxanes of Formula I, ##STR00001## wherein R, R.sup.1, R.sup.2, m, n1 and n2 are as...
2017/0096437 MUSCARINIC RECEPTOR AGONISTS
This invention relates to compounds that are agonists of the muscarinic M.sub.1 receptor and which are useful in the treatment of muscarinic M.sub.1 receptor...
2017/0096436 COMPOUNDS FOR TREATMENT OF FLUOROQUINOLONE-RESISTANT BACTERIA
Compounds that specifically kill fluoroquinolone (FQ) resistant bacteria have been developed and are described herein. The FQs are the most commonly prescribed...
2017/0096435 SEPIAPTERIN REDUCTASE INHIBITORS
Inhibitors of sepiapterin reductase and uses of sepiapterin reductase inhibitors in analgesia, treatment of acute and chronic pain, anti-inflammation, and...
2017/0096434 DERIVATIZED CORROLES AND METALLOCORROLES AND THEIR USE AS IMAGING AND THERAPEUTIC AGENTS
The present invention is directed to derivatized corroles, methods of making and using the same as imaging and therapeutic agents. In certain embodiments, the...
2017/0096433 HELQUATS WITH HETEROAROMATIC SUBSTITUENTS, PREPARATION THEREOF, AND USE THEREOF AS G-QUADRUPLEX STABILIZERS
Helquat derivatives of general formula I, in which substituents R.sup.1 and R.sup.2 are independently selected from a group comprising H and C.sub.1 to C.sub.4...
2017/0096432 (5,6-DIHYDRO)PYRIMIDO[4,5-E]INDOLIZINES
A compound of Formula I: ##STR00001## wherein, R.sup.1 and R.sup.2 independently are selected from the group consisting of optionally substituted (6-10C)aryl and...
2017/0096431 7-BENZYL-4-(2-METHYLBENZYL)-2,4,6,7,8,9-HEXAHYDROIMIDAZO [1,2-A]PYRIDO[3,4-E]PYRIMIDIN-5(1H)-ONE, ANALOGS...
This disclosure relates to methods of treatment using compound (1) or analogs thereof, and pharmaceutically acceptable salts thereof. Also disclosed are...
2017/0096430 COMPOSITIONS AND METHODS FOR INHIBITING BETA-LACTAMASE
Substituted dihydroisoxazole derivatives useful as inhibitors of .beta.-lactamases are provided. The invention further provides medical uses of substituted...
2017/0096429 MACROCYCLES WITH AROMATIC P2' GROUPS AS FACTOR XIA INHIBITORS
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables...
2017/0096428 Novel Cyclopropabenzofuranyl Pyridopyrazinediones
Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I ##STR00001## wherein X,...
2017/0096427 FLUORINATED 3-(2-OXO-3-(3-ARYLPROPYL)IMIDAZOLIDIN-1-YL)-3-ARYLPROPANOIC ACID DERIVATIVES
The invention relates to fluorinated compounds and their use as integrin receptor antagonists. Novel fluorinated ...
2017/0096426 Novel Tricyclic Modulators of Cannabinoid Receptors
The compounds of the invention are modulators of cannabinoid receptors CB1 or CB2. The compounds can be used for the prevention or treatment of, e.g., pain,...
2017/0096425 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS
Provided herein are compounds of the General Formula I: ##STR00001## and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B,...
2017/0096424 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases...
2017/0096423 ANTAGONISTS ACTING AT MULTIPLE PROSTAGLANDIN RECEPTORS FOR THE TREATMENT OF INFLAMMATION
Compounds, processes for their preparation, pharmaceutical compositions containing such compounds and their use in treating therapeutic conditions, in...
2017/0096422 HETEROCYCLIC COMPOUND
Provided is a compound having a superior PKC inhibitory action, and useful as a prophylactic or therapeutic agent for immune diseases, inflammatory diseases...
2017/0096421 Carboxamide Derivatives and Use Thereof
The present disclosure provides substituted pyridyl-, pyrimidinyl-, pyrazinyl-, pyridazinyl-, and triazinyl-based carboxamides of Formula I-A: ##STR00001## ...
2017/0096420 OPTICALLY ACTIVE PDE10 INHIBITOR
The present invention is directed to a pure enantiomer of 1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,- ...
2017/0096419 HETEROCYCLE-SUBSTITUTED PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS
This invention is directed to a compound of Formula I ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and...
2017/0096418 COMPOUNDS USEFUL AS MODULATORS OF TRPM8
The present disclosure relates to compounds which are useful as cooling sensation compounds.
2017/0096417 Multicyclic Compounds And Methods Of Using Same
The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as...
2017/0096416 PYRAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS
Compounds of the formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein, R.sup.1 is optionally substituted pyrazolyl, and R.sup.2,...
2017/0096415 BIFUNCTIONAL MOLECULES WITH ANTIBODY-RECRUITING AND ENTRY INHIBITORY ACTIVITY AGAINST THE HUMAN...
The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred...
2017/0096414 ALKYLATION OF PICOLINAMIDES WITH SUBSTITUTED CHLOROACYLALS UTILIZING A CROWN ETHER CATALYST
A process for the alkylation of picolinamides with substituted chloroacylals to produce a structure of Formula (III), wherein the reaction is performed in the...
2017/0096413 PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HDAC6 SELECTIVE INHIBITORS
The present invention relates to pyrimidine hydroxy amide compounds, the use of such compounds in the inhibition of HDAC6, and the use of such compounds in the...
2017/0096412 Diamide Compounds Having Muscarinic Receptor Antagonist and Beta2 Adrenergic Receptor Agonist Activity
This invention relates to a compound of formula I: ##STR00001## or a pharmaceutically acceptable salt thereof. Such compounds possess both muscarinic receptor...
2017/0096411 HETEROCYCLIC COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
The present application is concerned with heterocyclic compounds that inhibit the activity of Pim kinases and are useful in the treatment of diseases related...
2017/0096410 ANTIFUNGAL COMPOUND PROCESS
The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new...
2017/0096409 2,3-Disubstituted Pyridine Compounds as TGF-Beta Inhibitors and Methods of Use
The invention described herein comprises compounds of formula (IV) and a method of treating cancer comprising administering to a subject having cancer one of...
2017/0096408 POLYCYCLOCARBONATE COMPOUNDS AND POLYMERS FORMED THEREFROM
Polycyclocarbonate compounds and upgraded molecular weight polymers made from such compounds are provided. The polymers have particular utility in coating...
2017/0096407 CATALYST RECYCLE METHODS
The present invention provides novel solutions to the problem of recycling carbonylation catalysts in epoxide carbonylation processes. The inventive methods...
2017/0096406 Dual Inhibitor Compounds for Use in the Treatment of Neurodegenerative Disorders and Alzheimer's Disease
The present invention relates to Compounds of Formula (I) and pharmaceutical compositions containing the same. It further relates to their use in the...
2017/0096405 NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
The present invention relates to novel compounds having histone deacetylase 6 (HDAC6) inhibitory activity, isomers thereof, or pharmaceutically acceptable...
2017/0096404 DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS
Compounds and methods for treating diseases mediated by a P2X.sub.3 and/or a P2X.sub.2/3 receptor antagonist, the methods comprising administering to a subject...
2017/0096403 PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
The present invention relates to novel pyrimidine hydroxy amide compounds, and the use of such compounds in the inhibition of HDAC6 and in the treatment of...
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