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Patent # Description
2017/0101471 BLOCKADE OF TIM-1 FOR TREATING GRAFT-VERSUS-HOST DISEASE
TIM1 antagonists reduce GVHD by symptom score and show statistically significant improved survival.
2017/0101470 Use of Anti-MCAM Antibodies for Treatment or Prophylaxis of Giant Cell Arteritis, Polymyalgia Rheumatica or...
The invention provides anti-MCAM antibodies that inhibit the ability of human MCAM to bind a laminin alpha-4 chain and pharmaceutical compositions and...
2017/0101469 HUMAN-MOUSE CHIMERIC ANTI-CD147 ANTIBODY WITH NON-FUCOSYLATED GLYCOSYLATION
The present disclosure relates to a nucleotide sequence comprising the sequence of SEQ ID NO: 5, and/or sequence of SEQ ID NO: 6, vector and host cell line...
2017/0101468 HUMAN ANTI IL-6 ANTIBODIES WITH EXTENDED IN VIVO HALF-LIFE AND THEIR USE IN TREATMENT OF ONCOLOGY, AUTOIMMUNE...
The present invention provides human anti-IL-6 antibodies with extended in vivo half-life. The invention further relates to pharmaceutical compositions,...
2017/0101467 Nucleic Acid Encoding Anti-IL13 Human Antibodies
The present invention relates to human anti-IL-13 binding molecules, particularly antibodies, and to methods for using anti-IL-13 antibody molecules in...
2017/0101466 ANTI-BLYS ANTIBODIES
The present invention provides antibodies and antigen-binding fragments thereof that bind specifically to BlyS, immunoglobulin chains thereof, variants...
2017/0101465 Use of TNFalpha Antibody for Treatment of Hidradenitis Suppurativa (HS)
The invention provides methods, uses and compositions for the treatment of hidradenitis suppurativa. The invention describes methods and uses for treating...
2017/0101464 COMBINATION THERAPIES USING AGENTS THAT TARGET TUMOR-ASSOCIATED STROMA OR TUMOR CELLS AND TUMOR VASCULATURE
The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include:...
2017/0101463 BISPECIFIC ANTIBODY FRAGMENTS FOR NEUROLOGICAL DISEASE PROTEINS AND METHODS OF USE
The present invention relates to therapeutic agents comprising bispecific recombinant antibody fragments to selectively clear a protein associated with a...
2017/0101462 NOVEL CARBOHYDRATE ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
The present invention provides antibodies or the antigen-binding portion thereof to a tumor-associate carbohydrate antigen. Also disclosed herein are...
2017/0101461 Antiretroviral Drug Targeting Human Endogenous Retrovirus
The invention relates to an antibody, a fragment or a derivative thereof, for use as an antiretroviral drug targeting a virus belonging to human endogenous...
2017/0101460 TRANSGENIC ANIMALS CAPABLE OF PRODUCING HUMANIZED IGE AT MUCH HIGHER LEVELS THAN MOUSE IGE
The transgenic non-human animals are constructed, in whose genome the coding sequences of one of the animal's endogenous immunoglobulin C.gamma. constant...
2017/0101459 CLEAVAGE AND EXCHANGE OF MAJOR HISTOCOMPATIBILITY COMPLEX LIGANDS EMPLOYING AZOBENZENE-CONTAINING PEPTIDES
In one aspect, the disclosure relates to major histocompatibility complex (MHC) molecules comprising a ligand in the peptide binding groove of the MHC...
2017/0101458 LDLR VARIANTS AND THEIR USE IN COMPOSITIONS FOR REDUCING CHOLESTEROL LEVELS
A recombinant vector having an expression cassette is provided which comprises a modified human low density lipoprotein receptor (hLDLR) gene is provided,...
2017/0101457 FUSION PROTEINS OF COLLAGEN-BINDING DOMAIN AND PARATHYROID HORMONE
Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a...
2017/0101456 NON-STANDARD INSULIN ANALOGUES
An insulin analogue comprises a B-chain polypeptide containing a cyclohexanylalanine substitution at position B24 and optionally containing additional...
2017/0101455 LONG-ACTING INSULIN AND USE THEREOF
The present invention relates to an insulin analog that has reduced insulin receptor binding affinity for the purpose of increasing the blood half-life of...
2017/0101454 GLP-1/Glucagon Receptor Co-Agonists for Medical Use
The present invention relates to novel glucagon derivatives which are GLP-1/glucagon receptor co-agonists, and to the use of said glucagon derivatives in...
2017/0101453 A PROCESS FOR OBTAINING HMG-UP (HUMAN MENOPAUSAL GONADOTROPIN WITH ULTRA-PURITY GRADE) AND A COMPOSITION FREE...
The present invention refers to a method of purification of HMG (human menopausal gonadotropin) by multimodal chromatography in order to obtain HMG-UP (human...
2017/0101452 MODULATING GAMMA-C-CYTOKINE ACTIVITY
Embodiments relate to peptide antagonists of .gamma.c-family cytokines, which is associated with important human diseases, such as leukemia, autoimmune...
2017/0101451 PROTEASE RESISTANT MUTANTS OF STROMAL CELL DERIVED FACTOR-1 IN THE REPAIR OF TISSUE DAMAGE
The present invention is directed stromal cell derived factor-1 peptides that have been mutated to make them resistant to digestion by the proteases dipeptidyl...
2017/0101450 METHODS AND COMPOSITIONS COMPRISING HUMAN RECOMBINANT GROWTH AND DIFFERENTIATION FACTOR-5 (RHGDF-5)
Expression vector systems are provided for increased production of a recombinant GDF-5 (rhGDF-5) protein. Also provided are transformed host cells that were...
2017/0101449 CHIMERIC FIBROBLAST GROWTH FACTOR 19 PROTEINS AND METHODS OF USE
The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine...
2017/0101448 Novel Fusion Protein Comprising Transcription Modulation Domain Of p65 And Protein Transduction Domain, And...
The present invention relates to a novel fusion protein comprising the transcription modulation domain of the transcription factor NF-.kappa.B subunit p65 and...
2017/0101447 TOXIN GENES AND METHODS FOR THEIR USE
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding...
2017/0101446 MUTANT FRAGMENTS OF OSPA AND METHODS AND USES RELATING THERETO
The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a...
2017/0101445 NOVEL CYCLOSPORIN DERIVATIVES FOR THE TREATMENT AND PREVENTION OF A VIRAL INFECTION
The present invention relates to a compound of the formula (I), (II), (III), (IV), (V), or (VI): ##STR00001## ##STR00002## or pharmaceutically acceptable salt...
2017/0101444 Cyclic Peptidomimetic Compounds as Immunomodulators
The present invention relates to cyclic peptidomimetic compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signalling...
2017/0101443 CRYSTALLINE POWDER OF CYCLIC PEPTIDE COMPOUND, PREPARATION METHOD FOR SAME, AND USES THEREOF
Disclosed is a crystalline powder of a cyclic peptide compound, represented by formula I is the structure of same, and, also disclosed are a preparation method...
2017/0101442 Peptide Ligands for Hepatic Stellate Cells
Methods and compositions for identifying and using polypeptides that target hepatic stellate cells are described. Embodiments include a targeting composition...
2017/0101441 CHEMICAL AND BIOCHEMICAL ADDUCTS AS BIOMARKERS FOR ORGANOPHOSPHATE EXPOSURE
Provided are methods for identifying OP-adducted biomarkers of OP exposure as well as compounds containing OPs that can provide OP adducts and compounds of...
2017/0101440 METHODS OF TREATING OPHTHALMIC DISEASES USING NPR-B AGONISTS
Disclosed are novel compounds having NPR-B agonistic activity. Preferred compounds are linear peptides containing 8-13 conventional or non-conventional L- or...
2017/0101439 GAMMA-AA-PEPTIDE STAT3/DNA INHIBITORS AND METHODS OF USE
STAT3 hyperphosphorylation, dimerization and DNA binding are required for its ability to contribute to malignant transformation. As such, STAT3 has been...
2017/0101438 COSMETIC OR PHARMACEUTICAL METHODS FOR THE TREATMENT AND/OR CARE OF THE SKIN AND/OR HAIR USING TRIPEPTIDES...
A cosmetic or pharmaceutical method for the treatment and/or care of the skin and/or hair which includes administering to the skin and/or hair an effective...
2017/0101437 PROCESS FOR PURIFICATION OF DARBEPOETIN ALFA
The present invention provides sequential chromatography steps and conditions for purification of a recombinant protein, especially recombinant darbepoetin alfa.
2017/0101436 METHOD FOR USING NANOPARTICLES AS NUCLEATION AGENTS FOR THE CRYSTALLIZATION OF PROTEINS
The present invention relates to a method for the crystallization of protein using nanoparticles as nucleation agents. Precisely, the inventors performed the...
2017/0101435 HARVESTING AND PERFUSION APPARATUS
The present invention relates to an apparatus capable of harvesting a recombinant protein from a bioreactor having a porous container comprised of a...
2017/0101434 FARNESOID X RECEPTOR MODULATORS
The present application provides a compound of formula I: ##STR00001## or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof, wherein...
2017/0101433 COCRYSTALS OF PROGESTERONE
The present invention relates to a cocrystal of progesterone and a coformer selected from the group consisting of vanillic acid, benzoic acid, salicylic acid,...
2017/0101432 CRYSTALLINE 3',5'-CYCLIC DIGUANYLIC ACID
A crystal of free acid of 3',5'-cyclic diguanylic acid containing no metal salt with cobalt, magnesium or the like is provided. A method is sought for...
2017/0101431 NUCLEOSIDE DERIVATIVES FOR THE TREATMENT OF CANCER
Provided herein are compounds, compositions, and methods for the treatment of cancer, including leukemia. In one embodiment, compounds and compositions of...
2017/0101430 METHOD FOR PRODUCING SOLID LIGNIN
Lignin-rich starting material is suspended in a first medium, which is acidic and aqueous, to form a aqueous acidic suspension, which is heated and allowed to...
2017/0101429 METAL ORGANIC FRAMEWORKS COMPRISING A PLURALITY OF SBUS WITH DIFFERENT METAL IONS AND/OR A PLURALITY OF ORGANIC...
The disclosure provides for metal organic frameworks (MOFs) which comprise a plurality of SBUs comprising different metals or metal ions and/or a plurality of...
2017/0101428 METHOD FOR FUNCTIONALIZING TRANSITION METAL DICHALCOGENIDES
Embodiments of the invention provide a lithium-free metal dichalcogenides functionalization method where a metal dichalcogenide including a surface of...
2017/0101427 NOVEL KLK4 INHIBITORS
The present invention relates to novel compounds and probes which have a common chemical structure necessary to obtain potent inhibitory activity against KLK4...
2017/0101425 PROCESS FOR THE PURIFICATION OF L-ALPHA-GLYCEROPHOSPHORYLCHOLINE
A process for the purification of L-.alpha.-glycerophosphorylcholine is described, wherein L-.alpha.-glycerophosphorylcholine is crystallized from DMSO or from...
2017/0101424 PROCESS FOR HYDROSILYLATION WITH ADDITION OF ORGANIC SALTS
Hydrosilylation of aliphatically unsaturated compounds (B) with compounds (A) bearing silicon-bonded hydrogen using a metal-containing hydrosilylation catalyst...
2017/0101423 MONO-FUNCTIONAL BRANCHED ORGANOSILOXANE COMPOUND AND METHOD FOR PRODUCING THE SAME
The present invention is a mono-functional branched organosiloxane compound that is liquid and shown by the following general formula (1) ...
2017/0101422 Bicyclic compounds as pesticides
The present application relates to novel bicyclic compounds, to their use for controlling animal pests and to processes and intermediates for their preparation.
2017/0101421 METHOD
A method of forming a compound of formula (IIIa): ##STR00001## wherein: R.sup.1 in each occurrence is independently selected from H, halogen, amino, C.sub.1-5...
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