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Patent # Description
2017/0101420 ALKYL AND ARYL DERIVATIVES OF 1-OXA-4,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
The present invention relates to compounds of general formula (I) having dual pharmacological activity towards both the sigma (.sigma.) receptor, and the...
2017/0101419 Thienopyranones as Kinase Inhibitors
The invention relates to compounds of formula I (or pharmaceutically acceptable salts thereof) as defined herein, pharmaceutical compositions thereof, and...
2017/0101418 Thienopyranones as Kinase and Epigenetic Inhibitors
The invention relates to methods of treating diseases including but not limited to, cancer, non-cancer proliferative disease, sepsis, autoimmune disease, viral...
2017/0101417 USE OF POLYOLS TO OBTAIN STABLE POLYMORPHOUS FORMS OF RIFAXMIN
Polyols stabilize polymorphous form of rifaximin, in particular the .beta. form. When polyols having at least two hydroxy groups are added to rifaximin powder,...
2017/0101416 2-(ARYL- OR HETEROARYL-)PHENYL (AZA)BENZOFURAN COMPOUNDS FOR THE TREATMENT OF HEPATITIS C
##STR00001## Compounds of Formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have ...
2017/0101415 PROCESS FOR THE PREPARATION OF (S)-2-((4R,4AS,6R,7R,7AR,12BS)-7,9-DIMETHOXY-1,2,3,4,5,6,7,7A-OCTAHYDRO-4- ...
An invention includes a process for the preparation of (S)-2((4R,4aS,6R,7R,7aR,12bS)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a- ...
2017/0101414 NOVEL QUINOLINE-SUBSTITUTED COMPOUND
An object to be achieved by the present invention is to provide a novel compound having EGFR inhibitory effects and cell growth inhibitory effects, as well as...
2017/0101413 NOVEL COMPOUNDS
This invention relates to heterocyclic compounds, which are pyrimidinone derivatives having human neutrophil elastase inhibitory properties, and their use in...
2017/0101412 DIFLUOROETHYLPYRIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS
Disclosed are chemical entities of formula (I) wherein X, Y, Z, R.sup.1, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined herein, as NR2B subtype selective...
2017/0101411 CYCLIC ETHER DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYAMIDE
The invention relates to Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide of general formula (I) which are inhibitors of...
2017/0101410 SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to compounds that modulate the bioactivity of an orexin receptor such as OX.sub.1 or OX.sub.2, or both; to pharmaceutical...
2017/0101409 INDOLIN-2-ONE OR PYRROLO-PYRIDIN-2-ONE DERIVATIVES
The present invention is concerned with 2-oxo-2,3-dihydro-indoles of general formula ##STR00001## wherein Ar.sup.1 is phenyl or a five or six membered heteroaryl...
2017/0101408 HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS
The present disclosure is related to heteroaryl compounds as MEK inhibitors. These compounds include heteroaryl compounds of formula I, their pharmaceutically...
2017/0101407 6-CHLORINE-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE CARBOXAMIDES AND THE USE THEREOF AS SOLUBLE GUANYLATE CYCLASE...
The present application relates to novel 6-chloro-substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof,...
2017/0101406 SUBSTITUTED PYRAZOLO[3,4-b]PYRIDIN-6-CARBOXYLIC ACIDS AND METHOD OF USE
The present invention provides for compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 have any of the values defined in the...
2017/0101405 N-SULFONYLATED PYRAZOLO[3,4-b]PYRIDIN-6-CARBOXAMIDES AND METHOD OF USE
The present invention provides for compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 have any of the values...
2017/0101404 COMPOUNDS AND COMPOSITIONS FOR TREATMENT OF CANCER
Compounds and compositions for treating, preventing or managing cancer are disclosed. The compositions provided herein comprise SNS-595 and ...
2017/0101403 ISOTHIAZOLE DERIVATIVES AS CFTR MODULATORS
A compound having the structure of Formula II, or a stereoisomer, tautomer, or a pharmaceutically acceptable salt thereof: ##STR00001## The compound is useful as...
2017/0101402 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF
Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, or pharmaceutically acceptable salts thereof, compositions thereof, and methods of...
2017/0101401 BENZIMIDAZOLE ANALOGUES AND RELATED METHODS
The invention relates to compounds of the formula (VIII) wherein the moieties R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are as defined in the...
2017/0101400 TRAIL ENHANCERS FOR THE SELECTIVE KILLING OF CANCER CELLS
The invention is directed to methods of inducing apoptosis, arresting cell cycle, or inhibiting cellular proliferation, or any combination thereof, in a tumor...
2017/0101399 NOVEL COMPOUNDS
The present invention relates to novel retinoid-related orphan receptor gamma (ROR.gamma.) modulators and their use in the treatment of diseases mediated by...
2017/0101398 PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES
The invention relates to pyrazolyl substituted tetrahydropyranylsulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing...
2017/0101397 PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES
The invention relates to pyrazolyl substituted tetrahydropyranylsulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing...
2017/0101396 QUINOXALINE DERIVATIVES USEFUL AS FGFR KINASE MODULATORS
The invention relates to new quinoxaline derivative compounds of formula (I), to pharmaceutical compositions comprising said compounds, to processes for the...
2017/0101395 PYRIMIDINE DERIVATIVES AS CFTR MODULATORS
A compound having the structure of Formula II, or a stereoisomer, tautomer, or a pharmaceutically acceptable salt thereof: ##STR00001## The compound is useful as...
2017/0101394 PYRIDINE DERIVATIVES AS CFTR MODULATORS
A compound having the structure of Formula II, or a stereoisomer, tautomer, or a pharmaceutically acceptable salt thereof: ##STR00001## The compound is useful as...
2017/0101393 PROCESS FOR THE PREPARATION OF 3-(3-CHLORO-1H-PYRAZOL-1-YL)PYRIDINE
3-(3-Chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-dihydrochloride with commercially available 3-ethoxyacrylonitrile to provide...
2017/0101392 PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS
The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
2017/0101391 3-AMINO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES
Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals. ##STR00001##
2017/0101390 METHOD AND APPARATUS FOR PREPARATION OF LACTIDE USING LACTIDE PURIFICATION PROCESS
The present invention relates to a method and apparatus for preparation of lactide using a lactide purification process, comprising introducing an aqueous...
2017/0101389 LEVELING COMPOSITION AND METHOD FOR ELECTRODEPOSITION OF METALS IN MICROELECTRONICS
The present disclosure relates to a leveling composition for electrodepositing metals. The composition comprises a compound of formula (I): ##STR00001##
2017/0101388 C-GLYCOSIDE DERIVATIVE
The present invention involves a compound represented by general formula (I), a derivative thereof and a use thereof: ##STR00001## wherein R.sup.1, R.sup.2,...
2017/0101387 1,3,4-Oxadiazole and 1,3,4-Thiadiazole Derivatives as Immunomodulators
The present invention relates to 1,3,4-oxadiazole and 1,3,4-thiadiazole compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1)...
2017/0101386 1,2,4-Oxadiazole Derivatives as Immunomodulators
The present invention relates to 1,2,4-oxadiazole and 1,2,4-thiadiazole compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1)...
2017/0101385 NOVEL ISOXAZOLES, A PROCESS FOR THEIR PREPARATION AND USES THEREOF
The present invention relates to novel isoxazoles, a process for their preparation and their use in the preparation of technical textiles and PPE's (Personal...
2017/0101384 ANDROGEN RECEPTOR ANTAGONISTS
Disclosed herein are compositions and methods for modulating the androgen receptor.
2017/0101383 DIAMINOTRIAZINE DERIVATIVES AS HERBICIDES
The present invention relates to diaminotriazine compounds of the formula (I) and to their use as herbicides. The present invention also relates to ...
2017/0101382 PYRIMIDINE COMPOUND
Provided are a pyrimidine compound represented by formula (1) having excellent harmful pest-exterminating potency, a harmful pest-exterminating agent...
2017/0101381 UREA COMPOUNDS AND THEIR USE AS ENZYME INHIBITORS
A compound having the following structure: ##STR00001## or a pharmaceutically acceptable salt or derivative thereof. The compound may be used in the treatment or...
2017/0101380 PROCESS FOR THE PREPARATION OF (E)-3-(4-((E)-2-(2-CHLORO-4-FLUOROPHENYL)-1-(1H-INDAZOL-5-YL)BUT-1-EN-1-Y- ...
Processes are described for the preparation of estrogen receptor modulating compound, ...
2017/0101379 PYRIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC USE FOR TREATING PROLIFERATIVE...
Provided herein are pyridone compounds, for example, a compound of Formula I, and pharmaceutical compositions thereof. Also provided herein are methods of...
2017/0101378 COMPOSITIONS FOR MODULATING A KINASE CASCADE AND METHODS OF USE THEREOF
The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl) pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride...
2017/0101377 METHODS OF PRODUCING MOLINDONE AND ITS SALTS
The present invention is directed towards novel methods of synthesis of molindone, synthesis of the intermediates of molindone, and high-purity compositions of...
2017/0101376 PROCESS FOR THE SYNTHESIS OF 2-(2,5-DIMETHYL-1H-PYRROL-1-YL)-1,3-PROPANEDIOL AND ITS SUBSTITUTED DERIVATIVES
The present invention relates to a process for the synthesis of molecules that have a pyrrole ring bonded to a diol. In particular, the invention relates to...
2017/0101375 PROCESS FOR PRODUCING QUATERNARY AMMONIUM CATIONS AND IONIC LIQUIDS
The present invention provides a process and a method for producing a quaternary ammonium cation in an aqueous solution while reducing or preventing formation...
2017/0101374 METHOD FOR REMOVING PROTONATED AMINE COMPOUND FROM QUATERNARY AMINE COMPOUND
The present invention provides a method and process for removing at least a portion of a protonated amine compound that is present as an impurity or a...
2017/0101373 PROCESS FOR SEPARATING ASTAXANTHAN
Disclosed is a chromatographic process complex for the refining of krill oil extract including desalting, removal of impurities such as trimethylamine oxide...
2017/0101372 SWEETNESS RECEPTOR ANTAGONIST
Sweetness receptor antagonists represented by formula (I): ##STR00001## wherein each symbol is described herein, are useful for the prophylaxis or treatment of...
2017/0101371 Amine Mining Collectors
A family of amine mining collectors that uses alkoxylates allows for the easy adjustment of solubility and molecular weight useful because anionic and cationic...
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