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Patent # Description
2017/0137847 PROCESS FOR PRODUCING, IN PARTICULAR ETHANOL, BY SEQUENCED ENZYMATIC HYDROLYSIS OF CELLULOSE AND HEMICELLULOSES...
A process for producing ethanol includes steps of pre-treatment of the lignocellulosic vegetable raw material, including the steps consisting in destructuring...
2017/0137846 BACTERIA ENGINEERED FOR CONVERSION OF ETHYLENE TO N-BUTANOL
The present disclosure provides recombinant bacteria with elevated production of ethanol and/or n-butanol from ethylene. Methods for the production of the...
2017/0137845 METHODS AND COMPOSITIONS FOR INCREASING RNA ACTIVITY IN A CELL
Disclosed herein are methods and compositions for increasing RNA activity in a cell.
2017/0137844 Method for Producing Chimeric Microbial Hybrids
Described is a method to transfer chromosomal DNA between two microbial species without genetic engineering or vectors. The strains resulting from this method...
2017/0137843 Recombinant Poxviral Vectors Expressing both Rabies and OX40 Proteins, and Vaccines Made Therefrom
The present invention provides vectors that contain and co-express in vivo or in vitro immunogenic polypeptides or antigens together with an OX40L polypeptide,...
2017/0137842 NOVEL INSECT INHIBITORY PROTEINS
Pesticidal proteins exhibiting toxic activity against Coleopteran and Lepidopteran pest species are disclosed, and include, but are not limited to, TIC2421...
2017/0137841 DOUBLE STRAND RNA-MEDIATED RNA INTERFERENCE THROUGH FEEDING DETRIMENTAL TO LARVAL LYMANTRIA DISPAR (GYPSY MOTH)
The present invention relates to the field of double-stranded RNA (dsRNA)-mediated gene silencing in insect species. More particularly, the present invention...
2017/0137840 COMPOSITIONS AND METHODS FOR SELECTING MAIZE PLANTS WITH RESISTANCE TO BACTERIAL STALK ROT
Compositions and methods useful in identifying and/or selecting maize plants that have bacterial stalk rot resistance are provided herein. The resistance may...
2017/0137839 ACETOLACTATE SYNTHASE HERBICIDE RESISTANT SORGHUM
The present invention provides for compositions and methods for producing sorghum crop plants that are resistant to herbicides. In particular, the present...
2017/0137838 STRESS TOLERANT WHEAT PLANTS
The present invention, relates to stress tolerant transgenic wheat plants. In particular, the present invention relates to stress tolerant transgenic wheat...
2017/0137837 PLANT SYNTHESIZING HYPOALLERGENIC PAUCIMANNOSE TYPE N-GLYCAN AND USES THEREOF
A quadruple mutant (qm) plant is deficient of functions of core .alpha.1,3-fucosyltransferase A (FucTA), core .alpha.1,3-fucosyltransferase B (FucTB),...
2017/0137836 PLANTS WITH ENGINEERED ENDOGENOUS GENES
Genetically engineered plants expressing altered Glucan Water Dikinase and having elevated levels of starch are provided. Methods of genetically engineering...
2017/0137835 Transcription Factors that Regulate Nicotine Biosynthesis in Tobacco
The present invention provides nucleic acids encoding transcription factors and methods of using these nucleic acids to modulate nicotine production in plants...
2017/0137834 ZEA MAYS REGULATORY ELEMENTS AND USES THEREOF
Provided are constructs and methods for expressing a transgene in plant cells and/or plant tissues using Zea mays GRMZM2G015295 gene regulatory elements.
2017/0137833 AGROBACTERIUM AND METHOD FOR PRODUCING TRANSFORMED PLANT USING THE SAME
It is an object solved by the present invention to provide an Agrobacterium with increased gene targeting efficiency. The present invention provides an...
2017/0137832 PROCESS FOR PRODUCING CHIMERIC CYCLOOLIGODEPSIPEPTIDES IN FILAMENTOUS FUNGI
A method for obtaining at least one microbial secondary metabolite or a derivative thereof, the method includes the step of heterologous expression of at least...
2017/0137831 INDEPENDENTLY INDUCIBLE SYSTEM OF GENE EXPRESSION
The present invention is directed to the improved methods for the temporal induction of proteins using the condensed single protein production (cSPP) system.
2017/0137830 Regulation of Inducible Promoters
The present invention relates to the production of heterologous polypeptides in a recombinant bacterial host cell, wherein the bacterial host cell is rendered...
2017/0137829 GENETIC ENGINEERED BACTERIA AND METHODS FOR PROMOTING PRODUCTION OF SUCCINIC ACID OR LACTIC ACID
A genetic engineered bacteria without or comprising a plurality of important metabolic enzyme related genes is provided. When the by-product or waste of fruit...
2017/0137828 TREATMENT OF AGE-RELATED MACULAR DEGENERATION USING RNA COMPLEXES THAT TARGET MYD88 OR TLR3
In certain aspects, provided herein are RNA complexes that inhibit Myeloid differentiation primary response gene 88 (MyD88) and/or Toll-like receptor 3 (TLR3)...
2017/0137827 Compositions and Methods for Inhibiting Expression of RRM2 Genes
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a ...
2017/0137826 Antisense Compounds Targeting Leucine-Rich Repeat Kinase 2 (LRRK2) For The Treatment Of Parkinsons Disease
The present disclosure relates generally to compounds comprising oligonucleotides complementary to a Leucine-Rich-Repeat-Kinase (LRRK2) RNA transcript. Certain...
2017/0137825 APOPTOSIS INDUCER
The purpose of the present invention is to provide: a composition for effectively inducing apoptosis and/or proliferation inhibition in cells; and a method in...
2017/0137824 NEW TREATMENT AGAINST INFLUENZA VIRUS
The present application provides a method for treating an influenza virus infection in a subject characterised in that a therapeutically effective amount of a...
2017/0137823 INHIBITION OF PCSK9 THROUGH RNAI
The invention relates to various PCSK9 RNAi constructs with gene silencing activities, and uses thereof. The construct has a double-stranded region of 19-49...
2017/0137822 USE OF AN miRNA TO REDUCE PROLIFERATION OF A CANCER CELL
A method is provided for decreasing at least one of the proliferation and the migration of a cancer cell comprising contacting a cancer cell with an effective...
2017/0137821 MOLECULES AND AGENTS FOR TREATING HEPATITIS B VIRUS
This invention encompasses compounds and compositions useful in methods for medical therapy, in general, for inhibiting Hepatitis B virus in a subject. The...
2017/0137820 AGONISTS AND ANTAGONISTS OF TOLL-LIKE RECEPTOR (TLR) 13
The present invention relates to the field of immunology. The present invention provides agonists and antagonists of Toll-like receptor (TLR) 13. In...
2017/0137819 Method for Generating Aptamers with Improved Off-Rates
The present disclosure describes improved SELEX methods for producing aptamers that are capable of binding to target molecules and improved photoSELEX methods...
2017/0137818 APTAMER INHIBITING BIOLOGICAL ACTIVITY OF AUTOTAXIN BY BINDING WITH AUTOTAXIN, AND USE THEREOF
The present invention provides an aptamer that binds to an autotaxin, which contains a nucleotide sequence represented by the following formula (I): ...
2017/0137817 STAT5 INHIBITORS AND USE THEREOF
Provided is a composition of matter binding specifically to STAT5, preferably to STAT5B, including a nucleic acid aptamer, and methods of treatment of cancer,...
2017/0137816 DOUBLE-STRANDED OLIGONUCLEOTIDES
Antisense sequences, including duplex RNAi compositions, which possess improved properties over those taught in the prior art are disclosed. The invention...
2017/0137815 NOVEL SINGLE CHEMICAL ENTITIES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES
In an embodiment the instant invention discloses a modular composition comprising 1) an oligonucleotide; 2) one or more linkers, which may be the same or...
2017/0137814 ORGANIC COMPOSITIONS TO TREAT APOC3-RELATED DISEASES
The present disclosure relates to compositions and methods for treating APOC3-related diseases such as: hypertriglyceridemia (e.g., Type V ...
2017/0137813 miRNAs as Novel Therapeutic Targets and Diagnostic Biomarkers for Parkinson's Disease
The disclosure provides pharmaceutical compositions including an oligonucleotide that down-regulates the over-expression of at least one miRNA of SEQ ID NOs:...
2017/0137812 COMPOSITIONS AND METHODS FOR MODULATING MYELOID DERIVED SUPPRESSOR CELLS
Provided are methods of treating an inflammatory disease in a subject in need thereof by administering an amount of microRNA 142, an amount of microRNA 223 or...
2017/0137811 TARGETING MICRORNAS FOR THE TREATMENT OF LIVER CANCER
Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide,...
2017/0137810 NUCLEIC ACID DRUG FOR INDUCING SKIPPING OF VARIANT EXON OF CD44 GENE AND INCREASING EXPRESSION OF NORMAL TYPE...
Insertion of variant exons of CD44 gene of cancer stem cells into its mRNA is inhibited whereupon the cancer stem cells lose their properties so that they are...
2017/0137809 NUCLEIC ACID FUNTIONALIZED NANOPARTICLES FOR THERAPEUTIC APPLICATIONS
Materials and methods for modulating cellular uptake of functionalized nanoparticles are provided. Also provided are materials and methods for modulating the...
2017/0137808 IMPROVED SMALL INTERFERING RIBONUCLEIC ACID MOLECULES
Double-stranded siRNA molecules (100, 200, 300) are provided comprising a sense RNA strand (110, 210, 310) and an antisense RNA strand (120, 220, 320). The...
2017/0137807 IMPROVED NGS WORKFLOW
The present invention relates to improved semi-automated methods that permit the extraction of nucleic acids from samples, preparation of PCR and post-PCR...
2017/0137806 HIGH THROUGHPUT TRANSCRIPTOME ANALYSIS
Kits and methods for single cell or multiple cell transcriptome analysis are provided. An adapter polynucleotide is disclosed which comprises a double-stranded...
2017/0137805 SELECTIVE NUCLEIC ACID SEPARATION
Nucleic acids in non-rare cells in a sample containing non-rare cells and rare cells are selectively released from the non-rare cells. The sample is combined...
2017/0137804 Method of Stem Cell Preparation and Administration
The present invention is a method of testing and or treating SCs in preparation for administration of such SCs and a method of administering the prepared SCs...
2017/0137803 METHODS AND COMPOSITIONS FOR SYNTHETIC RNA ENDONUCLEASES
The present invention provides sequence specific restriction enzymes for site-specific cleavage of RNA, as well as methods of their use.
2017/0137802 SYSTEM FOR GENERATING HIGH CONCENTRATION FACTORS FOR LOW CELL DENSITY SUSPENSIONS
Acoustophoretic devices and methods for concentrating targeted biological cells in a reduced volume using multi-dimensional acoustic standing waves are...
2017/0137801 TISSUE-SPECIFIC GENOME ENGINEERING USING CRISPR-CAS9
The present application provides compounds, compositions, uses thereof for the treatment of diseases, conditions and/or disorders, and uses thereof as...
2017/0137800 COMPOSITIONS AND METHODS FOR TREATING DIABETES
Compositions containing an FKBP 11 peptide (i.e., FKBP11 polypeptide, a variant or a fragment thereof), a fusion protein containing an FKBP11 peptide, or a...
2017/0137799 PROTEOGLYCAN DEGRADING MUTANTS FOR TREATMENT OF CNS
The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of...
2017/0137798 SUBTILASE VARIANTS AND POLYNUCLOETIDES ENCODING SAME
The present invention relates to novel subtilase variants exhibiting increased stability and preferably on par or improved wash performance. The variants of...
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