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Patent # Description
2017/0137494 FIBRONECTIN BINDING DOMAINS WITH REDUCED IMMUNOGENICITY
Fibronectin type III (.sup.10Fn3) binding domains having novel designs that are associated with reduced immunogenicity are provided. The application describes...
2017/0137493 COMPOSITIONS AND METHODS FOR RENDERING TUMOR CELLS SUSCEPTIBLE TO CD8+ T CELL-MEDIATED KILLING
The present invention provides an immunoconjugate having the formula: T-c-E.sub.n-c-Fc.sub.n or T-c-Fc.sub.n-c-E.sub.n; wherein, T is a single chain variable portion...
2017/0137492 PROTEASE-ACTIVATED RECEPTOR-2 MODULATORS
Provided herein are peptides comprising a mutated fragment of a wild-type protease-activated receptor-2 (PAR2). The peptides comprising a hydrophobic moiety...
2017/0137491 Novel Method
The invention relates to a method of cell selection by using a nucleic acid molecule comprising a first nucleic acid sequence encoding a streptavidin binding...
2017/0137490 PEPTIDES, AND METHODS AND APPARATUS UTILISING SAME
The present invention relates to peptides that are able to bind to anti-PLA2R antibodies. The peptides comprise the amino acid sequence ...
2017/0137489 Process for the Synthesis of Therapeutic Peptides
A process for the large-scale synthesis of a therapeutic peptide using solid-phase Fmoc-chemistry.
2017/0137488 LONG-ACTING SINGLE-CHAIN INSULIN ANALOGUES
A single-chain insulin analogue containing a basic side chain at position A8 (Arginine, Histidine, Lysine, or Ornithine), a basic side chain at position B29...
2017/0137487 GLUCAGON-LIKE-PEPTIDE-2 (GLP-2) ANALOGUES
GLP-2 analogues are disclosed which comprise one of more substitutions as compared to [hGly2]GLP-2 and which improved biological activity in vivo and/or...
2017/0137486 PEPTIDE YY (PYY) ANALOGUES
Analogues of peptide YY (PYY), which are useful in treating disorders such as diabetes and obesity and also for inducing cosmetic weight loss, related...
2017/0137485 INTERLEUKIN-2 MUTEINS FOR THE EXPANSION OF T-REGULATORY CELLS
Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale...
2017/0137484 METHODS AND COMPOSITIONS FOR CANCER THERAPY USING MUTANT LIGHT MOLECULES WITH INCREASED AFFINITY TO RECEPTORS
Methods and compositions are disclosed to target tumor cells with embodiments of the LIGHT proteins linked fused or conjugated to a targeting agent. These...
2017/0137483 USE OF EPO-DERIVED PEPTIDE FRAGMENTS FOR THE TREATMENT OF INFLAMMATORY DISEASES
The described invention provides compositions having EPO-derived peptides, and methods and kits for administering the EPO-derived peptide to a subject...
2017/0137481 Use of Cell-Permeable Peptide Inhibitors of the JNK Signal Transduction Pathway for the Treatment of Various...
The present invention refers to the use of protein kinase inhibitors and more specifically to the use of inhibitors of the protein kinase c-Jun amino terminal...
2017/0137480 RPGR-OFR15 VARIANT GENE IN THE TREATMENT OF RETINITIS PIGMENTOSA
The present invention relates to the treatment of ocular disease, specifically retinitis pigmentosa, by gene therapy using a modified version of the RPGR-ORF15...
2017/0137479 PROTEIN EXTRACTION METHODS
Methods are provided for extracting DNA-compaction proteins from biological samples.
2017/0137478 ACTIVATING MITOTIC CHECKPOINT CONTROL MECHANISMS
Provided herein are compositions and methods for the treatment of cancer by activating the spindle assembly checkpoint (SAC) in cells. In particular, dimerized...
2017/0137477 METHOD FOR EXTRACTING SOLUBLE PROTEINS FROM MICROALGAL BIOMASS
A method for preparing a protein isolate of the biomass of microalgae of the genus Chlorella, includes the following steps: supplying a microalgal biomass...
2017/0137476 Chimeric Vaccine Against Fungal Infections
Chimeric double peptide vaccines are disclosed, useful for inducing active immunity against Candida fungal infections. The chimeric peptide comprises an Fba...
2017/0137475 EXPRESSION SYSTEM
Compositions and methods related to periplasmic expression of a toxin including diphtheria toxin or CRM197 are provided herein.
2017/0137474 PROTEIN ISOLATION
A general method and strains of bacteria are described by means where the endogenous DNAK protein or homolog of the DNAK protein is tagged with a recognizable...
2017/0137473 FLUOROGEN ACTIVATING AND SHIFTING TAG (FAST)
Disclosed is a functional derivative of a Photoactive Yellow Protein (PYP), or a functional fragment thereof, for fluorescently labelling particles, e.g....
2017/0137472 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION OR TREATMENT OF NEURODEGENERATIVE DISEASES
The present invention relates to methods and compositions for the prevention or treatment of neurodegenerative diseases.
2017/0137471 ANTIMICROBIAL PEPTIDE DENDRIMERS
The invention relates to a peptide dendrimer described by a general formula X--(B.sup.2--[Y.sup.2].sub.S-D.sup.1).sub.2-B.sup.1--Z, wherein X is (D.sup.2)4 or...
2017/0137470 Kv1.3 Potassium Channel Antagonists
The present invention relates to compounds which are capable of selectively binding to and inhibiting the activity of the potassium channel Kv1.3. The...
2017/0137469 POLYMYXIN DERIVATIVES AS ANTIMICROBIAL COMPOUNDS
The present invention relates to antimicrobial compounds and their uses, and in particular to peptide antibiotics which may be used in the treatment of...
2017/0137468 MODULATION OF COMPLEMENT ACTIVITY
The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.
2017/0137467 EPITOPE TAG AND METHOD FOR DETECTION AND/OR PURIFICATION OF TAGGED POLYPEPTIDES
Provided herein is a novel epitope that can be used as a tag in methods for rapid and effective characterization, purification, and subcellular localization of...
2017/0137466 PEPTIDE-INDUCED NK CELL ACTIVATION
This invention relates to NK cell activation and NK cell mediated immunity, immunogenic peptides, compositions and complexes; and associated methods of...
2017/0137465 C6S SPECIFIC TRANSPORTER MOLECULES
The present invention relates to isolated molecules, peptides, and polypeptides of specific consensus sequences or structures, and to compounds comprising or...
2017/0137464 ANTIBODY, EPITOPE TAG AND METHOD FOR DETECTION, CAPTURE AND/OR PURIFICATION OF TAGGED POLYPEPTIDES
Provided herein is a novel epitope that can be used as a tag in methods for rapid and effective characterization, purification, and subcellular localization of...
2017/0137463 HCV PROTEASE INHIBITORS AND USES THEREOF
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
2017/0137462 CATIONIC LIPID CORDIARIMIDE HYBRID COMPOUNDS AND A PROCESS FOR PREPARATION THEREOF
The present invention relates to the cationic lipid cordiaroimide hybrid compounds of formula I. The present invention provides a process for preparation of...
2017/0137461 Affinity Chromatography Devices
The present invention is directed to affinity chromatography devices that separate a targeted protein or antibody from an aqueous mixture containing the...
2017/0137460 Short Chain PEGylation of Amino Acid Monomers Glutamine, Lysine and Peptides Formed Thereby
Novel synthesized amino acids of glutamine and lysine that are directly PEGylated with small, monodisperse PEGs, and a novel process for creating novel amino...
2017/0137459 HYDROPHOBIC CERAGENIN COMPOUNDS AND DEVICES INCORPORATING SAME
A hydrophobic cationic steroidal anti-microbial (ceragenin) compound forms an amphiphilic compound having a hydrophobic sterol face and a hydrophilic cationic...
2017/0137458 OXYSTEROLS FOR USE IN THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY VIRUSES
The present invention relates to oxysterols of formula (I) for use in the treatment of infections caused by a naked virus, in particular a virus selected from...
2017/0137457 Labeled Nucleic Acids: A Surrogate for Nanopore-based Nucleic Acid Sequencing
Materials, methods, and systems for determining the sequence of a target nucleic acid are disclosed and described. Materials can include ssDNA, ssRNA, and...
2017/0137456 REVERSIBLE METAL ION CHELATORS
Provided herein are chelator constructs (e.g., nucleic acid, peptide, peptide nucleic acid, etc.) that sequester metal ions (e.g., Mg.sup.2+) under a first set...
2017/0137455 INHIBITORS OF PROTEIN METHYLTRANSFERASE DOT1L AND METHODS OF USE THEREOF
The present invention relates to DOT1L inhibitors and methods of identifying, designing, or optimizing them. The present invention also relates to crystals of...
2017/0137454 PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF
The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and...
2017/0137453 SOLID STATE FORMS OF SOFOSBUVIR
The present disclosure encompasses solid state forms of Sofosbuvir, processes for their production, and pharmaceutical compositions thereof.
2017/0137452 ALKYLGLYCOSIDE SULFOMETHYLSUCCINATE SURFACTANTS
The present invention relates to an alkyl glycoside sulfomethylsuccinate having the formula R.sup.1--O--S.sub.n--R.sup.2 wherein R.sup.1 is an alkyl radical...
2017/0137451 Stabilization of Lignin Fibers
A process for stabilizing lignin fibers, stabilized lignin fibers made by the process and carbonized fibers made from stabilized lignin fibers. The process...
2017/0137450 GREEN METHODS FOR PREPARING HIGHLY CO2 SELECTIVE AND H2S TOLERANT METAL ORGANIC FRAMEWORKS
A green route for preparing a metal organic framework include mixing metal precursor with a ligand precursor to form a solvent-free mixture; adding droplets of...
2017/0137449 Phosphorescent Meso-Unsubstituted Metallo-Porphyrin Probe Molecules for Measuring Oxygen and Imaging Methods
Oxygen levels in biological tissue or systems can be measured by the phosphorescence quenching method using phosphorescent porphyrin probes, also referred to...
2017/0137448 CYCLIC BENT ALLENE METAL COMPLEXES
The present invention provides stable, cyclic bent allene metal complexes and methods of conducting chemical processes, preferably olefin hydrogenation,...
2017/0137447 NOVEL METHOD FOR PRODUCING (E,Z)-7,9-DODECADIENYL-1-ACETATE
The present invention concerns a method to access (E,Z)-7,9-dodecadienyl-1-acetate in two synthesis steps with excellent yields and selectivity greater than...
2017/0137446 METHOD OF PREPARING AROMATIC COMPOUNDS FROM LIGNIN
The invention relates to a method of preparing monocyclic aromatic compounds from lignin and to the use of the method and/or the aromatic compounds obtained by...
2017/0137445 METHOD FOR PRODUCING POWDERS FROM ALKALI SALTS OF SILANOLS
Alkali metal siliconates with low contents of water and alcohol are economically prepared in a three stage process where organoalkoxysilanes are reacted with a...
2017/0137444 COMPOSITION, CURED FILM, NEAR INFRARED RAY ABSORPTION FILTER, SOLID-STATE IMAGING DEVICE, INFRARED SENSOR, AND...
It is possible to provide a composition that has absorption in a near infrared region and that can form a film having transparency in a visible region....
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