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Patent # Description
2017/0152244 bis-Pyridazine Compounds and Their Use in Treating Cancer
A compound of Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, where R.sup.1 can be hydro, methoxy, difluoromethoxy or trifluoromethoxy;...
2017/0152242 PYRAZINE DERIVATIVES
Provided is a novel pyrazine derivative represented by the following formula (I) or a pharmaceutically acceptable salt thereof, or a solvate thereof which is...
2017/0152241 BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR
The present invention provides: a bicyclic derivative comprising a pyrimidine ring, or a pharmaceutically acceptable salt thereof; a preparation method...
2017/0152240 COT MODULATORS AND METHODS OF USE THEREOF
The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
2017/0152239 BENZAMIDE AND HETEROBENZAMIDE COMPOUNDS
This invention relates to compounds of general formula ##STR00001## in which R.sup.1, R.sup.2, R.sup.6, U, V, W, X, Y and Z are as defined herein, and the...
2017/0152238 PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS
Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety,...
2017/0152237 PROCESS FOR THE PRODUCTION OF FURAN AND ITS DERIVATIVES
The present invention provides a process for the treatment of a liquid first furan stream comprising furan and carbon monoxide, said process comprising the...
2017/0152236 ENERGY EFFICIENT MANUFACTURING PROCESS FOR PREPARING N,O-TRIGLYCIDYL AMINOPHENOLS
The invention relates to an improved process for making monomeric triglycidyl compounds, wherein the triglycidyl compounds include N, O-triglycidyl compounds...
2017/0152235 NOVEL FORM OF TRIBENURON-METHYL, A PROCESS FOR ITS PREPARATION AND USE OF THE SAME
A crystalline form of tribenuron-methyl of formula (I), the crystal preparation process, the analyses of the crystal through various analytical methods and...
2017/0152234 COMPOSITIONS AND METHODS FOR QUADRICYCLANE MODIFICATION OF BIOMOLECULES
The present disclosure features a strain-promoted [2+2+2] reaction that can be carried out under physiological conditions. In general, the reaction involves...
2017/0152233 AMINO QUINAZOLINES AS KINASE INHIBITORS
Disclosed are compounds having the formula: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, and Z are as defined herein, and methods of making and using the same.
2017/0152232 NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND
As a result of studies on compounds having FGFR inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic...
2017/0152231 SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR
A method of preparing a 2,6 disubstituted anilines includes, reacting a 2-amino isophthalic acid diester with sufficient Grignard reagent R.sub.2CH.sub.2MgX to...
2017/0152230 NOVEL COMPOUNDS FOR SELECTIVE HISTONE DEACETYLASE INHIBITORS, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
The present invention relates to novel urea derivatives and, more particularly, to novel urea derivatives with histone deacetylase (HDAC) inhibitory activity,...
2017/0152229 TETRAHYDROISOQUINOLINONE DERIVATIVES AND THEIR USE IN THE INHIBITION OF THE HSP70 PROTEIN
The present invention relates to tetrahydroisoquinolinone derivatives, a pharmaceutical composition comprising the same and the use of these derivatives in the...
2017/0152228 SCREENING METHODS FOR THE BINDING AFFINITY OF CHEMICAL ENTITIES TO BIOLOGICAL MOLECULES AND NEDD4-1 INHIBITORS...
Disclosed are methods for preparing and screening for an inhibitor of the activity of a biological molecule having a catalytic or non-catalytic cysteine...
2017/0152227 Novel Polymorphic Form of N-[2-(6-fluoro-lH-indol-3-yl)ethyl]-3-2,2,3,3-tetrafluoropropoxy)benzylam- ine...
The present invention relates to a novel polymorphic form of N-[2-(6-fluoro-1H-indol-3-yl)ethyl]-3-(2,2,3,3-tetrafluoropropoxy)benzyla- mine hydrochloride.
2017/0152226 FUNCTIONALISED AND SUBSTITUTED INDOLES AS ANTI-CANCER AGENTS
The present invention relates to anti-tropomyosin compounds, processes for their preparation, and methods for treating or preventing a disease or disorder,...
2017/0152225 METHOD AND CATALYST FOR SYNTHESISING AZIRIDINE
The present invention relates to methods of synthesising aziridines including isotopically labelled aziridines, said methods comprising contacting an imine or...
2017/0152224 NOVEL PROSTAMIDES FOR THE TREATMENT OF GLAUCOMA AND RELATED DISEASES
Disclosed herein are compositions comprising an amide related to a prostaglandin and a biogenic amine. Other aspects relate to certain chemical compounds,...
2017/0152223 LIPID PARTICLES WITH CATIONIC LIPIDS FOR RNA DELIVERY
What is described is a lipid particle comprising the compound of formula I ##STR00001## wherein R.sub.1 consists of alkyl, alkenyl, alkynyl, or cholesteryl; ...
2017/0152222 COMPOUNDS AND METHODS FOR INHIBITING PRODUCTION OF TRIMETHYLAMINE
The invention provides a method of inhibiting the conversion of choline or carnitine to trimethylamine (TMA) and lowering TMAO in an individual comprising...
2017/0152221 ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF
Disclosed are compounds of Formula (IVA), or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those compounds, or a...
2017/0152220 O-ALKYL-BENZYLIDENEGUANIDINE DERIVATIVES AND THERAPEUTIC USE FOR THE TREATMENT OF DISORDERS ASSOCIATED AN...
The present invention relates to a compound of formula (I), or a tautomer and/or a pharmaceutically acceptable salt thereof Formula (I), and its uses to treat...
2017/0152219 METHOD FOR THE MANUFACTURE OF UREA
A method for producing urea. A methane-containing feed gas stream is reacted with oxygen by partial oxidation to form a synthesis gas stream containing...
2017/0152218 PROCESS FOR PRODUCTION OF AMMONIA AND DERIVATIVES, IN PARTICULAR UREA
A process for producing ammonia and a derivative of ammonia from a natural gas feed comprising conversion of natural gas into a make-up synthesis gas;...
2017/0152217 FINE PURIFICATION OF ISOPHORONENITRILE BY MELT CRYSTALLIZATION
The present invention relates to the fine purification of isophoronenitrile (IPN) by melt crystallization.
2017/0152216 METHOD FOR PREPARING N,N'-BIS(2-CYANOETHYL)-1,2-ETHYLENEDIAMINE BY USING CATION EXCHANGE RESIN AS CATALYST
A method for preparing N,N'-bis(2-cyanoethyl)-1,2-ethylenediamine involves using strongly acidic cation exchange resin as a catalyst for synthesis, and is...
2017/0152215 METHOD FOR PREPARING N,N'-BIS(2-CYANOETHYL)-1,2-ETHYLENEDIAMINE
A method for preparing N,N'-bis(2-cyanoethyl-1,2-ethylenediamine involves using glycol ether as a catalyst for synthesis reaction in which ethylenediamine and...
2017/0152214 INSECTICIDAL COMPOUNDS
The present invention relates to novel triazole derivatives of formula (I) having insecticidal activity, to processes and intermediates for preparing them, to...
2017/0152213 AMINE-CONTAINING LIPIDOIDS AND USES THEREOF
Provided herein are lipidoids that may be prepared from the conjugate addition of alkylamines to acrylates. In some embodiments, provided lipidoids are...
2017/0152212 METHOD FOR PREPARING N,N'-BIS(3-AMINOPROPYL)-1,2-ETHYLENEDIAMINE
A method for preparing N,N'-bis(3-aminopropyl)-1,2-ethylenediamine uses a glycol ether based solution, such as a solution containing dipropylene glycol...
2017/0152211 INTEGRATED PROCESS FOR NITRILE MANUFACTURE WITH ENHANCED LIQUID-LIQUID EXTRACTION
Phosphorus-containing ligands are recovered from mixtures comprising 3-pentenenitrile (3PN) and adiponitrile (ADN), using liquid-liquid extraction. ADN is...
2017/0152210 METHODS FOR PRODUCING CHEMICAL PRODUCTS WITH OPERATION INTERRUPTIONS
This invention relates to methods for producing chemical products, wherein the one or more feed materials are reacted to form a chemical product or a chemical...
2017/0152209 ULTRA HIGH-VISCOSITY ESTOLIDE BASE OILS AND METHOD OF MAKING THE SAME
Provided herein are methods of making estolide base oils, including those having a high kinematic viscosity. In certain embodiments, an ultra high-viscosity...
2017/0152208 METHOD FOR PROVIDING AN ACTIVE RUTHENIUM CATALYST SOLUTION FOR THE TRANSVINYLATION OF CARBOXYLIC ACIDS
The invention relates to a method for providing a ruthenium catalyst solution which is active during the transvinylation of a surfactant vinyl ester with a...
2017/0152207 COMPOSITIONS AND METHODS FOR HYDROCARBON FUNCTIONALIZATION
Embodiments of the present disclosure provide for methods of hydrocarbon functionalization, methods and systems for converting a hydrocarbon into a compound...
2017/0152206 IRE-1alpha INHIBITORS
Compounds which directly inhibit IRE-1.alpha. activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are...
2017/0152205 HIGH-AND LOW-VISCOSITY ESTOLIDE BASE OILS AND LUBRICANTS
Provided herein are compounds of the formula: ##STR00001## in which n is an integer equal to or greater than 1; R.sub.2 is selected from hydrogen and optionally...
2017/0152204 LACTIC ACID MANUFACTURING METHOD
A method of producing lactic acid includes subjecting a lactic acid-containing solution to distillation to collect lactic acid from the vapor side (Step A);...
2017/0152203 POLYETHYLENE TEREPHTHALATE DEPOLYMERIZATION
The present invention relates to the depolymerization of polymers and the recovery of the starting materials used for the production of the polymer. The...
2017/0152202 PROCESS FOR THE PREPARATION OF A PHENYLINDAN PHOTOINITIATOR
The present invention refers to a process for producing 5-[4-(2-hydroxy-2-methyl)-1-oxo-prop-1-yl]-3-[4-(2-hydroxy-2-methyl)-1-ox- ...
2017/0152201 Process and System for Making Cyclohexanone
Disclosed are processes and systems for making cyclohexanone from a mixture comprising phenol, cyclohexanone, and cyclohexylbenzene comprising a step of or a...
2017/0152200 Zeolite Catalyst for Lignin to Phenol Conversion
A method for converting lignin to a phenol product, the method comprising contacting a zeolite catalyst with a lignin under reaction conditions sufficient to...
2017/0152199 METHOD OF DEPOLYMERIZING LIGNIN
A method of depolymerizing lignin and to the use of this method in the production of fuels, electronic components, plastic polymers, rubber, medicines,...
2017/0152198 HEAT INTEGRATION IN DISPROPORTIONATION OR TRANSALKYLATION PROCESSES
Toluene disproportionation and C9/C10 transalkylation are a significant source of xylenes in a modern aromatics complex. Methods and apparatuses for improving...
2017/0152197 METHOD FOR PREPARING P-XYLENE AND CO-PRODUCING PROPYLENE WITH HIGH SELECTIVITY
A method for preparing p-xylene and co-producing propylene with a high selectivity, comprising: a) bringing a raw material containing toluene and methanol and/or ...
2017/0152196 IGNITION COMPOSITIONS, AND PREPARATIONS AND USES THEREOF
An ignition composition comprising a low electron affinity material, an oxidizer and a binder. The ignition composition may be made by A1) preparing a...
2017/0152195 Process for the Preparation of Humic Extracts from Fossil Sources
The present invention relates to a process for the preparation of fertilizing compositions and to the compositions obtained.
2017/0152194 METHOD FOR ENHANCING SOIL GROWTH USING BIO-CHAR
A method is described for rendering char from a biomass fractionator apparatus (BMF char) suitable for addition to soil in high concentrations, the method...
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