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Patent # Description
2017/0158779 PROCESS AND METHODS FOR EFFICIENT MANUFACTURING OF HIGHLY PURE ASYMMETRIC ANTIBODIES IN MAMMALIAN CELLS
The present invention provides a process and methods for producing asymmetric antibodies in a mammalian expression system. The asymmetric antibodies are...
2017/0158778 ANTI-KIT ANTIBODIES AND USES THEREOF
Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like...
2017/0158777 METHOD FOR INHIBITING INTRACELLULAR ACTIVATED RAS USING INTACT IMMUNOGLOBULIN-TYPE ANTIBODY HAVING...
The present invention relates to a method for inhibiting intracellular activated RAS using an intact immunoglobulin-type antibody having the ability to...
2017/0158776 TREATMENT OF LUNG CANCER USING A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND ANOTHER ANTI-CANCER AGENT
This disclosure provides a method for treating a subject afflicted with a lung cancer, which method comprises administering to the subject therapeutically...
2017/0158775 ANTI-C4.4A ANTIBODIES AND USES THEREOF
The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are...
2017/0158774 ANTI-LA ANTIBODIES AND THEIR USE FOR IMMUNOTARGETING
The invention relates to antibodies against the human La protein and to their use in immunotargeting, in particular the immunotargeting of tumour cells. The...
2017/0158773 IMMUNOGLOBULIN VARIANTS AND USES THEREOF
The invention provides humanized and chimeric anti-CD20 antibodies for treatment of CD20 positive malignancies and autoimmune diseases.
2017/0158772 COMPOSITIONS OF ANTIBODY CONSTRUCT - AGONIST CONJUGATES AND METHODS OF USE THEREOF
Various antibody construct compositions are disclosed. The compositions of antibody construct-immune stimulatory compound conjugates are also provided....
2017/0158771 MODIFIED ANTIBODIES CONTAINING MODIFIED IGG2 DOMAINS WHICH ELICIT AGONIST OR ANTAGONISTIC PROPERTIES AND USE...
Through a combination of in vitro and in vivo approaches, the inventors show that human IgG2 (h2) delivers unique Fc.gamma.R-independent agonistic activity to...
2017/0158770 COMPOSITIONS AND METHODS FOR TARGETED IMMUNOMODULATORY ANTIBODIES AND FUSION PROTEINS
The present invention is based on the seminal discovery that targeted immunomodulatory antibodies and fusion proteins can counter act or reverse immune...
2017/0158769 ANTI-FGFR3 ANTIBODIES AND METHODS USING SAME
The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.
2017/0158768 COMPOSITIONS AND METHODS FOR TARGETING OF THE SURFACTANT PROTEIN A RECEPTOR
Provided are compositions and methods for use in prophylaxis, therapy and diagnosis of conditions which involve surfactant protein receptors (SPR) including...
2017/0158767 HUMAN MONOCLONAL ANTIBODIES TO PROGRAMMED DEATH LIGAND 1 (PD-L1)
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to PD-L1 with high affinity....
2017/0158766 Modulation of Activity of Neurotrophins
The present invention relates to methods for modulating the activity of one or more neurotrophins, such as neural growth factor (NGF), brain derived...
2017/0158765 IMMUNOREGULATION BY ANTI-ILTS ANTIBODIES AND ILTS-BINDING ANTIBODY FRAGMENTS
Disclosed herein are methods of using anti-ILT5 antibodies and ILT5-binding fragments thereof to induce an immunostimulatory effect in a T cell when such a T...
2017/0158764 ANTI-CANINE PD-1 ANTIBODY OR ANTI-CANINE PD-L1 ANTIBODY
The object of the present invention is to provide an anti-canine PD-1 antibody or an anti-canine PD-L1 antibody, an agent for inhibiting binding between a...
2017/0158763 HUMANIZED ANTIBODIES WITH INCREASED STABILITY
The present invention provides antibodies having improved stability. Included are antibodies that are capable of binding to KIR3DL2 polypeptides. The...
2017/0158762 ANTIBODIES DIRECTED AGAINST DISCOIDIN DOMAIN RECEPTOR FAMILY, MEMBER 1 (DDR1)
The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to Discoidin...
2017/0158761 BINDING INHIBITOR BETWEEN TCTP DIMER TYPE IGE-DEPENDENT HISTAMINE RELEASING FACTOR AND RECEPTOR THEREOF, AND...
The present invention relates to a receptor-binding domain of an IgE-dependent histamine releasing factor (HRF), and a use thereof, and more specifically,...
2017/0158760 Isolation and Purification of Antibodies Using Protein A Affinity Chromatography
Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody...
2017/0158759 FORMULATION OF HUMAN ANTIBODIES FOR TREATING TNF-ALPHA ASSOCIATED DISORDERS
A liquid aqueous pharmaceutical formulation is described which has a high protein concentration, a pH of between about 4 and about 8, and enhanced stability.
2017/0158758 LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods,...
2017/0158757 IP-10 ANTIBODIES AND THEIR USES
The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of...
2017/0158756 CANINIZED ANTI-NGF ANTIBODIES AND METHODS THEREOF
The invention provides novel caninized anti-NGF antibodies (such as caninized anti-NGF antagonist antibodies and antigen binding proteins), and polynucleotides...
2017/0158755 ANTI-LAMININ4 ANTIBODIES SPECIFIC FOR LG1-3
The invention provides antibodies that specifically bind to the LG1-3 modules of the G domain of laminin .alpha.4. The antibodies have the capacity to inhibit...
2017/0158754 HUMAN MONOCLONAL ANTIBODIES DERIVED FROM HUMAN B CELLS AND HAVING NEUTRALIZING ACTIVITY AGAINST INFLUENZA A VIRUSES
The present invention relates to human monoclonal antibodies derived from human B cells present in the blood of patients who had recovered from infection with...
2017/0158753 MONOCLONAL ANTIBODIES DIRECTED AGAINST ENVELOPE GLYCOPROTEINS FROM MULTIPLE FILOVIRUS SPECIES
The disclosure provides binding molecules, e.g., antibodies or antigen-binding fragments thereof, that can bind to orthologous epitopes found on two or more...
2017/0158752 MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS NEUTRALIZING ANTIBODIES AND METHODS OF USE THEREOF
The present invention provides antibodies that neutralize MERS-CoV and methods of use thereof. The invented antibody is used to treat MERS-CoV infections and...
2017/0158751 MODULATING DISEASE THROUGH GENETIC ENGINEERING OF PLANTS
In certain embodiments transgenic plants (e.g., transgenic tomatoes) are provided that comprise cells that express a peptide one or more domains of which...
2017/0158750 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2017/0158749 CHIMERIC ANTIGEN RECEPTORS (CAR) AND METHODS FOR MAKING AND USING THE SAME
Chimeric antigen receptors (CARs) and CAR-expressing T cells are provided that can specifically target cells that express an elevated level of a target...
2017/0158748 GLUCOSE-REGULATING POLYPEPTIDES AND METHODS OF MAKING AND USING SAME
The present invention relates to compositions comprising glucose regulating peptides linked to extended recombinant polypeptide (XTEN), isolated nucleic acids...
2017/0158747 ANTIBODY CYTOKINE ENGRAFTED COMPOSITIONS AND METHODS OF USE FOR IMMUNOREGULATION
The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through interleukin 10 receptor....
2017/0158746 MODIFIED INTERLEUKIN-7 PROTEIN AND USES THEREOF
The present invention provides a modified interleukin-7 and a use thereof. The modified IL-7 or an IL-7 fusion protein of the present invention comprising the...
2017/0158745 IDR PEPTIDE COMPOSITIONS AND USE THEREOF FOR TREATMENT OF TH2-DYSREGULATED INFLAMMATORY CONDITIONS
A composition for treating or preventing a Th2-dysregulated inflammatory condition wherein the composition comprises a therapeutically effective amount of one...
2017/0158744 MIMOTOPES OF ALPHA-SYNUCLEIN AND VACCINES THEREOF FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
A method of treating a synucleinopathy with a peptide (C)DQPVLPD (SEQ ID NO: 59), (C)DMPVLPD (SEQ ID NO: 60), (C)DSPVLPD (SEQ ID NO: 61), (C)DQPVLPDN (SEQ ID...
2017/0158743 COMPOSITIONS AND METHODS FOR TREATMENT OF CELIAC DISEASE
The invention provides agents and vaccines for treating and diagnosing celiac disease. In particular, the present invention provides a combination of three...
2017/0158742 BIOTINYLATED PROTEIN
Disclosed are methods of screening a library of molecules to identify or select one or more molecules which selectively bind to a fused protein, or fragment...
2017/0158741 PEPTIDES INCLUDING A BINDING DOMAIN OF THE VIRAL PHOSPHOPROTEIN (P) SUBUNIT TO THE VIRAL RNA FREE NUCLEOPROTEIN...
The invention related to isolated peptides including a binding domain of the viral phosphoprotein (P) subunit to the viral RNA free nucleoprotein (N.sup.0)...
2017/0158740 A DENGUE VIRUS CHIMERIC POLYEPITOPE COMPOSED OF FRAGMENTS OF NON-STRUCTURAL PROTEINS AND ITS USE IN AN...
The present invention is directed to a dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic...
2017/0158739 MINICIRCLE DNA VECTOR VACCINE PLATFORM FOR FOOT-AND-MOUTH DISEASE AND METHODS THEREOF
This application is directed generally to minicircle DNA vectors for the vaccination of foot-and-mouth disease (FMD). The transgene expression cassette in the...
2017/0158738 MULTIPLEXED SAME TYPE-ANTIGENIC PEPTIDE
The present invention provides a synthetic peptide capable of inducing an antibody to an autoantigen, and specifically, provides: a multiplexed same...
2017/0158737 CANCER STEM CELL TARGETING PEPTIDE AND USE THEREOF
A synthetic peptide that targets cancer stem cells is provided. The peptide consists of the amino acid sequence of anyone of SEQ ID NO: 1 to SEQ ID NO: 15....
2017/0158736 COMPOSITIONS AND METHODS FOR TREATING MRSA INFECTIONS AND FOR SENSITIZING MRSA TO BETA-LACTAM ANTIBIOTICS
Provided herein are compounds and compositions having antibiotic activity against methicillin resistant Staphylococcus aureus (MRSA). In particular, provided...
2017/0158735 METHOD FOR PRODUCING A RECOMBINANT PEPTIDE AND RESULTANT PEPTIDE
The invention relates to peptides with the following general formula: A-Thr-Lys-Pro-B-C-D-X, where: A--0, Met, Met (O), Thr, Ala, His, Phe, Lys, Gly B--0, Gly, Asp,...
2017/0158734 EPOXYKETONE COMPOUNDS FOR ENZYME INHIBITION
The present disclosure relates to novel compounds and pharmaceutical compositions thereof which are useful as inhibitors of proteasomes. The compounds provided...
2017/0158733 PROCESS FOR THE PREPARATION OF RAMIPRIL
An enantioselective process for the production of (2S,3aS,6aS)-cyclopenta[b]pyrrole-2-carboxylic acid and its conversion into Ramipril is provided.
2017/0158732 VIRUS REDUCTION METHOD
Methods are provided for enhancing reduction of virus and viral DNA levels in protein preparations.
2017/0158731 NUCLEOPHILE-REACTIVE SULFONATED COMPOUNDS FOR THE (RADIO)LABELLING OF (BIO)MOLECULES; PRECURSORS AND CONJUGATES...
Nucleophile-reactive sulfonated compounds used as precursors to (radio)labelled (bio)molecules are produced by pre-introduction of a nucleophilic compound R*...
2017/0158730 HYDROXYSTEROID COMPOUNDS, THEIR INTERMEDIATES, PROCESS OF PREPARATION, COMPOSITION AND USES THEREOF
The present invention relates to novel steroidal compounds of formula (I), process for preparation of the same and composition comprising these compounds. ...
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