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Patent # Description
2017/0158729 METHOD OF SYNTHESIZING 25-HYDROXY CHOLESTEROL
The present invention discloses a method for synthesizing 25-hydroxy cholesterol. The method is as below: subjecting 24-dehydrocholesterol derivative as a raw...
2017/0158728 SULFATED-GLYCOLIPIDS AS ADJUVANTS FOR VACCINES
A synthetic charged glycolipid is described comprising a sulfated saccharide group covalently linked to the tree sn-1 hydroxyl group of the glycerol backbone...
2017/0158727 HAMAMELITANNIN ANALOGUES AND USES THEREOF
The present invention relates to hamamelitannin analogues, pharmaceutical compositions comprising the same, and combinations thereof with anti-microbial agents...
2017/0158726 ORGANODIARYL SELENOXIDES AND PROCESS FOR PREPARATION THEREOF
Novel organodiaryl selenoxides and processes for preparation thereof, and use thereof as ligand in complexes.
2017/0158725 PRODRUG COMPOUNDS AND USES THEROF
Provided herein are cyclic phosphorus-containing prodrug compounds, their preparation and their uses, such as treating diseases via modulating molecular...
2017/0158724 Novel Compounds
A compound of Formula (I) ##STR00001## wherein Y.sup.1, Y.sup.2, X.sup.1, X.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.8, and R.sup.9 are...
2017/0158723 HETEROCYCLIC SELENAMONOPHOSPHITES PROTECTED ON A HYDROXYL GROUP AND PROCESSES FOR PREPARATION THEREOF
Novel heterocyclic selenamonophosphites protected on the hydroxyl group, processes for preparation thereof and the use thereof as ligand.
2017/0158722 HETEROCYCLIC SELENOPHOSPHITES AND METHOD FOR THE PREPARATION THEREOF
Novel heterocyclic selenophosphites, method for preparation thereof and use thereof as ligand unit for preparing ligands for use in complexes.
2017/0158721 HETEROCYCLIC SELENAPHOSPHITES AND PROCESS FOR PREPARATION THEREOF
Novel heterocyclic selenaphosphites, process for preparation thereof and use thereof as ligand for employment in complexes.
2017/0158720 Antimicrobial Compounds
An antimicrobial compound, as well as the salts, derivatives and analogues thereof, said compound being represented by the general formula (I): ##STR00001## ...
2017/0158719 PROCESS FOR REDUCING THE CHLORINE CONTENT OF ORGANOTETRAPHOSPHITES
Universally usable process for reducing the chlorine content of organotetraphosphites.
2017/0158718 TITANIUM (IV) COMPOUNDS AND METHODS OF FORMING HETEROCYCLIC COMPOUNDS USING SAME
The present disclosure provides Titanium (IV) compounds and methods of making heterocyclic compounds such as pyrroles using Titanium (IV) compounds. In certain...
2017/0158717 AMINOSILICONE SOLVENT RECOVERY METHODS AND SYSTEMS
The present invention is directed to aminosilicone solvent recovery methods and systems. The methods and systems disclosed herein may be used to recover...
2017/0158716 METHOD FOR PRODUCING SILANE COMPOUND HAVING SULFONYL BOND
A method of producing a silane compound having a Formula (1) sulfonyl bond includes reacting a Formula (I) chlorosulfonyl compound with sodium sulfite in water...
2017/0158715 LIQUID CRYSTAL VERTICAL ALIGNMENT AGENT, LIQUID CRYSTAL DISPLAY ELEMENT AND MANUFACTURE METHOD OF LIQUID...
The present invention provides a liquid crystal vertical alignment agent, and the liquid crystal vertical alignment agent can make the liquid crystal molecules...
2017/0158714 Preparation and Medical Use of Triazenes
The present invention relates to a novel method for preparing triazenes. Further, the invention relates to novel triazenes and the use of N.sub.2O for...
2017/0158713 METHOD OF TREATING CANCER AND GOLD(III) COMPLEXES AS ANTI-CANCER AGENTS
A method for treating cancer and gold(III) complexes with diaminocyclohexane ligand as anticancer agents. Also described are a pharmaceutical composition...
2017/0158712 NOVEL MACROCYCLES AS FACTOR XIA INHIBITORS
The present invention provides compounds of Formula (Ia): ##STR00001## or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all...
2017/0158711 NOVEL INDUSTRIAL CRYSTALLIZATION METHOD OF CEFUROXIME SODIUM AND PREPARATION THEREOF
It discloses a new industrial crystallization method of Cefuroxime Sodium, wherein supercritical fluid extraction technology and traditional crystalline...
2017/0158710 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS
The present disclosure relates to tricyclic heterocycles which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the...
2017/0158709 BROMODOMAIN INHIBITORS
The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and...
2017/0158708 ANTIBACTERIAL COMPOUNDS
The invention relates to antibacterial and anti-mycobacterial drug compounds of formula I. It also relates to pharmaceutical formulations of antibacterial drug...
2017/0158707 ARYL RECEPTOR MODULATORS AND METHODS OF MAKING AND USING THE SAME
The present invention is generally directed towards compounds capable of binding the aryl hydrocarbon receptor and modulating its activity, methods of treating...
2017/0158706 THIENOPYRIMIDINE INHIBITORS OF ATYPICAL PROTEIN KINASE C
The present application provides a compound of formula (I) ##STR00001## or a salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, A, G, M,...
2017/0158705 METHOD FOR PREPARING ERIBULIN INTERMEDIATE
Intermediates used in the synthesis of Eribulin and methods for preparing the intermediates are described. For example, a compound of formula IV and a method...
2017/0158703 METHOD FOR PRODUCING SPIROOXINDOLE DERIVATIVE
The present invention is intended to provide a method for efficiently producing and providing a compound having a spirooxindole skeleton, for example, a...
2017/0158702 MULTIVALENT RAS BINDING COMPOUNDS
Described herein are compounds that modulate Ras signaling, methods of making such compounds, pharmaceutical compositions and medicaments comprising such...
2017/0158701 PROCESS FOR PREPARING CHIRAL DIPEPTIDYL PEPTIDASE-IV INHIBITORS
A process for preparing a compound of structural Formula Ia: comprising Boc deprotection with TFA of, reductive amination of: ##STR00001##
2017/0158700 3-SUBSTITUTED 2-AMINO-INDOLE DERIVATIVES
The present invention provides compounds of formula (I) (Formula (I)) and pharmaceutically acceptable salts thereof, wherein Q, X % X.sup.4, X.sup.5 X.sup.6,...
2017/0158699 ADDITION SALTS OF (S)-2-(1-(6-AMINO-5-CYANOPYRIMIDIN-4-YLAMINO)ETHYL)-4-OXO-3-PHENYL-3,4-DI- ...
The present invention is directed to novel pharmaceutically acceptable, addition salts of ...
2017/0158698 TrKA Kinase Inhibitors, Compositions and Methods Thereof
The present invention is directed to substituted five membered heteroaryl benzamide compounds of formula (I) (Formula (I)) which are tropomyosin-related kinase...
2017/0158697 Protein Kinase Inhibitors
The present invention relates to a novel family of protein kinase inhibitors, more specifically the present invention is directed to inhibitors of the members...
2017/0158696 N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS
The present invention provides N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines derivatives that modulate the activity of phosphoinositide 3-kinases (PI3Ks)...
2017/0158695 Method For Preparation of Alkylated or Fluoro, Chloro and Fluorochloro Alkylated Compounds By Heterogeneous...
The invention discloses a method for preparation of alkylated or fluoro, chloro and fluorochloro alkylated compounds by a heterogeneous Pt/C-catalyzed...
2017/0158694 COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY
Compounds of formula (I), defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention...
2017/0158693 HEXAHYDRODIAZEPINOQUINOLINES CARRYING A CYCLIC RADICAL
The present invention relates to tricyclic hexahydrodiazepinoquinolines carrying a cyclic substituent, to a method for producing them, to a pharmaceutical...
2017/0158692 COMPOUNDS AND METHODS FOR INHIBITING FASCIN
Provided are compounds, compositions and methods for inhibiting fascin activity or treating a condition or disorder mediated by fascin activity in a subject in...
2017/0158691 Derivatives And Methods Of Treating Hepatitis B Infections
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of...
2017/0158690 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
Disclosed are compounds of Formula I: ##STR00001## or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof,...
2017/0158689 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS
The present invention relates to substituted pyrrolopyridinones and substituted pyrazolopyridinones which are inhibitors of BET proteins such as BRD2, BRD3,...
2017/0158688 Imidazopyridine Derivatives as Modulators of TNF Activity
A series of substituted 1H imidazo[4,5-c]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the...
2017/0158687 ATX MODULATING AGENTS
Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds...
2017/0158686 Compounds Useful as Raf Kinase Inhibitors
The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of...
2017/0158685 HISTONE DEMETHYLASE INHIBITORS
The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine...
2017/0158684 NOVEL COMPOUND, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, METHOD FOR PREPARING THE SAME, AND...
The present invention relates to a novel compound, to a pharmaceutically acceptable salt or optical isomer thereof, to a method for preparing same, and to a...
2017/0158683 COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY
Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in...
2017/0158682 METHOD FOR PRODUCING FUSED HETEROCYCLIC COMPOUND
A compound represented by formula (4) is produced by a step A of reacting a compound represented by formula (2): ##STR00001## wherein R.sup.1 represents an ethyl...
2017/0158681 HISTONE DEMETHYLASE INHIBITORS
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine...
2017/0158680 HETEROCYCLIC COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF
The present invention provides a heterocyclic compound represented by the formula (I), its stereoisomers, or a pharmaceutically acceptable salt thereof,...
2017/0158679 PROCESS FOR PREPARING A NOVEL CRYSTALLINE FORM OF THIFENSULFURON-METHYL AND USE OF THE SAME
A the crystalline form of thifensulfuron-methyl of formula (I), the crystal preparation process, the analyses of the crystal through various analytical methods...
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