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Patent # Description
2017/0165279 Compositions and Methods for the Treatment of Neurodegenerative and Other Diseases
In one embodiment, the present application discloses methods of treating diseases and disorders with sulfasalazine and pharmaceutical formulations of...
2017/0165278 C17-HETEROARYL DERIVATIVES OF OLEANOLIC ACID AND METHODS OF USE THEREOF
Disclosed herein are novel C17-heteroaryl derivatives of oleanolic acid, including those of the formula: ##STR00001## wherein the variables are defined herein....
2017/0165277 TREATMENT OF FIBROSIS USING FXR LIGANDS
The present invention relates to a method for inhibiting fibrosis that occurs in an organ where the farnesoid X receptor (FXR) is expressed. This method...
2017/0165276 CORTICOSTERIOD CONTAINING FOAM COMPOSITIONS AND METHOD OF MANUFACTURE THEREOF
The present invention provides a method of manufacturing foamable, corticosteroid containing compositions as well as methods for treating various skin diseases.
2017/0165275 HALOBETASOL FOAM COMPOSITION AND METHOD OF USE THEREOF
The present invention provides a composition and method for treating various skin diseases. The composition is formulated as a foamable composition and...
2017/0165274 COMPOSITION
The invention provides a composition in the form of a liquid or liquid suspension, comprising an iron hydroxypyrone and a taste masking agent, and wherein the...
2017/0165273 METHODS OF TREATMENT USING SELECTIVE 5-HT2A INVERSE AGONISTS
Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In...
2017/0165272 PHARMACEUTICAL COMPOSITION COMPRISING INDOLE COMPOUND
The present invention relates to a pharmaceutical composition comprising a compound of formula (1), (2) or (3) as defined in the specification for the...
2017/0165271 Compositions and Methods for the Delivery of Therapeutics
The present invention provides compositions and methods for the delivery of antivirals to a cell or subject.
2017/0165270 Heteroaromatic Compounds and their Use as Dopamine D1 Ligands
The present invention provides, in part, compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts thereof and N-oxides thereof; processes for...
2017/0165269 SUSTAINED RELEASE DRUG DELIVERY SYSTEM
Disclosed is a controlled release dosage form comprising a therapeutically effective amount of a pharmaceutically active agent, which may be Acyclovir, that...
2017/0165268 Modulators of Androgen Synthesis
The present specification discloses compositions comprising at least one therapeutic compound capable of modulating androgen production and methods and uses...
2017/0165267 CRYSTALLINE FORM OF (S)-N-(5-((R)-2-(2,5-DIFLUOROPHENYL)-PYRROLIDIN-1-YL)-PYRAZOLO[1,5-A]PYRI- ...
A novel crystalline form of (S)--N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyri- midin-3-yl)-3-hydroxypyrrolidine-1-carboxamide,...
2017/0165265 HEAT SHOCK PROTEIN BINDING COMPOUNDS, COMPOSITIONS, AND METHODS FOR MAKING AND USING SAME
The present subject matter relates to a compound represented by the general formula (I) or (I') or a pharmacologically acceptable salt thereof; pharmaceutical...
2017/0165264 COMBINATION OF CREATINE, AN OMEGA-3 FATTY ACID, AND CITICOLINE
In one aspect, the invention relates to compositions comprising at least one creatine or creatine analog, at least one omega-3 fatty acid, and citicoline...
2017/0165263 SUBSTITUTED IMIDAZOPYRIDAZINES AND BENZIMIDAZOLES AS INHIBITORS OF FGFR3
The present invention relates to substituted imidazopyridazines and substituted benzimidazoles, as well as pharmaceutical compositions comprising the same,...
2017/0165262 PHARMACEUTICAL COMPOSITION FOR TREATING FLT3 MUTATION-POSITIVE CANCER, MUTANT FLT3 INHIBITOR AND USES THEREOF
Provided are a pharmaceutical composition for treating an FLT3 mutation-positive cancer; a mutant FLT3 inhibitor; and uses thereof. Disclosed are a...
2017/0165261 COMBINATION OF A BRAFV600E INHIBITOR AND MERTK INHIBITOR TO TREAT MELANOMA
The invention relates to a pharmaceutical combination which comprises (a) a compound inhibiting BRAF.sup.V600E and (b) a compound which inhibits MerTK...
2017/0165260 LIQUID PREPARATION COMPRISING PIMOBENDAN
A liquid preparation includes an etherified cyclodextrin derivative and a substituted benzimidazol, where the etherified cyclodextrin derivative is one of...
2017/0165259 COMBINED MODULATION OF IRE1
Described herein, inter alia, are combined compositions of an Ire1 kinase modulating compound and an Ire1 ribonuclease modulating compound and methods of using...
2017/0165258 TABLET COMPRISING 7-[4-(4-BENZO[B]THIOPHEN-4-YL-PIPERAZIN-1-YL)BUTOXY]-1H-QUINOLIN-2-ONE OR A SALT THEREOF
This invention relates to a tablet containing, as an active ingredient, 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or a salt...
2017/0165256 COMPOSITIONS FOR TREATING CMT AND RELATED DISORDERS
The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders.
2017/0165255 Oral Drug Delivery System
Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of...
2017/0165254 TREATING FLAVIVIRUS INFECTIONS WITH AMODIAQUINE AND DERIVATIVES THEREOF
Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a...
2017/0165253 TREATMENT OF SEXUAL DYSFUNCTION AND FOR IMPROVED SEXUAL QUALITY OF LIFE
Compositions and methods for treating sexual dysfunction and enhancing sexual satisfaction using topical application of alpha-1 adrenergic receptor agonists,...
2017/0165252 PROTEIN-ENRICHED THERAPEUTIC COMPOSITION
The present disclosure provides protein-enriched, nicotine-containing products, suitable for use as oral formulations. Products of the present disclosure...
2017/0165251 METHOD OF TREATING THERMOREGULATORY DYSFUNCTION WITH PAROXETINE
The present invention relates to a method for treating a patient suffering from a thermoregulatory dysfunction, especially hot flashes and flushes associated...
2017/0165250 TREATMENT OF SCHIZOPHRENIA
Aspects of the invention relate generally to the treatment of schizophrenia and to monitoring for specific adverse reactions.
2017/0165249 COMPOSITIONS AND METHODS FOR TREATING DISEASES OF THE NAIL
Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are...
2017/0165248 SOLID DOSAGE FORM COMPRISING PROTON PUMP INHIBITOR AND SUSPENSION MADE THEREOF
A solid, rapidly gelling oral pharmaceutical dosage form, as well as an aqueous formulation prepared thereof, comprising a) an acid sensitive proton pump...
2017/0165247 CRYSTALLINE COMPOUNDS OF DABIGATRAN ETEXILATE
The present invention relates to new crystalline compounds of dabigatran etexilate, namely to crystalline compounds comprising mixtures of dabigatran etexilate...
2017/0165246 PHARMACEUTICAL COMBINATIONS COMPRISING A PI3K INHIBITOR FOR THE TREATMENT OF CANCER
A pharmaceutical combination comprising: (a) an alpha-isoform specific phosphatidylinositol-3-kinase inhibitor (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide ...
2017/0165245 Sustained Release Aminopyridine Composition
A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a...
2017/0165244 METHODS FOR TREATING AN IMPAIRMENT IN GAIT AND/OR BALANCE IN PATIENTS WITH MULTIPLE SCLEROSIS USING AN...
Disclosed herein is use of one or more aminopyridines in methods and compositions for treatment of impairments in gait or balance in patients with multiple...
2017/0165243 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS
This invention relates to novel pharmaceutical compositions comprising a solid dispersion of the compound of Formula I below, to processes for preparing these...
2017/0165242 TREATMENT OF CANCERS WITH ACQUIRED RESISTANCE TO KIT INHIBITORS
The present invention provides compositions and methods for treating cancers which have acquired resistance to a KIT inhibitor by administering effective...
2017/0165241 COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY
Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it...
2017/0165240 NEW STRATEGIES FOR TREATING MELANOMA
The present invention relates to a p53-activating agent capable of transferring wild-type tumor protein p53 (p53) from an inactive conformation into an active...
2017/0165239 USE OF BETA-CARBOLINE ALKALOID IN INHIBITING XANTHINE OXIDASE ACTIVITY
A method for inhibiting xanthine oxidase and for reducing uric acid levels using a beta-carboline alkaloid compound of formula (I), wherein R.sub.1 is selected...
2017/0165238 ENHANCED DELIVERY OF IMMUNOSUPPRESSIVE DRUG COMPOSITIONS FOR PULMONARY DELIVERY
The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate...
2017/0165237 COMPLEXES OF SIROLIMUS AND ITS DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS...
The invention is directed to a stable complex with controlled particle size, increased apparent solubility and increased dissolution rate comprising as active...
2017/0165236 SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND COMBINATION THERAPY THEREWITH
Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided, including compounds which modulate subtype 1 of the S1P receptor, and...
2017/0165235 DEXMEDETOMIDINE PREMIX FORMULATION
The presently disclosed subject matter relates to pharmaceutical compositions comprising dexmedetomidine or a pharmaceutically acceptable salt thereof wherein...
2017/0165234 GPR142 Agonist Compounds
The present invention provides compounds of the Formula (Ia) wherein R is selected from the group consisting of CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CN,...
2017/0165233 ANTIMICROBIAL DRUG SYNTHESIS AND THERAPEUTIC COMPOSITIONS
This invention relates to the medical use of an antimicrobial agent, racemic Ornidazole, its (R) and (S) enantiomers, or pharmaceutically acceptable salts or...
2017/0165232 THREE-PHASE CONTROLLED-RELEASE TABLET COMPRISING MELATONIN AND PROCESS OF PREPARATION
The invention relates, in one aspect, to a tablet having an internal core and external coating, both comprising melatonin and separated by an internal coating...
2017/0165231 TREATING EWING'S SARCOMA AND EWS-FLI1 RELATED DISORDERS
The field relates to compositions and methods for treating Ewing's Sarcoma and other disorders related to EWS-FLI1.
2017/0165230 USE OF GSK-3 INHIBITORS OR ACTIVATORS WHICH MODULATE PD-1 OR T-BET EXPRESSION TO MODULATE T CELL IMMUNITY
The present application generally relates to the discovery that glycogen synthase kinase 3 (GSK-3) is an upstream signalling molecule that controls PD-1...
2017/0165229 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS
Compounds of the general structural formula (I) and (II) and use of the compounds and salts and hydrates thereof, as therapeutic agents are disclosed....
2017/0165228 METHODS AND COMPOSITIONS EMPLOYING BICIFADINE FOR TREATING DISABILITY OR FUNCTIONAL IMPAIRMENT ASSOCIATED WITH...
Methods and compositions are provided for formulating and administering bicifadine and related compounds to treat or prevent functional impairment and...
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