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Patent # Description
2017/0175146 PROCESS FOR PREPARATION OF BIODEGRADABLE BIOCOMPOSTABLE BIODIGESTIBLE PEPLENE POLYMER
This invention relates to a process for preparation of biodegradable biocompostable biodigestible PEPlene polymer comprising steps of: Mixing at least one...
2017/0175145 PRODUCTION OF ISOPRENE BY METHANE-PRODUCING ARCHAEA
Plasmid vectors and use of plasmid vectors in methods for producing methane and isoprene using Archaea are disclosed. Particularly, plasmid vectors that...
2017/0175144 GENOME EDITING USING CAS9 NICKASES
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of...
2017/0175143 METHOD FOR EDITING A GENETIC SEQUENCE
This disclosure describes methods, polynucleotides, cells, compositions, and treatment methods that involve channeling a genomic nucleotide sequence....
2017/0175142 CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors...
2017/0175141 PROTEIN HAVING NUCLEASE ACTIVITY, FUSION PROTEINS AND USES THEREOF
The present invention relates to a nucleic acid molecule encoding (I) a polypeptide having the activity of an endonuclease, which is (a) a nucleic acid...
2017/0175139 EFFICIENT DELIVERY OF LARGE CARGOS INTO CELLS ON A POROUS SUBSTRATE
In various embodiments, method and devices for delivering large cargoes (e.g., organelles, chromosomes, bacteria, and the like) into cells are provided. In...
2017/0175138 ADENOVIRAL VECTORS COMPRISING PARTIAL DELETIONS OF E3
This disclosure provides replication-incompetent adenoviral vectors useful in vaccine development and gene therapy. The disclosed vectors comprise a selective...
2017/0175137 RETROVIRAL VECTOR HAVING IMMUNE-STIMULATING ACTIVITY
The disclosure provides vectors for treating cancers, method of producing such vectors and methods of use of the vectors.
2017/0175136 GENOMIC INSULATOR ELEMENTS AND USES THEREOF
Provided herein are methods for identifying high potency genomic insulator elements that can be used in a vector composition e.g., that are useful for...
2017/0175135 Virus Purification
A process for producing a retroviral or lentiviral vector formulation comprising a filter-sterilisation step wherein the filter-sterilisation step is not the...
2017/0175134 Pesticidal genes and methods of use
Compositions having pesticidal activity and methods for their use are provided. Compositions include isolated and recombinant polypeptides having pesticidal...
2017/0175133 COMPOSITIONS AND METHODS FOR THE SUPPRESSION OF TARGET POLYNUCLEOTIDES FROM LEPIDOPTERA
Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lepidoptera order, they are...
2017/0175132 Ribosomal Protein L40 (RPL40) Nucleic Acid Molecules That Confer Resistance To Coleopteran And Hemipteran Pests
This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran and/or hemipteran pests through RNA interference-mediated...
2017/0175131 COMPOSITIONS AND METHODS FOR EFFICIENT TARGETING OF TRANSGENES
The invention provides recombinant DNA molecules and constructs useful for providing efficient transgene sub-cellular localization of proteins in transgenic...
2017/0175130 IMPROVED BACILLUS HOST
The invention provides Bacillus host cell deficient in the production of a neutral protease and of a alkaline protease which host cell comprises a nucleic acid...
2017/0175129 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
2017/0175128 CRISPR-CAS-RELATED METHODS, COMPOSITIONS AND COMPONENTS FOR CANCER IMMUNOTHERAPY
CRISPR/Cas-related composition and methods for treatment of cancer, in particular by using gRNA molecules comprising a targeting domain which is complementary...
2017/0175127 METHODS OF TREATING CANCER
A method of treating cancer is disclosed. The method comprises administering to the subject a therapeutically effective amount of a pharmaceutical composition...
2017/0175126 EXON SKIPPING TECHNOLOGY IN VCP DISEASE
Provided herein are methods, compositions and transgenic mice useful in treating and developing treatments for VCP-associated neurodegenerative diseases.
2017/0175125 Inhibition of Bruton's Tyrosine Kinase (Btk) in the Lung to Treat Severe Lung Inflammation and Lung Injury
Bruton's tyrosine kinase (Btk) plays an important role in the pathophysiology of local inflammation in acute lung injury (ALI)/acute respiratory distress...
2017/0175123 Diagnosis And Treatment Of Cancers With MicroRNA Located In Or Near Cancer-Associated Chromosomal Features
MicroRNA genes are highly associated with chromosomal features involved in the etiology of different cancers. The perturbations in the genomic structure or...
2017/0175122 RNA-BASED COMPOSITIONS AND ADJUVANTS FOR PROPHYLACTIC AND THERAPEUTIC TREATMENT
The present invention is directed towards an artificial RNA nanostructure comprising multiple external strands of RNA, each external strand comprising about...
2017/0175121 SELF ASSEMBLING NUCLEIC ACID NANOSTRUCTURES
Stable self-assembling nucleic acid nanostructures comprising: --a plurality of oligonucleotides, --a plurality of G-quadruplex forming nucleic acids linked to...
2017/0175120 METHODS OF CONTROLLING CELL FATE AND CONSEQUENCES FOR DISEASE
Provided herein are methods for performing cellular reprogramming that include treatment of somatic cells with an inhibitor of CAF-1, Sumo2, Nutd21, or...
2017/0175119 LEPIDOPTERAN MOTH CONTROL USING DOUBLE-STRANDED RNA CONSTRUCTS
Disclosed is a dsRNA construct that relates to a method to control Lepidopteran moths via double-stranded RNA interference of the PBAN/Pyrokinin gene.
2017/0175118 COMPOSITION AND METHOD OF USING MIR-302 PRECURSORS AS ANTI-CANCER DRUGS FOR TREATING HUMAN LUNG CANCER
This invention generally relates to a composition and method of using mam-made small RNAs, such as small interfering RNAs (siRNA), microRNAs (miRNA) and their...
2017/0175117 ANTISENSE OLIGONUCLEOTIDE DIRECTED REMOVAL OF PROTEOLYTIC CLEAVAGE SITES FROM PROTEINS
The invention relates to means and methods for removing a proteolytic cleavage site from a protein comprising providing a cell that expresses pre-mRNA encoding...
2017/0175116 COMPOSITIONS AND METHODS FOR DECREASING TAU EXPRESSION
Provided herein are compositions and methods for decreasing tau mRNA and protein expression. These compositions and methods are useful in treating tau-related...
2017/0175115 METHOD FOR TREATING FIBROSIS USING SIRNA AND A RETINOID-LIPID DRUG CARRIER
What is described is a method for treating a fibrotic disease by administering a pharmaceutical composition comprising a drug carrier, which comprises a lipid...
2017/0175114 COMPOSITIONS FOR MODULATING ATAXIN 2 EXPRESSION
Disclosed herein are antisense compounds and methods for decreasing Ataxin 2 mRNA and protein expression. Such methods, compounds, and compositions are useful...
2017/0175113 METHODS FOR MODULATING ATAXIN 2 EXPRESSION
Disclosed herein are methods for decreasing Ataxin 2 mRNA and protein expression. Such methods are useful to treat, prevent, or ameliorate Ataxin 2 associated...
2017/0175112 MIR-21-3P INHIBITORS IN SKIN DISORDERS
The present invention is related to miR-21-3p inhibitors, which are particularly useful in the prevention and/or treatment of skin disorders.
2017/0175111 RIBOREGULATOR COMPOSITIONS AND METHODS OF USE
The invention provides novel and versatile classes of riboregulators, including inter alia activating and repressing riboregulators, switches, and trigger and...
2017/0175110 Libraries of Nucleic Acids and Methods for Making the Same
Methods for designing and producing non-random libraries of nucleic acids are presented. In particular, synthesis of nonrandom libraries by multiplexed...
2017/0175109 COMPOSITIONS AND METHODS FOR REPRESENTATIONAL SELECTION OF NUCLEIC ACIDS FROM COMPLEX MIXTURE
The invention provides a method of selecting a representational sample of nucleic acid sequences from a complex mixture. The method includes: (a) contacting a...
2017/0175108 BARCODED PEPTIDES
Disclosed are peptide-mRNA fusion products, oligoribonucleotide structures, and methods of producing and using the same.
2017/0175106 CASSETTE FOR SAMPLE PREPARATION
Apparatuses for preparing a sample are disclosed herein. The apparatuses include a chamber, a first valve at least partially disposed in the first chamber, a...
2017/0175105 EXTRACTION OF MATERIALS FROM REGIONS OF INTEREST IN A SAMPLE
A system for extracting material from a region of interest includes a fluid delivery base comprising an inlet channel and an outlet channel formed within the...
2017/0175104 METHODS AND COMPOSITIONS FOR USING ARGONAUTE TO MODIFY A SINGLE STRANDED TARGET NUCLEIC ACID
The present disclosure provides compositions, kits, genetically modified cells, non-human transgenic organisms, and methods for binding and/or cleaving a...
2017/0175103 Apparatus and Method for Culturing Cells and Tissue
A method of culturing cells or tissue comprises: (a) disposing cells or tissue in the cavity of a deformable cell culture container; and (b) applying...
2017/0175102 METHODS FOR EFFICIENT INTRACELLULAR DELIVERY USING ANISOTROPIC MAGNETIC PARTICLES
In various embodiments methods are provided for delivering an agent of interest (e.g., protein, antibody, nucleic acid) into cells. In certain embodiments the...
2017/0175101 MESOPOROUS CATALYSTS OF MAGNETIC NANOPARTICLES AND FREE-RADICALPRODUCING ENZYMES, AND METHODS OF USE
A composition comprising mesoporous aggregates of magnetic nanoparticles and free-radical producing enzyme (i.e., enzyme-bound mesoporous aggregates), wherein...
2017/0175100 Composite of Paracoccus denitrificans immobilized on modified graphene oxide and its preparation method and...
This invention provided a preparation method of the composite which was immobilized Paracoccus denitrificans on modified graphene oxide and its application....
2017/0175099 Rapid N-Glycan Release from Glycoproteins using Immobilized Glycosylase Columns
N-glycosylation profiling of glycoprotein biotherapeutics is an essential step in each phase of product development in the biopharmaceutical industry. For...
2017/0175098 Enzyme Variants and Polynucleotides Encoding Same
The present invention relates to enzyme variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs,...
2017/0175097 Cellobiohydrolase variants and polynucleotides encoding same
The present invention relates to variants of a parent cellobiohydrolase II. The present invention also relates to polynucleotides encoding the variants;...
2017/0175083 ISOLATION AND USE OF SOLID TUMOR STEM CELLS
A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem...
2017/0175081 Methods of Obtaining Islet Cells
The present invention provides methods and materials relating to obtaining or expanding populations of islet cells, and uses of the islet cells obtained by...
2017/0175063 AUTOMATED TISSUE ENGINEERING SYSTEM
The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue...
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