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Patent # Description
2017/0198028 CRYSTALLIZATION METHODS FOR PURIFICATION OF MONOCLONAL ANTIBODIES
This disclosure relates to methods for crystallization of antibodies from cell-free culture supernatant.
2017/0198027 PROCESS OF AFOD AND AFCC AND MANUFACTURING AND PURIFICATION PROCESSES OF PROTEINS
Manufacturing and purification processes of proteins, KH 1-through KH-52, and more KH proteins are being discovered in good healthy cells--named KH CELLS. KH...
2017/0198026 Compositions And Methods For Treating Tumors And Immune Based Inflammatory Diseases
This present invention provides compositions and methods for treating cancer and immune inflammatory disorders by modulating EMR2 signaling pathway.
2017/0198025 METHOD FOR PROMOTING VIRUS INFECTION AND INCREASING VIRUS PRODUCTION, BY USING CELL LINE HAVING LOST BST2 GENE...
The present invention relates to a method for promoting virus infection and increasing virus production, by using a cell line having lost Bst2 gene functions...
2017/0198024 Soluble TNF Receptors and Their Use in Treatment of Disease
The present invention relates to tumor necrosis factor (TNF) antagonists and corresponding nucleic acids derived from tumor necrosis factor receptors (TNFRs)...
2017/0198023 COMPOUNDS AND METHODS OF MODULATING ANGIOGENESIS
A pharmaceutical composition includes a synthetic peptide consisting of about 10 to about 50 amino acids and having an amino acid sequence substantially...
2017/0198022 FELINE BITTER TASTE RECEPTORS AND METHODS
A family of novel feline bitter taste receptors, referred to as feline TAS2R (fTAS2R), are disclosed herein. Isolated polynucleotides encoding the novel feline...
2017/0198021 METHODS OF TREATING DIABETES AND COMPOSITIONS CAPABLE OF SAME
A composition of matter is disclosed which comprises isolated oligomers of human islet amyloid polypeptide (IAPP). Antibodies recognizing same are also...
2017/0198020 NUCLEOTIDE REPEAT EXPANSION-ASSOCIATED POLYPEPTIDES AND USES THEREOF
Isolated polypeptides that are endogenously expressed from nucleotide repeat expansions are disclosed. In some cases, the polypeptides include polypeptide...
2017/0198019 CELL-PERMEABLE (ICP)-SOCS3 RECOMBINANT PROTEIN AND USES THEREOF
The present invention relates to providing improved cell-permeable (iCP)-SOCS3 recombinant protein and uses thereof. Preferably, the iCP-SOCS3 recombinant...
2017/0198018 HCBI, MSBI, MSSI AND CMI SEQUENCES AS AN EARLY MARKER FOR THE FUTURE DEVELOPMENT OF CANCER AND DISEASES OF THE...
Described are HCBI (Healthy Cattle Blood Isolate), MSBI (Multiple Sclerosis Brain Isolate), MSSI (Multiple Sclerosis Serum Isolate) and CMI (Cow Milk Isolate)...
2017/0198017 LIGHT-SENSITIVE ION-PASSING MOLECULES
The invention provides polynucleotides and methods for expressing light-activated proteins in animal cells and altering an action potential of the cells by...
2017/0198016 A NON-NATURALLY OCCURING PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV) AND METHODS OF USING
A non-naturally occurring porcine reproductive and respiratory syndrome virus (PRRSV) is provided herein, and methods of making and using the non-naturally...
2017/0198015 RED GENETICALLY ENCODED CALCIUM INDICATORS AND METHODS OF USE
Protein indicators useful for calcium imaging, in particular, red genetically-encoded calcium indicators (GECIs) disclosed herein rival best-of-class green...
2017/0198014 POLYPEPTIDES AND THEIR USE FOR TREATING INFLUENZA
Provided herein are scaffold polypeptides, fusion proteins of the scaffold polypeptides and hemagglutinin (HA) binding proteins, and methods for using the...
2017/0198013 CRYSTAL OF CYCLIC PEPTIDE COMPOUND, PREPARATION METHOD FOR SAME AND USES THEREOF
Disclosed is a novel polymorph of a cyclic peptide compound, the structure whereof is represented by formula I; also disclosed are a preparation method for...
2017/0198012 SOLVATE OF CYCLIC PEPTIDE COMPOUND, PREPARATION METHOD FOR SAME, AND USES THEREOF
Provided in the invention is a solvate of a cyclic peptide compound, represented by formula I is the structural formula of the cyclic peptide compound, and,...
2017/0198011 COMPOSITION FOR TREATING SEPSIS OR SEPTIC SHOCK COMPRISING THE PEPTIDE ORIGINATED FROM THE SMAD6
Disclosed is a pharmaceutical composition comprising a Smad6-derived peptide as an active ingredient. Having ability to specifically bind to Pellino-1, the...
2017/0198010 TOMM34 PEPTIDES AND VACCINES INCLUDING THE SAME
The present invention provides isolated peptides or the fragments derived from SEQ ID NO: 42, which bind to an HLA antigen and induce cytotoxic T lymphocytes...
2017/0198009 METHOD FOR THE PREPARATION OF IMMUNOGLOBULINS
The present invention relates to a method for the preparation of a solution of immunoglobulins based on an initial solution of immunoglobulins with a purity...
2017/0198008 METHODS AND REAGENTS FOR PURIFICATION OF PROTEINS
The present disclosure provides compositions and methods for purifying a protein such as DNase using a chromatographic process. The methods include a single...
2017/0198007 METHODS FOR IDENTIFICATION OF SITES FOR IGG CONJUGATION
The present disclosure relates to immunoglobulins and immunoglobulin conjugates with reduced oligomerization and efficient labeling and compositions, methods...
2017/0198006 PRMT5 INHIBITORS AND USES THEREOF
Described herein are compounds of Formula (I)-(XIII), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the...
2017/0198005 2'-DICHLORO AND 2'-FLUORO-2'-CHLORO NUCLEOSIDE ANALOGUES FOR HCV INFECTION
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments,...
2017/0198004 NOVEL SEMI-SYNTHETIC MENINGOCOCCAL CONJUGATE VACCINE
The present invention relates to novel semi-synthetic meningococcal conjugate vaccine comprising novel synthetic oligosaccharide conjugated to a carrier...
2017/0198003 DEFINED ENZYMATIC SYNTHESIS OF LIPID A ANALOGS
Provided herein include methods and compositions for synthesis of Lipid IV.sub.A and derivatives thereof, using a defined set of pathway enzyme, which may be...
2017/0198002 High Purity Low Endotoxin Carbohydrate (HPLE) Compositions, and Methods of Isolation Thereof
Provided herein is a highly pure carbohydrate composition, and a method of making a highly pure carbohydrate composition. The method includes passing an...
2017/0198001 NICKEL COMPOUND AND METHOD OF FORMING THIN FILM USING THE NICKEL COMPOUND
Provided are a heterostructured nickel compound including a nickel amidinate ligand and an aliphatic alkoxy group and a method of forming a thin film including...
2017/0198000 PROCESS FOR PREPARING HYDRIDOCARBONYLTRIS(TRIPHENYLPHOSPHINE)RHODIUM(I)
The present invention relates to a process for preparing hydridocarbonyltris(triphenylphosphine)rhodium(I), RhH(CO)(PPh.sub.3).sub.3, also referred to...
2017/0197999 TREATMENT OF ANTIMONY BEARING RESIDUES FOR PRODUCTION OF POTASSIUM ANTIMONY TARTRATE
A method for production of potassium antimony tartrate by utilizing one or more residues bearing antimony includes the step of leaching of the one or more...
2017/0197998 PHOSPHAZENE COMPOUND COMPRISING CYANO GROUP, PREPARATION METHOD AND USES THEREOF
The present invention relates to a phosphazene compound comprising cyano group having a molecular structure of Formula (I); wherein, Y and Y' are independently...
2017/0197997 GOLD(I) COMPLEXES WITH ANTICANCER PROPERTIES AND METHODS OF USE THEREOF
Monomeric and dimeric gold(I) complexes as anticancer agents. The gold(I) complexes are coordinated to mixed ligands: one phosphine-based ligand that may be...
2017/0197996 Cholinesterase Inhibitors
The invention provides compounds that inhibit cholinesterases, such as acetylcholinesterase and butyrylcholinesterase. Such compounds are useful to prevent or...
2017/0197995 PROCESS FOR PREPARATION OF 3-METHACRYLOXYPROPYLDIMETHYLCHLOROSILANE IN CONTINUOUS FLOW REACTOR
A process for the preparation of 3-methacryloxypropyldimethylchlorosilane by reaction of allylmethacrylate with dimethylchlorosilane in the presence of a...
2017/0197994 METHOD FOR RECOVERY OF IONIC LIQUID AND SYSTEM THEREOF
The instant disclosure relates to liquid salts such as but not limiting to ionic liquids; and method for recovering liquid salts including ionic liquids. Ionic...
2017/0197993 PHOTODYNAMIC THERAPY PHOTOSENSITIZERS
A compound of formula (I) useful as a photosensitizer in photodynamic therapy is provided. There is also provided a photosensitizing composition for use in...
2017/0197992 4,5-DIARYLIMIDAZOLE DERIVATIVES AS HDAC INHIBITORS
The present invention relates to a 4,5-diarylimidazole derivative of formulae (I), (II) or (III): or a pharmaceutically acceptable salt thereof, wherein the...
2017/0197991 HETEROBICYCLO-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES
Disclosed are compounds of Formula G1: ##STR00001## where "R.sup.G3". "R.sup.d1" to "R.sup.d4", "n", "m", "p", "W", "X", "Y", and "Z" are defined herein, which...
2017/0197990 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
The present invention provides compounds of formula (I) ##STR00001## wherein A, R.sup.1, R.sup.2 and R.sup.3 are as described herein, as well as...
2017/0197989 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel....
2017/0197988 MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT
The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell...
2017/0197987 [1-3]-THIAZINE-FULLEROPYRROLO DERIVATIVES OF C60 AND C70 AS HIV-INHIBITOR AGENTS
Certain embodiments are directed to fullerene derivatives tetrahydro-1H--C.sub.60-fulleropyrrolo[1,2-c][1,3]thiazine salts (Formula I) or...
2017/0197986 DIHYDROPYRIMIDO LOOP DERIVATIVE AS HBV INHIBITOR
Disclosed is a dihydropyrimido fused ring derivative as a HBV inhibitor, and in particular relates to a compound shown as formula (I) or a pharmaceutically...
2017/0197985 SODIUM (2R,5S,13AR)-7,9-DIOXO-10-((2,4,6-TRIFLUOROBENZYL)CARBAMOYL)-2,3,4,- ...
The present Invention relates to sodium (2R,5S,13aR)-7,9-dioxo-10 ((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-metha- nopyrido[1',2':4,5]...
2017/0197984 AMIDE DERIVATIVES OF 1-OXA-4,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
The present invention relates to compounds having dual pharmacological activity towards both the sigma (.sigma.) receptor, and the .mu.-opiod receptor and more...
2017/0197983 HETEROCYCLIC COMPOUNDS HAVING CHOLESTEROL 24-HYDROXYLASE ACTIVITY
An object of the present invention is to provide a compound having a superior CH24H inhibitory action, which is useful as an agent for the prophylaxis or...
2017/0197982 THIOPHENE DERIVATIVES
Disclosed is a compound of formula (I), ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are as defined in the...
2017/0197981 INHIBITORS OF BACTERIAL DNA GYRASE WITH EFFICACY AGAINST GRAM-NEGATIVE BACTERIA
The present invention provides N-benzyl-3-sulfonamidopyrrolidines and related compounds, as well as pharmaceutical compositions and sanitizing compositions...
2017/0197980 N-(4-PHENYL)-N'-(3-FLUOROPHENYL)UREA DOCUSATE
Docusate salts of N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-- 3-yl}phenyl)-N'-(3-fluorophenyl)urea are suitable pharmaceutical ...
2017/0197979 BENZOTHIADIAZOLAMINES
The present invention relates to substituted benzothiadiazolamine compounds of general formula (I) as described and defined herein, to methods of preparing...
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