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Patent # Description
2017/0197977 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE
This invention relates to novel diarylamino compounds that bind to the sigma-2 receptor, to pharmaceutical compositions comprising such compounds, and to...
2017/0197976 MTH1 INHIBITORS FOR TREATMENT OF CANCER
A compound of formula I, (I) or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer. ##STR00001##
2017/0197975 ACETATE SALT OF BUPRENORPHINE AND METHODS FOR PREPARING BUPRENORPHINE
The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts...
2017/0197974 ORGANIC COMPOUNDS
Provided are PDE1 inhibitors of Formula I, processes for their production, their use as pharmaceuticals, and pharmaceutical compositions comprising them....
2017/0197973 IMMUNOREGULATORY AGENTS
Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such...
2017/0197972 BENZODIAZEPINE BROMODOMAIN INHIBITOR
The present invention relates to a benzodiazepine compound, processes for its preparation, pharmaceutical compositions containing such a compound and to its...
2017/0197971 3-(Carboxymethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives
The invention relates to 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in...
2017/0197970 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives
The invention relates to 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in...
2017/0197969 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
The present invention provides compounds of formula (I) ##STR00001## wherein A, X.sup.1, X.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as...
2017/0197968 Compositions and Methods for Inhibiting BMP
The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and...
2017/0197967 PERIPHERALLY RESTRICTED GABA POSITIVE ALLOSTERIC MODULATORS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME AND...
The present invention provides compounds and compositions which are positive allosteric modulators of GABA-A receptors that selectively target the peripheral...
2017/0197966 PYRAZOLOTRIAZINES AS INHIBITORS OF NUCLEASES
The invention provides compounds represented by the structural formula (1): ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in the ...
2017/0197965 Imidazopyridazine Derivatives As Modulators of the GABAA Receptor Activity
The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of...
2017/0197964 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The...
2017/0197963 Process for preparation of (2S, 5R)-7-oxo-6-sulphooxy-2-[((3R)-piperidine-3-carbonyl)-hydrazino ...
A process for preparation of (2S, 5R)-7-oxo-6-sulphooxy-2-[((3R)-piperidine-3-carbonyl)-hydrazino carbonyl]-1,6-diaza-bicyclo[3.2.1]octane is disclosed.
2017/0197962 HETEROARYL COMPOUNDS FOR KINASE INHIBITION
Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical...
2017/0197961 SERINE DERIVATIVES AS GHRELIN RECEPTOR AGONISTS
The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof, processes for their preparation,...
2017/0197960 ATX MODULATING AGENTS
Compounds of formula (I) can modulate the activity of autotaxin (ATX). ##STR00001##
2017/0197959 Pyridopyrimidinedione derivatives
The invention relates to compound of the formula (I) or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to...
2017/0197958 AGONISTS OF THE APELIN RECEPTOR AND METHODS OF USE THEREOF
Provided herein are small molecule agonists of the apelin receptor for the treatment of disease. The compounds disclosed herein are useful for the treatment of...
2017/0197957 METHODS OF MANUFACTURING BENZOQUINOLINE COMPOUNDS
The present invention relates to new methods of manufacturing benzoquinoline inhibitors of vesicular monoamine transporter 2 (VMAT2), and intermediates...
2017/0197956 BENZOTHIAZOLE COMPOUND AND MEDICINE CONTAINING SAME
It is intended to provide: a compound useful as an amyloid oxidation catalyst which is applicable in vivo and is applicable not only to A.beta. peptides but to...
2017/0197955 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF
[Problem] To provide a compound which is useful as an active ingredient for a pharmaceutical composition for preventing or treating urine storage dysfunction,...
2017/0197954 1,3,4-Thiadiazole compounds and their use in treating cancer
The specification relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, where Q, R, R.sup.1 and R.sup.2 have any of the meanings...
2017/0197953 FACTOR XIa INHIBITORS
The present invention provides a compound of Formula I (The chemical formula should be inserted here.) and pharmaceutical compositions comprising one or more...
2017/0197952 THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND...
The invention relates to a compound comprising the following general formula (1) and said compound for use as a medicament, in particular for use in the...
2017/0197951 Process of Preparing Potassium Salt of Azilsartan Medoxomil
The present invention relates to a process for the preparation of Azilsartan Medoxomil Potassium. The invention further relates to novel highly crystalline...
2017/0197950 THIOPHEN-2-YL-PYRIDIN-2-YL-1H-PYRAZOLE-4-CARBOXYLIC ACID DERIVATIVES AND THE USE THEREOF AS SOLUBLE GUANYLATE...
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the...
2017/0197949 8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives
The invention relates to 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of...
2017/0197948 METHOD FOR PRODUCING CARBOXYLIC ANHYDRIDE
Method for producing carboxylic anhydride, the method includes heating raw material compound represented by the following general formula (1): ##STR00001## [in...
2017/0197947 3-((Hetero-)Aryl)-Alkyl-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives
The invention relates to 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine,...
2017/0197946 KOJIC ACID-DERIVED MANNICH BASES WITH BIOLOGICAL EFFECT
The present invention relates to kojic acid-derived mannich base compounds with biological effect, and hydrates, solvates, pharmacologically acceptable salts...
2017/0197945 2-SUBSTITUTED QUINAZOLINE COMPOUNDS COMPRISING A SUBSTITUTED HETEROCYCLIC GROUP AND METHODS OF USE THEREOF
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): ##STR00001## or a...
2017/0197944 PROCESS FOR THE PREPARATION OF LEDIPASVIR
An improved process is provided for the preparation of Ledipasvir and its pharmaceutically acceptable salts or solvates thereof, which is useful as an...
2017/0197943 PROCESS FOR PRODUCING ALKYNYLKETONE DERIVATIVE
The present invention relates to a Sonogashira-Carbonylation reaction using two types of gas, as well as novel crystals which can control a heat of the said...
2017/0197942 SELECTIVE METHODS FOR THE SEPARATION OF ONDANSETRON AND RELATED IMPURITIES
The present disclosure generally relates to methods for separating ondansetron and related impurities using CO.sub.2-based chromatography.
2017/0197941 CYCLOHEXEN-1-YL-PYRIDIN-2-YL-1H-PYRAZOLE-4-CARBOXYLIC ACID DERIVATIVES AND THE USE THEREOF AS SOLUBLE GUANYLATE...
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the...
2017/0197940 INDANE AND INDOLINE DERIVATIVES AND THE USE THEREOF AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the...
2017/0197939 Tropomyosin-Related Kinase Inhibitors Containing Both A 1H-Pyrazole And A Pyrimidine Moiety
The present invention relates to compounds of Formula I ##STR00001## and their prodrugs and pharmaceutically acceptable salts, wherein the substituents are as...
2017/0197938 A QUINOLINE DERIVATIVE FOR THE TREATMENT OF INFLAMMATORY DISEASES AND AIDS
The present invention relates to a compound of formula (1) in the form of a base or addition salt with an acid, particularly a pharmaceutically acceptable...
2017/0197937 NEW CRYSTAL FORM OF PANTOPRAZOLE SODIUM COMPOUND AND PREPARATION METHOD THEREFOR
A novel crystalline form is defined by using diffraction angle 2.theta..degree. of X-ray powder diffraction pattern and characteristic peaks of differential...
2017/0197936 ENANTIOMERS OF 8-HYDROXYQUINOLINE DERIVATIVES AND THE SYNTHESIS THEREOF
Our invention relates to novel enantiomer derivatives of 8-hydroxyquinoline derivatives with general formula (I) and (II) and the synthesis thereof and...
2017/0197935 INHIBITORS OF DNA GYRASE FOR THE TREATMENT OF BACTERIAL INFECTIONS
The present invention relates to compounds which specifically inhibit bacterial DNA Gyrase and can be used for the treatment of respiratory tract infections.
2017/0197934 SOLID FORMS OF 2-(4-CHLOROPHENYL)-N-((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-5-YL)M- ...
Solid forms comprising 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)m- ethyl)-2,2-difluoroacetamide, compositions comprising the...
2017/0197933 ANTIPROLIFERATIVE COMPOUNDS, AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES
Compounds of formula A-I and B-I, compositions comprising the compounds, methods of making the compounds and methods of their uses are disclosed.
2017/0197932 NOVEL STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL INHIBITORS
The present invention relates to a novel naphtho class of compounds as Stat3 pathway inhibitors and as cancer stem cell inhibitors; to methods of using such...
2017/0197931 APPARATUS AND METHOD FOR PRODUCING CYCLIC CARBONATE
Disclosed herein are an apparatus and method for continuously producing a cyclic carbonate. The apparatus includes an adiabatic reactor to be filled with a...
2017/0197930 PROCESSES FOR THE PREPARATION OF 2,5-FURANDICARBOXYLIC ACID AND INTERMEDIATES AND DERIVATIVES THEREOF
The present disclosure provides processes for the production of 2-5-furandicarboxylic acid (FDCA) and intermediates thereof by the chemocatalytic conversion of...
2017/0197929 CHELATE-CONTROLLED DIASTEREOSELECTIVE HYDROGENATION WITH HETEROGENEOUS CATALYST
A catalyst, method of using, and use of a hydrogenation catalyst, preferably palladium on a support, preferably alumina or activated charcoal support. This in...
2017/0197928 ARYL COMPOUND AND MAKING METHOD
An aryl compound terminated with at least three glycidyl groups and at least three (meth)allyl groups, having formula (1) wherein R.sup.1 is a C.sub.3-C.sub.20...
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