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Patent # Description
2017/0210764 CYCLOBUTENEDIONE DERIVATIVE, NONAQUEOUS ELECTROLYTIC SOLUTION, AND LITHIUM ION SECONDARY BATTERY
A nonaqueous electrolytic solution comprising a cyclobutenedione derivative represented by the following general formula (1): ##STR00001## wherein R.sup.1...
2017/0210763 PROCESS FOR PREPARING A COMPOSITION CONTAINING 2-ETHYLHEXYL SILICATE
A composition containing 2-ethylhexyl silicate, is produced by heating a reaction mixture of ethyl silicate with an excess amount of 2-ethylhexanol in the...
2017/0210762 BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS
This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds,...
2017/0210761 9H-PYRIMIDO [4,5-B]INDOLES AND RELATED ANALOGS AS BET BROMODOMAIN INHIBITORS
The present disclosure provides substituted 9H-pyrimido[4,5-b]indoles and 5H-pyrido[4,3-b]indoles and related analogs represented by Formula I: ##STR00001## and...
2017/0210760 CRYSTALLINE FREE BASES OF C-MET INHIBITOR OR CRYSTALLINE ACID SALTS THEREOF, AND PREPARATION METHODS AND USES...
Crystalline free bases and crystalline acid salts of 9-((8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridine-- ...
2017/0210759 ACTIVATORS OF AUTOPHAGIC FLUX AND PHOSPHOLIPASE D AND CLEARANCE OF PROTEIN AGGREGATES INCLUDING TAU AND...
The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further...
2017/0210758 POLYMORPHIC FORMS ALPHA, BETA AND GAMMA OF RIFAXIMIN
Crystalline polymorphous forms of rifaximin (INN) antibiotic named rifaximin .alpha. and rifaximin .beta., and a poorly crystalline form named rifaximin...
2017/0210757 PHARMACEUTICAL COMPOSITIONS COMPRISING POLYMORPHIC FORMS ALPHA, BETA, AND GAMMA OF RIFAXIMIN
Crystalline polymorphous forms of rifaximin (INN), referred to as rifaximin .alpha. and rifaximin .beta., and a poorly crystalline form referred to as...
2017/0210756 SYNTHESIS OF AN ANTIVIRAL COMPOUND
The present disclosure provides processes for the preparation of a compound of formula I: ##STR00001## which is useful as an antiviral agent. The disclosure also...
2017/0210755 PYRIDINE COMPOUNDS
The present invention relates to a compound or a pharmacologically acceptable salt thereof having excellent tissue non-specific alkaline phosphatase inhibitory...
2017/0210754 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS
The present invention relates to tricyclic heterocycles which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the...
2017/0210753 PRODUCTION METHOD OF THIENOPYRIMIDINE DERIVATIVE
The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH)...
2017/0210752 TETRA-HETEROARYL INDACENODITHIOPHENE-BASED POLYCYCLIC POLYMERS AND THEIR USE
The present invention relates compounds comprising a tetra-heteroaryl indacenodithiophene-based structural unit, the synthesis of such compounds as well as...
2017/0210751 PRMT5 INHIBITORS AND USES THEREOF
Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof: wherein Y1 is of formula (x)...
2017/0210750 Polyesters From Assymetrical Monomers Based Upon Bisanhydrohexitols
Asymmetrically substituted compounds of bisanhydrohexitols are described, including the bisanhydrohexitol isosorbide. The compounds are useful as AB monomers....
2017/0210749 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE
Provided are compounds of formula (I), wherein X, Y, Z, W, V, R.sup.2, R.sup.3 and m are defined as in the description. Their pharmaceutical compositions and...
2017/0210748 ASK 1 INHIBITING PYRROLOPYRIMIDINE DERIVATIVES
This invention relates to pyrrolopyrimidine derivatives of formula (I): ##STR00001## where R.sub.1, X, p, R.sub.4, R.sub.2 and R.sub.3 are as defined herein, and...
2017/0210747 [1,2,4]TRIAZOLO[4,3-B]PYRIDAZINES FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES
The invention concerns compounds of Formula (I) (Formula (I)) or pharmaceutically-acceptable salts thereof, wherein R.sup.1, R.sup.2 and n have any of the...
2017/0210746 SUBSTITUTED THIOXANTHENONE AUTOPHAGY INHIBITORS
Autophagy inhibitors useful for the treatment of cancer and other diseases are described. The autophagy inhibitors are a compound of formula: I wherein R.sup.1...
2017/0210745 Processes for the Preparation of AZD5363 and Novel Intermediate Used Therein
There is provided a process for the preparation of AZD5363, or a salt of AZD5363, comprising: (a) the reaction of ...
2017/0210744 PROCESS FOR PREPARING A CARBAPENEM ANTIBIOTIC
A process for the preparation of a carbapenem, includes the step of treating a solution of a protected carbapenem with hydrogen gas in the presence of a...
2017/0210743 NOVEL HDAC6 INHIBITORS AND THEIR USES
The present invention relates to small molecule compounds and their use as HDAC inhibitors and in the treatment of various diseases, such as cancer. The...
2017/0210742 NOVEL CRYSTALLINE FORMS OF TRANS-7-OXO-6-(SULPHOOXY)-1,6-DIAZABICYCLO[3,2,1]OCTANE-2-CARBOXAMIDE SODIUM SALT
The present invention relates to novel crystalline forms of sodium salt of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide (e.g.,...
2017/0210741 Benzimidazole Compounds, Use As Inhibitors of WNT Signaling Pathway in Cancers, and Methods for Preparation Thereof
The present disclosure is concerned with benzimidazole compounds that are capable of inhibiting Wnt signaling and methods of treating disease states such as,...
2017/0210740 PYRAZOLE DERIVATIVE MANUFACTURING METHOD
The present invention provides a method for manufacturing a compound represented by formula (I). With this method, provided is a method for manufacturing a ...
2017/0210739 PYRIDINYLAMINOPYRIMIDINE DERIVATIVES, PREPARATION PROCESS AND USE THEREOF
The present invention relates to pyridinylaminopyrimidine derivatives represented by the following formula (I), and pharmaceutically acceptable salts,...
2017/0210738 GLUCOSE TRANSPORT INHIBITORS
The present invention relates to chemical compounds of formula (I) that selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said...
2017/0210737 IMIDAZOLE AND THIAZOLE COMPOSITIONS FOR MODIFYING BIOLOGICAL SIGNALING
Compounds having General Formula (I) or General Formula (II): in which R.sup.1 is chosen from C.sub.1 to C.sub.10 aliphatic or heteroaliphatic groups,...
2017/0210736 PHENYL TETRAHYDROISOQUINOLINE COMPOUND SUBSTITUTED WITH HETEROARYL
The present invention provides a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof which has an excellent NHE3...
2017/0210735 CRYSTAL OF AZOLE BENZENE DERIVATIVE
There are provided crystals of 2-[4-(2,2-dimethylpropoxy)-3-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-4-methyl-1- ,3-thiazole-5-carboxylic acid which is useful as a...
2017/0210734 Substituted Azaspiro(4.5)Decane Derivatives
The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the .mu. opioid receptor and/or the ORL1 receptor,...
2017/0210733 BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS AND METHODS OF USE
Described herein are benzoxazepin oxazolidinone compounds with phosphoinositide-3 kinase (PI3K) modulation activity or function having the Formula I...
2017/0210732 Factor XIa Inhibitors
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said...
2017/0210731 SUBSTITUTED PHENYL ALKANOIC ACID COMPOUNDS AS GPR120 AGONISTS AND USES THEREOF
The present invention relates to substituted phenyl alkanoic acid compounds designated as the compound of Formula (I) (as described herein) or a tautomer, a...
2017/0210730 HETEROARYL SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS KINASE MODULATORS
Compounds having the following formula: ##STR00001## or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R.sup.2 is a monocyclic heteroaryl...
2017/0210729 ERK INHIBITORS AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same.
2017/0210728 Cannabinergic Nitrate Esters And Related Analogs
The present technology relates to novel cannabinergic nitrate esters and related analogs, process of preparation, pharmaceutical compositions and their methods...
2017/0210727 [5,6]-FUSED BICYCLIC ANTIDIABETIC COMPOUNDS
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may...
2017/0210726 2-H-INDAZOLE DERIVATIVES AS CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS AND THERAPEUTIC USES THEREOF
Indazole compounds of formula (I) as cyclin-dependent kinase (CDK) and cellproliferation inhibitors, and therapeutic uses and methods of preparation thereof,...
2017/0210725 6-MEMBERED AZA-HETEROCYCLIC CONTAINING DELTA-OPIOID RECEPTOR MODULATING COMPOUNDS, METHODS OF USING AND MAKING...
The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for...
2017/0210724 ALKYNYL ALCOHOLS AND METHODS OF USE
The invention relates to compounds of Formula (0): ##STR00001## wherein A.sup.1-A.sup.8, R.sup.4 and R.sup.5 each has the meaning as described herein. Compounds...
2017/0210723 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce...
2017/0210722 NOVEL ANTIBIOTIC
The present invention relates to novel compounds, comprising an 8-or 9-membered cyclic structure, wherein an (E)-1,4-dioxo-but-2-ene moiety is embedded in said...
2017/0210721 METHODS FOR EXTRACTING AND CONVERTING HEMICELLULOSE SUGARS
The present disclosure relates to methods of producing hemicellulose and conversion products thereof from a biomass. Also provided are hemicellulose products...
2017/0210720 ENANTIOSELECTIVE PROCESS FOR SYNTHESIS OF (+)- PETROMYROXOL AND ITS DIASTEREOMERS
An enantioselective process for the synthesis of (+)-petromyroxol and its Diastereomers from ...
2017/0210719 ELECTROCONDUCTIVE MEMBER FOR ELECTROPHOTOGRAPHY AND QUATERNARY AMMONIUM SALT
Provided is an electroconductive member for electrophotography in which movement of a quaternary ammonium salt toward the surface of a binder resin is...
2017/0210718 PROCESS FOR THE EPOXIDATION OF AN OLEFIN
In a process for the epoxidation of an olefin, where a mixture comprising olefin, hydrogen peroxide, water and methanol with a weight ratio of water to...
2017/0210717 SYNTHESIS OF BENZOTHIAZEPINES
Methods for preparing the following compound are disclosed. ##STR00001##
2017/0210716 SUBSTITUTED N-ACETYL-L-CYSTEINE DERIVATIVES AND RELATED COMPOUNDS
Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or...
2017/0210715 MONOCYCLIC ISOXAZOLINES AS INHIBITORS OF CHOLESTEROL ESTER TRANSFER PROTEIN
Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein D1, D2 and D3 are each N, CH, or substituted...
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