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Patent # Description
2017/0209603 COMPOSITIONS TARGETING RADIATION-INDUCED MOLECULES AND METHODS OF USE THEREOF
The present invention is directed towards the compositions of peptide constructs that bind to GRP78 and the methods of use thereof.
2017/0209602 METHOD AND COMPOSITIONS FOR ORALLY ADMINISTERED CONTRAST AGENTS FOR MR IMAGING
Disclosed is CT or MR contrast agent which comprises a base or carrier scaffold formed of a polyhydroxol compound having a linker to which a Gd-DOTA is...
2017/0209601 Biopolymer-Nanoparticle Composite Implant for Tumor Cell Tracking
A method of detecting migration of tumor cells is provided by implanting in a region of tumor cells one or more implants having a matrix material of a...
2017/0209600 LIVER-SPECIFIC NUCLEIC ACID REGULATORY ELEMENTS AND METHODS AND USE THEREOF
Described are nucleic acid regulatory elements that are able to enhance liver-specific expression of genes, methods employing these regulatory elements and...
2017/0209599 Functionalized DNA Dendrimers For Gene Delivery To Cells
Compositions are disclosed which comprise a DNA dendrimer having one or more DNA sequences linked thereto, the DNA sequences comprising DNA sequences encoding...
2017/0209598 RECOMBINANT ADENO-ASSOCIATED VIRUS DELIVERY OF ALPHA-SARCOGLYCAN POLYNUCLEOTIDES
The present invention relates to recombinant adeno-associated virus (rAAV) delivery of an alpha-sarcoglycan gene. The invention provides rAAV products and...
2017/0209597 CAPPED AND UNCAPPED RNA MOLECULES AND BLOCK COPOLYMERS FOR INTRACELLULAR DELIVERY OF RNA
The present invention relates to the use of at least one tetra functional non-ionic amphiphilic block copolymer as a vehicle for capped or uncapped mRNA for...
2017/0209596 Inclusion Compounds of Fumagillol Derivative or its Salt, and Pharmaceutical Compositions Comprising the Same
The present invention relates to an inclusion compound of fumagillol derivative or its salt with hydroxypropyl-.beta.-cyclodextrin or ...
2017/0209595 DISULFUR BRIDGE LINKERS FOR CONJUGATION OF A CELL-BINDING MOLECULE
The present invention relates to novel disulfur bridge linkers containing hydrazine used for the specific conjugation of compounds/cytotoxic agents to a...
2017/0209594 SYNERGISTIC EFFECT OF ANTI-TROP-2 ANTIBODY-DRUG CONJUGATE IN COMBINATION THERAPY FOR TRIPLE-NEGATIVE BREAST...
The present invention relates to combination therapy with ADCs against a tumor-associated antigen, such as Trop-2, and drugs, such as microtubule inhibitors...
2017/0209593 METHODS OF CONJUGATING AN AGENT TO A THIOL MOIETY IN A PROTEIN THAT CONTAINS AT LEAST ONE SULFIDE BOND
The invention provides improved methods of conjugating an agent to a thiol moiety in a protein that contains at least one disulfide bond and at least one...
2017/0209592 Delivery Agents Targeted to Degraded Elastic Fibers
Methods and delivery agents for treatment of connective tissue that includes elastic fibers are described. Delivery agents are nano- or micro-sized particles...
2017/0209591 MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE
Provided herein are maytansinoid compounds, derivatives thereof, conjugates thereof, and methods of treating or preventing proliferative diseases with the same.
2017/0209590 METHODS AND REAGENTS FOR EFFICIENT AND TARGETED DELIVERY OF THERAPEUTIC MOLECULES TO CXCR4 CELLS
Conjugates comprising a targeting moiety specific for the CXCR4 and based on the polyphemusin-derived peptide and a therapeutic or imaging agent are provided....
2017/0209589 NOVEL CONJUGATION REAGENTS
The invention provides compound of the general formula: ##STR00001## in which each X independently represents a polymer chain; n represents an integer greater...
2017/0209588 PEGYLATED INTERFERON-BETA VARIANT
The present invention provides a PEGylated IFN-.beta. variant and a composition for preventing or treating hyperproliferative diseases, inflammatory diseases,...
2017/0209587 FORMULATIONS OF INTRAARTICULAR PHARMACEUTICAL AGENTS AND METHODS FOR PREPARING AND USING THE SAME
Provided herein are compositions and methods for preparing intraarticular formulations comprising biocompatible pharmaceutical agents and use thereof in the...
2017/0209586 AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME
The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating amino acids, such as...
2017/0209585 HIGH PENETRATION COMPOSITIONS AND USES THEREOF
The present invention relates to compositions and uses of novel high penetration compositions or high penetration prodrugs (HPP), in particular HPPs for...
2017/0209584 COMPOSITIONS FOR TARGETING MACROPHAGES AND OTHER CD206 HIGH EXPRESSING CELLS AND METHODS OF TREATING AND DIAGNOSIS
Provided are compounds and compositions for targeting macrophages and other CD206 high expressing cells.
2017/0209583 COMPOSITIONS AND METHODS FOR DELIVERING AN AGENT TO A WOUND
The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open...
2017/0209582 PROTEIN FORMULATIONS
The present disclosure provides solid protein formulations that are stable over a variety of temperatures for extended time periods. The present disclosure...
2017/0209581 Compositions with a Rheological Modifier to Reduce Dissolution Variability
The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while...
2017/0209580 PHASE-CHANGE NANOPARTICLE
Apparatus and methods are described for use with a subject suffering from cancer. A nanoparticle (22) includes an inner core (30) that comprises a phase-change...
2017/0209579 NON-INVASIVE RADIOFREQUENCY FIELD TREATMENT FOR CANCER THERAPY
Embodiments of the disclosure concern methods and compositions for treating a subject with cancer, including overcoming resistance to a cancer drug using...
2017/0209578 LITHOGRAPHICALLY DEFINED NANOPARTICLES FOR MICROWAVE ABSORPTION
A group of Hyperthermia micro/nano particles are prepared. Each nanoparticle has a first diameter between 1 micron to 50 micron and a first thickness between...
2017/0209577 DIRECTED DELIVERY OF ACTIVE AGENTS USING QUANTUM DOTS
This invention relates to the use of functionalized quantum dots to effect the targeted delivery of active agents to a diseased cell.
2017/0209576 DELIVERY COMPOSITIONS AND METHODS
This disclosure describes composition and methods for delivering a substance to a subject. Generally, the compositions include a liposome that includes a...
2017/0209575 INDUCED PHOTODYNAMIC THERAPY USING NANOPARTICLE SCINTILLATORS AS TRANSDUCERS
Photodynamic therapy systems comprising a nanoparticle that emits electromagnetic radiation having a first wavelength when irradiated with electromagnetic...
2017/0209574 COMBINATION THERAPIES
Combination therapies are disclosed. The combination therapies can be used to treat or prevent cancerous conditions and/or disorders. The combination may...
2017/0209573 TREATMENT METHOD
The present invention relates to methods of treating a disease, and methods for reduction of the formation of anti-drug antibodies (ADAs) in response to the...
2017/0209572 Classifiers of NF-kB Pathway Activation, Devices, and Methods of Use Thereof
This disclosure relates to classifiers of NF-.kappa.B pathway activation, devices, and methods of use thereof. In certain embodiments, the disclosure relates...
2017/0209571 PHARMACEUTICAL COMPOSITION COMPRISING BISPECIFIC ANTIBODY CONSTRUCTS
The present invention provides novel and stable pharmaceutical compositions comprising bispecific single chain antibody constructs, cyclodextrins and a buffer.
2017/0209570 Carbon Nanotube Compositions and Methods of Use Thereof
Carbon nanotube (CNT)-based compositions for activating cellular immune responses are provided. The CNTs function as high surface area scaffolds for the...
2017/0209569 MONOVALENT ANTI-CD3 ADJUVANTS
This document provides methods and materials related to using monovalent anti-CD3 antibodies (e.g., monovalent anti-CD3 Fab fragments) as adjuvants to increase...
2017/0209568 ADJUVANTS
The present invention relates to a family of carbohydrate monosulphate fatty acid esters, which contain less than 10 mole % of carbohydrate polysulphate fatty...
2017/0209567 METHODS FOR EFFECTIVELY AND RAPIDLY DESENSITIZING ALLERGIC PATIENTS
Methods and compositions for delivering antigens to the lymphatic system in doses that desensitize patients to future exposure to antigens have been developed....
2017/0209566 NOVEL MACADAMIA ALLERGEN
Provided is a polypeptide comprising a macadamia protein running in a 2D SDS PAGE at pH 6.3 to 8.7 and 53 to 67 kDa or a protein running in a 2D SDS PAGE at pH...
2017/0209565 NEUROATTENUATED HERPES SIMPLEX VIRUS
A mutant HSV-1 (referred to herein as KOS-NA) was generated. KOS-NA contains novel mutations in the UL39 gene, which encodes for a protein that is a large...
2017/0209564 INFLUENZA VIRUS VACCINES AND USES THEREOF
Provided herein are influenza hemagglutinin stem domain polypeptides, methods for providing hemagglutinin stem domain polypeptides, compositions comprising the...
2017/0209563 GLYCOCONJUGATE VACCINES COMPRISING BASIC UNITS OF A MOLECULAR CONSTRUCT EXPRESSING BUILT-IN MULTIPLE EPITOPES...
The present invention refers to new glycoconjugate antigens expressing built-in multiple epitopes and to polyvalent glycoconjugate vaccines intended for the...
2017/0209562 IMMUNOGENIC COMPOSITION
The present disclosure relates to the field of Neisserial immunogenic compositions and vaccines, their manufacture and the use of such compositions in...
2017/0209561 VACCINE COMPOSITION AGAINST STREPTOCOCCUS SUIS INFECTION
Described is a vaccine composition comprising an effective amount of at least one polypeptide selected from the group of IdeSsuis, rIdeSsuis, an analogue or a...
2017/0209560 MYCOPLASMA HYOPNEUMONIAE VACCINE
This invention provides an immunogenic composition including the supernatant of a Mycoplasma hyopneumoniae (M.hyo) culture, wherein the supernatant of the...
2017/0209559 Polymer-Protein Core-Shell Particles as Effective Vaccine Delivery Vehicles and Treatments Methods Using the Same
A polymer-protein core-shell nanoparticle is generally provided. In one embodiment, the polymer-protein core-shell nanoparticle includes a pyridinyl group...
2017/0209558 TREATMENT AND PREVENTION OF MALARIA
There are provided antigens, vectors encoding the antigens, and antibodies and other binding compounds to the antigens and uses thereof in the prevention or...
2017/0209557 METHOD FOR PREPARING DENDRITIC CELLS WITH INCREASED SPECIFIC GENE EXPRESSION, AND COMPOSITION FOR TREATING OR...
The present invention relates to a method for generating semi-mature dendritic cells by treating immature dendritic cells with the auto-antigen, cytokine, and...
2017/0209556 ANTI-SIGLEC-8 ANTIBODIES AND METHODS OF USE THEREOF
The invention provides humanized anti-Siglec-8 antibodies and their use in treating and preventing eosinophil-mediated disorders and/or mast cell-mediated...
2017/0209555 Compositions and Methods for Modulating Cardiac Conditions
Embodiments herein report methods and compositions for treating cardiac conditions. In certain embodiments, compositions and methods relate to reducing,...
2017/0209554 THROMBOPOIETIC ACTIVITY OF TYROSYL-TRNA SYNTHETASE POLYPEPTIDES
Thrombopoietic compositions are provided comprising tyrosyl tRNA synthetase polypeptides, including truncations and/or variants thereof. Also provided are...
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