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Patent # Description
2017/0209452 HETEROCYCLIC COMPOUND
Provided is a compound useful for the prophylaxis or treatment of cancer. The present invention relates to a compound represented by formula (I): ##STR00001## ...
2017/0209451 COMPOSITION FOR INDUCING DIFFERENTIATION OF MULTIPOTENT NEURAL STEM CELLS INTO DOPAMINERGIC NEURONS AND METHOD...
Disclosed is a composition for inducing the differentiation of neural stem cells into dopaminergic neurons. The composition includes the compound represented...
2017/0209450 MEK INHIBITORS IN THE TREATMENT OF VIRUS DISEASES
The present invention relates to MEK inhibitors that are capable of displaying one or more beneficial therapeutic effects. The MEK inhibitors can be used in...
2017/0209449 PYRROLOPYRIMIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS
Disclosed are chemical entities of formula I: ##STR00001## wherein X, Y, Z, R.sup.1, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined herein, as NR2B subtype...
2017/0209448 TREATMENT REGIMENS USING MULTIPLE PHARMACEUTICAL AGENTS
The present invention provides for methods and pharmaceutical compositions for treating disorders using treatment regimens involving multiple agents. In one...
2017/0209447 Use of PNP Inhibitor to Treat Relapse of Malignancy after Hematopoietic Stem Cell Transplant
Compositions and methods including at least one PNP inhibitor or at least one PNP inhibitor in combination with guanosine identified as endogenous adjuvant...
2017/0209446 INHIBITORS OF IRAK4 ACTIVITY
The present invention relates to inhibitors of IRAK4 of Formula I and provides compositions comprising such inhibitors, as well as methods therewith for...
2017/0209445 KINASE INHIBITORS
Compounds of formula I, ##STR00001## have anti-inflammatory activity. Exemplary mechanisms of action include inhibition of one or more of members of: the family...
2017/0209444 METHODS OF TREATING CANCER AND PREVENTING CANCER DRUG RESISTANCE
Provided herein are methods of using antagonists of G9a, for example, for treating cancer and/or preventing drug resistance in an individual. For example, a...
2017/0209443 ANTI-INFLAMMATORY EFFECT OF ORALLY ACTIVE FYN KINASE INHIBITOR SARA-CATINIB (AZD 0530) AGAINST PARKINSON'S...
The present invention describes novel pharmaceutical compositions and methods for treatment of diseases, disorders, or conditions characterized by...
2017/0209442 IMMUNOLOGICAL REAGENTS AND USES THEREFOR
The present invention provides ligands which bind to MR1, some of which induce MR1 to bind to MAIT cells thereby activating or inhibiting MAIT cell activation.
2017/0209441 AMINOQUINOLINE DERIVATIVES AND USES THEREOF
Described herein are aminoquinoline and aminoacridine based hybrids, pharmaceutical compositions and medicaments that include such aminoquinoline and...
2017/0209440 METHODS AND COMPOSITIONS FOR TREATING HIV-RELATED DISORDERS
Certain adjunctive therapies comprising a kynurenine-3-monooxygenase inhibitor and an antiviral agent for treating HIV-related disorders are provided herein....
2017/0209439 COMPOSITIONS AND METHODS FOR TREATING REBOUND ERYTHEMA ASSOCIATED WITH TOPICAL ALPHA-ADRENERGIC AGONISTS
The present disclosure provides methods and compositions for treating or preventing erythema, including rebound erythema associated with the use of topical...
2017/0209438 A Compound For Anti-Cancer Therapy That Acts By Targeting GOF Mutant P53 And Stimulates P73 To Restore The P53...
The invention includes compositions comprising NSC59984 or a derivative or analogue thereof and a pharmaceutically acceptable carrier. The invention further...
2017/0209437 2-PYRIDONE ANTIMICROBIAL COMPOSITIONS
Disclosed herein are compounds of Formula I ##STR00001## wherein R.sup.1, R.sup.2, X, and Y are defined herein. These compounds are type II topoisomerase...
2017/0209436 ITRACONAZOLE ANALOGUES AND METHODS OF USE THEREOF
Disclosed herein are analogues of itraconazole that are both angiogenesis and hedgehog signaling pathway inhibitors. The compounds are expected to be useful in...
2017/0209435 METHODS AND COMPOSITIONS FOR KILLING SENESCENT CELLS AND FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic...
2017/0209434 PROTEIN PHOSPHATASE 2A INHIBITORS FOR TREATING MYELODYSPLASTIC SYNDROMES
Disclosed are methods for treating a meylodysplastic syndrome (MDS) in a subject that involves administering to the subject a therapeutically effective amount...
2017/0209433 METHOD OF USING DIKETOPIPERAZINES AND COMPOSITION CONTAINING THEM
The invention provides a method of inhibiting the effects of platelet activating factor (PAF). For instance, a disease or condition mediated by PAF...
2017/0209432 LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE OR LYMPHOPROLIFERATIVE DISEASES OR DISORDERS
The present invention relates to methods and compositions for the treatment or prevention of diseases and disorder associated with myeloproliferative and...
2017/0209431 SUBLINGUAL AND BUCCAL FILM COMPOSITIONS
The present invention relates to products and methods for treatment of narcotic dependence in a user. The invention more particularly relates to ...
2017/0209430 Polymorphic Forms of Naltrexone
This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and...
2017/0209429 ABUSE DETERRENT OPIOD/OPIOD-ANTAGONIST TRANSDERMAL PATCH
The present invention relates to an abuse deterrent transdermal patch.
2017/0209428 METHODS FOR INHIBITING TIE-2 KINASE USEFUL IN THE TREATMENT OF CANCER
The present invention relates to methods of inhibiting TIE2 kinase useful in the treatment of tumor growth, invasiveness, intravasation, dissemination,...
2017/0209427 USE OF LAQUINIMOD TO DELAY HUNTINGTON'S DISEASE PROGRESSION
The subject invention provides methods of treating or delaying disease progression in a subject afflicted with Huntington's disease (HD) comprising...
2017/0209426 ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFNalpha RESPONSES
Compounds having the following formula I: ##STR00001## or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R.sup.1, R.sup.2, R.sup.3,...
2017/0209425 METHODS AND COMPOSITIONS FOR TREATING PATHOLOGIES ASSOCIATED WITH BDNF SIGNALING
A method of treating non-neurodegenerative pathologies associated with derangement in brain-derived neurotrophic factor signaling in the brain stem includes...
2017/0209424 SELECTIVE SEROTONIN 2A/2C RECEPTOR INVERSE AGONISTS AS THERAPEUTICS FOR NEURODEGENERATIVE DISEASES
Behavioral pharmacological data with the compound of formula (I), a novel and selective 5HT2A/2C receptor inverse agonist, demonstrate in vivo efficacy in...
2017/0209423 SOLID FORMS OF AN ASK1 INHIBITOR
Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-y- l)pyridin-2-yl)-2-fluoro-4-methylbenzamide (Compound I) were...
2017/0209422 METHODS OF USING SUSTAINED RELEASE AMINOPYRIDINE COMPOSITIONS
A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a...
2017/0209421 SUSTAINED RELEASE AMINOPYRIDINE COMPOSITION
A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a...
2017/0209420 USES OF 4'-DESFERRITHIOCIN ANALOGS
Macular degeneration, closed head injury, stroke, irritable bowel disease, and reperfusion injury are all associated with biological injury due to reactive...
2017/0209419 METHODS OF TREATING RESPIRATORY DISORDERS
A method of treating a hyperoxia induced disease or disorder associated with GSNO deficiency in a subject in need thereof includes administering to the subject...
2017/0209418 USE OF PROSTACYCLIN ANTAGONISTS FOR TREATING OCULAR SURFACE NOCICEPTION
The present invention relates generally to the use of compositions and methods for treating nociceptive events that occur on the ocular surface in association...
2017/0209417 POLYCOMPLEX GEL FOR TREATING DISEASES OF INTESTINAL/DIGESTIVE TRACT
The invention relates to the chemical and pharmaceutical industry and consists of a rectal gel substance for treating diseases of the intestinal/digestive...
2017/0209416 COMPOSITIONS COMPRISING MELATONIN AND FLAVONOIDS FOR USE IN THE TREATMENT OF TUMOURS RESISTANT TO CHEMOTHERAPY
Compositions having at least one flavonoid of natural or synthetic origin in association with melatonin to increase the effectiveness of chemotherapeutic...
2017/0209415 USE OF (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE TO TREAT ADDICTIVE DISORDERS INCLUDING NICOTINE...
The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable active salts, polymorphs, glycosylated...
2017/0209414 PREPARATION OF MICRONIZED PARTICLES OF AN ANTIMUSCARINIC COMPOUND BY HYDRODYNAMIC CAVITATION
Crystalline micronized particulate of a glycopyrronium salt may be prepared by hydrodynamic cavitation. The resulting drug particles are physically stable with...
2017/0209413 USE OF ASPARAGUSIC ACID AND DERIVATIVES THEREOF TO TREAT SYMPTOMS AND DISORDERS OF NEUROLOGICAL DISEASE
Embodiments disclosed herein provide methods for treating and/or ameliorating symptoms of certain neurological diseases. The methods encompass administration...
2017/0209412 TREATMENT OF SICKLE CELL DISEASE
The present invention includes embodiments for treatment and/or prevention of sickle cell disease that employ Hydroxyfasudil or Isocoronarin D alone or either...
2017/0209411 Use of butylidenephthalide (Bdph), method of using the same, and method for preparing pharmaceutical...
The present invention discloses use of butylidenephthalide (Bdph), a method of using the same, and a method for preparing a pharmaceutical composition...
2017/0209410 SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS
The present invention provides calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing,...
2017/0209409 MDI RELATED PRODUCTS AND METHODS OF USE
Provided herein are embodiments related to metered dose inhalers and formulations for such inhalers. In some embodiments, the inhalers are configured so as to...
2017/0209408 HSP90 INHIBITORS FOR THE TREATMENT OF OBESITY AND METHODS OF USE THEREOF
HSP 90 inhibitors for the promotion of weight loss, as well as formulations containing these inhibitors and methods of using thereof, are described herein....
2017/0209407 METHOD OF TREATING HER2-POSITIVE BREAST CANCERS WITH SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS)
This invention relates to the treatment of breast cancer in a subject, for example a female subject. Including methods of: treating metastatic breast cancer;...
2017/0209406 EXTERNAL WOUND-HEALING AGENT, AND EXTERNAL WOUND-HEALING MATERIAL
An external wound-healing agent includes, as an active ingredient, at least one compound of a glycerol alkyl ester represented by Formula (I) or a diglycerol...
2017/0209405 APPLICATION OF COMPOUND MIXTURES TO CONTROL OXIDATION
A combination of antioxidants is proposed as a supplement based on the best available clinical data. The present invention proposes a research-driven approach...
2017/0209404 HIGH PENETRATION COMPOSITIONS AND USES THEREOF
The present invention relates to compositions and uses of novel high penetration compositions or high penetration prodrugs (HPP), in particular HPPs for...
2017/0209403 METHOD FOR REGULATING ALDEHYDE DEHYDROGENASE 1
The present invention provides a method for regulating aldehyde dehydrogenase 1 (ALDH1) comprises administering all-trans retinoic acid to a subject. Further,...
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