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Patent # Description
2017/0216456 Stable Gene Transfer to Proliferating Cells
Provided herein are methods for facilitating or inducing stable transgene integration and expression in a proliferating cell, comprising administering to the...
2017/0216455 HYPERBRANCHED POLY ( -AMINO ESTER) FOR GENE THERAPY
The invention relates to branched polymers which find use in gene therapy applications as nucleic acid transfection agents. In particular, the invention...
2017/0216454 RPGR GENE THERAPY FOR RETINITIS PIGMENTOSA
Methods for treating a human subject who has X-linked Retinitis Pigmentosa (XLRP) or another clinically-defined ophthalmological condition due to a...
2017/0216453 Treating Lymphomas
This document provides methods and materials related to treating lymphomas. For example, methods and materials relating to the use of a composition containing...
2017/0216451 TARGETED PHARMACOLOGICAL CHAPERONES
The present invention relates to the preparation End use of therapeutic compounds for the treatment of diseases at specific subcellular target areas such as...
2017/0216450 CROSSLINKED POLYMER NANO-ASSEMBLIES AND USES THEREOF
The invention provides a novel system of nano-assemblies and related method for delivery of therapeutic, diagnostic or imaging agent to biological sites. The...
2017/0216449 THERAPEUTIC VITAMIN D CONJUGATES
The invention provides non-hormonal vitamin D conjugated to apelin proteins that result in increased absorption, bioavailability or circulating half-life when...
2017/0216448 INHIBITORS OF FUSION BETWEEN VIRAL AND CELL MEMBRANES AS WELL AS COMPOSITIONS AND METHODS OF USING THEM
The present application relates to an inhibitor of fusion between a viral membrane from an enveloped virus and a cell membrane, where the viral membrane...
2017/0216447 COMBINATION THERAPY WITH ANTI-HLA-DR ANTIBODIES AND KINASE INHIBITORS IN HEMATOPOIETIC CANCERS
The present invention relates to combination therapy with drugs, such as Bruton's tyrosine kinase inhibitors or PI3K inhibitors, with antibodies or ADCs...
2017/0216446 POLYMER-FLAVONOID CONJUGATE AND USES THEREOF
There is provided a polymer-flavonoid conjugate, or a pharmaceutically acceptable salt thereof, uses thereof, and methods of making thereof. The disclosed...
2017/0216445 CXCR4 INHIBITING CARRIERS FOR NUCLEIC ACID DELIVERY
The present invention generally relates to carriers including polymers and lipids that comprise a CXCR4 inhibiting moiety. More specifically, these carriers...
2017/0216444 PREPARATION FOR FORMING EMBOLI AND MICROCATHETER
An object is to provide a preparation for forming emboli highly safe in a living body and capable of retaining and controlled-releasing an anticancer agent,...
2017/0216443 ABIRATERONE DERIVATIVES AND NON-COVALENT COMPLEXES WITH ALBUMIN
The present disclosure provides derivatives of abiraterone, non-covalently bound complexes of the abiraterone derivatives with serum albumin, pharmaceutical...
2017/0216442 ERODIBLE ANHYDROUS POLYETHYLENE OXIDE FILM
An erodible anhydrous film useful in delivering active agents to a surface including keratinous surfaces, and hard or soft surfaces is disclosed. The erodible...
2017/0216441 COMPOSITIONS AND KITS FOR COMPOUNDING PHARMACEUTICALS
The invention provides compositions and methods for the convenient compounding of pharmaceuticals. Single and multiple unit of use kits are provided which...
2017/0216439 OTIC FORMULATIONS FOR THE TREATMENT OF CERUMINOSIS
Disclosed herein are compositions, formulations, methods, devices and kits for modulating the production of cerumen, the treatment of ceruminosis, and the...
2017/0216438 PLANT VIRUS PARTICLES FOR DELIVERY OF PHOTOSENSITIVE AGENTS
Photodynamic virus particles including a plant virus particle associated with a photosensitizing agent are described. Methods of treating cancer in a subject...
2017/0216437 TECHNIQUES FOR RELEASE OF MATERIAL INTO AN ENVIRONMENT
Systems and methods for releasing a material into an environment. The material may be encapsulated in a receptacle or otherwise packaged for movement into the...
2017/0216436 A METHOD FOR TREATING CANCER BASED ON METALLOFULLERENE MONOCRYSTALLINE NANOPARTICLES THAT SPECIFICALLY DISRUPT...
Metallofullerene monocrystalline nanoparticles are used as tumor vascular disrupting agents. The monocrystalline nanoparticles are water-soluble ...
2017/0216435 SELECTIVE REMOVAL OF AGE-MODIFIED CELLS FOR TREATMENT OF ATHEROSCLEROSIS
A method of treating atherosclerosis comprises removing AGE-modified cells from a patient. The AGE-modified cells include erythrocytes, intima cells,...
2017/0216434 COMPOSITIONS AND METHODS FOR TREATMENT OF SICKLE CELL DISEASE
This invention relates to methods of treating sickle cell disease with VLA-4 antagonists and methods for evaluating the responsiveness of patients having...
2017/0216433 AN ANTI-CTLA4 MONOCLONAL ANTIBODY OR ITS ANTIGEN BINDING FRAGMENTS, PHARMACEUTICAL COMPOSITIONS AND USES
The present invention belongs to the fields of tumor therapy and molecular immunology, and provides an anti-CTLA4 monoclonal antibody or antigen binding...
2017/0216432 METHODS OF TREATING A DISEASE OR DISORDER ASSOCIATED WITH BRUTON'S TYROSINE KINASE
The present invention provides methods of treating, stabilizing or lessening the severity or progression of a disease or disorder associated with BTK.
2017/0216431 VACCINE PHARMACEUTICAL COMPOSITION FOR TRANSDERMAL ADMINISTRATION
The present invention provides a vaccine pharmaceutical composition for transdermal administration which is safe, usable as a prophylactic or therapeutic agent...
2017/0216430 IMMUNE-INDUCTION-PROMOTING COMPOSITION INCLUDING NUCLEAR RECEPTOR LIGAND, AND VACCINE PHARMACEUTICAL COMPOSITION
The present invention aims to provide a composition for promoting immunity induction and a vaccine pharmaceutical composition which are universally usable for...
2017/0216429 COMPOSITION FOR ENHANCING INDUCTION OF HUMORAL IMMUNITY, AND VACCINE PHARMACEUTICAL COMPOSITION
The present invention aims to provide a composition for promoting humoral immunity induction and a vaccine pharmaceutical composition that can be universally...
2017/0216427 Coronavirus
The present invention provides a live, attenuated coronavirus comprising a variant replicase gene encoding polyproteins comprising a mutation in one or more of...
2017/0216426 COMPOSITIONS AND METHODS FOR TRANSIENT IMMUNE RESPONSE MODULATION DURING VACCINATION
In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce...
2017/0216425 AVOIDING NARCOLEPSY RISK IN INFLUENZA VACCINES
The invention provides influenza vaccines and methods which improve the safety of influenza vaccines further, in particular in relation to the risk of causing...
2017/0216424 VACCINE FOR PCV2 AND MYCOPLASMA
A premixed multivalent vaccine in ready-to-use form comprising PCV2 ORF2 capsid antigen and M. hyopneumoniae antigen that reduces or prevents PCV2 infection...
2017/0216423 PCV/MYCOPLASMA HYOPNEUMONIAE/LAWSONIA INTRACELLULARIS COMBINATION VACCINE
This invention provides a multivalent immunogenic composition including a soluble portion of a Mycoplasma hyopneumoniae (M.hyo) whole cell preparation; a...
2017/0216422 RECOMBINANT ADENOVIRUS VECTORED FMDV VACCINES AND USES THEREOF
The present invention encompasses FMDV vaccines or compositions. The invention encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes...
2017/0216421 MANUFACTURING OF MULTI-DOSE INJECTION READY DENDRITIC CELL VACCINES, COMBINATION THERAPIES FOR BLOCKING HER2...
The present embodiments relate to an FDA-approved injectable multi-dose antigen pulsed dendritic cell (DC) vaccine. In one embodiment, the activated...
2017/0216420 BACTERIAL VACCINES DEFICIENT IN THE 2-C-METHYL-D-ERYTHRITOL-4-PHOSPHATE PATHWAY AND METHODS OF PREPARATION AND...
The present invention relates to the preparation and use in primates of whole organismvaccines in which the MEP pathway is disrupted such that synthesis of...
2017/0216419 COMPOSITIONS AND METHODS FOR CANCER IMMUNOTHERAPY
The invention provides compositions and methods for cancer immunotherapy. Specifically, the invention provides an antigen-presenting cell, for example, a...
2017/0216418 IMMUNOGENIC LHRH COMPOSITION AND USE THEREOF IN PIGS
A vaccine composition for castrating pigs, comprising a peptide immunogen and a veterinarily acceptable delivery vehicle or adjuvant, wherein the peptide...
2017/0216417 POPULATION OF IMMUNOREGULATORY T CELLS SPECIFIC FOR AN IRRELEVANT ANTIGEN AND USES THEREOF FOR PREVENTING OR...
The present invention relates methods and compositions for preventing or treating various immune diseases including graft-versus-host disease (GVHD) using...
2017/0216416 Pigment Epithelium-Derived Factor (PEDF) and Peptide Derivatives Thereof for Use in Osteoblast Differentiation...
The present invention provides compositions and methods for differentiating a stem cell into an osteoblast or osteoblast progenitor cell. In certain...
2017/0216415 COMPOSITIONS FOR THE INHIBITION OF GIARDIA LAMBLIA
The present invention relates to a composition exhibiting a bile-salt hydrolase activity for its use for the treatment or the prevention of giardiasis, said...
2017/0216414 DERMAL FILLER
Improved dermal filler formulation comprising a hyaluronic acid and a botulinum toxin.
2017/0216413 METHODS OF TREATING MUCOPOLYSACCHARIDOSIS IIIB (MPSIIIB)
Methods for treating the central nervous system (CNS) in a human patient with mucopolysaccharidosis (MPS) MB who has an intact blood brain barrier, comprising...
2017/0216412 RECOMBINANT HUMAN NAGLU PROTEIN AND USES THEREOF
The present invention provides compositions comprising an isolated mixture of recombinant human NaGlu proteins in which a substantial amount of the NaGlu...
2017/0216411 TREATMENT OF ALPHA-GALACTOSIDASE A DEFICIENCY
The invention provides methods of treating .alpha.-galactosidase A deficiency. Dosage forms, methods of administration, and methods of analyzing human...
2017/0216410 SOLUBLE BACTERIAL AND FUNGAL PROTEINS AND METHODS AND USES THEREOF IN INHIBITING AND DISPERSING BIOFILM
The present disclosure relates to methods of treating or preventing a biofilm-related infection and methods of preventing and treating biofilm formation on...
2017/0216409 MODULATION OF LAMININ ALPHA-4 IN THE PREVENTION, TREATMENT, AND MANAGEMENT OF METABOLIC SYNDROMES
The disclosure provides methods of preventing or treating metabolic syndrome in a subject by administering an effective amount of an inhibitor of laminin...
2017/0216408 CpG REDUCED FACTOR VIII VARIANTS, COMPOSITIONS AND METHODS AND USES FOR TREATMENT OF HEMOSTASIS DISORDERS
CpG reduced nucleic acid variants encoding FVIII protein and methods of use thereof are disclosed. In particular embodiments, CpG reduced nucleic acid variants...
2017/0216407 TMD1 PROTEIN FOR TREATING BONE LOSS DISEASES
The present invention relates to a method for treating a bone loss disease, condition, or disorder in a subject in need thereof, comprising administering to...
2017/0216406 FUNCTIONALIZED EXENDIN-4 DERIVATIVES
The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including...
2017/0216404 INFUSION DELIVERY DEVICES AND METHODS
Devices that include multi-reservoir infusion devices and systems for dispensing compositions for the treatment of subjects with an amylin agonist (e.g., the...
2017/0216403 SYNERGISTIC TUMOR TREATMENT WITH IL-2, A THERAPEUTIC ANTIBODY, AND AN IMMUNE CHECKPOINT BLOCKER
The present invention provides a method of treating cancer with a combination of IL-2 (e.g., extended-PK IL-2), a therapeutic antibody or fragment thereof, and...
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