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Patent # Description
2017/0216301 NOVEL BICYCLIC BROMODOMAIN INHIBITORS
The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical...
2017/0216300 EZH2 INHIBITORS FOR TREATING LYMPHOMA
The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and their use for the treatment of cancer.
2017/0216299 3-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINE AND THERAPEUTIC USES THEREOF
Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole...
2017/0216298 Beta2-ADRENOCEPTOR AGONIST FOR THE TREATMENT OF COUGH
This invention relates to the B2-adrenoceptor agonist Olodaterol or a pharmaceutically acceptable salt thereof, ##STR00001## for use in a method of treatment of...
2017/0216297 EFFICIENT INHIBITION OF HSP27
The present invention relates to novel HSP27 inhibitors, in particular purine derivatives according to general formula (I) or (II) and phenothiazine...
2017/0216296 METHODS OF TREATING HYPERGLYCEMIA
The present invention relates to a novel method of treating hyperglycemia in a patient with poor glycemic control. The method comprises administering to the...
2017/0216295 CCR9 ANTAGONIST COMPOUNDS
Provided herein are compounds that inhibit CCR9 receptor function. Also provided herein are methods of treating inflammatory disease in a subject, comprising...
2017/0216294 Methotrexate for Proliferative Vitreoretinopathy
The use of methotrexate, e.g., repeated dosing or sustained-release formulations of methotrexate, for treating or reducing risk of proliferative...
2017/0216293 THIENOPYRIMIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Compounds of formula (I): ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.12, X, A and n are as defined in the...
2017/0216292 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF
The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of...
2017/0216291 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF
The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of...
2017/0216290 HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME
Disclosed are chemical entities which are compounds of formula (I): ##STR00001## or pharmaceutically acceptable salts thereof; wherein Y, R.sup.a, R.sup.a',...
2017/0216289 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
The present disclosure provides compositions and methods for the treatment of cancer, relating to the specific inhibition of Abelson (ABL) kinases.
2017/0216288 IMMUNOPOTENTIATOR POTENTIATING TUMOR IMMUNITY OR INFECTION IMMUNITY
An object of the present invention is to provide an immunopotentiating agent for reducing Tregs (in particular, effector Tregs) and potentiating tumor immunity...
2017/0216287 TREATING NEURAL DISEASE WITH TYROSINE KINASE INHIBITORS
Provided herein are methods of treating or preventing a neurodegenerative disease, a myodegenerative disease or a prion disease in a subject comprising...
2017/0216286 KILLING SENESCENT CELLS AND TREATING SENESCENCE-ASSOCIATED CONDITIONS USING A SRC INHIBITOR AND A FLAVONOID
Provided herein are methods and uses for treatment or prophylaxis of a senescent cell associated disease or disorder by administering a senolytic combination...
2017/0216285 SMALL MOLECULE INHIBITORS FOR CANCER THERAPY
Compounds, including quinoxaline derivatives of Formula (I), for use in the treatment of cancer are described. In general, the compounds inhibit the import of...
2017/0216284 ANTIVIRAL THERAPY
The present invention relates to combinations of compounds comprising HIV integrase inhibitors and other therapeutic agents. Such combinations are useful in...
2017/0216283 COMPOUNDS AND USES
There is provided compounds of formula I, ##STR00001## wherein E.sup.1, E.sup.2, E.sup.3, E.sup.4, L.sup.1, Y.sup.1, Y.sup.2, Y.sup.3, R.sup.a and z have...
2017/0216282 Compounds, Formulations, and Methods for Treating or Preventing Inflammatory Skin Disorders
In methods, compounds, and topical formulations for treatment of inflammatory skin disorders incorporating compounds represented by the formulas below: ...
2017/0216281 OPTICAL CORRECTION
The present disclosure describes compositions which improve visual acuity and to methods for their use.
2017/0216280 SUBSTITUTED DIKETOPIPERAZINE ANALOGS FOR USE AS DRUG DELIVERY AGENTS
Disclosed are drug delivery systems for the delivery of small molecule and macromolecular drugs. More particularly, disclosed are substituted analogs of...
2017/0216279 METHODS FOR TREATING DEPRESSIVE SYMPTOMS
The present application relates methods for treating a depressive symptom comprising administering an effective amount of a .mu. opioid receptor agonist or a...
2017/0216278 TRANSMUCOSAL DELIVERY DEVICES WITH ENHANCED UPTAKE
The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices....
2017/0216277 THERAPEUTIC USE OF NALBUPHINE WITHOUT AQUARETIC EFFECTS
The present invention relates to methods for treating pruritus with anti-pruritic compositions, wherein the method provides a therapeutic effect without...
2017/0216276 METHODS AND THERAPEUTIC COMBINATIONS FOR TREATING TUMORS
Methods and therapeutic combinations useful for increasing cell-mediated anti-tumor responses are described. The methods include administering to a subject a...
2017/0216275 PHOSPHODIESTERASE INHIBITORS AND USES THEREOF
The invention provides for compounds that are phosphodiesterase inhibitors. The invention further provides for a method for screening compounds that bind to...
2017/0216274 Enhanced Erythropoiesis and Iron Metabolism
The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron...
2017/0216273 Nicotine Derivatives and Methods of Use
This invention provides a compound selected from the group consisting of L-nicotine(X.sub.1)(X.sub.2) and D-nicotine(X.sub.1) (X.sub.2), or a pharmaceutically...
2017/0216272 COMPOSITIONS FOR TREATING OR PREVENTING OBESITY AND INSULIN RESISTANCE DISORDERS
Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance...
2017/0216271 SALTS OF HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE
The present disclosure relates to salts of heterocyclic compounds and methods that inhibit HIF pathway activity. The compounds are designed to treat or prevent...
2017/0216270 Methylphenidate Extended Release Chewable Tablet
An oral methylphenidate extended release tablet is described, which can be scored and still retain its extended release profile. The tablet contains a...
2017/0216269 METHODS OF TREATING DEVELOPMENTAL DISORDERS USING PIPRADROL
Methods of treating developmental disorders by administering a pharmaceutical composition of pipradrol or a pharmaceutically acceptable salt thereof are...
2017/0216268 GEL CONTAINING PIRFENIDONE
The invention relates to a gel composition containing pirfenidone, which is advantageous over other cutaneously administered pharmaceutical forms known in the...
2017/0216267 CONTROLLED DELIVERY SYSTEM
The present invention relates to novel anesthetic compositions containing a non-polymeric carrier material and an anesthetic, where the compositions are...
2017/0216266 MULTI-COMPONENT CRYSTALS OF VISMODEGIB AND SELECTED CO-CRYSTAL FORMERS OR SOLVENTS
The present invention primarily relates to multi-component crystals comprising a compound of formula 1 ##STR00001## and a second compound selected from the group...
2017/0216265 INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR MODULATING HEMATOPOIETIC STEM CELLS AND HEMATOPOIESIS
A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.
2017/0216263 ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS
The present invention provides compounds of Formula (I): ##STR00001## or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the...
2017/0216262 AMIDO SPIROCYCLIC AMIDE AND SULFONAMIDE DERIVATIVES
Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such...
2017/0216261 COMBINATION THERAPY USING AZABICYCLO COMPOUND FOR CANCER
Provided is a novel method for treating cancer using an HSP90 inhibitor which exhibits a markedly superior antitumor effect and has a reduced side effect. An...
2017/0216260 OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION
The present invention provides a oxazole compound represented by Formula (1), or a salt thereof: ##STR00001## wherein R.sup.1 is an aryl group which may have one...
2017/0216259 COMPOSITIONS AND METHODS FOR TARGETING RECEPTORS EXPRESSED IN THE GUT
The invention relates to novel compounds and pharmaceutical preparations thereof, as well as methods of making an using these compounds. The invention further...
2017/0216258 MAZINDOL COMBINATION IN THE TREATMENT OF ATTENTION-DEFICIT/HYPERACTIVITY
The present invention relates to the field of human health, and more particularly to the treatment of attention deficit/hyperactivity disorder (ADHD) with...
2017/0216257 NOVEL SUBSTITUTED BICYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS
The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical...
2017/0216256 METHOD OF TREATING A CNS DISORDER USING A WATER-SOLUBLE HISTONE DEACETYLASE INHIBITOR
A method of treating a CNS disorder. The method comprises providing a water-soluble histone deacetylase inhibitor, and administering the water-soluble histone...
2017/0216255 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND
The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the...
2017/0216254 FK506 DERIVATIVE MAINTAINING NERVE REGENERATION ACTIVITY WITHOUT IMMUNOSUPPRESSIVE ACTIVITY, AND USE THEREOF
The present invention relates to an FK506 derivative which has reduced immunosuppressive activity but maintains nerve regeneration activity, a preparing method...
2017/0216252 ANTI-BACTERIAL PYRUVATE KINASE MODULATOR COMPOUNDS, COMPOSITIONS, USES AND METHODS
Compounds of general formula I that are capable of inhibiting bacterial pyruvate kinase and/or bacterial growth. The compounds may find use as antibacterial...
2017/0216251 USE OF (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE TO TREAT ADDICTIVE AND ALCOHOL-RELATED DISORDERS
The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable salts thereof, compositions comprising ...
2017/0216250 METHODS OF TREATING DIABETES BY ADMINISTERING A GLUCAGON RECEPTOR ANTAGONIST IN COMBINATION WITH A CHOLESTEROL...
Use of a glucagon receptor antagonist in combination with a cholesterol absorption inhibitor for the treatment of diabetes and related conditions is disclosed.
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