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Patent # Description
2017/0218381 Stable Genomic Integration of Multiple Polynucleotide Copies
Methods of constructing a cell comprising in its chromosome one or more copies of an open reading frame (ORF) or operon encoding at least one polypeptide of...
2017/0218380 METHOD FOR DIRECTIONAL CLONING
Described herein are techniques for directional cloning an insert DNA segments into a target vector. The techniques mix the target vector, the insert DNA...
2017/0218379 COMPOSITIONS AND METHODS FOR SELF-REGULATED INDUCIBLE GENE EXPRESSION
A self-regulating gene expression construct comprises a single promoter in operative association with a repressor sequence (e.g., bacterial repressor lacI or...
2017/0218377 Aspergillus Fumigatus Cellulolytic Enzyme Compositions And Uses Thereof
The present invention relates to recombinant Trichoderma host cells producing Aspergillus fumigatus cellulolytic enzyme compositions and methods of producing...
2017/0218376 TREATMENT OF ATOPIC DERMATITIS AND ASTHMA USING RNA COMPLEXES THAT TARGET IL4Ra, TRPA1, OR F2RL1
In certain aspects, provided herein are RNA complexes (e.g., asymmetric RNA complexes, such as asiRNAs or cell penetrating asiRNAs) that inhibit IL4R.alpha.,...
2017/0218375 MORPHOLINOS, MORPHOLINO UPREGULATING, AND ASSOCIATED METHODS
Various methods and compositions relating to vascular endothelial growth factor receptor 2 (VEGFR2) are provided. In one aspect, a method of increasing...
2017/0218374 Treatment of Angiogenesis-Associated Diseases Using RNA Complexes that Target ANGPT2 and PDGFB
In certain aspects, provided herein are RNA complexes (e.g., asymmetric RNA complexes, such as asiRNAs or cell penetrating asiRNAs) that inhibit ANGPT2 and/or...
2017/0218373 COMPOSITION FOR DIAGNOSIS OF LIVER METASTASIS OF COLORECTAL CANCER AND THE USE THEREOF
The present disclosure relates to a composition for diagnosis of liver metastasis of colorectal cancer and the use thereof, and more particularly to a...
2017/0218372 COMPOSITIONS AND METHODS TO TREATING HEMOGLOBINOPATHIES
Embodiment herein provide specially designed synthetic BCL11A-targeting microRNAs for RNA polymerase II expression, and methods o use to treat ...
2017/0218371 MICRORNA COMPOUNDS AND METHODS FOR MODULATING MIR-122
Described herein are compositions and methods for the inhibition of miR-122 activity. The compositions have certain nucleoside modifications that yield potent...
2017/0218370 PEPTIDE NUCLEIC ACID OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS AND USES THEREOF
The present invention discloses a peptide nucleic acid for porcine reproductive and respiratory syndrome virus (PRRSV) and use thereof. The peptide nucleic...
2017/0218369 AN ANTAGONISTIC PD-1 APTAMER AND ITS APPLICATIONS IN CANCER THERAPY RELATED APPLICATIONS
Aptamers that bind to and antagonize PD-1 and uses thereof in promoting T cell proliferation, treating cancer or infectious diseases such as HIV infection.
2017/0218368 TARGETING MICRORNAS FOR METABOLIC DISORDERS
Provided herein are methods and compositions for the treatment of metabolic disorders. Also provided herein are methods and compositions for the reduction of...
2017/0218367 NUCLEIC ACID AMPHIPHILES AND NANOSTRUCTURES
Provided herein are nucleic acid amphiphiles and nanostructures such as nanotubes twisted nanotapes and helical nanotapes that comprise the amphiphiles as well...
2017/0218365 METHODS FOR MALIGNANT TUMORS WITH RNAI MOLECULES TARGETED TO HSP47
This invention provides methods for preventing, treating or ameliorating one or more symptoms of a malignant tumor in a mammal in need thereof, by ...
2017/0218364 miR-96-5p INHIBITOR AND A SCREENING METHOD FOR THE INHIBITOR
The present invention provides novel medical means to facilitate glutathione (GSH) synthesis in the brain. These means are miR-96-5p inhibitor increasing GSH...
2017/0218363 MORPHOLINO-MEDIATED INCREASE IN SOLUBLE FLT-1 EXPRESSION RESULTS IN DECREASED OCULAR AND TUMOR NEOVASCULARIZATION
Methods of inhibiting lymphangiogenesis and/or angiogenesis in a subject are provided. In one aspect, for example, a method of inhibiting angiogenesis in a...
2017/0218362 COMPOSITION AND METHOD OF USING MIR-302 PRECURSORS AS DRUGS FOR TREATING ALZHEIMER'S DISEASES
This invention generally relates to a composition and method of using recombinant microRNAs (miRNA) and their hairpin-like precursors (pre-miRNA) as...
2017/0218361 MORPHOLINO OLIGONUCLEOTIDE MANUFACTURING METHOD
Morpholino oligonucleotides can be produced efficiently in a high yield by a liquid-phase synthesis method, which includes subjecting a reaction mixture of a...
2017/0218360 OLIGONUCLEOTIDES FOR MODULATING TARGET RNA ACTIVITY
The present invention describes oligonucleotides that bind to microRNA target sites in target RNAs, such as mRNAs. The oligonucleotides of the invention may...
2017/0218359 CRUDE BIOLOGICAL DERIVATIVES COMPETENT FOR NUCLEIC ACID DETECTION
The invention relates to methods for the detection of a specific sequence of RNA in a cell or tissue sample. The invention also relates to methods to...
2017/0218358 ONE-POT MULTIPLEX GENE SYNTHESIS
The present invention provides methods for generating a library of synthetic polynucleotides. The present invention also provides methods for generating...
2017/0218357 METHODS AND KITS
A method of detection and identification of one or more microorganism/s in a biological sample comprising the following steps: (a) extracting DNA from the...
2017/0218356 BEAD BEATING TUBE AND METHOD FOR EXTRACTING DEOXYRIBONUCLEIC ACID AND/OR RIBONUCLEIC ACID FROM MICROORGANISMS
The present disclosure provides improved methods for bead beating and a bead beating system useful therefor. The bead beating system comprises a sample tube,...
2017/0218355 Microfluidic Assay For Rapid Optimization Of Cell Electroporation
An electroporation device with a volume of varying cross sectional area that as a fast assay device for determining the optimal conditions for plasma membrane...
2017/0218354 HIGHLY POTENT CELLULOLYTIC ENZYME PREPARATIONS AND PROCESSES FOR PRODUCING SAME
Compositions comprising unprocessed cell pellets of a cellulosome-producing microorganism grown on cellulosic biomass are provided. Further provided are...
2017/0218353 Ligand-Directed Covalent Modification of Protein
The present invention relates to enzyme inhibitors. More specifically, the present invention relates to ligand-directed covalent modification of proteins;...
2017/0218352 GRIMONTIA-HOLLISAE-DERIVED RECOMBINANT COLLAGENASE AND ENZYME AGENT FOR CELL SEPARATION
Recombinant collagenases with a stable specific activity and enzyme agents for cell and tissue dissociation such a recombinant are provided. The recombinant...
2017/0218351 COMPOSITIONS COMPRISING BETA-MANNANASE AND METHODS OF USE
The present compositions and methods relate to a beta-mannanase from Paenibacillus macerans, polynucleotides encoding the beta-mannanase, and methods of make...
2017/0218350 SACCHARIFICATION ENZYME COMPOSITION, SACCHARIFICATION REACTION SOLUTION, AND SUGAR PRODUCTION METHOD
The saccharification reaction mixture can saccharify at least one of cellulose and hemicellulose and contains, in a dispersion state, at least one of cellulose...
2017/0218349 COMPOSITIONS FOR LINKING DNA-BINDING DOMAINS AND CLEAVAGE DOMAINS
Disclosed herein are compositions for linking DNA binding domains and cleavage domains (or cleavage half-domains) to form non-naturally occurring nucleases...
2017/0218348 VARIANTS OF PHOSPHOTRIESTERASE FOR THE HYDROLYSIS AND DETOXIFICATION OF NERVE AGENTS
Variants of phosphotriesterase have been created that exhibit enhanced hydrolysis of V-type and G-type nerve agents over wild-type phosphotriesterase. V- and...
2017/0218347 PROCESS FOR THE PREPARATION OF HALO-SUBSTITUTED TRIFLUOROACETOPHENONES
The invention relates to a process for the preparation of a compound of formula I (I), wherein R.sub.1 is hydrogen, fluoro or chloro; which process comprises...
2017/0218346 Heme Protein Catalysts for Carbon-Silicon Bond Formation In Vitro and In Vivo
The present invention provides compositions and methods for catalyzing the formation of carbon-silicon bonds using heme proteins. In certain aspects, the...
2017/0218345 KETOREDUCTASES
The invention relates to ketoreductases and the use thereof. The ketoreductases of the invention are particularly useful for enzymatically catalyzing the...
2017/0218344 POLYPEPTIDES AND BACTERIOPHAGES SPECIFIC TO KLEBSIELLA PNEUMONIAE CAPSULAR TYPE STRAINS
The present invention relates to novel bacteriophages specific to Klebsiella pneumoniae strains, and compositions comprising the same. Particularly,...
2017/0218343 METHOD FOR CULTURING PLURIPOTENT STEM CELLS
Provided is a method for efficiently culturing pluripotent stem cells with higher safety. The present invention relates to a method for culturing pluripotent...
2017/0218342 USE OF RNA FOR REPROGRAMMING SOMATIC CELLS
The present invention provides methods for de-differentiating somatic cells into stem-like cells without generating embryos or fetuses. More specifically, the...
2017/0218341 WNT PATHWAY STIMULATION IN REPROGRAMMING SOMATIC CELLS WITH NUCLEAR REPROGRAMMING FACTORS
The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for...
2017/0218340 METHOD OF CULTURING CELLS
A method for producing a population of cells, enriched for non-adherent endothelial progenitor cells (EPCs), the method comprising culturing an EPC containing...
2017/0218339 MICROPHYSIOLOGIC METHODS AND COMPOSITIONS
The present invention provides, among other things, methods for producing platelets including the steps of providing a silk membrane about 2 .mu.m and 100...
2017/0218338 SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS
The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon...
2017/0218337 IMPROVED T CELL COMPOSITIONS
The invention provides improved T cell compositions and methods for manufacturing T cells. More particularly, the invention provides methods of T cell...
2017/0218336 ENHANCED EXPRESSION OF HUMAN OR HUMANIZED IMMUNOGLOBULIN IN NON-HUMAN TRANSGENIC ANIMALS
The present invention describes transgenic animals with human(ized) immunoglobulin loci and transgenes encoding human(ized) Ig.alpha. and/or Ig.beta....
2017/0218335 SYNTHETIC RETINA
The invention provides a method of producing a synthetic retina, comprising: i) providing a three dimensional stem cell culture throughout the differentiation...
2017/0218334 Cells Useful for Immuno-Based Botulinum Toxin Serotype A Activity Assays
The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting...
2017/0218333 KITS AND METHODS FOR REPROGRAMING NON-HEPATOCYTE CELLS INTO HEPATOCYTE CELLS
A method for inducing reprogramming of a cell of a first type which is not a non-hepatocyte (non-hepatocyte cell), into a cell with functional hepatic drug...
2017/0218332 Regionalised Endoderm Cells and Uses Thereof
The present invention relates to the generation of anterior definitive endoderm (ADE) cells from embryonic stem cells and the differentiation of such cells to,...
2017/0218331 Method and device for cell modification
The invention relates to a cell modification device, comprising a centrifugation chamber with at least one cell modifying surface with a normal vector having...
2017/0218330 SYSTEMS AND METHODS FOR THE SEPARATION OF CELLS FROM MICROCARRIERS USING A SPINNING MEMBRANE
Methods and systems for processing suspensions of biological cells and microcarriers are disclosed. The biological cells are separated from the microcarriers...
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