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Patent # Description
2017/0218073 ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) ANTIBODIES
Provided are anti-epidermal growth factor receptor (EGFR) antibodies, aglycosylated CDR-H2 anti-EGFR antibodies, and antigen binding fragments thereof. Also...
2017/0218072 ANTIBODY GENE EXPRESSION-SECRETION SYSTEM
It is an object of the present invention to provide signal sequence information capable of secreting an antibody to the outside of cells in generation of the...
2017/0218071 ANTI-cMET ANTIBODY
The invention relates to a novel antibody capable of binding specifically to the human c-Met receptor and/or capable of specifically inhibiting the tyrosine...
2017/0218070 ANTI-ALPHA-V INTEGRIN ANTIBODY FOR THE TREATMENT OF PROSTATE CANCER
The invention is directed to the treatment of prostate cancer by means of antibodies. Above all, the invention relates to the administration of an anti-alpha-v...
2017/0218068 Method for the Identification of Immunotherapy-Drug Combinations Using a Network Approach
This invention relates to systems and methods for evaluating the differentiality of a set of discrete random variables between two or more conditions, such as...
2017/0218067 Antibodies Against T Cell Immunoglobulin Domain and Mucin Domain 1 (TIM-1) Antigen and Uses Thereof
The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies. In particular, there are provided fully...
2017/0218066 ANTIGEN BINDING PROTEINS THAT BIND PD-L1
There is disclosed anti-PD-L1 IgG class antibodies that have an improved ability to be manufactured at higher yields. More specifically, there is disclosed...
2017/0218065 ANTI-GLUCAGON ANTIBODIES AND USES THEREOF
The present invention provides antibodies that bind to glucagon and methods of using the same. According to certain embodiments, the antibodies of the...
2017/0218064 COMPOSITIONS AND METHODS FOR MEASURING NMU AND FOR TREATMENT USING ANTI-NMU AGENTS
The inventors have produced two high specificity and high affinity monoclonal antibodies that bind to human neuromedin U (NMU). Methods and compositions are...
2017/0218063 Methods of Using IL-1beta Compounds
This invention relates to methods employing IL-1.beta.-Ligand/IL-1 receptor disrupting compounds (herein referred to as "IL-1beta Compounds"); such as small...
2017/0218062 METHODS FOR TREATING CROHN'S DISEASE USING AN ANTI-IL23 ANTIBODY
The invention relates to products and methods for treating Crohn's disease. The products relate to antibodies that inhibit native human IL-23 while sparing...
2017/0218061 ANTI-GM-CSF ANTIBODIES
The present invention provides recombinant antigen-binding regions, antibodies and functional fragments thereof that are specific for GM-CSF, which plays an...
2017/0218060 NOVEL POLYPEPTIDE FOR BINDING TO COMPLEMENT PROTEIN C5A, AND USE OF SAME
The present invention relates to novel polypeptide for binding to a complement protein C5a. More particularly, the present invention relates to polypeptide...
2017/0218059 Methods for Treating Thrombosis Using Chimeric and Humanized Anti-Histone Antibodies
The present invention concerns chimeric or humanized antibodies or antigen-binding fragments thereof that comprise specific CDR sequences, disclosed herein....
2017/0218058 ANTI-APOE4 ANTIGEN-BINDING PROTEINS AND METHODS OF USE THEREOF
The present disclosure generally relates to antigen-binding proteins (ABPs) that specifically bind to apolipoprotein E (ApoE), compositions comprising such...
2017/0218057 ANTI-NEUROTENSIN LONG FRAGMENT ANTIBODIES AND USES THEREOF
The present invention relates to a neutralising antibody which is capable of binding to neurotensin with high affinity. The antibody of the present invention...
2017/0218056 HUMANIZED ANTIBODIES SPECIFIC FOR HSP65-DERIVED PEPTIDE-6, METHODS AND USES THEREOF
The present invention relates to humanized antibodies that specifically bind a polypeptide comprising peptide-6 as denoted by SEQ ID NO. 15, that is an HSP65...
2017/0218055 COMPOSITIONS AND METHODS RELATED TO ANTIBODIES TO STAPHYLOCOCCAL PROTEIN A
Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects...
2017/0218054 NEUTRALIZING ANTI-INFLUENZA B ANTIBODIES AND USES THEREOF
The invention relates to antibodies and antigen binding fragments thereof that are capable of binding to influenza B virus hemagglutinin (HA) and neutralizing...
2017/0218052 CROSS-REACTIVE ANTIBODIES AGAINST DENGUE VIRUS AND USES THEREOF
The invention relates to a human anti-dengue virus antibody (an anti-DENV antibody) that binds to a DENV envelope protein and is cross-reactive with DENV...
2017/0218051 METHODS TO PRODUCE A HUMAN PLASMA-DERIVED IGG PREPARATION ENRICHED IN BRAIN DISEASE-RELATED NATURAL IGGS
The present invention provides, among other aspects, methods for the manufacture of plasma-derived immunoglobulin G compositions highly enriched for anti-brain...
2017/0218050 Polypeptides With Enhanced Anti-Inflammatory And Decreased Cytotoxic Properties And Relating Methods
The invention provides a polypeptide containing at least one IgG Fc region region, said polypeptide having a higher anti-inflammatory activity and a lower...
2017/0218049 IMMUNOGLOBULIN CONSTANT REGION FC RECEPTOR BINDING AGENTS
IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are...
2017/0218048 COLLECTION AND METHODS FOR ITS USE
The present disclosure enables methods of identifying the VH and VL class pairs in the human immune repertoire, determining the VH and VL class pairs that are...
2017/0218047 NOVEL FUSION PARTNERS FOR THE PURPOSE OF CRYSTALLIZING G-PROTEIN COUPLED RECEPTORS
GPCR-fusion partner proteins comprising G protein coupled receptors (GPCRs) of GPCRs and fusion partners such as rubredoxin, cytochrome b562 RIL (Bril, bRIL,...
2017/0218046 METHODS AND COMPOSITIONS FOR MODULATING THE ACTIVITY OF THE INTERLEUKIN-35 RECEPTOR COMPLEX
The receptor for Interleukin 35 (IL-35) is provided. The Interleukin 35 Receptor (IL-35R) comprises a heterodimeric complex of the Interluekin12R.beta.2...
2017/0218045 ISOLATED POLYPEPTIDES OF CD44 AND USES THEREOF
Isolated polypeptides of CD44 are provided. Accordingly, there is provided an isolated polypeptide consisting of an amino acid sequence selected from the group...
2017/0218043 T CELL RECEPTORS
The present invention relates to T cell receptors (TCRs) which bind the HLA-A*02 restricted peptide GLYDGMEHL (SEQ ID NO: 1) derived from the MAGE-A10 protein....
2017/0218042 METHODS OF ISOLATING T CELL RECEPTORS HAVING ANTIGENIC SPECIFICITY FOR A CANCER-SPECIFIC MUTATION
Disclosed are methods of isolating a TCR having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation, the method...
2017/0218041 Wnt Antagonists and Methods of Treatment and Screening
The present invention relates to compositions comprising Wnt antagonists and methods of treating Wnt-associated diseases and disorders, such as cancer,...
2017/0218040 PROTEOLICALLY RESISTANT CYCLOTIDES WITH ANGIOTENSIN 1-7 LIKE ACTIVITY
Described herein is a novel cyclotide able to activate the unique receptor of angiotensin-(1-7) (AT1-7), the MAS1 receptor. This cyclotide may be used in the...
2017/0218039 N-TERMINALLY TRUNCATED INTERLEUKIN-38
The present invention pertains to an N-terminally truncated interleukin (IL)-38 protein, or functional variants thereof, as well as to nucleic acids and...
2017/0218038 PHARMACEUTICAL COMPOSITIONS CONTAINING, AS ACTIVE INGREDIENT, GRANULOCYTECOLONY STIMULATING FACTOR MUTANT...
The present invention relates to a fusion protein in which transferrin is peptide-bonded to a terminal of a granulocyte-colony stimulating factor (G-CSF)...
2017/0218037 COMPOSITIONS AND METHODS FOR TREATMENT OF MUSCULAR DYSTROPHY
The present invention features modified human transcription factors capable of increasing utrophin expression, recombinant adeno-associated vectors for...
2017/0218036 INNATE IMMUNE SYSTEM MODIFICATION FOR ANTICANCER THERAPY
The present invention relates to the discovery of a role of the nuclear receptor retinoid-related orphan receptor gamma (RORgamma) in tumor suppression. The...
2017/0218035 COMPOSITIONS AND METHODS FOR TREATMENT WITH HEMOPEXIN
Compositions and methods are provided for therapeutic treatment using recombinant Hemopexin molecules having sufficient sialyation and/or absence of neutral...
2017/0218034 HOUSE DUST MITE ALLERGEN
An immobilized polypeptide including a polypeptide bound to a surface of a polypeptide array or a chip, wherein the polypeptide has the amino acid sequence of...
2017/0218032 YEAST O-MANNOSE NUCLEOCYTOPLASMIC GLYCOSYLATION
The present disclosure provides, inter alia, compositions and methods for modulating and/or utilizing nucleocytoplasmic alpha-mannosyltransferase enzyme...
2017/0218031 CLOSTRIDIUM DIFFICILE IMMUNOGENIC COMPOSITION
Immunogenic compositions comprising isolated Clostridium difficile CDTb proteins, including modified proteins, and fusion proteins comprising a CDTa protein...
2017/0218030 RESPIRATORY SYNCYTIAL VIRUS (RSV) VACCINE
The present invention relates to an mRNA sequence, comprising a coding region, encoding at least one antigenic peptide or protein of RSV infections Respiratory...
2017/0218029 POLYPEPTIDES FOR USE IN SELF-ASSEMBLING PROTEIN NANOSTRUCTURES
Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures...
2017/0218028 TANDEM FC BISPECIFIC ANTIBODIES
Provided herein are tandem Fcs and tandem Fc antibodies ("TFcAs"), e.g., tandem Fc bispecific antibodies ("TFcBAs"), which comprise one or at least two binding...
2017/0218027 FUNCTIONAL LIPID CONSTRUCTS
The invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional...
2017/0218026 BETA-HAIRPIN PEPTIDOMIMETICS
Beta-hairpin peptidomimetics of the general formula (I), cyclo[P.sup.1-P.sup.2-P.sup.3-P.sup.4-P.sup.5-P.sup.6-P.sup.7-P.sup.8-P.s- ...
2017/0218025 BOUVARDIN DERIVATIVES AND THERAPEUTIC USES THEREOF
The present invention is directed at bouvardin analogs arid related compounds for the treatment of disorders including cancer. Provided herein are bouvardin...
2017/0218024 LOW SUBSTITUTED POLYMYXINS AND COMPOSITIONS THEREOF
The present invention relates to novel low substituted polymyxins and compositions thereof.
2017/0218023 SYNTHETIC ANALOGUES OF NEURAL REGENERATION PEPTIDES
Embodiments of this invention include synthetic compounds (NRP analogues) of peptides termed neural regeneration peptides (NRPs). NRP analogues are made by...
2017/0218022 TARGETED CONFORMATIONALLY-CONSTRAINED KINKED ENDOSOMAL DISRUPTING PEPTIDES
A peptide can have a sequence of one of SEQ ID NOs: 78-91. A conformationally-constrained kinked peptide includes: a conformationally-constraining portion and...
2017/0218021 BOTULINUM NEUROTOXIN-SPECIFIC CAPTURE AGENTS, COMPOSITIONS, AND METHODS OF USING AND MAKING
The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis...
2017/0218020 PEPTIDE COMPOUNDS FOR INHIBITIONS OF PLATELET AGGREGATION
The invention relates to a peptide compound and its pharmaceutical composition for inhibiting platelet aggregation and preventing/treating thrombogenic...
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