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Patent # Description
2017/0218019 PEPTIDE FOR INDUCING MULTINUCLEATION IN CELLS, AND USE THEREFOR
Provided are a synthetic peptide having a multinucleation-inducing activity that can cause multinucleation in a target cell, a multinucleation-inducing agent...
2017/0218017 MELANOCORTIN 1 RECEPTOR LIGANDS AND METHODS OF USE
The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or...
2017/0218016 AROMATIC-CATIONIC PEPTIDES AND USES OF SAME
Disclosed herein are compositions and methods related to aromatic-cationic peptides. In particular, the compositions and methods relate to aromatic-cationic...
2017/0218015 PROCESS FOR THE LIQUID PHASE SYNTHESIS OF H-INP-(D)BAL-(D)TRP-PHE-APC-NH2, AND PHARMACEUTICALLY ACCEPTABLE...
The present invention provides a process for the liquid phase synthesis of the Ghrelin analog H-Inp-(D)Bal-(D)Trp-Phe-Apc-NH2 (SEQ ID NO: 1, Formula (I)),...
2017/0218014 AZAINDOLINE COMPOUNDS AS GRANZYME B INHIBITORS
Azaindoline compounds as granzyme B inhibitors, compositions that include the compounds, and methods for using the compounds. Methods for treating cutaneous...
2017/0218013 Immobilisation of Chelating Groups for Immobilised Metal Ion Chromatography (IMAC)
The present invention refers to a method for binding a polycarboxylic acid to a solid phase. Further, the invention refers to a solid phase having a...
2017/0218012 Integrated Continuous Manufacturing of Therapeutic Protein Drug Substances
Provided herein are integrated continuous biomanufacturing processes for producing a therapeutic protein drug substance. Also provided are systems that are...
2017/0218011 PURIFICATION OF BIOLOGICAL PRODUCTS BY CONSTRAINED COHYDRATION CHROMATOGRAPHY
Materials and methods for use of constrained cohydration agents in the purification of biological materials such as antibodies, viruses, cells, and cellular...
2017/0218010 METHOD FOR PEPTIDE SYNTHESIS AND APPARATUS FOR CARRYING OUT A METHOD FOR SOLID PHASE SYNTHESIS OF PEPTIDES
The invention relates to a method for peptide synthesis, wherein said method comprises the steps of reacting a first amino acid or a first peptide with an...
2017/0218009 COMPOUNDS FOR TREATING EYE DISORDERS OR DISEASES
Described herein are compounds that inhibit or prevent protein aggregation, methods of making such compounds, pharmaceutical compositions and medicaments...
2017/0218008 COMPOSITIONS AND METHODS FOR INHIBITING "STIMULATOR OF INTERFERON GENE" -DEPENDENT SIGNALLING
The present invention provides cyclic-di-nucleotide (CDN) compounds that inhibit signaling at a recently discovered cytoplasmic receptor known as STING...
2017/0218007 A PROCESS FOR THE PREPARATION OF NUCLEOSIDE PHOSPHORAMIDATE
The present invention pertains to process for preparing nucleoside phosphoramidate and its intermediate. The present invention provides novel intermediate, its...
2017/0218006 Synthesis of Phosphoramidates
A process for the preparation of a compound of formula (I) including all isomers, stereoisomers, enantiomers and diastereomers thereof (I), and salts thereof;...
2017/0218005 COMPOSITIONS AND METHODS RELATED TO GENTAMICIN
Various aspects of the invention relate to compositions comprising C-2a gentamicin. A composition may be substantially free from one or more of C-1 gentamicin,...
2017/0218004 FERULOYL-CoA:MONOLIGNOL TRANSFERASE
The invention relates to nucleic acids encoding a feruloyl-CoA:monolignol transferase and the feruloyl-CoA:monolignol transferase enzyme that enables...
2017/0218003 PHARMACEUTICAL COMPOUNDS
Therapeutically-effective amounts of novel analogs or derivatives of alkyl fatty acids, such as but not limited to lipoic acid, and pharmaceutical formulations...
2017/0218002 METHOD FOR PRODUCING TEBBE COMPLEX
The present invention relates to a method for producing a Tebbe complex having high purity and high activity and having excellent storage stability in a high...
2017/0218001 PHOSPHONATE NUCLEOSIDES USEFUL IN THE TREATMENT OF VIRAL DISEASES
The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or prodrug thereof, and their use in medicine particular as...
2017/0218000 PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS
The invention features compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use. ##STR00001##
2017/0217999 SURFACE PRIMER COMPOSITIONS AND METHODS OF USE
In one embodiment, the present application discloses a surface binding compound of the Formula I or Formula II: ##STR00001## wherein the variables EG, EG1, SP1,...
2017/0217998 PHARMACEUTICAL COMPOUNDS
Therapeutically-effective amounts of novel analogs or derivatives of alkyl fatty acids, such as but not limited to lipoic acid, and pharmaceutical formulations...
2017/0217997 PHOTO-CLEAVABLE PRIMER COMPOSITIONS AND METHODS OF USE
In one embodiment, the present application discloses a photo-cleavable surface binding compound of the Formula I and Formula II: ##STR00001## wherein the...
2017/0217996 Large-scale diastereoselective syntheses of cycloheptadienylsulfones and stereotetrads
The invention relates to processes for large-scale diastereoselective syntheses of cycloheptadienylsulfone and stereotetrads, key intermediates for the...
2017/0217995 Guanidine-Functionalized Particles and Methods of Making and Using
Guanidine-functionalized particles and methods of making and using such particles.
2017/0217994 GOLD(III) ANTI-CANCER AGENTS
A method for treating cancer and gold(III) complexes with diaminocyclohexane ligand as anticancer agents. Also described are a pharmaceutical composition...
2017/0217993 LUBRICANT ADDITIVES
Lubricant additives useful as friction reducing additives are disclosed herein that have a structure according to general formula I, where M is metal such as...
2017/0217992 ORGANIC ELECTROLUMINESCENT COMPOUNDS AND ORGANIC ELECTROLUMINESCENT DEVICES COMPRISING THE SAME
The present invention relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. By using the organic...
2017/0217991 NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES
The present invention relates to compounds and pharmaceutically acceptable salts of Formulas A and B: ##STR00001## wherein A, B, R.sup.1, R.sup.2, R.sup.3,...
2017/0217990 NOVEL COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES
The present invention relates to compounds of formula (I), ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as described herein,...
2017/0217989 MACROCYCLIC BENZOFURAN COMPOUNDS FOR THE TREATMENT OF HEPATITIS C
Compounds of formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against...
2017/0217988 Process for the Synthesis of Everolimus and Intermediates Thereof
The present invention relates to a novel process for the synthesis of everolimus of formula (I): and intermediates thereof. ##STR00001##
2017/0217987 Novel Hydrates Of Dolutegravir Sodium
The invention relates to novel hydrates of dolutegravir sodium and to processes for their preparation. Furthermore, the invention relates to a novel...
2017/0217986 HIV PROTEASE INHIBITORS
The present invention is directed to 2,6-morpholine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein Z.sup.1, Z.sup.2,...
2017/0217985 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS
The present invention relates to tricyclic heterocycles which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the...
2017/0217984 Ligands for Alpha-7 Nicotinic Acetylcholine Receptors and Methods of Treating Neurological and Inflammatory...
Compounds are provided which bind to an allosteric site on the mammalian alpha-7 nicotinic acetylcholine receptor (alpha-7 nAChR) and act as positive...
2017/0217983 COMPOUNDS FOR THE TREATMENT OF CLOSTRIDIUM DIFFICILE ASSOCIATED DISEASE
Disclosed are compounds of formula (I): ##STR00001## and pharmaceutically acceptable N-oxides, salts, hydrates, solvates, complexes, bioisosteres, metabolites,...
2017/0217982 Compound isolated from Pseudolysimachion rotundum var. subintegrum, the composition comprising the same for...
A compound (3R,5S,5aS,6R,7S,8R,8aS)-8-chloro-8a-hydroxy-5-(2-hydroxy acetoxy) hexahydro-1H-3,6-methanocyclopenta[e][1,3]dioxepin-7-yl 3,4-dihydroxybenzoate...
2017/0217981 INHIBITORS OF IRAK4 ACTIVITY
The present invention relates to inhibitors of IRAK4 of Formula I and provides compositions comprising such inhibutors, as well as methods therewith for...
2017/0217980 AMLEXANOX ANALOGS
Provided herein are amlexanox analogs and methods for the treatment and/or prevention of diabetes, impaired insulin signaling, obesity, or other related...
2017/0217979 6-ARYL AMINO PYRIDONE FORMAMIDE COMPOUND CRYSTAL AND PREPARATION METHOD THEREFOR
The present invention provides a crystal of 6-arylamino pyridone carboxamide compound and a preparation method thereof. The crystal is obtained by dissolving ...
2017/0217978 METHOD OF PREPARING BUPRENORPHINE
An improved process for preparing buprenorphine and a method for increasing the yield of buprenorphine or a derivative thereof.
2017/0217977 8-CARBOXAMIDO-2,6-METHANO-3-BENZAZOCINES
8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is --CH.sub.2--OH, --CH.sub.2NH.sub.2, --NHSO.sub.2CH.sub.3, ##STR00001## and Y is O,...
2017/0217976 6-(AMINO ACID)-MORPHINAN DERIVATIVES IN COMBINATION WITH PERMEATION ENHANCERS FOR USE AS AN ORALLY, RECTALLY,...
The present invention relates to a composition for use in an orally, or rectally, transdermally or nasally administered medicament, characterized in that it...
2017/0217975 ORGANIC COMPOUNDS
The invention relates to novel inhibitors of phosphodiesterase 1 (PDE1), useful for the treatment of diseases or disorders characterized by disruption of or...
2017/0217974 HEPATITIS B ANTIVIRAL AGENTS
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: X-A-Y-Z-R (I) which inhibit the...
2017/0217973 NOVEL COMPOUNDS FOR USE IN COGNITION IMPROVEMENT
Novel compounds for use in cognition improvement It relates to certain compounds having a polycyclic structure and a --(C.dbd.O)NR.sup.aR.sup.b moiety, wherein...
2017/0217972 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2...
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic...
2017/0217971 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2...
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic...
2017/0217970 NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUND OR SALT THEREOF
To provide a novel compound having a HER2 inhibitory effect and having a cytostatic effect. It is also intended to provide a medicament useful in the...
2017/0217969 NOVEL COELENTERAZINE COMPOUNDS AND METHODS OF USE
Calcium reacting photoproteins are a class of self-illuminating proteins that emit light upon contact with calcium. Fluorescent Proteins are small proteins...
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