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Patent # Description
2017/0226094 HETEROCYCLE-SUBSTITUTED PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS
This invention is directed to a compound of Formula I ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and...
2017/0226093 CYANOQUINOLINE DERIVATIVES
Disclosed is a compound of formula I, a stereoisomer thereof, a cis-trans-isomer thereof, a tautomer thereof, or a mixture thereof, or a pharmaceutically...
2017/0226092 FLUORINATED BENZOFURANYL-PYRIMIDINE DERIVATIVES CONTAINING A SUFLONE GROUP
The present invention relates to fluorinated benzofuranyl-pyrimidine derivatives containing a sulfone group of general formula (I) as described and defined...
2017/0226091 2,2,2-TRIFLUOROETHYL-THIADIAZINES
The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and...
2017/0226090 INDOLINE SULFONAMIDE INHIBITORS OF DAPE AND NDM-1 AND USE OF THE SAME
Indoline sulfonamide compounds that can inhibit DapE and/or bacterial metallo-.beta.-lactamases (MBLs), such as NDM-1, are disclosed. Also disclosed are...
2017/0226089 SUBSTITUTED 1,2,3-TRIAZOLES AS NR2B-SELECTIVE NMDA MODULATORS
Substituted 1,2,3-triazoles as NR2B receptor ligands. Such compounds may be used in NR2B receptor modulation and in pharmaceutical compositions and methods for...
2017/0226088 SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'-INDOLIN]-2'-ONES
The present invention is directed to novel synthetic methods for preparing cyclopropyl indolinone compound represented by Structural Formula (A): (A) or its...
2017/0226087 TRIAZOLES AS NR2B RECEPTOR INHIBITORS
Provided here in are compounds of Formula I having the structure: Also provided herein are compositions comprising compounds of Formula I and methods of using...
2017/0226086 COMPOUNDS FOR TREATMENT OF CANCER
The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and...
2017/0226085 DIHYDROQUINOLINE PYRAZOLYL COMPOUNDS
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, ...
2017/0226084 PYRIDINE-SUBSTITUTED 2-AMINOPYRIDINE PROTEIN KINASE INHIBITORS
The present invention discloses pharmaceutically acceptable acid salts of pyridine-substituted 2-aminopyridine derivatives as protein kinase inhibitors,...
2017/0226083 FORMS AND COMPOSITIONS OF AN ERK INHIBITOR
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of one or both of ERK1 and ERK2.
2017/0226082 Diamide Compounds Having Muscarinic Receptor Antagonist and Beta2 Adrenergic Receptor Agonist Activity
This invention relates to a compound of formula I: ##STR00001## or a pharmaceutically acceptable salt thereof. Such compounds possess both muscarinic receptor...
2017/0226081 GLUCOSE TRANSPORT INHIBITORS
The present invention relates to chemical compounds that selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said compounds, to...
2017/0226080 PYRROLIDINONE DERIVATIVES AS METAP-2 INHIBITORS
Compounds according to Claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumours.
2017/0226079 DIHYDROQUINOLINE PYRAZOLYL COMPOUNDS
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, ...
2017/0226078 PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS
The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
2017/0226077 Production of 11-Hydroxy-THC
The invention involves a method of producing 11-Hydroxy-THC by first creating a mixture of oil and cannabis material. This mixture is subjected to a...
2017/0226076 PROCESS FOR PREPARING FURFURAL FROM BIOMASS
Furfural is produced from biomass material containing pentosan, in high yields, in a production process comprising treating the biomass with a solution...
2017/0226075 Synthesis of Non-Ionic Surfactants From 5-Hydroxymethyl-2-Furfural, Furan-2,5-Dimethanol and...
The present disclosure is directed to methods of making non-ionic, amphiphilic surfactants from 5-hydroxymethyl-2-furfural, furan-2,5-dimethanol and...
2017/0226074 ANTIFIBROTIC EFFECTS OF OXETANYL SULFOXIDES
A compound, or a pharmaceutically acceptable salt thereof, having a structure of ##STR00001## wherein Z is aryl or substituted aryl, heteroaryl, or ...
2017/0226073 COMPOUNDS AND METHODS FOR TREATING CANCER
This document provides compounds, compositions, and methods for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian,...
2017/0226072 1,4-Disubstituted Piperidines, 1,4-Disubstituted Piperazines, 1,4-Disubstituted Diazepines, and...
The present invention is directed to 1,4-disubstituted piperidines, 1,4-disubstituted piperazines, 1,4-disubstituted diazepanes, and 1,3-disubstituted...
2017/0226071 DICHROIC DYE COMPOUND, POLARIZING FILM, AND USES THEREOF
A compound having a maximum absorption in a wavelength range of 350 nm to 550 nm that functions as a dichroic dye is provided. In particular, a compound...
2017/0226070 METHODS AND COMPOSITIONS FOR GAMMA-GLUTAMYL CYCLE MODULATION
The present disclosure provides pharmaceutical compositions comprising Gamma-glutamyl cycle inhibitors (GGCI) and certain pharmaceutically acceptable salts...
2017/0226069 POLYESTER RESIN COMPOSITION CONTAINING AMINO-TRIAZINE DERIVATIVE
A polyester resin composition containing 100 parts by mass of a polyester resin and 0.01 to 10 parts by mass of a 2-amino-1,3,5-triazine derivative of Formula...
2017/0226068 PHENAZINIUM MEDIATORS
The present invention relates to a chemical compound or a salt or solvate thereof being an 1-amino-phenazine derivative and to uses thereof. The present...
2017/0226067 PIPERAZINE DERIVATIVES AS LIVER X RECEPTOR MODULATORS
Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are liver X receptor...
2017/0226066 METHOD OF PRODUCING OPTICALLY ACTIVE 2-METHYLPIPERAZINE
A method of producing an optically active 2-methylpiperazine includes: adding a solvent to a solution of the optically active 2-methylpiperazine to carry out...
2017/0226065 POTENT DUAL BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS
Disclosed herein are compounds that are inhibitors of BRD4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BRD4 are...
2017/0226064 Synthesis of Triethylenetetramines
Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and...
2017/0226063 DNA2 INHIBITORS FOR CANCER TREATMENT
Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.
2017/0226062 6-HETEROARYLOXY- OR 6-ARYLOXY-QUINOLINE-2-CARBOXAMIDES AND METHOD OF USE
Compounds of formula (I) ##STR00001## and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R.sup.1, R.sup.2, and...
2017/0226061 CRYSTAL FORM OF QUINOLINE COMPOUND AND PROCESS FOR ITS PRODUCTION
A method for producing a drug substance of crystalline pitavastatin calcium excellent in stability, is presented. In the production of a compound (pitavastatin...
2017/0226060 Process for Manufacturing Substituted 5-Methoxymethylpyridine-2,3-Dicarboxylic Acid Derivatives
A process for manufacturing a compound of formula (I), ##STR00001## Comprising reacting a compound of formula (II) ##STR00002## in a methanol/H.sub.2O mixture....
2017/0226059 APOE4-TARGETED THERAPUTICS THAT INCREASE SIRT1
A link between ApoE4 allele and sirtuins expression level is identified that is believed to be associated with elevated risk for the promotion of processing of...
2017/0226058 N-(5-((ARYL OR HETEROARYL)METHYLOXY)PENTYL)-SUBSTITUTED IMINOSUGARS AS INHIBITORS OF GLUCOSYLCERAMIDE SYNTHASE
Deoxynojirimycin and deoxygalactonojirimycin derivatives according to the present invention are N-alkylated D-galacto, D-gluco- or L-ido-deoxynojirimycin with...
2017/0226057 BENZENECARBOTHIOCCYCLOPENTA[C] PYRROLE-1,3-DIONE COMPOUNDS AND PROCESS FOR SYNTHESIS THEREOF
The present invention relates to a novel analogues of benzenecarbothioccyclopenta[c]pyrrole-1,3-dione of formula (I) useful for treating various viral...
2017/0226056 CONTROLLED CONVERSION OF DIMETHYL BENZYL ALCOHOL TO CUMENE HYDROPEROXIDE FORMED DURING THE CUMENE OXIDATION PROCESS
The disclosure concerns systems and methods for the production of phenol and acetone from cumene oxidation products. One method comprises reacting cumene and...
2017/0226055 THIOL GROUP-CONTAINING POLYMER AND CURABLE COMPOSITION THEREOF
A thiol group-containing polymer represented by: HS--(R--S.sub.r).sub.n--R--SH wherein R is an organic group including a --O--CH.sub.2--O-- bond and a branched...
2017/0226054 FLUORINE-BASED COMPOUND FOR BRANCHER, POLYMER USING SAME, AND POLYMER ELECTROLYTE MEMBRANE USING SAME
The present specification relates to a fluorine-based compound for a brancher, a polymer using the same, a polymer electrolyte membrane using the same, a fuel...
2017/0226053 NOVEL SULFONYLAMINOBENZAMIDE COMPOUNDS AS ANTHELMINTICS
The present invention relates to a new compound of formula (I) wherein the variables have the meaning as indicated in the claims; or an enantiomer or salt...
2017/0226052 EPOXY RESIN OLIGOMER WITH SECOND ORDER NONLINEAR OPTICAL PROPERTIES, CHROMOPHORES, AND METHOD OF MANUFACTURING...
Epoxy/MMT composite material and a crosslinking method for epoxy/MMT composite material with second order nonlinear optical properties are introduced....
2017/0226051 10-SUBSTITUTED COLCHICINOIDS AS POTENT ANTICANCER AGENTS
The present invention relates to the compounds of formula I wherein R is as herein described. The present invention particularly relates to synthesis and...
2017/0226050 BIO-BASED ACRYLIC MONOMERS AND POLYMERS THEREOF
The invention provides a bio-based acrylic monomer, particularly a plant oil-based acrylic monomer, which is well-suited for emulsion polymerization and latex...
2017/0226049 METHOD FOR PRODUCING A-HYDROXYISOBUTYRIC ACID AMIDE AND REACTOR
The present invention provides a method for producing .alpha.-hydroxyisobutyric acid amide by hydration of acetone cyanohydrin under the presence of a catalyst...
2017/0226048 Process For Preparing Acylglycinates And Compositions Comprising Such Compounds
A process for preparing acylglycinates of the formula (I) wherein R.sup.1 is a linear or branched, saturated alkanoyl group having 6 to 30 carbon atoms, or is...
2017/0226047 PROCESS FOR THE PURIFICATION OF MELPHALAN
A method for the purification and preparation of melphalan that allows to obtain melphalan with purity higher than 99.5% is described.
2017/0226046 METHOD FOR PRODUCING 2-AMINO-SUBSTITUTED BENZALDEHYDE COMPOUND
The present invention provides a method for producing a benzaldehyde in which an amino group is bonded in the 2 position, a halogeno group or an alkoxy group...
2017/0226045 METHOD FOR THE SYNTHESIS OF MIRABEGRON AND ITS DERIVATIVES
The present invention refers to a method for the synthesis of a compound of formula (I), solvates, stereoisomers or salts thereof, a key intermediate in the...
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