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Patent # Description
2017/0224823 PLATINUM-CATALYZED SILICONE DRUG DELIVERY DEVICES AND METHODS OF USE THEREOF
The present invention provides intravaginal drug delivery devices, such as intravaginal rings, comprising active pharmaceutical ingredients (APIs) having...
2017/0224822 METHODS FOR KILLING CANCER CELLS AND CELLULAR IMAGING USING MAGNETO-ELECTRIC NANO-PARTICLES AND EXTERNAL...
This invention provides methods for achieving high-specificity killing of targeted cells using Magneto-Electric Nano-Particles (MENPs). Embodiments comprise...
2017/0224821 IONIZING-RADIATION-RESPONSIVE COMPOSITIONS, METHODS, AND SYSTEMS
A method, composition and system respond to ionizing radiation to adjust biological activity. In some approaches the ionizing radiation is X-ray or extreme...
2017/0224820 COMPOSITIONS AND METHODS USEFUL FOR STABILIZING PROTEIN-CONTAINING FORMULATIONS
The invention relates to use of non-surfactant compounds including, for example, polyoxyethylene (POE) sorbitans and polyethylene glycols (PEGs), for...
2017/0224819 Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor, a JAK-2 Inhibitor, and/or a CDK 4/6 Inhibitor
Therapeutic combinations of a phosphoinositide 3-kinase (PI3K) inhibitor, including PI3K inhibitors selective for the .gamma.- and .delta.-isoforms and...
2017/0224818 SUBCUTANEOUSLY ADMINISTERED BISPECIFIC ANTIBODIES FOR USE IN THE TREATMENT OF CANCER
The present invention relates to the use of T cell redirecting, bispecific, in particular trifunctional, antibodies for the treatment of a cancer disease,...
2017/0224817 METHODS FOR TREATING MULTIPLE MYELOMA
The present disclosure provides methods of treating multiple myeloma in an individual, the methods comprising genotyping an HLA allele and a KIR allele in the...
2017/0224816 METHODS FOR REDUCING LDL-CHOLESTEROL
The present invention relates to methods for the treatment of reducing LDL-cholesterol levels in a subject infected with hepatitis C virus (HCV) or at high...
2017/0224815 Method of Preventing and Treating Retinal Microvasculature Inflammation Using C-Met Signaling Pathway Inhibition
The present invention provides methods for preventing retinal microvasculature inflammation in patients with diabetes who are highly susceptible to developing...
2017/0224814 METHODS FOR TREATING CANCER USING INOS-INHIBITORY COMPOSITIONS
Disclosed are methods for treating one or more mammalian cancers, and in particular, methods for treating human melanoma, or a head or neck cancer, that employ...
2017/0224813 VACCINE PHARMACEUTICAL COMPOSITION FOR SUPPRESSING APOPTOSIS OF CTL OR INHIBITING SUPPRESSION OF INDUCTION OF CTL
The present invention aims to provide a vaccine pharmaceutical composition that can be universally used for induction of cellular immunity to various antigens...
2017/0224812 LIQUID IMMUNITY INDUCTION-PROMOTING COMPOSITION AND VACCINE PHARMACEUTICAL COMPOSITION THAT INCLUDE THROMBOSIS...
The present invention aims to provide a humoral immunity induction-promoting composition and a vaccine pharmaceutical composition which can universally be used...
2017/0224811 VACCINE ADJUVANT COMPOSITIONS
Embodiments described herein relate to combinatorial compositions and uses thereof, for example, as vaccine adjuvant compositions, for enhancing immune...
2017/0224810 Reduction of in vitro genotoxicity of pollen extracts by removal of flavonoids
The invention relates to grass pollen extracts containing reduced amount of flavonoid glycosides in order to minimize the risks of genotoxicity of the grass...
2017/0224809 USE OF SUPERANTIGENS FOR IMPROVING MUCOSAL ALLERGEN SPECIFIC IMMUNOTHERAPY IN NON-HUMAN MAMMALS
Use of a superantigen in mucosal allergen specific immune therapy (ASIT) in a non-human mammal to enhance the effect thereof. In order to enhance the effect of...
2017/0224808 THERAPEUTIC COMPOSITIOJNS AND METHODS FOR INDUCING AN IMMUNE RESPONSE TO HERPES SIMPLEX VIRUS TYPE 2 (HSV-2)
Disclosed are therapeutic compositions and methods for inducing an immune response to herpes simplex virus type 2 (HSV-2). More particularly, the invention...
2017/0224807 NEWCASTLE DISEASE VIRUS VECTORED AVIAN VACCINES
The present invention encompasses engineered Newcastle Disease Virus (NDV) vaccines or compositions. The vaccine or composition may be a recombinant vaccine....
2017/0224806 RECOMBINANT BACTERIUM AND METHODS OF ANTIGEN AND NUCLEIC ACID DELIVERY
The present invention provides a recombinant bacterium and methods of using the recombinant bacterium to induce an immune response.
2017/0224805 FORMULATIONS FOR SMALL INTESTINAL DELIVERY
Provided herein are compositions and methods for generating an immunogenic response in humans. Such compositions include an immunogenic biological agent...
2017/0224804 GLYCOCONJUGATION PROCESSES AND COMPOSITIONS
The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a ...
2017/0224803 CARRIER MOLECULE FOR ANTIGENS
The invention provides a conjugate comprising an antigen and a carrier molecule, wherein the carrier molecule comprises a BP-2a antigen and a spb1 antigen....
2017/0224802 METHOD FOR CONTROLLING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE MOLECULAR WEIGHT USING CARBON DIOXIDE
The present invention provides improved methods for producing a solution containing high molecular weight isolated Streptococcus pneumoniae capsular...
2017/0224801 NANOPARTICLES FOR TREATMENT OF ALLERGY
The present invention encompasses the surprising finding that nanoparticle compositions can have beneficial effects on allergy even when prepared without a...
2017/0224800 METHODS OF ISOLATING T CELLS HAVING ANTIGENIC SPECIFICITY FOR A CANCER-SPECIFIC MUTATION
Disclosed are methods of isolating T cells having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation, the method...
2017/0224799 IDENTIFICATION OF IMMUNOLOGICALLY PROTECTIVE NEO-EPITOPES FOR THE TREATMENT OF CANCERS
Described herein are methods of identifying immunologically protective neo-epitopes from the cancer tissue DNA of cancer patients using biophysical principles...
2017/0224798 HUMAN APPLICATION OF ENGINEERED CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELLS
The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In...
2017/0224797 Cancer Therapy Using a Vaccine in Combination with a Cell-Based Immunotherapeutic Agent
A cancer therapy composition and a method of cancer treatment by inducing humoral and cellular immune responses against cancer cells in a patient is provided....
2017/0224796 Therapeutic Cancer Vaccine Containing Tumor-Associated Neoantigens and Immunostimulants in a Delivery System
A therapeutic vaccine and a method of cancer treatment by inducing humoral and cellular immune responses against malignant cells is provided. The vaccine...
2017/0224795 CDCA1 EPITOPE PEPTIDES FOR TH1 CELLS AND VACCINES CONTAINING THE SAME
Isolated CDCA1-derived epitope peptides having Th1 cell inducibility are disclosed herein. Such peptides can be recognized by MHC class II molecules and induce...
2017/0224794 YEAST-MUC1 IMMUNOTHERAPEUTIC COMPOSITIONS AND USES THEREOF
Disclosed are yeast-based immunotherapeutic compositions comprising mucin-1 (MUC1), as well as methods for the prevention and/or treatment of cancers...
2017/0224793 TUMOR IMMUNITY
Disclosed herein are materials and methods for treating cancer. In particular, compositions for stimulating tumor immunity through modulation of MFG-E8 are...
2017/0224792 METHODS FOR DIAGNOSING AND TREATING ALZHEIMER'S DISEASE
Methods for diagnosing and treating Alzheimer's disease are provided. In particular, methods of restoring blood-brain barrier integrity and/or promoting...
2017/0224791 THERAPEUTIC AGENT FOR CANCER WHICH COMPRISES COMBINATION OF IL-18 AND MOLECULE-TARGETING ANTIBODY
A cancer therapeutic agent according to an embodiment of the present invention contains, as active ingredients, IL-18 and one or more antibodies selected from...
2017/0224790 FUNGAL GLUCOSYLCERAMIDE AS A VACCINE FOR FUNGAL INFECTIONS
The present invention features compositions that include a fungal glucosylceramide (GlcCer) purified from a non-pathogenic fungus (e.g., Candida utilis) and,...
2017/0224789 STABLE INJECTABLE COMPOSITION OF BIVALIRUDIN AND PROCESS FOR ITS PREPARATION
The present invention relates to a non-aqueous, stable and ready-to-use injectable composition of bivalirudin or pharmaceutically acceptable salt(s) or...
2017/0224788 C1-INH COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF DISORDERS ASSOCIATED WITH C1 ESTERASE...
Compositions and methods for the treatment and/or prevention of disorders associated with C1 esterase inhibitor deficiency are disclosed.
2017/0224787 COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIA
Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of...
2017/0224786 BOTULINUM TOXIN COMPOSITIONS
A high potency botulinum toxin pharmaceutical composition comprising two excipients (such as albumin and sodium chloride) in a weight to weight ratio of...
2017/0224785 SUBCUTANEOUS ADMINISTRATION OF ADAMTS13
This invention relates to methods of subcutaneous administration of ADAMTS13 formulations to a treat a disease or condition associated with ADAMTS13 and VWF...
2017/0224784 FUNCTIONAL FOODS COMPRISING DIAMINE OXIDASE AND USES THEREOF
The present invention relates to functional foods comprising DAO and their use for the prevention or treatment of diseases or pathological conditions...
2017/0224783 METHODS AND COMPOSITIONS FOR TREATMENT OF MITOCHONDRIAL DISORDERS
The present invention concerns in general novel fusion proteins comprising a membrane transferring moiety and an enzymatic moiety. The present invention...
2017/0224782 TREATMENT OF DEPRESSION AND PTSD
Depression and PTSD are treated by administration of hCG, or an hCG analog, or a prodrug or metabolite of hCG or an hCG analog, in an amount equivalent to a...
2017/0224781 Y1 receptor activator for treating an anticancer agent-induced nephrotoxic injury
There is provided a method for treating or reducing an anticancer agent-induced nephrotoxic injury, the method comprising the step of administering a Y1...
2017/0224780 METHODS FOR PREVENTING TRANSPLANTATION-INDUCED FOLLICLE ACTIVATION
Provided are compositions and methods for preventing premature follicle activation and loss induced by transplantation of ovaries or tissues derived from...
2017/0224779 METHODS FOR TREATING CARDIOVASCULAR DYSFUNCTION AND IMPROVING FLUID HOMEOSTASIS WITH A PEPTIDE HORMONE
The present invention generally to methods of treating subjects suffering from a cardiac condition or having a risk factor for developing a cardiac condition...
2017/0224778 COMPOSITIONS AND METHODS THAT TARGET REGULATION OF BREATHING
Activation of neurons in the preBotC with neuromedin B or gastrin releasing peptide increases frequency of sighs.
2017/0224777 SYNERGISTIC TUMOR TREATMENT WITH IL-2, A THERAPEUTIC ANTIBODY, AND A CANCER VACCINE
The present invention provides a method of treating cancer with a combination of IL-2 (e.g., extended-PK IL-2), a therapeutic antibody or fragment thereof, and...
2017/0224776 METHODS TO ENHANCE NERVE REGENERATION UTILIZING NEURAL STEM CELLS AND IL12P40
The present application provides a composition and methods to enhance nerve regeneration utilizing at least one component of neural stem cells or IL12p40. The...
2017/0224775 Lv PEPTIDE, ANTI-Lv ANTIBODY AND METHODS THEREOF
Embodiments of the invention are directed to the administration of the composition containing a portion of the peptide Lv to a subject to promote angiogenesis....
2017/0224774 METHOD FOR USING SUPPLEMENTAL VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) OR ANALOG TO PREVENT OXYGEN INDUCED...
Disclosed herein is a method for administering systemic (e.g., by intravenous injection) supplemental vascular endothelial growth factor (VEGF) to premature...
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