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Patent # Description
2017/0224723 METHOD FOR PRODUCING POLYGUANIDINES
A method for preparing polycondensation products of guanidine, aminoguanidine or diaminoguanidine G with one or more benzyl or allyl derivatives BA according...
2017/0224722 COMPOSITION AND METHOD FOR PRE-SURGICAL SKIN DISINFECTION
This invention provides a pre-surgical disinfecting composition that includes at least about 50 percent by weight of a C.sub.1-6 alcohol, based upon the total...
2017/0224721 ORAL CHOLESTYRAMINE FORMULATION AND USE THEREOF
The invention relates to an oral formulation for targeted delivery of cholestyramine to the colon, comprising a plurality of cholestyramine pellets that are...
2017/0224720 ORAL CHOLESTYRAMINE FORMULATION AND USE THEREOF
The invention relates to an oral formulation for targeted delivery of cholestyramine to the colon, comprising a plurality of cholestyramine pellets that are...
2017/0224719 CHOLESTYRAMINE PELLETS AND METHODS FOR PREPARATION THEREOF
The invention relates to small cholestyramine pellets that can be prepared by extrusion. The pellets have a high cholestyramine loading and are stable enough...
2017/0224718 METHOD OF TREATING AND PREVENTING NEURO-OLFACTORY TRIGGERED OR AGGRAVATED ILLNESSES OR RELATED CONDITIONS
A composition and method for preventing or treating an olfactory triggered response within a subject. The method includes applying a thixotropic composition to...
2017/0224717 RENAL INSUFFICIENCY PROGRESSION INHIBITOR, PROPHYLACTIC AGENT FOR RENAL INSUFFICIENCY AND INDOXYL SULFATE...
Provided are a novel renal failure progression inhibitor, prophylactic agent for renal failure, and indoxyl sulfate production inhibitor, intended for human...
2017/0224716 Methods and Compositions for Treating Pain
The invention provides a new use of adenosine analogs for the treatment of pain through activation of neurokinin 1 (NK1) receptor signaling pathway, thereby...
2017/0224715 REMOTE LOADING OF SPARINGLY WATER-SOLUBLE DRUGS INTO LIPID VESICLES
The present invention provides liposome compositions containing sparingly soluble drugs that are used to treat life-threatening diseases. A preferred method of...
2017/0224714 METHODS FOR DECREASING THE INCIDENCE OF NECROTIZING ENTEROCOLITIS IN INFANTS, TODDLERS, OR CHILDREN USING HUMAN...
Disclosed are methods of reducing the incidence of necrotizing enterocolitis in an infant, toddler, or child using nutritional compositions including human...
2017/0224713 HETEROCYCLIC COMPOUNDS FOR TREATING OR PREVENTING DISORERS CAUSED BY REDUCED NEUROTRANSMISSION OF SEROTONIN,...
A heterocyclic compound represented by the general formula (1) or a salt thereof: ##STR00001## wherein m, l, and n respectively represent an integer of 1 or...
2017/0224712 PROCHELATORS AS BROAD-SPECTRUM ANTIMICROBIAL AGENTS AND METHODS OF USE
The present disclosure provides methods of treating (including ameliorating and/or preventing) pathogenic infections by administering a therapeutically...
2017/0224711 COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
In some embodiments, the present disclosure pertains to a composition for modulating the expression of at least one gene associated with neuronal cell survival...
2017/0224710 COMPOSITIONS FOR ORAL ADMINISTRATION OF ZOLEDRONIC ACID OR RELATED COMPOUNDS FOR TREATING COMPLEX REGIONAL PAIN...
Oral dosage forms of osteoclast inhibitors, such as zoledronic acid, in an acid or a salt form can be used to treat or alleviate pain or related conditions,...
2017/0224708 MODIFIED HYALURONIC ACID POLYMER COMPOSITIONS AND RELATED METHODS
The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled...
2017/0224707 CHOLESTEROL LOWERING CAPSULES
The invention relates to a capsule consisting of a shell and a filling, which contains plant sterol ester and/or plant stanol ester and emulsifier. The capsule...
2017/0224706 AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF
Disclosed herein are formulations of pirfenidone or pyridone analog compounds for aerosolization and use of such formulations for aerosol administration of...
2017/0224705 BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY
The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the...
2017/0224704 TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS
Tropomyosin-related kinase inhibitors (Trk inhibitors) are small molecule compounds useful in the treatment of disease. Trk inhibitors can be used as...
2017/0224703 ANTIFUNGAL AGENTS AND USES THEREOF
Antimicrobial agents, compositions that include the agent(s) and use(s) thereof are provided. Also disclosed are screening assays for identifying antimicrobial...
2017/0224702 COMBINATION ALZHEIMER THERAPY USING ANTI-N3PGLU ABETA ANTIBODIES + A BACE INHIBITOR
The present invention provides a method of treating a cognitive or neurodegenerative disease, comprising administering to a patient in need of such treatment...
2017/0224701 INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 and TDO) AND THEIR USE IN THERAPY
Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is...
2017/0224700 USES OF SALT-INDUCIBLE KINASE (SIK) INHIBITORS
The present disclosure provides methods of treating and/or preventing inflammatory bowel disease (IBD) and graft-versus-host disease (GVHD) using...
2017/0224699 NOVEL IMMUNE SYSTEM MODULATORS
The present invention relates to a compound of Formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the...
2017/0224698 USE OF PARTHENOLIDE DERIVATIVES AS ANTILEUKEMIC AND CYTOTOXIC AGENTS
The present invention provides compounds of the formula (I) ##STR00001## wherein: X.sub.1, X.sub.2 and X.sub.3 are heteroatoms; R.sub.4, R.sub.5, R.sub.6,...
2017/0224697 3-(1H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-B]PYRIDINE AND THERAPEUTIC USES THEREOF
Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole...
2017/0224696 TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS
Compounds of formula I ##STR00001## wherein: R.sup.1 is ##STR00002## and R.sup.2, R.sup.4, and R.sup.6-9 are defined herein, and pharmaceutically acceptable...
2017/0224693 INDUCTION OF TUMOR HYPOXIA FOR CANCER THERAPY
Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions...
2017/0224692 Combination Therapy
The present disclosure relates to pharmaceutical products comprising a combination of (i) a MET inhibitor which is INC280 or a pharmaceutically acceptable salt...
2017/0224691 PDE INHIBITORS IN IMMUNOTHERAPY
The invention features methods and compositions featuring a PDE5 inhibitor for treating or preventing immunological-mediated disease in a subject.
2017/0224690 SMALL MOLECULE TRAIL GENE INDUCTION BY NORMAL AND TUMOR CELLS AS AN ANTICANCER THERAPY AND TUMOR CELLS AS AN...
Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating...
2017/0224689 NOVEL PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF PROTEIN KINASES
The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including...
2017/0224688 Methods of Using BTK Inhibitors to Treat Dermatoses
In certain embodiments, the invention includes therapeutic methods of using a BTK inhibitor to treat dermatoses, such as psoriasis, atopic dermatitis, contact...
2017/0224687 COMPOUNDS FOR MODULATING TRPV3 FUNCTION
The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
2017/0224686 TARGETING CYB5R3
A method for regulating arterial vascular tone in a subject, comprising administering to a subject in need thereof, a therapeutically effective amount of a...
2017/0224685 PRMT5 INHIBITORS AND USES THEREOF
Described herein are methods of treating cancer using one or more PRMT5 inhibitors, for example using one or more compounds of Formulae (1-5) or (A-F),...
2017/0224684 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF
Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use. ##STR00001##
2017/0224683 TREATMENT OF MELANOMA BY BLOCKING BENZAMIL SENSITIVE ION CHANNELS/EXCHANGERS
Methods of treatment for melanoma, and compositions for use in such methods are provided. An effective dose of an agent that blocks benzamil-sensitive proteins...
2017/0224682 SHIP1 MODULATORS AND METHODS RELATED THERETO
Compounds of formula (I): ##STR00001## where ##STR00002## n, R.sup.1, R.sup.4a, R.sup.4b, R.sup.5, R.sup.7 and R.sup.8 are defined herein, or pharmaceutically...
2017/0224681 METHOD OF TREATING BIPOLAR I AND II DISORDERS
The present invention relates to a method of treating a patient suffering from a disorder of the central nervous system associated with 5-HT.sub.1A receptor...
2017/0224680 METHODS AND COMPOSITIONS FOR KILLING SENESCENT CELLS AND FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic...
2017/0224679 Use of CXCR2 Antagonists For The Prevention and/or Treatment of Chemotherapy Induced Peripheral Neuropathy (CIPN)
The invention relates to the use of a CXCR2 antagonist for the prevention and/or treatment of chemotherapy induced peripheral neuropathy (CIPN).
2017/0224678 INHIBITORS OF BCL-2
Compounds and pharmaceutical compositions thereof for inducing apoptosis in a cell expressing Bcl-2 and IP.sub.3R and their use in a method for treating...
2017/0224677 Liquid formulations of salts of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]-piperazine
Liquid formulations of lactic acid addition salts of 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine are provided.
2017/0224676 TRANSDERMAL THERAPEUTIC SYSTEM FOR ADMINISTERING THE ACTIVE SUBSTANCE BUPRENORPHINE
The invention relates to a transdermal therapeutic system for administering the active substance buprenorphine. Said system comprises at least one carboxylic...
2017/0224675 Treatment of Multiple Sclerosis With Combination of Laquinimod and Dimethyl Fumarate
This invention provides a method of treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome comprising administering...
2017/0224674 Treatment Of Neurodegenerative Diseases With Combination Of Laquinimod And Fingolimod
This invention provides a method of treating a subject afflicted with a neurodegenerative disease comprising periodic administration of an amount of laquinimod...
2017/0224673 Enhanced Erythropoiesis and Iron Metabolism
The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron...
2017/0224672 Drug Combinations to Treat Multiple Myeloma
This invention relates to the combination of a C-Met inhibitor and a proteasome inhibitor to treat cancer, particularly multiple myeloma.
2017/0224671 METHOD FOR RELIEVING NICOTINE WITHDRAWAL SYMPTOMS
A method of releasing nicotine from a compressed chewing gum tablet, wherein the chewing gum tablet includes two modules; a first module including nicotine and...
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