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Patent # Description
2017/0233430 Novel Compounds
A compound of Formula (I) ##STR00001## wherein Y.sup.1, Y.sup.2, X.sup.1, X.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.8, and R.sup.9 are...
2017/0233429 THIONUCLEOSIDE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION
Disclosed are a compound and a pharmaceutical composition that exhibit an excellent drug efficacy against a tumor, in particular a tumor which has acquired...
2017/0233428 NUCLEOSIDE ANALOGS FOR TREATMENT OF THE FLAVIVIRIDAE FAMILY OF VIRUSES AND CANCER
The present invention is directed to compounds, compositions and methods for treating or preventing Flaviviridae family of viruses (including HCV, Yellow...
2017/0233427 SCALABLE SYNTHESIS OF REDUCED TOXICITY DERIVATIVE OF AMPHOTERICIN B
Disclosed is a simplified, readily scalable series of individual methods that collectively constitute a method for the synthesis of C2'epiAmB, an efficacious...
2017/0233426 METHOD FOR 2-SULFATION OF GLYCOSIDES
Method for selective 2-sulfation of glycosides.
2017/0233425 THE CHEMICAL SYNTHESIS METHOD OF PHILLYRIN
The present invention relates to a chemical synthesis method for phillyrin. The method of the present invention comprises: first dissolving a glycosyl receptor...
2017/0233424 CHLORINATION OF SUCROSE-6-ESTERS
There is provided a method for the chlorination of a sucrose-6-acylate to produce a 4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose-6-acylate, wherein said...
2017/0233423 PT (IV) Complexes Containing 4,4'-Disubstituted-2,2'-Bipyridyl and Their Use in Cancer Therapy
Platinum-containing compounds for the treatment of disease, such as, for example, cancer, are provided herein. Specifically, platinum Pt(IV) complexes with a...
2017/0233422 COMPOSITIONS AND METHODS COMPRISING OSMIUM FOR THE TREATMENT OF CANCERS
Compositions and methods comprising osmium are provided. In some embodiments, the osmium compounds comprise a bidentate ligand. In some embodiments, the osmium...
2017/0233421 CRYSTAL OF CYCLIC PHOSPHONIC ACID SODIUM SALT AND METHOD FOR MANUFACTURING SAME
An object of the present invention is to provide a crystal of a cyclic phosphonic acid sodium salt (2ccPA) with high purity and excellent storage stability and...
2017/0233420 HYPERVALENT IODINE CF2CF2X REAGENTS AND THEIR USE
A hypervalent iodine of formula (I) or formula (II) wherein R is a nucleophile and a method for their production is described. Such compounds can be used for...
2017/0233419 Guanine Analogs as Telomerase Substrates and Telomere Length Affectors
This invention relates to compounds useful for inhibiting telomere elongation. More specifically, the invention provides nucleotide analogs that are...
2017/0233418 N-(PHOSPHINOALKYL)-N-(THIOALKYL)AMINE DERIVATIVE, METHOD FOR PRODUCING SAME, AND METAL COMPLEX THEREOF
The purpose of the present invention is to provide: a ligand that is useful in a catalytic organic synthetic reaction; a method for producing said ligand; and...
2017/0233417 HYDROSILYLATION REACTION CATALYST
A hydrosilylation reaction catalyst prepared from: a catalyst precursor comprising a transition metal compound, excluding platinum, belonging to group 8-10 of...
2017/0233416 Quaternary amino alcohol functional organosilicon compounds, composition containing the latter and their...
The invention relates to novel quaternary amino alcohol functional organosilicon compounds, aqueous compositions containing the latter, and a method for their...
2017/0233415 NOVEL GROUP 4 TRANSITION METAL COMPOUND AND USE THEREOF
The present invention relates to a novel group 4 transition metal compound, a method for preparing the compound, a catalyst composition containing the...
2017/0233414 DERIVATIVES OF BODIPY
Derivatives of BODIPY with improved properties (such as longer Stokes shift relative to existing fluorophores) are disclosed.
2017/0233413 SUBSTITUTED ANNULATED PYRIMIDINES AND USE THEREOF
The present application relates to novel substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the...
2017/0233412 INHIBITORS OF HIF PROLYL HYDROXYLASE
The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for...
2017/0233411 THIAZOLYL-CONTAINING COMPOUNDS FOR TREATING PROLIFERATIVE DISEASES
The present disclosure provides thiazolyl-containing compounds of Formula (I), (II), or (III). The compounds described herein may be able to inhibit protein...
2017/0233410 A TETRAHYDROPYRROLO[3,4-D][1,3]THIAZINE-DERIVATIVE AS BACE INHIBITOR
The present invention provides a compound of Formula I: which is crystalline. The compound of Formula (I) is useful in the treatment of Akzheimer's disease...
2017/0233409 TYPE IV SECRETION SYSTEM INHIBITORS
Described are compounds, compositions, and methods for treating or preventing conditions or disorders caused by or associated with bacterial type IV secretion...
2017/0233408 SALT FORMS OF CEFTOLOZANE
This disclosure relates to salt forms of ceftolozane, processes for making these salt forms, and compositions comprising the same. Also disclosed are...
2017/0233407 TRICYCLIC P13K INHIBITOR COMPOUNDS AND METHODS OF USE
Tricyclic PI3k inhibitor compounds of Formula I with anti-cancer activity, anti-inflammatory activity, or immunoregulatory properties, and more specifically...
2017/0233406 CRYSTALLINE FORM OF 1-(1-METHYL-1H-PYRAZOL-4-YL)-N-((1R,5S,7S)-9-METHYL-3-OXA-9-AZABICYCLO[3.- ...
Disclosed is a crystalline polymorph 1-(1-methyl-1H-pyrazol-4-yl)-N-((1R,5S,7S)-9-methyl-3-oxa-9-azabicyclo[3.- 3.1]nonan-7-yl)-1H-indole-3-carboxamide, Form G,...
2017/0233405 MAX BINDERS AS MYC MODULATORS AND USES THEREOF
The present disclosure provides compounds of Formula (I'), Formula (I), Formula (II), Formula (II-A), Formula (III), and Formula (IV). The compounds described...
2017/0233404 ISOERGOLINE COMPOUNDS AND USES THEREOF
Provided herein are isoergoline compounds and pharmaceutical compositions thereof. In other embodiments, provided herein are methods of treatment, prevention,...
2017/0233403 PHILLYGENIN IBUPROFEN ESTER, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
The present invention provides a pharmaceutical compound of phillygenin ibuprofen ester as represented by formula (I), preparation method thereof, and...
2017/0233402 TETRAHYDROISOQUINOLINE DERIVATIVES
Novel tetrahydroisoquinoline derivative compounds are disclosed herein that may be used as an active ingredient for a pharmaceutical composition, and in...
2017/0233401 SUBSTITUTED THIOHYDANTOIN DERIVATIVES AS ANDROGEN RECEPTOR ANTAGONISTS
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such...
2017/0233400 METHODS FOR MAKING 3-O-PROTECTED MORPHINONES AND 3-O-PROTECTED MORPHINONE DIENOL CARBOXYLATES
Disclosed are methods for making aldehydes and ketones comprising allowing the corresponding primary or secondary alcohol to react in the presence of...
2017/0233399 ORGANIC COMPOUNDS
The invention relates to novel inhibitors of phosphodiesterase 1 (PDE1), useful for the treatment of diseases or disorders characterized by disruption of or...
2017/0233398 11,13-MODIFIED SAXITOXINS FOR THE TREATMENT OF PAIN
Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and...
2017/0233397 PROCESS FOR PREPARING 7H-PYRROLO[2,3-D]PYRIMIDINE COMPOUNDS
Described herein are improved processes for the preparation of the 7H-pyrrolo[2,3-d]pyrimidine compound, ...
2017/0233396 PDE1 INHIBITOR
The present invention provides a compound of Formula I: ##STR00001## useful for treating chronic kidney disease and diabetic kidney disease.
2017/0233395 2,4-DISUBSTITUTED 7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE, PREPARATION METHOD AND MEDICINAL USE THEREOF
The present invention relates to a 2,4-disubstituted 7H-pyrrolo[4,3-d]pyrimidin derivative, a preparation method and a medicinal use thereof. In particular,...
2017/0233394 Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid
The invention is directed towards stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid and its hemisulfate salt as well as pharmaceutical...
2017/0233393 BETA-LACTAMASE INHIBITOR AND PROCESS FOR PREPARING THE SAME
A process for preparing a diazabicyclooctane compound represented by the following formula (I): ##STR00001## wherein A represents RcO--; B represents NH or...
2017/0233392 HETEROARYLENE-BRIDGED BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING
Benzodiazepine dimers having a structure represented by ##STR00001## wherein X comprises a heteroaromatic moiety and is as further defined in the application;...
2017/0233391 FUSED TRICYCLIC UREA COMPOUNDS AS RAF KINASE AND/OR RAF KINASE DIMER INHIBITORS
Provided are certain fused tricyclic urea compounds and salts thereof, compositions thereof, and methods of use therefor.
2017/0233390 Methyl- and Trifluoromethyl-Substituted Pyrrolopyridine Modulators of RORC2 and Methods of Use Thereof
The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating ROR.gamma....
2017/0233389 PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS
Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers...
2017/0233388 TRIAZOLOPYRIDINE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS
The invention relates to a compound of Formula I or IA and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective...
2017/0233387 ISOERGOLINE COMPOUNDS AND USES THEREOF
Provided herein are isoergoline compounds and pharmaceutical compositions thereof. In other embodiments, provided herein are methods of treatment, prevention,...
2017/0233386 Compounds Which Have a Protective Activity with Respect to the Action of Toxins and of Viruses with an...
The subject matter of the present invention is novel families of compounds which are aromatic amine, imine, aminoadamantane and benzodiazepine derivatives,...
2017/0233385 PIPERIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONIST
The present invention discloses a series of piperidine derivatives as orexin receptor antagonists and compositions thereof, and relates to the application...
2017/0233384 Thienothiadiazole Compounds and Related Semiconductor Devices
The present invention relates to new semiconducting compounds having at least one optionally substituted thienothiadiazole moiety. The compounds disclosed...
2017/0233383 NOVEL CRYSTALLINE FORMS OF A BACE INHIBITOR, COMPOSITIONS, AND THEIR USE
The present invention provides four crystalline forms of verubecestat, as well as pharmaceutically acceptable compositions thereof, each of which may be useful...
2017/0233382 PROCESSES FOR THE PREPARATION OF A BACE INHIBITOR
This invention provides processes for the preparation of verubecestat (Compound of Formula (I)), a potent inhibitor of BACE-1 and BACE-2. In addition, the...
2017/0233381 DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE
Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further...
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