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Patent # Description
2017/0233380 NOVEL COMPOUNDS AS ROR GAMMA MODULATORS
The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R.sup.1, R.sup.2,...
2017/0233379 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY
The present disclosure features disclosed compounds which can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human...
2017/0233378 1-OXO-1,2-DIHYDROISOQUINOLIN-7-YL-(5-SUBSTITUTED-THIOPHEN-2-YL)-SULFONAMID- E COMPOUNDS, FORMULATIONS CONTAINING...
1-Oxo-1,2-dihydroisoquinolin-7-yl-(5-substituted-thiophen-2-yl)-sulfonami- de compounds, formulations containing those compounds, and their use as AICARFT...
2017/0233377 HETEROCYCLIC COMPOUNDS AS NAV CHANNEL INHIBITORS AND USES THEREOF
The present invention relates to heterocyclic compounds, and pharmaceutically acceptable compositions thereof, useful as Nav1.6 inhibitors.
2017/0233376 CARBOXYLIC ACID COMPOUND, METHOD FOR PREPARATION THEREOF, AND USE THEREOF
The present invention relates to the technical field of medicine, and specifically relates to the carboxylic acid compound represented by the chemical formula...
2017/0233375 CANCER THERAPEUTICS
This invention relates to compounds that bind to wild-type CBF.beta. and inhibit CBF.beta. binding to RUNX proteins. The potent compounds of the invention...
2017/0233374 T-TYPE CALCIUM CHANNEL MODULATOR AND USES THEREOF
The present invention provides T-type calcium channel modulators and methods for producing and using the same. In some embodiments, compounds of the invention...
2017/0233373 Crystalline (2S)-3-[(3S,4S)-3-[(1R)-1-hydroxyethyl]-4-(4-methoxy-3-phenyl)-3-methylpy- ...
The invention provides crystalline (2S)-3-[(3S,4S)-3-[(1R)-1-hydroxyethyl]-4-(4-methoxy-3-{[1-(5-methylpyrid- ...
2017/0233372 NOVEL SALTS OF NILOTINIB AND POLYMORPHS THEREOF
The present invention provides novel salts of nilotinib and polymorphs thereof. The acid addition salts of nilotinib with benzenesulfonic acid, ...
2017/0233371 RORC2 INHIBITORS AND METHODS OF USE THEREOF
The present invention provides compounds, pharmaceutical compositions, methods of inhibiting ROR.gamma. activity and/or reducing the amount of IL-17 in a...
2017/0233370 COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS
The present invention provides, inter alia, a compound having the structure: ##STR00001## Also provided are compositions containing a pharmaceutically...
2017/0233369 METALLOENZYME INHIBITOR COMPOUNDS AS FUNGICIDES
The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms...
2017/0233368 ARYL AND HETEROARYL FUSED LACTAMS
This invention relates to compounds of general formula (I) ##STR00001## in which R.sup.1, R.sup.2, U, V, L, M, R.sup.5, m, X, Y and Z are as defined herein, and...
2017/0233367 PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS
The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
2017/0233366 METHOD FOR PREPARING TRIOXANE
The present invention concerns a method for preparing 1,3,5-trioxane by trimerization of formaldehyde in the presence of methanesulfonic acid. The invention...
2017/0233365 CYCLOOCTENES FOR BIOORTHOGONOL REACTIONS
This disclosure relates to trans-cyclooctene compounds and methods of using the same in bioorthogonal labeling experiments.
2017/0233364 Versatile Non-Destructive Surface Modification of Carbonaceous Materials and Process for Grafting Into Polymer...
Disclosed is a non-destructive universal method of functionalization of graphitic carbonaceous materials that enables their alignment, cross-linking, and...
2017/0233363 PROCESS FOR THE PRODUCTION AND ISOLATION OF 5-HYDROXYMETHYLFURFURAL
The present invention relates to a process for the synthesis of 5-hydroxymethyl furfural (HMF) comprising the steps of: 1) dehydrating at least one saccharide...
2017/0233362 ONE-STEP PRODUCTION OF FURFURAL FROM BIOMASS
Methods and processes for the production of valuable organic products and alcohols from biomass using a single-step dehydration extraction process having...
2017/0233361 PROCESS FOR THE MANUFACTURE OF FURURAL AND FURFURAL DERIVATIVES
The present invention provides a process for preparing furfural and furfural derivatives using a furfural-derived solvent.
2017/0233360 CLOSED-LOOP PRODUCTION OF FURFURAL FROM BIOMASS
Methods and processes for the production of valuable organic products and alcohols from biomass material using a closed-loop process having numerous advantages...
2017/0233359 ENERGY-EFFICIENT AND ENVIRONMENTALLY FRIENDLY PROCESS FOR THE PRODUCTION OF TARGET CHEMICAL COMPOUNDS FROM...
The present invention is directed to an energy-efficient and environmentally friendly process for the production of chemical target compounds from cellulosic...
2017/0233358 MONO- AND DIALKYL ETHERS OF FURAN-2,5-DIMETHANOL AND (TETRA-HYDROFURAN-2,5-DIYL)DIMETHANOL AND AMPHIPHILIC...
Linear mono- and dialkyl ethers of furan-2,5-dimethanol (FDM) and/or (tetrahydrofuran-2,5-diyl)dimethanol (bHMTHF), methods for their preparation, and...
2017/0233357 PHENOLIC EPOXY COMPOUNDS
Disclosed herein are compositions and methods of making phenolic compounds, and resins comprising these phenolic compounds. The compounds include...
2017/0233356 NEUROACTIVE SUBSTITUTED CYCLOPENT[a]ANTHRACENES AS MODULATORS FOR GABA TYPE-A RECEPTORS
The present disclosure is generally directed to neuroactive substituted cyclopent[a]anthracenes as referenced herein, and pharmaceutically acceptable salts...
2017/0233355 EPOXIDATION USING PEROXYGENASE
The invention relates to enzymatic methods for epoxidation of a non-cyclic aliphatic alkene, or a terpene.
2017/0233354 FLT3 RECEPTOR ANTAGONISTS
The invention pertains to novel FLT3 receptor antagonists of general formula (1). The compounds are useful for the treatment or the prevention of pain...
2017/0233353 PROCESS FOR THE PREPARATION OF TRIAZINE CARBAMATES
This invention relates to a process for the preparation of triazine carbamates by reacting a mixture of an aminotriazine A having at least two amino groups per...
2017/0233352 HSP70 MODULATORS AND METHODS FOR MAKING AND USING THE SAME
The present invention provides compounds I and II and compositions thereof for use in the modulation of Hsp70. In some embodiments, the present invention...
2017/0233351 Process for the Preparation of Olaparib and Intermediates Thereof
The present invention provides processes for the preparation of intermediate compounds of formulas (4) and (5) useful in the preparation of Olaparib. ...
2017/0233349 PERSISTENT CARBENE ADDUCTS AND RELATED METHODS
Persistent carbene adducts and methods of forming the same are generally described, as well as compositions comprising the persistent carbene adduct. In some...
2017/0233348 Process for the preparation of 5-fluoro-1H-pyrazoles starting from hexafluoropropene
A new process for the preparation of 5-fluoro-1H-pyrazoles of the general formula (I) as described herein and further reactions with this compound.
2017/0233347 PRMT1 INHIBITORS AND USES THEREOF
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein...
2017/0233346 CRYSTALLINE ANTI-TRICHOPHYTON AGENTS AND PREPARATION PROCESS THEREOF
A crystal form of 2-(3,5-dimethyl-1H-pyrazol-1-yl)-5-methylphenol which is stable and has high purity for preservation, industrial manufacturing, and...
2017/0233345 SUBSTITUTED QUINOLINE-4-CARBOXAMIDES AND USE THEREOF
The present application relates to novel substituted quinoline-4-carboxamides and use thereof, to processes for their preparation, to their use, alone or in...
2017/0233344 HIGH-PURITY QUINOLINE DERIVATIVE AND METHOD FOR MANUFACTURING SAME
Provided is a compound represented by formula (IV) or a salt thereof, wherein the content of the compound represented by formula (I) is 350 ppm by mass or...
2017/0233343 PRODRUG
The present invention provides a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: ##STR00001## wherein R is a hydrogen...
2017/0233342 NEW DERIVATIVES OF INDOLE FOR THE TREATMENT OF CANCER, VIRAL INFECTIONS AND LUNG DISEASES
The present invention relates to a new class of indole derivatives, having a particular MKlp2 inhibition profile and useful as a therapeutic agent, in...
2017/0233341 CRYSTAL OF PYRROLE DERIVATIVE AND METHOD FOR PRODUCING THE SAME
The present invention provides a production intermediate of an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic...
2017/0233340 NOVEL SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC...
Compounds of formula (I): ##STR00001## wherein R1 and R2 represent hydrogen or deuterium atoms; R3 represents a hydrogen atom or a --COOH, a --OH or a...
2017/0233339 HETEROCYCLIC COMPOUND
Provided is a heterocyclic compound having a superior RBP4-lowering action and useful as a medicament for the prophylaxis or treatment of a disease or symptom...
2017/0233338 METHOD FOR PRODUCING ASTAXANTHIN FROM ASTACIN
The invention relates to a method for the non-stereoselective and also for the stereoselective synthesis of astaxanthin from astacin. For this purpose, a...
2017/0233337 NON-IONIC AMPHIPHILES AND METHODS OF MAKING THE SAME
Sugar-derived tetrol, non-ionic amphiphilic amine-esters are prepared facilely and efficaciously in a few steps. The process is initiated by the esterification...
2017/0233336 SULFONATE COMPOUND, PHOTOACID GENERATOR, AND RESIN COMPOSITION FOR PHOTOLITHOGRAPHY
Provided are: a non-ionic photoacid generator containing a sulfonate compound having a high photosensitivity to i lines, exhibiting excellent heat-resistance...
2017/0233335 INHIBITORS OF HIV-1 ENTRY AND METHODS OF USE THEREOF
The disclosure provides compositions and methods for sensitizing primary HIV-1, including transmitted/founder viruses, to neutralization by monoclonal...
2017/0233334 METHOD FOR PREPARING D-ARGININE
Disclosed is a method of preparing D-arginine, wherein D-arginine is obtained by the optical resolution of DL-arginine using D-3-bromocamphor-10-sulfonic acid...
2017/0233333 PROCESS FOR THE SYNTHESIS OF (+) AND (-)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE
The present invention is concerned with novel processes for the preparation of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically...
2017/0233332 COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as...
2017/0233331 Method for Obtaining Crystalline L-Alanine
The present invention relates to a method for obtaining crystalline L-alanine from an aqueous solution of L-alanine, in particular from an aqueous solution of...
2017/0233330 Process for the preparation of 3-[(1R,2R)-3-(Dimethylamino)-1-ethyl-2-methylpropyl]-phenol
A process for the preparation of a compound of formula (I) and of a acid salt (T) wherein R.sup.1 is selected from the group consisting of alkyl, aryl,...
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