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Patent # Description
2017/0233735 ALLELE SELECTIVE INHIBITION OF MUTANT C9ORF72 FOCI EXPRESSION BY DUPLEX RNAS TARGETING THE EXPANDED...
Provided herein are compositions and methods for reducing expression of C9orf72 transcripts in cells containing expanded intronic GGGGCC regions, including...
2017/0233734 NUCLEIC ACID LIPID PARTICLE FORMULATIONS
The present invention relates to lipid nanoparticles containing a biodegradable cationic lipid which provide improved delivery of active pharmaceutical...
2017/0233733 TWIST SIGNALING INHIBITOR COMPOSITIONS AND METHODS OF USING THE SAME
The present invention relates to compositions comprising TWIST signaling inhibitors and optionally one or more anti-cancer agents, and methods of using the...
2017/0233732 MODULATION OF APOLIPOPROTEIN C-III (APOCIII) EXPRESSION IN LIPOPROTEIN LIPASE DEFICIENT (LPLD) POPULATIONS
Provided herein are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein in a patient with Fredrickson Type I dyslipidemia,...
2017/0233731 NOVEL TETRAGALNAC CONTAINING CONJUGATES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES
Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or...
2017/0233730 REGULATION OF MIR-33 MICRORNAS IN THE TREATMENT OF CHOLESTEROL-RELATED DISORDERS
Compositions comprising nucleic acid sequences that target MiR-33 microRNAs are described, together with uses of the same in the treatment of...
2017/0233729 COMPOSITIONS AND METHODS FOR TRANSCRIPTION-BASED CRISPR-CAS DNA EDITING
Provided are compositions and methods for cleaving a DNA sequence in a cell. The methods involve comprising introducing into a cell a recombinant vector...
2017/0233728 LINKER ELEMENT AND METHOD OF USING SAME TO CONSTRUCT SEQUENCING LIBRARY
Provided is a linker element and a method of using the linker element to construct a sequencing library, wherein the linker element consists of a linker A and...
2017/0233727 METHODS FOR GENERATING AND DECODING BARCODES
The present disclosure provides methods and systems for generating and decoding a set of barcodes, which include the utilization of a hash function. The...
2017/0233726 Method for Making an Enriched Library
A method for making an enriched library comprising specific nucleic acid sequence information allowing to identifying at least one binding entity that binds to...
2017/0233725 Scavenger Compounds for Improved Sequencing-by-Synthesis
The present invention discloses methods of applications of indole-3-propionic acid, L-carnitine and O-acetyl-L-carnitine in one or more different reactive...
2017/0233724 Partitioning of DNA Sequencing Libraries into Host and Microbial Components
Described herein is a method for isolating microbial DNA from a sample that comprises host DNA and microbial DNA. In some embodiments, the method may comprise:...
2017/0233723 Method For Affinity Purification
The disclosure relates to a switchable aptamer having a high affinity for a selected target such as a virus, cell or antibody when in the presence of a binding...
2017/0233722 COMBINATORIAL PHOTO-CONTROLLED SPATIAL SEQUENCING AND LABELING
Methods of labeling or barcoding molecules within one or more portions of a plurality of cells are provided. Kits and systems for labeling or barcoding...
2017/0233721 Devices and Methods for Plasmid Purification
The invention provides columns (including pipette tip columns) and automated methods for the purification of nucleic acids including plasmids. Nucleic acids...
2017/0233720 Sample Preparation Device and Methods of Use
A device for isolating DNA from a sample containing cells, including a cartridge having an entrance port and an exit port, a membrane disposed between the...
2017/0233719 METHODS FOR SEPARATING NUCLEIC ACIDS WITH GRAPHENE COATED MAGNETIC BEADS
Disclosed herein are methods for separating and identifying nucleic acids by utilizing carbon coated magnetic beads. The method teaches that multivalent...
2017/0233718 CONTINUOUS SONICATION FOR BIOTECHNOLOGY APPLICATIONS AND BIOFUEL PRODUCTION
A system and method for sonication of multiple samples and continuous sonication of an input fluid stream in flow-through arrangements useful for economical...
2017/0233717 Methods and Systems for Generation, Use, and Delivery of Activated Stem Cells
Harvested stem cells are activated by treating them with an amplitude modulated laser beam having a wavelength lying in the range of 405 to 980 nanometers. The...
2017/0233716 DEVICE AND METHOD FOR LARGE VOLUME TRANSFECTION
The invention relates to a device for applying an electric field to a suspension of cells, comprising at least one chamber which comprises at least one...
2017/0233715 DEVICE AND METHOD FOR LARGE VOLUME TRANSFECTION
The invention relates to a device (1) for applying an electric field to a suspension of cells, cell derivatives, organelles, sub-cellular particles and/or...
2017/0233714 POLYMER CONJUGATES HAVING REDUCED ANTIGENICITY AND METHODS OF USING THE SAME
Disclosed herein are compositions and methods for reducing the antigenicity of molecules, wherein the molecule comprises a uricase. The antigenicity of a...
2017/0233713 HYDROCARBON SYNTHASE GENE AND USE THEREOF
A hydrocarbon synthase gene encoding protein having excellent capacity to synthesize a hydrocarbon such as alkane and novel functions is provided. The gene...
2017/0233712 PROCESS FOR THE PREVENTION AND SUPPRESSION OF BACTERIAL DISEASES IN PLANTS
The invention is directed to methods and compositions that inhibit pathogen proliferation. More specifically, in various embodiments the present invention...
2017/0233711 ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME
The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor X and factor Xa protein derivatives that bind to the...
2017/0233710 SERINE PROTEASES OF BACILLUS SPECIES
The present disclosure relates to serine proteases cloned from Bacillus spp., and variants thereof. Compositions containing the serine proteases are suitable...
2017/0233709 Subtilases
The present invention relates to methods for producing variants of a parent TY145 subtilase and of a parent BPN' subtilase and to TY145 and BPN' variants...
2017/0233708 EVOLUTION OF PROTEASES
Some aspects of this disclosure provide methods for phage-assisted continuous evolution (PACE) of proteases. Some aspects of this invention provide methods for...
2017/0233707 COMPOSITIONS COMPRISING BETA-MANNANASE AND METHODS OF USE
The present compositions and methods relate to a beta-mannanase from Actinosynnema mirum, polynucleotides encoding the beta-mannanase, and methods of make...
2017/0233706 CHIMERIC ANTIBACTERIAL POLYPEPTIDES
Provided herein are antibacterial compositions and methods of making and using the compositions.
2017/0233705 MODIFIED -GALACTOSIDASE
The present invention has a purpose of providing a technique for increasing the heat resistance of a .beta.-galactosidase. According to the present invention,...
2017/0233704 PRODUCTION FOR RECOMBINANT HUMAN DNASE I
Disclosed is a method for production of recombinant human DNase I which is of such high purity as may be directly used as a medical drug. The method includes...
2017/0233703 Genetic indicator and control system and method utilizing split Cas9/CRISPR domains for transcriptional control...
While genetic engineering has undergone rapid advancement with the discovery of CRISPR/Cas9, there is room for improvement for genetic circuit control,...
2017/0233702 ERK-DERIVED PEPTIDES AND USES THEREOF
An isolated peptide being no longer than 20 amino acids comprising a sequence at least 95% homologous to the sequence GQLNHILGILGX.sub.1PX.sub.2QED (SEQ ID NO:...
2017/0233701 NOVEL SYNTHETIC PEPTIDE AND USE THEREOF
Provided are a synthetic peptide that induces the reprogramming of a differentiated cell, a reprogramming-inducing pharmaceutical composition that contains...
2017/0233700 Method for Proliferation of Pancreatic Progenitor Cells
The present invention relates to a method for preparing highly pure pancreatic progenitor cells by using pluripotent stem cells such as ES cells or iPS cells...
2017/0233699 TISSUE-SPECIFIC DIFFERENTIATION MATRICES AND USES THEREOF
In some aspects, this invention provides a method of making a bone marrow-derived tissue-specific stem cell proliferation, expansion, isolation and...
2017/0233698 CULTURED MAMMALIAN LIMBAL STEM CELLS, METHODS FOR GENERATING THE SAME, AND USES THEREOF
The invention provides an isolated limbal stem or progenitor cell (LSC) population or LSC-like population comprising a chemically synthesized, recombinant or...
2017/0233697 Composition and Methods of Using Umbilical Cord Lining Stem Cells
The invention provides methods for using Umbilical Cord Lining Stem Cells (ULSCs) to produce therapeutic factors including growth factors, cytokines,...
2017/0233695 Cell Culture Media Composition and Methods of Producing Thereof
A serum free cell culture media, wherein the media is adapted to be conditioned by culturing a first set of eukaryotic cells in the media, wherein the first...
2017/0233694 New Paenibacillus Sp. Strain, Cultivation Method and Use of the Same
Provided are a new Paenibacillus sp. strain, the deposit number of which is CGMCC No. 8333, and a method for culturing the exopolysaccharide; and an...
2017/0233693 INSERT SHELF AND INCUBATOR
The insert shelf (1) is characterized in that it has at least one means (3) with which an incubation medium located in an incubation vessel placed on the...
2017/0233692 Method For Mechanical and Hydrodynamic Microfluidic Transfection and Apparatus Therefor
Methods for introducing exogenous material into a cell are provided, which include exposing the cell to a transient decrease in pressure in the presence of the...
2017/0233691 SELF-CONTAINED ANAEROBIC CULTURE DEVICE FOR SULFATE-REDUCING MICROORGANISMS
The present disclosure provides a culture device for enumerating colonies of sulfate-reducing microorganisms. The device includes a body having a waterproof...
2017/0233690 Quantum Dot-Containing Composition for Growth Enhancement in Photosynthetic Organisms
Quantum dot (QD) LEDs useful for plant, algael and photosynthetic bacterial growth applications. The QD LEDs utilizes a solid state LED (typically emitting...
2017/0233689 METHODS AND MATERIALS FOR CULTIVATION AND/OR PROPAGATION OF A PHOTOSYNTHETIC ORGANISM
The present disclosure provides methods and materials for the cultivation and/or propagation of a photosynthetic organism. Such methods may comprise the use of...
2017/0233688 METHOD FOR RAPID MATURATION OF DISTILLED SPIRITS USING LIGHT, HEAT, AND NEGATIVE PRESSURE PROCESSES
An improved system and process for rapidly producing distilled spirits having characteristics associated with a much longer maturation process is provided. The...
2017/0233687 SEMICONDUCTOR ELEMENT CLEANING SOLUTION THAT SUPPRESSES DAMAGE TO TANTALUM-CONTAINING MATERIALS, AND CLEANING...
According to the present invention, it is possible to provide a cleaning method for removing a photoresist and dry etching residue on a surface of a...
2017/0233686 SYSTEM AND A PROCESS OF A FABRIC MATERIAL
A water-soluble antimicrobial liquid delivery, quality control tracking and monitoring system and method can be directly integrated into commercial laundry...
2017/0233685 POLYFUNCTIONAL POLYMERS BASED ON PHOSPHONATE UNITS AND AMINE UNITS
The invention relates to polyfunctional polymers suitable in particular for the treatment of metal surfaces (metal finishing) and comprising: monomer units u1...
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