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Patent # Description
2017/0246303 NANOEMULSIONS
The present invention relates to oil-in-water nanoemulsions, processes for their preparation and their use as delivery vehicles for active components for use...
2017/0246302 POLYMER COATING COMPOSITIONS AND COATED PRODUCTS
Described herein are coating compositions for consumer and/or medical products. The coating compositions can be used to confer desirable properties to the...
2017/0246301 FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME
The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating fatty acids to...
2017/0246300 C5-C6-FUSED TRICYCLIC IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE
In its many embodiments, the present invention provides certain C5-C6 fused tricyclic iminothiadiazine compounds, including compounds Formula (I): or a...
2017/0246299 COMPOSITIONS AND METHODS FOR TREATMENT OF PRE-CANCEROUS SKIN LESIONS
The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic...
2017/0246298 METHODS AND COMPOSITIONS FOR CANCER TREATMENT AND TREATMENT SELECTION
In some aspects, the disclosure provides methods of treating cancer or an infection. In some aspects, the disclosure provides methods of enhancing the efficacy...
2017/0246297 ANTI-CD40 ANTIBODIES AND METHODS OF USE
The present invention provides high affinity anti-CD40 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic...
2017/0246296 INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF...
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements...
2017/0246295 ALPHA-TOCOPHEROL-BASED ADJUVANTED SOLVENT FOR DNA VACCINES
The present invention discloses a delivery system for nucleic acid vaccines comprising an emulsion of tocol and esters hereof. Vaccines and new ways of...
2017/0246294 NANOEMULSION COMPOSITIONS FOR PREVENTING, SUPPRESSING OR ELIMINATING ALLERGIC AND INFLAMMATORY DISEASE
The present invention provides methods and compositions for the stimulation of immune responses and for treating or preventing allergic disease and responses...
2017/0246293 SYNTHETIC LONG PEPTIDES (SLP) FOR THERAPEUTIC VACCINATION AGAINST HEPATITIS B VIRUS INFECTION
The present invention relates to the fields of medicine and immunology. In particular, it relates to novel peptides that may be used in the treatment and/or...
2017/0246292 GENETICALLY STABLE RECOMBINANT MODIFIED VACCINIA ANKARA (RMVA) VACCINES AND METHODS OF PREPARATION THEREOF
A vaccine comprising an immunologically effective amount of recombinant modified vaccinia Ankara (rMVA) virus which is genetically stable after serial passage...
2017/0246291 T20 CONSTRUCTS FOR ANTI-HIV (HUMAN IMMUNODEFICIENCY VIRUS) THERAPY AND/OR VACCINES
The present invention concerns methods and compositions for treatment of HIV infection using a T20 expression vector, such as that shown in SEQ ID NO:1 or SEQ...
2017/0246290 OIL-IN-WATER EMULSION INFLUENZA VACCINE
The present invention provides an immunogenic influenza composition in a dose volume suitable for human use, comprising an influenza virus antigen or antigenic...
2017/0246289 Method of quickly producing antibodies against avian influenza and maintain antibody titer of duck
The present invention provides a method for enabling ducklings to quickly produce anti-avian influenza antibodies and maintain antibody titer, including: step...
2017/0246288 MULTILAMELLAR LIPID VESICLE COMPOSITIONS AND METHODS OF USE
The present invention provides novel and inventive drug delivery systems with higher loading capability, a capacity to sequester high tumors levels of both...
2017/0246287 VACCINE COMPOSITION FOR TRANSDERMAL ADMINISTRATION
Disclosed is a vaccine composition for transdermal administration to induce cellular immunity, comprising an antigen, wherein Th1 cell ratio in a model animal...
2017/0246286 Attenuated Mannheimia haemolytica Vaccines and Methods of Making and Use
The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said...
2017/0246285 Conjugation of Streptococcal Capsular Saccharides
Three conjugation methods for use with the capsular saccharide of Streptococcus agalactiae. In the first method, reductive amination of oxidized sialic acid...
2017/0246284 STAPHYLOCOCCUS AUREUS MATERIALS AND METHODS
The disclosure generally relates to the field of prevention and treatment of Staphylococcus aureus infections. In particular, the disclosure relates to...
2017/0246283 COMPOSITION FOR INDUCING PROLIFERATION OR ACCUMULATION OF REGULATORY T CELLS
It was found that bacteria belonging to the genus Clostridium induce accumulation of regulatory T cells (Treg cells) in the colon. Moreover, the present...
2017/0246282 MULTIVALENT BRUCELLA VACCINE FOR PROTECTION AGAINST MYCOBACTERIAL INFECTIONS AND METHODS OF USING THE SAME
Provided herein is a multivalent Brucella vaccine expressing at least one heterologous M. tuberculosis antigen. The vaccines described herein serve as an...
2017/0246281 PATHOGEN VACCINES AND METHODS OF PRODUCING AND USING THE SAME
The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating...
2017/0246280 Modified Immunization Vectors
The disclosure relates to recombinant vectors and methods for using the same. In certain embodiments, the recombinant vectors are immunogenic.
2017/0246279 COMPOSITIONS AND METHODS FOR BOOSTING THE EFFICACY OF ADOPTIVE CELLULAR IMMUNOTHERAPY
The present disclosure provides compositions and methods for boosting, augmenting or enhancing the efficacy of the adoptive cellular immunotherapy by using...
2017/0246278 BIPARTITE AND TRIPARTITE SIGNALING IMMUNE CELLS
Embodiments of the disclosure include compositions and methods effective for immunotherapy, such as for cancer. The embodiments include cells that recognize a...
2017/0246277 REAGENTS AND METHODS FOR IDENTIFYING, ENRICHING, AND/OR EXPANDING ANTIGEN-SPECIFIC T CELLS
Antigen-specific T cells, including nave T cells, and including rare precursor cells are enriched and expanded in culture. Enrichment and expansion provides a...
2017/0246276 YEAST-BRACHYURY IMMUNOTHERAPEUTIC COMPOSITIONS
Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers...
2017/0246275 CANCER IMMUNE-BASED THERAPY
The present disclosure provides a novel therapeutic vaccine approach that triggers a therapeutic antitumor response. The inventive approach is to selectively...
2017/0246274 IMMUNOGENIC POLYPEPTIDE COCKTAIL FOR THE TREATMENT OF MEDULLARY THYROID CARCINOMA
Disclosed are immunogenic compositions that include one or more polypeptides that, when administered to a subject with adjuvant, elicit an immune response...
2017/0246273 RECOMBINANT LISTERIA STRAIN EXPRESSING HETEROLOGOUS ANTIGEN FUSION PROTEINS AND METHODS OF USE THEREOF
Disclosed herein are recombinant nucleic acids encoding tumor antigens fused to immunogenic polypeptides and recombinant Listeria strains comprising the same,...
2017/0246272 COMPOSITIONS AND METHODS FOR TREATING B CELL MEDIATED AUTOIMMUNE DISORDERS
Provided herein are methods, kits, compositions and uses related to the treatment of a B cell mediated autoimmune disorder with a T cell vaccine comprising a...
2017/0246271 INNATE IMMUNE MODULATING MOLECULE COMPLEX FOR THE ACTIVATION OF THE INNATE IMMUNE SYSTEM OF AQUATIC ANIMALS AND...
A method for application of an innate immune modulating molecule complex to activate the innate immune system of aquatic animals includes selecting a...
2017/0246270 PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF
Disclosed herein are chimeric antigen receptor effector cells (CAR-ECs) and CAR-EC switches. The switchable CAR-ECs are generally T cells. The one or more...
2017/0246269 METHODS OF TREATING OR PREVENTING PERIODONTITIS AND DISEASES ASSOCIATED WITH PERIODONTITIS
The present disclosure describes methods for preventing or treating periodontitis or diseases associated with periodontitis. The present disclosure also...
2017/0246268 Longevity Enhancement Induced by Repetitive Injections of Botulinum Toxin (Centurion Effect)
Described herein is a novel application involving the use of therapeutic or cosmetic formulations of botulinum toxin involving an increase and enhancement of...
2017/0246266 Novel Cell Penetrating Peptide, Conjugate Thereof with Botulinum Toxin, and Use Thereof
The present invention relates to: a novel cell penetrating peptide; a cell penetrating botulinum toxin recombinant protein composition in which the cell...
2017/0246265 PHARMACEUTICAL PREPARATIONS FOR ATTENTION DEFICIT DISORDER, ATTENTION DEFICIT HYPERACTIVITY DISORDER AND OTHER...
A pharmaceutical preparation for the treatment of attention deficit disorders combines a therapeutically effective amount of digestive enzymes, such as...
2017/0246264 SOLUBLE HYALURONIDASE GLYCOPROTEIN (sHASEGP), PROCESS FOR PREPARING THE SAME, USES AND PHARMACEUTICAL...
Provided are soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration of other...
2017/0246263 LYSOSOMAL TARGETING AND USES THEREOF
The invention provides compositions and methods for effective lysosomal targeting mediated by SORT1. In particular, the compositions and methods provided by...
2017/0246262 COMPOSITIONS AND METHODS FOR PROTECTING AGAINST AIRBORNE PATHOGENS AND IRRITANTS
The present disclosure features methods and compositions for enhancing the ability of the respiratory membranes to filter airborne pathogens and protect a...
2017/0246261 ANTIVIRAL TREATMENT WITH LOW IMMUNOGENICITY
Compositions and methods are disclosed for reducing toxicity and immunogenicity of nucleases, especially when in use for cutting viral nucleic acids in host...
2017/0246260 MODIFIED ANTIVIRAL NUCLEASE
A modified programmable nuclease provided as an antiviral therapeutic includes a programmable nuclease such as an RNA-guided nuclease, a DNA-guided nuclease,...
2017/0246259 Compositions and Methods of Using Interleukin-4 Induced Gene 1 (IL-4I1)
The invention is directed to methods of promoting myelin formation in central nervous system (CNS) tissue in a subject in need thereof, the method comprising...
2017/0246258 AGENT, PRODUCT AND USE
The present invention relates to a composition for modulating tumor cell dissemination, in particular metastatic cancer cells. In particular, the invention...
2017/0246257 POSTPRANDIAL GASTROKINETIC AGENT
To provide a therapeutic agent for gastrointestinal disorder such as diabetic gastroparesis. A postprandial gastrokinetic agent containing (A) ghrelin or a...
2017/0246256 METHODS OF ADMINISTERING HEPCIDIN
The present disclosure relates to the use of hepcidin in therapeutic methods for the treatment of various conditions in which decreasing serum iron...
2017/0246255 Stable Analogs of Peptide and Polypeptide Therapeutics
The present invention relates to compositions of peptide and polypeptide analogs that are resistant to proteolysis, pharmaceutical uses thereof, and methods of...
2017/0246254 LYOPHILISED PHARMACEUTICAL FORMULATION AND ITS USE
A pharmaceutical formulation in a lyophilised form, which comprises pharmacologically effective amount of interferon beta-1a as an active ingredient,...
2017/0246253 Interleukin-15 Compositions and Uses Thereof
Interleukin-15 muteins and other interleukin-15-related molecules are described, as well as methods of identifying interleukin-15 muteins and other...
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