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Patent # Description
2017/0246201 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
Preparations of glycan therapeutics, pharmaceutical compositions and medical foods thereof, optionally comprising micronutrients, polyphenols, prebiotics,...
2017/0246200 MICRORNA-132/212 FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
The present relates to the use of miRNA-132/212 mimics or activators comprising a doubled stranded ribonucleic acid molecule comprising a seed region sequence...
2017/0246199 Compositions and Methods of Aloe Polysaccharides
The present invention describes a method for preparing a polymannan extract from freeze-dried aloe powder. The polymannan extract of the present invention is...
2017/0246198 Process for Making Nucleoside Phosphoramidate Compounds
The present invention is directed to a process for making Nucleoside Phosphoramidate Compounds of formula (I): which are useful for the treatment and...
2017/0246197 High-Purity Phospholipids
Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids, are disclosed....
2017/0246196 COMPOSITION AND METHODS OF USE OF SMALL MOLECULES AS BINDING LIGANDS FOR THE MODULATION OF PROPROTEIN...
This invention is related to the field of PCSK9 biology and the composition and methods of use of small molecule ligands for modulation of PCSK9 biological...
2017/0246195 MITOQUINONE DERIVATIVES USED AS MITOCHONDRIALLY TARGETED ANTIOXIDANTS
This invention relates to pharmaceutically acceptable amphiphilic antioxidant compounds, compositions and dosage forms comprising said compounds and methods...
2017/0246194 Acetaminophen-Containing Analgesic Formulations With Reduced Hepatotoxicity
An analgesic composition is provided which is safe and effective to patients requiring pain modulation. The analgesic composition contains (a) acetaminophen...
2017/0246193 FATTY ACID ACETYLATED SALICYLATES AND THEIR USES
The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate...
2017/0246192 USE OF ANDROGEN FOR TREATING GASTROINTESTINAL DISORDERS
By lowering the amount of Sexual Hormone Binding Globulin (SHBG) and, thereafter, raising the serum testosterone level in a person's body, an effective method...
2017/0246191 19-NOR C3, 3-DISUBSTITUTED C21-N-PYRAZOLYL STEROIDS AND METHODS OF USE THEREOF
Provided herein are 19-nor C3,3-disubstituted C21-pyrazolyl steroids of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof; wherein ,...
2017/0246190 METHODS AND FORMULATION FOR IMPROVING ORAL AVAILABILITY OF CPT-11 WHILE REDUCING CPT-11 INDUCED...
Disclosed herein are methods and formulation for enhancing oral availability of CPT-11 during cancer therapy while at the same time, reducing its...
2017/0246189 METHOD FOR TREATING UTERINE FIBROIDS
The invention relates to a method for treating uterine fibroids, which method comprises administering to a patient in need thereof, an effective amount of...
2017/0246188 METHOD OF TREATING ORGANOPHOSPHATE INTOXICATION
The present invention provides new compositions and methods for treating and/or reversing organophosphate intoxication, manifested by both cholinergic and...
2017/0246187 (17- )-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
Described here are substantially pure (17-.beta.)-3-Oxoandrost-4-en-17-yl tridecanoate compositions, methods of their preparation and uses thereof.
2017/0246186 HIGH-STRENGTH TESTOSTERONE UNDECANOATE COMPOSITIONS
The present disclosure is drawn to pharmaceutical compositions and oral dosage capsules containing testosterone undecanoate, as well as related methods. The...
2017/0246185 Methods of Reducing Mammographic Breast Density and/or Breast Cancer Risk
The present disclosure is directed to generally methods for treating mammographic breast density and/or breast stiffness in a patient in need thereof, such as...
2017/0246184 METHODS OF TREATING TESTOSTERONE DEFICIENCY
Methods of treating a testosterone deficiency or its symptoms with a pharmaceutical formulation of testosterone esters are provided. The methods are designed...
2017/0246183 MULTIPHASIC CONTRACEPTIVE REGIMEN FOR ORAL COMBINATION DRUG FORMULATION OF PROGESTIN AND ESTROGEN
A method of contraception in a female is provided. The method includes administering to the female daily for a first number of successive days an oral...
2017/0246182 TEXAPHYRIN-PT(IV) CONJUGATES AND COMPOSITIONS FOR USE IN OVERCOMING PLATINUM RESISTANCE
The present disclosure relates platinum(IV) and texaphyrin linked conjugates and compositions comprising a texaphyrin and a platinum(IV) agent. The present...
2017/0246181 TREATMENT OF CEREBRAL CAVERNOUS MALFORMATIONS AND CEREBRAL ANEURYSMS WITH RHO KINASE INHIBITORS
Provided are methods of treating a cerebral cavernous malformation (CCM) and methods of treating cerebral aneurysm in a mammal with certain rho kinase inhibitors.
2017/0246180 ACYCLIC CUCURBIT[N]URIL TYPE MOLECULAR CONTAINERS TO TREAT INTOXICATION AND DECREASE RELAPSE RATE IN SUBSTANCE...
Provided are methods for reversing the effects of drugs of abuse. The method involves administering acyclic CB[n]-type compounds to a mammal in need of the...
2017/0246179 MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT
The present invention relates to methods for weight management that utilize modified-release dosage forms comprising ...
2017/0246178 Novel Formulation of Meloxicam
Unit dosage forms of meloxicam containing either 5 mg or 10 mg of meloxicam that provide effective pain relief and have desirable pharmacokinetic properties...
2017/0246177 Methods of Treating Age-Related Symptoms in Mammals and Compositions therefor
A method of alleviating age-related symptoms in a mammal, which comprises a step of administering to a mammal in need thereof, an effective amount of a...
2017/0246176 PHACOSCLEROSIS INHIBITOR
The present invention provides a crystalline lens hardening inhibitor, containing a compound represented by the formula (I): ##STR00001## wherein R.sup.1-R.sup.4...
2017/0246175 SUSTAINED TIMOLOL MALEATE DELIVERY FROM LIPOSOMES FOR GLAUCOMA THERAPY AND OCCULAR HYPERTENSION
Various embodiments relate to the field of liposomal formulations for drug delivery, in particular, liposomal formulations for ocular drug delivery. More...
2017/0246174 METHODS OF TREATMENT OF MALIGNANCIES
Provided are methods and compositions for treating cancers in patients carrying an IDH1 mutation or IDH2 mutation.
2017/0246173 Methods and Pharmaceutical Compositions for Treating Lymphoid Malignancy
The present invention provides, inter alia, methods for treating, preventing, or ameliorating the effects of a lymphoid malignancy, such as those associated...
2017/0246172 CONCENTRATED METHOTREXATE SOLUTIONS
Concentrated methotrexate solutions are described which are suitable for the use of an active substance in the production of a parenterally administered...
2017/0246171 Treatment Of RB-Negative Tumors Using Topoisomerase Inhibitors In Combination With Cyclin Dependent Kinase 4/6...
This invention is in the area of improved therapeutic combinations for and methods of treating selected retinoblastoma (Rb)-negative cancers and Rb-negative...
2017/0246170 Tricyclic Compounds Having Antimitotic and/or Antitumor Activity and Methods of Use Thereof
The present invention provides tricyclic compounds, pharmaceutically acceptable salts, solvates, or hydrates thereof, having antimitotic activity,...
2017/0246169 Inhibitors of Bruton's Tyrosine Kinase for the Treatment of Solid Tumors
Described herein are irreversible Btk inhibitor compounds, and methods for using such irreversible inhibitors in the treatment of diseases and disorders...
2017/0246168 COMPOSITIONS AND METHODS OF TREATMENT OF CANCER
This invention generally relates to compositions and methods for cancer treatment and, in particular, to compositions able to interact (e.g., bind to) with...
2017/0246167 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical...
2017/0246166 1,2-BENZOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF KIDNEY DISORDERS
The present invention provides 1,2-benzothiazole compounds particularly useful in the treatment of diabetic nephropathy and other chronic kidney disorders and...
2017/0246165 AN IMPROVED PROCESS FOR THE PREPARATION OF LURASIDONE HYDROCHLORIDE
Disclosed herein is an improved process for the preparation of Lurasidone and its pharmaceutically acceptable salts via novel intermediate and use thereof for...
2017/0246164 SMALL MOLECULES TARGETING ANDROGEN RECEPTOR NUCLEAR LOCALIZATION AND/OR LEVEL IN PROSTATE CANCER
A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein...
2017/0246163 METHODS OF IMPROVING BALANCE, GAIT OR BOTH IN PATIENTS WITH NEUROLOGICAL DISEASE
Disclosed herein are compositions and methods for reducing the frequency of falls, improving balance, improving gait, or some combination thereof in subjects...
2017/0246161 ABUSE-RESISTANT PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF OPIOID DEPENDENCE
There is provided pharmaceutical compositions for the treatment of e.g. opioid dependency comprising microparticles of a pharmacologically-effective amount of...
2017/0246160 SOLID PHARMACEUTICAL COMPOSITION
[Problem] Provided is a pharmaceutical composition which suppresses gelation of the 7-{(3S,4S)-3-[(cycloproropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-flu- ...
2017/0246159 BENZOQUINOLONE INHIBITORS OF VMAT2
The present invention relates to new benzoquinolone inhibitors of VMAT2, pharmaceutical compositions thereof, and methods of use thereof. ##STR00001##
2017/0246158 ATROPINE SULFATE RAPIDLY-DISINTEGRATING SUBLINGUAL TABLETS, METHODS FOR MANUFACTURE THEREOF, AND METHODS FOR...
The invention provides atropine sulfate (AS) rapidly-disintegrating sublingual tablets (RDSTs) in a sublingual dosage form and methods for therapeutic use of...
2017/0246157 PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS
The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus...
2017/0246156 USE OF CDK9 INHIBITORS TO REDUCE CARTILAGE DEGRADATION
The present invention relates to the use of cyclin-dependent kinase 9 (CDK9) inhibitors to reduce, inhibit and/or prevent cartilage degradation. CDK9...
2017/0246155 COMPOSITIONS AND METHODS FOR SELECTIVELY DEPLETING SENESCENT CELLS
The present disclosure provides compositions and methods for selectively killing senescent cells, wherein the composition comprises piperlongumine (PL) or...
2017/0246154 B- AND y -DIKETONES AND y -HYDROXYKETONES AS WNT/ B -CATENIN SIGNALING PATHWAY ACTIVATORS
The present application discloses a compound which is ##STR00001## which activates Wnt/.beta.-catenin signaling and thus treats or prevents diseases related to...
2017/0246153 SPIRO-THIAZOLONES
Spiro-thiazolones of formula I ##STR00001## wherein X.sup.1, X.sup.2, X.sup.3, X.sup.4, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are as defined...
2017/0246152 METHODS OF TREATING DEVELOPMENTAL DISORDERS USING GABOXADOL
Methods of treating a developmental disorder such as Dravet syndrome by administering a pharmaceutical composition of gaboxadol or a pharmaceutically...
2017/0246151 WILD BIRD TREATMENT COMPOSITION AND METHODS
Compositions, methods of preparing compositions, and methods of treating parasitic nematode infections in wild birds include a fenbendazole premix and a grain...
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