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Patent # Description
2017/0247370 COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR
Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for...
2017/0247369 BICYCLIC AZA COMPOUNDS AS MUSCARINIC M1 RECEPTOR ANTAGONISTS
This invention relates to compounds (Formula (1)) that are agonists of the muscarinic M1 receptor and which are useful in the treatment of muscarinic M1...
2017/0247368 FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME
The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating fatty acids to...
2017/0247367 AMINOPYRIMIDINE KINASE INHIBITORS
Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of CK1, CK1.gamma.1,...
2017/0247366 SUBSTITUTED 4-ALKOXYPICOLINAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND...
Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds;...
2017/0247365 NOVEL COMPOUNDS
The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention...
2017/0247364 AZOLE BENZENE DERIVATIVE AND CRYSTALLINE FORM THEREOF
There are provided: 4-methyl-2-[4-(2-methylpropoxy)-3-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-1,3-t- hiazole-5-carboxylic acid, a sodium salt thereof and crystals of...
2017/0247363 CYTOCHROME P450 INHIBITORS AND USES THEREOF
The present invention provides compounds having the general structural formula (I) (I) and pharmaceutically acceptable derivatives thereof, as described...
2017/0247362 OPTICAL ISOMER OF 1,4-BENZOTHIAZEPINE-1-OXIDE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION PREPARED USING SAME
The present invention provides: a novel compound which is characterized by being capable of increasing the number of heart beats or a blood pressure mildly to...
2017/0247361 PROCESS FOR THE PREPARATION OF THIETANE DERIVATIVES
The present invention relates to processes for the preparation of thietane derivatives of the formula IA ##STR00001## and thietane derivatives of the formula IB ...
2017/0247360 HETEROCYCLIC SULFONAMIDES, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF
The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: ...
2017/0247359 PROCESS FOR THE PREPARATION OF CANAGLIFLOZIN
A process for the preparation of canagliflozin. The process may be effectively implemented on an industrial scale. Several compounds useful as intermediates...
2017/0247358 PYRIMIDINE-DIAMINE DUAL HSP90/TRAP1 INHIBITORS
Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical composition thereof, which are useful as dual...
2017/0247357 PYRIDINE DERIVATIVES AS SOFT ROCK INHIBITORS
The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such...
2017/0247356 PROCESSES FOR THE PREPARATION OF EMPAGLIFLOZIN
The present invention relates to processes for the preparation of empagliflozin. In particular, the present invention relates to the preparation of...
2017/0247355 PROTEOSTASIS REGULATORS
The present invention is directed to compounds having the Formulae (Ia-Ie), (II), (IIIa-IIId), (IVa-IVc), (Va-Vb), (VIa-VIe), (VII), (VIIIa-VIIIc), and (IX),...
2017/0247354 NOVEL FORM OF RIMSULFURON, A PROCESS FOR ITS PREPARATION AND USE OF THE SAME
A crystal form of rimsulfuron is provided that exhibits improved solubility and decreased viscosity. Furthermore, a process for its preparation is provided....
2017/0247353 BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AND COSMETICS
Compounds having formula (I) are described. ##STR00001## Also described, are methods of using these compounds to treat diseases, conditions, and disorders.
2017/0247352 METHOD FOR PREPARING ALECTINIB
A method for preparing Alectinib (Alectinib, I), comprising the preparation steps: subjecting 6-cyano-1H-indole-3-carboxylate and ...
2017/0247351 NOVEL EPISULFIDE COMPOUND AND OPTICAL MATERIAL COMPOSITION CONTAINING SAME
According to the present invention, it is possible to provide an optical material composition that contains an episulfide compound represented by formula (1)...
2017/0247350 RECOVERY OF MONOMER FROM POLYURETHANE MATERIALS BY DEPOLYMERIZATION
Methods for recovering monomers from polymers, such as polyurethanes (including thermoset polyurethanes) include heating the polymer to depolymerize the...
2017/0247349 SYNTHESIS OF CHIRALLY ENRICHED 2,4-DISUBSTITUTED TETRAHYDROPYRAN-4-OL AND ITS DERIVATIVES
The present invention discloses a process for synthesis of chiral 2,4-disubstituted-tetrahydropyran-4-ol and its derivatives having a general formula (I)...
2017/0247348 USE OF CARBOXYLIC ACIDS IN THE PRODUCITON OF 2,5-FURANDICARBOXYLIC ACID
Methods for providing effective, efficient and convenient ways of producing 2-5-furandicarboxylic acid are presented. In addition, compositions of...
2017/0247347 PROCESS FOR PREPARING ORGANIC ESTERS
The present invention relates to a process for preparing an ester having formula R--COO--R' (I), wherein R represents a group selected from: (i) a linear or...
2017/0247346 TETRAHYDROFURAN DERIVATIVES
The invention relates to tetrahydrofuran derivatives of the formula (I) ##STR00001## in which the radical R1 has the definition ...
2017/0247345 PROCESS FOR PREPARING DIHYDROISOXAZOLE DERIVATIVES
The present invention relates to a novel process for preparing dihydroisoxazole derivatives.
2017/0247344 Benzylideneguanidine Derivatives and Therapeutic Use for the Treatment of Protein Misfolding Diseases
The present invention relates to a compound of formula (I), or a tautomer and/or a pharmaceutically acceptable salt thereof, wherein: R.sub.1 is alkyl, Cl, F...
2017/0247343 THIOETHER TRIAZOLOPYRIDINE AND TRIAZOLOPYRIMIDINE INHIBITORS OF MYELOPEROXIDASE
The present invention provides compounds of Formula (I): wherein A, X and Y are as defined in the specification, and compositions comprising any of such novel...
2017/0247342 PRODUCTION METHOD FOR 3,3-DIMETHYL-3,4-DIHYDRO-1H-QUINOXALIN-2-ONE DERIVATIVE AND INTERMEDIATE FOR SAID...
An object is to provide a novel production method suitable for industrial production of a 3,3-dimethyl-3,4-dihydro-1H-quinoxalin-2-one derivative and a...
2017/0247341 PHARMACEUTICALLY ACTIVE PYRAZINE DERIVATIVES
The invention provides compounds which inhibit or modulate the activity of Chk-1 kinase and which are useful in the treatment of cancer. The compounds have the...
2017/0247340 Inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase and Uses Thereof
Herein are provided, inter alia, compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and methods...
2017/0247339 QUINAZOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
Disclosed are a quinazoline derivative, a preparation method therefor, and a pharmaceutical composition and an application thereof. The present invention...
2017/0247338 PROCESS FOR PREPARING (CYCLOPENTYL[d]PYRIMIDIN-4-YL)PIPERAZINE COMPOUNDS
The present disclosure relates to processes for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds, and more particularly relates to processes for...
2017/0247337 PROCESS FOR MAKING HYDROXYLATED CYCLOPENTYLPYRIMIDINE COMPOUNDS
The invention provides processes for preparing a compound of formula I ##STR00001## and salts thereof, wherein R.sup.1 is defined herein, and compounds and ...
2017/0247336 SUBSTITUTED PYRIMIDINES AS INHIBITORS OF HIF PROLYL HYDROXYLASE
The present invention concerns compounds of Formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and...
2017/0247335 FLUORINATED PYRIDAZIN-3-ONES FOR THE USE THEREOF IN THE TREATMENT OF LUNG DISEASES
The present invention concerns compounds belonging to the family of fluorinated pyridazin-3-ones, for the use thereof in the treatment of broncho-pulmonary...
2017/0247334 IMIDAZOLE COMPOUND, METAL SURFACE TREATMENT LIQUID, METAL SURFACE TREATMENT METHOD, AND LAMINATE PRODUCTION METHOD
A novel imidazole compound that yields a surface treatment liquid that is very effective at suppressing migration and oxidation of a wiring surface; a metal...
2017/0247333 BACKFUNCTIONALIZED IMIDAZOLINIUM SALTS AND NHC CARBENE-METAL COMPLEXES
Backfunctionalized imidazolinium salts and methods of synthesizing the same and NHC carbene-metal complexes therefrom. For backfunctionalized imidazolinium...
2017/0247331 PROCESS FOR THE PREPARATION OF 4-[-(AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE AND ITS ...
The present invention relates to a process for the preparation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluophenoxy- ...
2017/0247330 PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS
4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 2-hydroxypicolinonitrile in a series of chemical steps selected from chlorination, chloro...
2017/0247329 "Fluorinated Derivatives of 3-Hydroxypyridin-4-Ones"
Compounds of Formula I which are derivatives of 3-Hydroxypyridin-4-ones. The compounds may be used in treatment of a medical condition related to a toxic...
2017/0247328 IMPROVED PROCESS FOR THE PREPARATION OF ...
The present invention relates to an improved process for the preparation of [[2(S)-[[4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-1-piperidinyl]methyl]-- ...
2017/0247327 OCTAHYDROCYCLOPENTAPYRROLES, THEIR PREPARATION AND USE
The present invention provides Octahydrocyclopentapyrrole compounds having the structure: (structurally represented) wherein psi is absent or present, and when...
2017/0247326 Substituted Pyrrolidine Carboxamide Compounds
The present disclosure provides pyrrolidine carboxamide compounds having Formula I and the pharmaceutically acceptable salts and solvates thereof, wherein A,...
2017/0247325 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF
Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors. Also provided are methods for making and using...
2017/0247324 ALDEHYDE CAPTURE LIGATION TECHNOLOGY FOR SYNTHESIS OF AMIDE BONDS
The present invention relates to ligation agents and their use in making an amide ligation product. Methods of making the ligation agents are also disclosed.
2017/0247323 SALT AND PHOTORESIST COMPOSITION CONTAINING THE SAME
A salt having a group represented by the formula (aa): ##STR00001## wherein X.sup.a and X.sup.b independently each represent an oxygen atom or a sulfur atom, the...
2017/0247322 POLYTHIOL COMPOSITION AND METHOD FOR PRODUCING SAME
The present invention provides a polythiol composition containing, as the main component, a polythiol compound (a) having two or more mercapto groups, and...
2017/0247321 TETRALIN AND INDANE DERIVATIVES AND USES THEREOF
The application discloses pharmaceutical compounds of formula I useful for treating CNS diseases wherein m, s, R.sup.1 R.sup.5, R.sup.6 and R.sup.7 are as...
2017/0247320 NOVEL AMINO-PHENYL-SULFONYL-ACETATE DERIVATIVES AND USE THEREOF
The present invention relates to a novel amino-phenyl-sulfonyl-acetate derivative or a pharmaceutically acceptable salt thereof; and a pharmaceutical...
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