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Patent # Description
2017/0253631 HEXAPEPTIDE FOR NEUROPROTECTION AGAINST A BETA TOXICITY
The present investigation involves designing of a novel hexapeptide, which spontaneously self-assembles to form nanovesicles in physiological conditions. This...
2017/0253630 METHOD FOR PRODUCING AMINO ACID CRYSTALS AND METHOD FOR PRODUCING PROTEIN CRYSTALS
The object of the present invention is to provide a new application of an optical vortex. For the object, a method for producing crystalline amino acid comprises...
2017/0253629 2' AND/OR 5' AMINO-ACID ESTER PHOSPHORAMIDATE 3'-DEOXY ADENOSINE DERIVATIVES AS ANTI-CANCER COMPOUNDS
Disclosed are chemical compounds, the compounds for use in a method of treatment, particularly in a method of prophylaxis or treatment for cancer, a process...
2017/0253628 PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF
The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and...
2017/0253627 CRYSTAL OF ALKALI METAL N-ACETYLNEURAMINATE ANHYDRATE, AND PROCESS FOR PRODUCING SAME
According to the present invention, a crystal of an alkali metal N-acetylneuraminate anhydrate, and a process for producing a crystal of an alkali metal...
2017/0253625 MOLYBDENUM IMIDE COMPOUND
In the method of the present invention for producing a thin film, including introducing, onto a substrate, a vapor that has been obtained by vaporizing a...
2017/0253624 THIN-FILM-FORMING MATERIAL INCLUDING A MOLYBDENUM IMIDE COMPOUND
In the method of the present invention for producing a thin film, including introducing, onto a substrate, a vapor that has been obtained by vaporizing a...
2017/0253623 IRIDIUM COMPLEX PRODUCTION METHOD
A method for manufacturing tris(.beta.-diketonato)iridium by reacting .beta.-diketone with an iridium compound, in which an activation treatment including (a)...
2017/0253622 COMPOUNDS FOR PH-CONTROLLED RELEASE OF HYDROGEN SULFIDE
The embodiments herein generally relates to compounds and methods for releasing H.sub.2S in a pH dependent manner. In particular, the invention provides...
2017/0253621 METATITANIC ACID PARTICLE AND METHOD FOR PRODUCING THE SAME
A metatitanic acid particle surface-treated with a silane compound having a hydrocarbon group has absorption at a wavelength of about 400 nm or more and about...
2017/0253620 PROCESSES FOR FORMING COORDINATION COMPLEXES CONTAINING MONOSULFONATED CATECHOLATE LIGANDS
Coordination complexes can have a metal center with at least one unsubstituted catecholate ligand and at least one monosulfonated catecholate ligand or a salt...
2017/0253619 TRANSFER AGENT FOR THE PREPARATION OF A FUNCTIONAL OR TELECHELIC POLYOLEFIN
A compound and the use thereof to prepare a functional or telechelic polyolefin is provided. compound has the following formula (II): ...
2017/0253618 NOVEL IMIDAZOPYRIDAZINE COMPOUNDS AND THEIR USE
This disclosure provides novel imidazopyridazine compounds of formula (I) and pharmaceutical acceptable salt thereof, pharmaceutical compositions containing...
2017/0253617 Substituted 5-Membered Heterocyclic Analogs as Protease Activated Receptor 4 (PAR-4) Antagonists
Embodiments of the invention include compounds and compositions thereof to inhibit protease activated receptor-4. Also described are methods of preparation of...
2017/0253616 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY
The present invention is to provide a novel compound (I) shown below, having the anti-virus activity; particularly the HIV integrase inhibitory activity, and a...
2017/0253615 Spirocyclic derivatives
The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the...
2017/0253614 HEPATITIS C VIRUS INHIBITORS AND USES THEREOF IN PREPARATION OF DRUGS
A series of hepatitis C virus (HCV) inhibitors and compositions and applications thereof in the preparation of drugs for treating chronic HCV infection....
2017/0253613 NOVEL CHROMONE OXIME DERIVATIVE AND ITS USE AS ALLOSTERIC MODULATOR OF METABOTROPIC GLUTAMATE RECEPTORS
The present invention provides a novel chromone oxime derivative of formula (I), which is a modulator of nervous system receptors sensitive to glutamate and,...
2017/0253612 PYRIMIDINE COMPOUNDS AND PYRIMIDO INDOLE COMPOUNDS AND METHODS OF USE
The present invention discloses a compound comprising the formula: ##STR00001## wherein R is hydrogen or an alkyl group having from one to ten carbon atoms, or a...
2017/0253611 COMPOSITIONS COMPRISING THIENOPYRIMIDINE AND THIENOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF
The present disclosure relates generally to thienopyrimidine and thienopyridine compounds and methods of use thereof. In particular embodiments, the present...
2017/0253610 NITROGEN-CONTAINING ANALOGS OF SALINOMYCIN, SYNTHESIS AND USE AGAINST CANCER STEM CELLS AND MALARIA
The present invention concerns compounds of formula (I), enantiomers, mixture of enantiomers, diastereoisomers and mixture of diasteroisomers thereof formula...
2017/0253609 HEPATITIS B ANTIVIRAL AGENTS
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: X-A-Y-L-R (I) which inhibit the...
2017/0253608 Method for Preparing Anhydrosugar Alcohol Using Two-Step Hydrothermal Reaction
A method for producing anhydrosugar alcohol according to the present invention can increase the yield of anhydrosugar alcohol even in the absence of a catalyst...
2017/0253607 LONG-ACTING HIV PROTEASE INHIBITOR
The present invention provides useful compounds for HIV protease inhibitor. A compound represented by the following formula or its pharmaceutically acceptable...
2017/0253606 A Rapamycin Derivative, and a Preparation Method, Pharmaceutical Composition and Use Thereof
The present invention pertains to the field of pharmaceutical chemicals, and relates to a rapamycin derivative of Formula I, and a preparation method,...
2017/0253605 PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF
Disclosed are pyrazole compounds, and pharmaceutically acceptable compositions thereof. The compounds and the compositions can be used for positive allosteric...
2017/0253604 PROCESS FOR IMPROVED OXYMORPHONE SYNTHESIS
Processes for preparing oxymorphone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxymorphinone salt in the presence of...
2017/0253603 BENZODIAZEPINE DERIVATIVES, COMPOSITIONS, AND METHODS FOR TREATING COGNITIVE IMPAIRMENT
This invention relates to benzodiazepine derivatives, compositions comprising therapeutically effective amounts of those benzodiazepine derivatives and methods...
2017/0253602 SUBSTITUTED PYRIDOBENZODIAZEPINONE-DERIVATIVES AND USE THEREOF
The present application relates to novel (3-hydroxyphenyl)amino-substituted pyrido[2,3-b][1,5]benzodiazepin-5-one derivatives, to processes for preparation...
2017/0253601 Substituted Pyrrolidine Compounds
The present disclosure provides substituted pyrrolidine compounds having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein...
2017/0253600 PYRROLOPYRIMIDINES FOR USE IN INFLUENZA VIRUS INFECTION
The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections. ##STR00001##
2017/0253599 STABLE AMORPHOUS TICAGRELOR AND A PROCESS FOR ITS PREPARATION
The present invention relates to a stable amorphous ticagrelor and a process for its preparation.
2017/0253598 AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS
The present invention provides azetidinyl phenyl, pyridyl, or pyrazinyl carboxamide derivatives, as well as their compositions and methods of use, that...
2017/0253597 CRYSTALLINE FORMS OF PEMETREXED DIACID AND MANUFACTURING PROCESSES THEREFOR
Crystalline forms of pemetrexed diacid are provided (Forms 1 and 2) which are readily produced for either laboratory-scale or industrial scale. Processes for...
2017/0253596 SHIP1 MODULATORS AND METHODS RELATED THERETO
Compounds of formula (I): ##STR00001## where R.sup.1, R.sup.2, R.sup.3, R.sup.4a, R.sup.4b, R.sup.5, R.sup.6 and R.sup.7 are defined herein, or stereoisomers or...
2017/0253595 SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER
This invention provides a medicament for the treatment of cancer, which cause a reduction of cancer. This invention relates to use of a compound which has...
2017/0253594 HETEROARYL COMPOUNDS FOR KINASE INHIBITION
Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical...
2017/0253593 INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR
Described herein are inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to...
2017/0253592 N-(HETERO)ARYL-SUBSTITUTED HETEROYCLIC DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES OR CONDITIONS RELATED...
The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the...
2017/0253591 HETEROCYCLIC COMPOUND
The problem of the present invention is to provide a compound having a superior ROR.gamma.t inhibitory action, and useful as a prophylactic or therapeutic...
2017/0253590 SMALL MOLECULE IRE1-ALPHA INHIBITORS
Described herein are IRE1.alpha. inhibitors, compositions containing such inhibitors, and methods of treatment that include administration of such compounds....
2017/0253589 ANTITUMOR DERIVATIVES FOR DIFFERENTIATION THERAPY
Imidazopyridine derivatives according to formula I are described ##STR00001## wherein X is selected from CH, N, S, and O, Y is selected from S, CO, and O,...
2017/0253588 SALT OF NAPHTHYRIDINE CARBOXYLIC ACID DERIVATIVE
7-(3-Aminomethyl-4-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-- oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate and hydrates...
2017/0253587 BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
The present disclosure describes bicyclic aromatic carboxamide derivatives, as well as their compositions and methods of use. The compounds inhibit the...
2017/0253586 Substituted Oxazole- and Thiazole-Based Carboxamide and Urea Derivatives as Vanilloid Receptor Ligands II
The invention relates to oxazole and thiazole-based carboxamide and urea derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing...
2017/0253585 PROCESSES FOR THE PREPARATION OF INTERMEDIATES OF RALTEGRAVIR
The present disclosure provides a process for the preparation of 2-(2-amino propan-2-yl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyri- ...
2017/0253584 PREPARATION OF 2'-FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND...
The present invention provides (i) processes for preparing a 2'-deoxy-2'-fluoro-2'-methyl-D-ribonolactone derivatives, (ii) conversion of intermediate lactones...
2017/0253583 HETEROAROMATIC CHALCONE DERIVATIVES AND THEIR MEDICAL USE
The present invention relates to heteroaromatic chalcone derivatives, particularly the compounds of formula (I) as described and defined herein, pharmaceutical...
2017/0253582 TRIAZOLE MODIFIED COUMARIN AND BIPHENYL AMIDE-BASED HSP90 INHIBITORS
Provided herein are compounds of the formulas: which are 90-kDa heat shock protein inhibitors. Pharmaceutical compositions of the compounds are also provided....
2017/0253581 SUBSTITUTED HETEROCYCLES AS c-MYC TARGETING AGENTS
Disclosed are substituted heterocycles compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted...
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