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Patent # Description
2017/0283810 Nucleic acid constructs for presentation of CD4 and CD8 epitopes, cellular transfection and uses thereof
The invention relates to constructs, cells and methods for modulating the immune system that optimize presentation of CD4 and CD8 epitopes to ...
2017/0283809 RECOMBINANT MICROORGANISM PRODUCING ALKENES FROM ACETYL-COA
Disclosed is a recombinant microorganism comprising endogenous enzymes that convert CO and/or CO.sub.2 to acetyl-CoA. The recombinant microorganism contains a...
2017/0283808 MIR-520B SEQUENCE FOR INHIBITING CANCER GROWTH AND SPREAD AND MEDICINE THEREFOR
A miR-520b sequence for inhibiting cancer growth and spread includes miR-520b sequence for inhibiting cancer growth and spread wherein the miR-520b sequence is...
2017/0283807 COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF PROSTATE CANCER
The invention provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating subjects having TMPRSS2:ERG...
2017/0283806 KRAS NUCLEIC ACIDS AND USES THEREOF
Disclosed herein are molecules and pharmaceutical compositions that mediate RNA interference against KRAS. Also described herein include methods for treating a...
2017/0283805 Antisense RNA for Treating Cancer and Inhibition of Metastasis and Vectors for Antisense Sequestration
Provided is the use of antisense RNA and methods for the treatment, diagnosis and prophylaxis of cancer comprising administering said antisense RNA,...
2017/0283804 ANTISENSE COMPOUNDS AND USES THEREOF
The present disclosure provides methods for sensitizing a cell for modulation by oligomeric compounds. Certain such oligomeric compounds are useful for...
2017/0283803 RNA INTERFERENCE COMPOSITIONS TARGETING HEAT SHOCK PROTEIN 90 AND METHODS OF USE THEREOF
This disclosure relates to RNA interference (RNAi) compositions that target expression of heat shock protein 90 (HSP90) in a subject. Polymeric delivery...
2017/0283802 DESIGN OF NUCLEIC ACID BINDING MOLECULES WITH NON-WATSON CRICK AND NON-CANONICAL PAIRING BASED ON ARTIFICIAL...
Universal nucleic acid binding molecules (e.g., antisense oligonucleotides or RNAi molecules) having an inhibitory or activating nucleic acid sequence which...
2017/0283801 THERAPEUTIC COMPOSITIONS
This application relates to therapeutic siRNA agents and methods of making and using the agents.
2017/0283800 DOWNREGULATING MIR-132 FOR THE TREATMENT OF LIPID RELATED DISORDERS
A method of treating a lipid-related disorder in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically...
2017/0283799 COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY
Improved compositions and methods for treating muscular dystrophy by administering antisense molecules capable of binding to a selected target site in the...
2017/0283798 TTV MIRNA SEQUENCES AS AN EARLY MARKER FOR THE FUTURE DEVELOPMENT OF CANCER AND AS A TARGET FOR CANCER...
Described are TTV miRNAs and probes and primers comprising part of said TTV miRNA polynucleic acid. The use of said compounds for diagnosis of cancer or...
2017/0283797 Compositions and methods relating to synthetic RNA polynucleotides created from synthetic DNA oligonucleotides
Compositions and methods are provided for forming a single RNA polynucleotide from a plurality of DNA oligonucleotides in a single reaction chamber using...
2017/0283796 GENE EXPRESSION ANALYSIS METHOD USING TWO DIMENSIONAL cDNA LIBRARY
The present invention provides a method and/or means for collecting and analyzing an individual cell in a tissue, and at the same time, quantitatively...
2017/0283795 PHOSPHATIDYLINOSITOL-3-KINASE NUCLEIC ACIDS AND USES THEREOF
Disclosed herein are molecules and pharmaceutical compositions that mediate RNA interference against PI3K. Also described herein include methods for treating a...
2017/0283794 METHODS FOR SELECTING AND AMPLIFYING POLYNUCLEOTIDES
The invention provides methods for generating a nucleic acid library. Target-specific primer-probes are hybridized to a target nucleic acid fragment to create...
2017/0283793 DNA SEQUENCE AND A MUTATOR INSERTION SEQUENCE FOR INCREASING MUTATION RATE
The invention relates to a DNA sequence for increase of a mutation rate over a specific region of DNA. Particularly, the invention provides a unique guanine...
2017/0283792 Nucleic Acid Purification Cartridge
A microfluidic device is disclosed having an enclosed chamber containing a filter for purifying biological or chemical analytes from a complex biological...
2017/0283791 NUCLEIC ACID-BINDING SOLID-PHASE CARRIER AND NUCLEIC ACID EXTRACTION METHOD
A nucleic acid-binding solid-phase carrier includes a magnetic particle of an amorphous metal containing Fe, Cr, Si, and B, and a silicon oxide film provided...
2017/0283790 Sample Processing Methods
A method of processing a sample may include introducing a sample into a vessel, the vessel having proximal and distal ends, the sample being introduced into...
2017/0283789 METHODS FOR COLLECTING CERVICAL-VAGINAL FLUIDS AND ISOLATING EXOSOME AND MICROVESICLES FOR MOLECULAR ANALYSIS
The present disclosure relates to methods of collecting cervical-vaginal fluid exosomes and microvesicles and isolating corresponding mRNA. In particular,...
2017/0283788 EXTRACTION OF cfDNA FROM BIOLOGICAL SAMPLES
Focused acoustic treatment of samples including a target biomolecule, such as cfDNA, may aid in the recovery of the biomolecule from a sample. cfDNA in a...
2017/0283787 METHOD FOR NON-ENZYMATIC COMBINATION OF NUCLEIC ACID CHAINS
Provided, as a technique for binding a nucleic acid chain and a nucleic acid chain by a natural structure or an analogous structure thereto, is a non-enzymatic...
2017/0283786 METHOD FOR PREPARING KAOLIN IMMOBILIZED GY2B BACTERIA AND APPLICATION THEREOF
Provided are a method for preparing kaolin immobilized GY2B bacteria and use thereof.
2017/0283785 SMALL ENZYME-CONTAINING GRANULES
The invention provides small enzyme-containing granules having an inorganic salt core and an enzyme-containing layer coated over the core, and methods for...
2017/0283784 IMPROVED NITRILE HYDRATASE
Provided is a novel improved nitrile hydratase with improved resistance to amide compounds under high temperatures. Specifically provided is a nitrile...
2017/0283783 HUMAN BETA-ADRENERGIC RECEPTOR KINASE POLYPEPTIDE AND METHODS
Various embodiments of the invention provide human kinases and phosphatases (KPP) polypeptides and polynucleotides which identify and encode KPP. Embodiments...
2017/0283782 TRPV1 MODULATORY GENE PRODUCT THAT AFFECTS TRPV1-SPECIFIC PAIN BEHAVIORAL RESPONSES IDENTIFIED IN A FUNCTIONAL...
The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by...
2017/0283781 BIOCATALYSTS AND METHODS FOR SYNTHESIZING DERIVATIVES OF TRYPTAMINE AND TRYPTAMINE ANALOGS
The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host...
2017/0283780 FATTY ACID DESATURASES FROM PRIMULA
The invention relates generally to methods and compositions concerning desaturase enzymes that modulate the number and location of double bonds in long chain...
2017/0283779 BACTERIOPHAGE ENGINEERING METHODS
The present disclosure provides methods and kits for generating recombinant bacteriophage genomes.
2017/0283778 ARTIFICIAL PERITONEAL TISSUE AND METHOD FOR PRODUCING SAME
The present disclosure relates to: an artificial peritoneal tissue comprising a cellular tissue and a mesothelial cell layer that covers the surface of the...
2017/0283777 MAMMALIAN CHIMERIC COMPLEMENTATION
Disclosed herein are chimeric mammals, such as a chimeric mammal comprising cells derived from at least a first mammal and a second mammal, wherein the cells...
2017/0283776 REPROGRAMMING CELLS
The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a...
2017/0283775 Compositions and Methods for Treatment of Cancer
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified...
2017/0283774 METHODS FOR EFFICIENT DERIVATION OF HUMAN MOTOR NEURONS FROM DIVERSE SPINAL REGIONS
Described herein are chemically defined, adherent culture protocols for generating functional motor neurons characteristic of diverse hindbrain and spinal cord...
2017/0283773 METHODS FOR IMPROVING PROLIFERATION AND STEMNESS OF LIMBAL STEM CELLS
Provided are methods for improving the proliferation and sternness of limbal stem cells (LSCs) by adding a Wnt inhibitor to a medium for limbal explant...
2017/0283772 METHODS FOR DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS TO BRAIN MICROVASCULAR ENDOTHELIAL CELLS
Methods for generating functional brain microvascular endothelial cells (BMECs) under chemically defined, serum-free conditions are provided. In particular,...
2017/0283771 Methods of in vitro Oocyte Development
Methods of preparing ovarian tissue for primordial follicle growth are presented comprising the steps: providing an ovarian tissue sample comprising cortical...
2017/0283770 DOWNREGULATION OF SINE/ALU RETROTRANSPOSON TRANSCRIPTION TO INDUCE OR RESTORE PROLIFERATIVE CAPACITY AND/OR...
In certain embodiments methods are provided for inducing and/or restoring and/or maintaining a non-senescent phenotype, or aspects thereof (e.g., proliferative...
2017/0283769 Modified Cells Evoking Reduced Immunogenic Responses
The present disclosure describes composition, methods, and systems associated with a genetically modified stem cell. The modified stem cell includes a reduced...
2017/0283768 METHOD FOR INDUCING THREE-DIMENSIONAL OSTEOGENIC DIFFERENTIATION OF STEM CELLS USING HYDROGEL
The present invention relates to a method for inducing osteogenic differentiation of mesenchymal stem cells and, more particularly, to a short-time osteogenic...
2017/0283767 THREE-DIMENSIONAL CELL CULTURE SYSTEM AND CELL CULTURE METHOD USING SAME
The present invention relates to a composition for preserving cells and a cell preservation method and, more specifically: to a composition for preserving...
2017/0283766 METHOD FOR FABRICATION OF MICROWELLS FOR CONTROLLED FORMATION OF 3-DIMENSIONAL MULTICELLULAR-SHAPES
Using 3D printing, a microwell is formed by providing a plurality of masks, each mask representing a cross-section of a layer of the concave structure....
2017/0283765 Partial Adaption for Butanol Production
Provided herein are processes for producing an improved culture of cells comprising an engineered butanol biosynthetic pathway. The processes comprise (a)...
2017/0283764 PROCESSING OF PLANT MATERIAL INTO BACTERIAL FEEDSTOCK
Methods and compositions relating to processing of plant material into bacterial feedstock, such as bacterial feedstock suitable for nanocellulose production,...
2017/0283763 METHODS AND SYSTEM FOR INTERFERING WITH VIABILITY OF BACTERIA AND RELATED COMPOUNDS AND COMPOSITIONS
Provided herein are methods and systems for interfering with viability of bacteria and related compounds and compositions.
2017/0283762 METHOD OF ISOLATING PROBIOTICS OF HUMAN INTESTINE
A method of isolating probiotics of human intestine, including preparing bases for culturing liquid and solid mucoproteins; and filtering, which includes...
2017/0283761 System, Device and Method for Electroporation of Cells
A system, device and method for electroporation of living cells and the introduction of selected molecules into the cells utilizes a fluidic system where...
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