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Patent # Description
2017/0283456 PROTEIN LABELING WITH CYANOBENZOTHIAZOLE CONJUGATES
The invention provides compounds and methods for site-specifically labeling proteins with cyanobenzothiazole derivatives of formula I. For example, the...
2017/0283455 STABLE TOPICAL PHAMACEUTICAL COMPOSITIONS OF HALOBETASOL PROPIONATE
The present invention provides a stable topical pharmaceutical composition of halobetasol propionate. The present invention discloses an impurity of compound...
2017/0283454 COMPOSITIONS COMPRISING CYCLIC PURINE DINUCLEOTIDES HAVING DEFINED STEREOCHEMISTRIES AND METHODS FOR THEIR...
It is an object of the present invention to provide novel and highly active cyclic-di-nucleotide (CDN) immune stimulators that activates DCs via a recently...
2017/0283453 COFACTOR ANALOGUES FOR METHYLTRANSFERASES
Cofactor analogues for methyltransferases are disclosed. The compounds are represented by formula (I) wherein R1 is COOH or COO--; X is an organic or inorganic...
2017/0283452 N-ALKYL 2-(DISUBSTITUTED)ALKYNYLADENOSINE-5-URONAMIDES AS A2A AGONISTS
The present invention provides N-alkyl 2-(disubstituted)alkynyladenosine-5'-uronamides and derivatives thereof and pharmaceutical compositions containing the...
2017/0283451 DNA SEQUENCING BY SYNTHESIS USING RAMA AND IFRARED SPECTROSCOPY DETECTION
This invention provides a process of labeling a polynucleotide analogue to be detected by Raman and/or infrared spectroscopy detection.
2017/0283450 TRITERPENE SAPONINS, METHODS OF SYNTHESIS AND USES THEREOF
The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent...
2017/0283449 STEVIA EXTRACTS
A Stevia extract made from leaves of the Stevia rebaudiana plant is described. The extract has desired levels of steviol glycosides and is useful in food,...
2017/0283448 METHOD FOR MANUFACTURING LIGNIN DEGRADATION PRODUCT
Provided is a method for producing a lignin degradation product that includes (1) a degradation step of degrading a raw material containing a plant biomass, in...
2017/0283447 RUTHENIUM COMPLEXES AND THEIR USES AS CATALYSTS IN PROCESSES FOR FORMATION AND/OR HYDROGENATION OF ESTERS,...
The present invention relates to novel Ruthenium complexes of formulae A1-A4 and their use, inter alia, for (1) dehydrogenative coupling of alcohols to esters;...
2017/0283446 SOLUBLE C5aR ANTAGONISTS
Compounds are provided to modulate the C5a receptor. The compounds have the following Formula (I): ##STR00001## including stereoisomers and pharmaceutically...
2017/0283445 Small Molecule Inhibitors Selective For Polo-Like Kinase Proteins
Disclosed are small molecule PLK inhibitors that can target the polo box domain (PBD). Inhibitors can have an atomic mass of about 1000 Da or less and a...
2017/0283444 STERICALLY HINDERED AMINE AND OXYALKYL AMINE LIGHT STABILIZERS
Compounds having hindered amine and oxyalkyl amine light stabilizers can mitigate the adverse effects of actinic radiation, such as visible and ultraviolet...
2017/0283443 FLUOROSILICON NITRILE COMPOUNDS
Novel fluorosilicon nitrile compounds, and methods of preparing them, are described. The fluorosilicon nitrile compounds are characterized by having a total of...
2017/0283442 Methods and Compositions for Improved F-18 Labeling of Proteins, Peptides and Other Molecules
The present application discloses compositions and methods of synthesis and use of .sup.18F- or .sup.19F-labeled molecules of use in PET, SPECT and/or MR...
2017/0283441 PRODUCTION METHOD FOR 2-FLUORO-4-BORONO-L-PHENYLALANINE, AND PRECURSOR OF 2-FLUORO-4-BORONO-L-PHENYLALANINE
The present invention involves preparing compounds represented by the following formula: ##STR00001## from a compound of the following formula: ##STR00002## ...
2017/0283440 CARM1 INHIBITORS AND USES THEREOF
Provided herein are compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X, R.sup.1,...
2017/0283439 PROBES FOR IMAGING HUNTINGTIN PROTEIN
Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use. ##STR00001##
2017/0283438 SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLE CARBOXAMIDE COMPOUNDS
Disclosed are compounds of Formula (I) ##STR00001## wherein: the two dotted lines represent either two single or two double bonds; Q is: ##STR00002## R.sub.1...
2017/0283437 Inhibitors of UDP-Galactopyranose Mutase
Compounds and salts thereof which inhibit microbial growth or attenuate the virulence of pathogenic microorganisms and which inhibit UDP-galactopyranose mutase...
2017/0283436 PROBES FOR IMAGING HUNTINGTIN PROTEIN
Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use. ##STR00001##
2017/0283435 MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS
Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R.sup.2, R.sup.2a, R.sup.3, R.sup.3a, and Z are as...
2017/0283434 NK1 ANTAGONISTS
A NK.sub.1 antagonist having the formula (I), ##STR00001## wherein Ar.sup.1 and Ar.sup.2 are optionally substituted phenyl or heteroaryl, X.sup.1 is an ether,...
2017/0283433 PHARMACEUTICAL FORMULATIONS CONTAINING 3-(4-CINNAMYL-L-PIPERAZINYL) AMINO DERIVATIVES OF 3-FORMYLRIFAMYCIN SV...
The present invention related to a process of preparation of pharmaceutically acceptable formulations containing as active substance ...
2017/0283431 INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHOD OF THEIR USE
The present disclosure is directed to compounds of formula I' and methods of their use and preparation, as well as compositions comprising compounds of formula...
2017/0283430 INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHOD OF THEIR USE
The present disclosure is directed to compounds of Formula (I) and methods of their use and preparation, as well as compositions comprising compounds of...
2017/0283429 COMPOUNDS FOR THE TREATMENT OF PARAMYXOVIRUS VIRAL INFECTIONS
Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of...
2017/0283428 METHOD FOR EXTRACTING HIGH-PURITY ASARININ BY SUPERCRITICAL CARBON DIOXIDE EXTRACTION METHOD AND USE THEREOF
The invention discloses a method for extracting high-purity asarinin and use thereof. The method comprises: putting crude asarum powder in an SFE-CO.sub.2...
2017/0283427 COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF
The present invention relates to compounds, and pharmaceutically acceptable compositions thereof, useful as inhibitors of cyclophilins, and for the treatment...
2017/0283426 COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF
The present invention relates to compounds, and pharmaceutically acceptable compositions thereof, useful as inhibitors of cyclophilins, and for the treatment...
2017/0283425 COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF
The present invention relates to compounds, and pharmaceutically acceptable compositions thereof, useful as inhibitors of cyclophilins, and for the treatment...
2017/0283424 PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS
A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2 and R.sup.3 are defined...
2017/0283423 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described, wherein the compounds...
2017/0283422 PYRIMIDO-DIAZEPINONE COMPOUNDS AND METHODS OF TREATING DISORDERS
The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), LRKK2,...
2017/0283421 SUBSTITUTED N-(PYRROLIDINE-3-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE-4-AMINE AS JANUS KINASE INHIBITOR
A novel substituted N-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine and a use thereof as a Janus kinase (JAK) inhibitor are provided.
2017/0283420 INDOLINE ANALOGS AND USES THEREOF
Indoline derivative compounds that act as EWS-FLI1 transcription factor inhibitors are provided. Also provided are pharmaceutical compositions of the indoline...
2017/0283419 PURINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
The present invention relates to purine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
2017/0283418 SOLID FORMS OF (1S,4S)-4-(2-(((3S,4R)-3-FLUOROTETRAHYDRO-2H-PYRAN-4-YL)AMINO)-8-((2,4,6-- ...
Provided herein are formulations, solid forms and methods of use relating to (1s,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4- ,...
2017/0283417 ORGANIC COMPOUNDS
The invention relates to particular substituted heterocycle fused gamma-carbolines, their prodrugs, in free, pharmaceutically acceptable salt and/or...
2017/0283416 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The...
2017/0283415 PROCESS FOR PRODUCING DIAZABICYCLOOCTANE DERIVATIVE
A process for producing a compound represented by a Formula (III), including reacting a compound of the following formula ##STR00001## with a compound selected...
2017/0283414 TETRAHYDROPYRIDOPYRAZINES MODULATORS OF GPR6
The present invention provides compounds of formula I: ##STR00001## which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for...
2017/0283413 CANCER TREATMENT UTILIZING SP-141 TO BIND WITH MDM2 AND ACT AS AN INHIBITOR OF MDM2 EXPRESSION
An SP-141 compound is a novel small molecule that can serve as a molecular-targeted chemotherapeutic agent. In one embodiment, the labeled compound can...
2017/0283412 SUBSTITUTED OXOPYRIDINE DERIVATIVES
The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of...
2017/0283411 Optically Active a-Trifluoromethyl-B-Amino Acid Derivative Production Method
A method for producing an optically active .alpha.-trifluoromethyl-.beta.-amino acid derivative, the method including: allowing a compound represented by the...
2017/0283410 FUSED HETEROCYCLIC COMPOUNDS AS GPR120 AGONISTS
The present invention relates to fused heterocyclic compound of Formula (I), a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a pharmaceutically...
2017/0283409 SUBSTITUTED THIAZOLE OR OXAZOLE P2X7 RECEPTOR ANTAGONISTS
The present invention refers to novel substituted thiazole and oxazole compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties: ...
2017/0283408 BENZO-HETEROCYCLIC COMPOUNDS AND THEIR APPLICATIONS
The present invention relates to benzoxazole derivatives having the following Formula (I): ##STR00001## The compounds of the present invention are found to...
2017/0283407 TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS
A compound of formula (I) wherein: R.sup.1 is optionally one or more halo or methyl groups; R.sup.2a and R.sup.2b are independently selected from the group...
2017/0283406 HETEROCYCLIC COMPOUND
The present invention provides a compound having an MAGL inhibitory action, and useful as an agent for the prophylaxis or treatment of neurodegenerative...
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