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Patent # Description
2017/0291958 Compositions and Methods For the Modulation of Ras Proteins
Described herein is a method of modulating sumoylation of a Ras protein by small ubiquitin-like modifier (SUMO) proteins. Provided herein is a method for...
2017/0291957 USE OF ERBB3 INHIBITORS IN THE TREATMENT OF TRIPLE NEGATIVE AND BASAL-LIKE BREAST CANCERS
Provided are methods of suppressing growth of triple negative breast tumors and basal-like breast tumors by contacting tumor cells with an ErbB3 inhibitor,...
2017/0291956 HER3 Inhibition in Low-grade Serous Ovarian Cancers
Methods of treatment of cancer are provided. In particular, methods of treatment of low-grade serous ovarian cancers by inhibiting signaling of an EGFR family...
2017/0291955 BISPECIFIC HER2 ANTIBODIES
The present invention relates to anti-HER2 binding molecules (e.g., antibodies and antigen binding fragments thereof), derived HER2-binding molecules (e.g.,...
2017/0291954 Glypican-3 Antibody And Uses Thereof
The present invention relates to compositions and methods of isolated polynucleotides that encode or polypeptides comprising glypican-3 (GPC3). The invention...
2017/0291953 CAR EXPRESSION VECTOR AND CAR-EXPRESSING T CELLS
An object of the present invention is to provide CAR-expressing T cells that coexpress a chimeric antigen receptor (CAR) and a T cell immune function-enhancing...
2017/0291952 Carrier-Binding Agent Compositions and Methods of Making and Using the Same
Described herein are compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic. Also...
2017/0291951 ANTI-LIGHT ANTIBODIES
The present invention relates to anti-human LIGHT antibodies, new medical uses and methods.
2017/0291950 METHOD FOR TREATING MULTILOCULATED HYDROCEPHALUS BY ADMINISTERING AN ANTI-IL6 RECEPTOR ANTIBODY
The invention is directed to a method of treating multiloculated hydrocephalus comprising administering to a subject who is suffering from multiloculated...
2017/0291949 Antibody Therapeutics That Bind CD123
There is disclosed compositions and methods relating to or derived from anti-CD123 antibodies. More specifically, there is disclosed fully human antibodies...
2017/0291948 ANTIBODY BINDING TO NEUROPILIN 1 AND USE THEREOF
The present disclosure relates to an antibody binding to Neuropilin 1 (NRP1) or an antigen-binding fragment thereof, a nucleic acid encoding the same, a vector...
2017/0291947 NEUTRALIZATION OF INHIBITORY PATHWAYS IN LYMPHOCYTES
The present invention relates to methods for the treatment, prevention and diagnostic of diseases using compounds that specifically bind and inhibit human...
2017/0291946 MODULATION OF STIMULATORY AND NON-STIMULATORY MYELOID CELLS
Provided herein are methods and compositions for enhancing an immune response and/or for the treatment of an immune-related condition in an individual, e.g.,...
2017/0291945 TARGETING ANEURYSM DISEASE BY MODULATING PHAGOCYTOSIS PATHWAYS
In the methods of the invention, an agent that increases phagocytosis and/or efferocytosis of cellular components of coronary plaque is administered to the...
2017/0291944 JAM-C ANTIBODIES AND METHODS FOR TREATMENT OF CANCER
A novel method to reduce B-cell lymphoma cell migration to and engraftment of the spleen in patients with JAM-C positive B-cell lymphomas is described. In...
2017/0291943 ANTI-INTERFERON GAMMA ANTIBODIES AND METHODS OF USE THEREOF
The invention relates to fully human antibodies, and fragments thereof, that bind to human interferon gamma (hIFN.gamma.), thereby modulating the interaction...
2017/0291942 Treatment of Depression Using Agents that Block Binding of IL-6 to IL-6 Receptor
A method for treating depression or fatigue in a subject comprises administering an agent that blocks binding of IL-6 to IL-6 receptor, for example, an...
2017/0291941 DIAGNOSTIC METHOD FOR DETERMINING THE PRESENCE AND AMOUNT OF HUMAN INTERLEUKIN-3 IN A SAMPLE USING NOVEL IL-3...
For determining the presence and amount of human interleukin 3 (IL-3) in a sample, the present invention provides a diagnostic method, wherein an ...
2017/0291940 IL-17A/F HETEROLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF
The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F...
2017/0291939 ANTIBODIES SPECIFIC FOR IL-17A FUSED TO HYALURONAN BINDING PEPTIDE TAGS
The present disclosure relates to antibodies and proteins comprising an antigen-binding portion thereof that specifically bind to the pro-inflammatory cytokine...
2017/0291938 PRODUCTION CELL LINE ENHANCERS
The present invention relates to discovery of the ectopic expression of EDEM2 in a production cell to improve the yield of a useful multi-subunit protein....
2017/0291937 Methods for Treating Hyperlipidemia with an ANGPTL8 Inhibitor and an ANGPTL3 Inhibitor
The present invention provides methods for treating patients suffering from hyperlipidaemia, wherein the patient is non-responsive to, inadequately controlled...
2017/0291936 ANTIBODY LIGHT CHAINS
The present invention relates to methods for improving biophysical properties, including the stability of antibody lambda light chains, to antibody lambda...
2017/0291935 METHODS FOR TREATING EYE DISORDERS
Disclosed herein are compositions and methods for increasing visual acuity in patients in need thereof and for treating vascular disorders of the eye.
2017/0291934 IMPROVED THERAPEUTIC CONTROL OF HETERODIMERIC AND SINGLE CHAIN FORMS OF INTERLEUKIN-12
The present invention relates to modified forms of IL-12. These modified forms of IL-12 may be engineered to have a shortened in vivo half-life compared and/or...
2017/0291933 BMPRII POLYPEPTIDES AND USES THEREOF
In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of bone...
2017/0291932 OSTEOGENIC BIOMATERIAL
A composition for enhancing bone tissue repair or regeneration is described. The composition includes osteoactivin or an active peptide fragment thereof and a...
2017/0291931 FGF2 TRUNCATIONS AND MUTANTS AND USES THEREOF
The present disclosure provides FGF2 mutant proteins, such as those having an N-terminal deletion, point mutation(s), or combinations thereof, which can reduce...
2017/0291930 Histatin-5 Based Synthetic Peptides and Uses Thereof
Provided herein are synthetic peptides or synthetic fragments thereof based on a Histatin-5 peptide, for example with a sequence DSHAKRHHGYKRKFHEKHHSHRGY (SEQ...
2017/0291929 Growth Differentiation Factor 15 (GDF-15) Polypeptides
GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15,...
2017/0291928 LECTINS AND USES THEREOF
Provided herein are chemical compounds, methods for their discovery, and their therapeutic and research use. Further provided herein are antiviral and...
2017/0291927 GENE REGULATING BIN2 FUNCTION AND TRANSGENIC PLANT TRANSFORMED BY THE GENE
The present invention relates to a gene that regulates BIN2 function and a transgenic plant into which the gene is introduced. When the gene of the present...
2017/0291926 Method of Preparing Functional Peptides from Germinated Beans
The present invention discloses a method of preparing a functional peptide from a germinated bean, including the steps of: germinating a bean until a sprout...
2017/0291925 MODIFIED VIP3 POLYPEPTIDES
The present invention is directed to vegetative insecticidal proteins (Vips) modified to comprise heterologous carbohydrate binding modules and methods of use...
2017/0291924 HYPERSENSITIVE RESPONSE ELICITOR-DERIVED PEPTIDES AND USE THEREOF
Disclosed are hypersensitive-response eliciting peptides and non-hypersensitive response eliciting peptides that induce active plant responses, and that...
2017/0291923 ANTIBACTERIAL CYCLIC LIPOPEPTIDES
Described are design and generation of a set of novel cyclic lipopeptides as potential antibacterial agents. New daptomycin analogues are generated by chemical...
2017/0291922 DELTA RECEPTOR AGONIST PEPTIDES AND USE THEREOF
Peptides effective as delta opioid receptor agonists and compositions comprising same are provided. Further provided are methods for targeting medical...
2017/0291921 CYCLIC PEPTIDE DERIVATIVE, METHOD FOR PREPARING SAME AND COMPOSITION THEREOF
Provided is a cyclic peptide derivative which is derived from Paecilomyces tenuipes having an astrocyte proliferative activity, or a salt thereof.
2017/0291920 NITRIC OXIDE DONATING CARNOSINE COMPOUNDS
The present invention relates to nitric oxide donor carnosine derivatives having a great efficacy in reducing elevated intraocular pressure, to processes for...
2017/0291919 Soluble Intein Fusion Proteins And Methods For Purifying Biomolecules
The present invention relates to fusion proteins comprising an N-intein polypeptide and an N-intein solubilization partner, and affinity chromatography...
2017/0291918 METHOD FOR PURIFYING PROTEIN
Disclosed is a method for purifying a protein, comprising steps of: preparing a sample containing a fusion protein containing an amino acid sequence of a...
2017/0291917 KINASE INHIBITORS
There are provided compounds of formula I, ##STR00001## wherein T, A, Q, Z, G, R.sup.4, R.sup.5a, R.sup.5b and n have meanings given in the description, which...
2017/0291916 COORDINATION COMPOUNDS HAVING REDOX NON-INNOCENT LIGANDS AND FLOW BATTERIES CONTAINING THE SAME
Electrolyte solutions for flow batteries and other electrochemical systems can contain an active material capable of transferring more than one electron per...
2017/0291915 CARBOSILANE SUBSTITUTED AMINE PRECURSORS FOR DEPOSITION OF Si-CONTAINING FILMS AND METHODS THEREOF
Disclosed are Si-containing film forming compositions comprising carbosilane substituted amine precursors. The carbosilane substituted amine precursors have...
2017/0291914 ESTER-MODIFIED ORGANOSILICON-BASED SURFACTANTS, METHODS OF MAKING SAME AND APPLICATIONS CONTAINING THE SAME
There is provided herein a polyalkylene-oxide-free surfactant composition comprising an ester-modified organosilicon having the general formula (I) ...
2017/0291912 PROCESS FOR PREPARING A ZIRCONIUM-BASED METAL ORGANIC FRAMEWORK
There is provided a process for preparing a zirconium-based metal organic framework (Zr-MOF), the process comprising the steps (i) preparing a reaction mixture...
2017/0291911 Ataxia Telengiectasia And RAD3-Related (ATR) Inhibitors And Methods Of Their Use
The disclosure is directed to compounds and compositions that inhibit Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase and methods of their use.
2017/0291910 NOVEL COMPOUNDS AS GPR119 AGONISTS
The present invention relates to novel compounds of formula (I) as GPR119 agonist, composition compositions containing such compounds and method of preparation...
2017/0291909 Prodrugs of 2,4-Pyrimidinediamine Compounds and Their Uses
The present disclosure provides prodrugs of biologically active 2,4-pyrimidinediamine compounds, compositions comprising the prodrugs, intermediates and...
2017/0291908 SUBSTITUTED BENZOTHIOPHENYL DERIVATIVES AS GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are...
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