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Patent # Description
2017/0291907 Thienopyrimidine Compounds
Compounds of formula (I) are A.sub.2B receptor antagonists: ##STR00001## Wherein R.sub.1 is optionally substituted aryl or an optionally substituted 5- or...
2017/0291906 COMPOUNDS FROM RENEWABLE RESOURCES
Compounds of formula III: ##STR00001## and salts thereof are disclosed. Also disclosed are methods for preparing compounds of formula III, intermediates useful...
2017/0291905 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF
Described herein are compounds of Formula (S-I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein...
2017/0291904 COMPOUNDS AND METHODS
The subject matter generally relates to compounds and methods of treatment and/or prophylaxis of CNS diseases, disorders, and/or injuries. In one aspect, the...
2017/0291903 Imidazopyrazinones as PDE1 Inhibitors
The present invention provides imidazopyrazinones as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative...
2017/0291902 sGC STIMULATORS
The present patent application discloses at least the compounds according to Formula I' shown below, or pharmaceutically acceptable salts thereof, ##STR00001## ...
2017/0291901 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-ones as PDE1 Inhibitors
The present invention provides 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-ones of formula (I) as PDE1 ...
2017/0291900 FLUORINATED INTEGRIN ANTAGONISTS
The present invention relates to fluorinated compounds of formula I and methods of synthesizing these compounds. The present invention also relates to...
2017/0291899 NAPHTHYRIDINE DERIVATIVES AS ALPHA V BETA 6 INTEGRIN ANTAGONISTS FOR THE TREATMENT OF E.G. FIBROTIC DISEASES
A compound of formula (I) or a salt thereof: ##STR00001## wherein R.sub.1 represents a five-membered aromatic heterocycle selected from a N- or a C-linked mono-...
2017/0291898 LIFE-EXTENDING AGENT, LIFE EXTENSION METHOD USING THE LIFE-EXTENDING AGENT, NOVEL DUAL OXIDASE ACTIVATOR,...
The present invention provides a life-extending agent comprising pyrroloquinoline quinone and/or a derivative of the pyrroloquinoline quinone.
2017/0291897 THERAPEUTIC COMPOUNDS AS INHIBITORS OF THE OREXIN-1 RECEPTOR
The present invention relates to compounds that are inhibitors of the orexin-1 receptor. The compounds have the structural formula I defined herein. The...
2017/0291896 PYRAZOLO[3,4-C]PYRIDINE DERIVATIVES
Disclosed are a compound of formula (I), a tautomer, an optical isomer or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition...
2017/0291895 GLS1 INHIBITORS FOR TREATING DISEASE
Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: ...
2017/0291894 NOVEL GPR119 AGONIST COMPOUNDS
The present invention relates to novel compounds of formula (I), process for preparation of the same and composition comprising these compounds. ##STR00001##
2017/0291893 PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS AND METHODS OF USE THEREOF
The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with...
2017/0291892 SUBSTITUTED OXOPYRIDINE DERIVATIVES
The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of...
2017/0291891 SUBSTITUTED PYRIDINE-PIPERAZINYL ANALOGUES AS RSV ANTIVIRAL COMPOUNDS
The invention concerns novel substituted pyridine-piperazinyl analogues of formula (I) having antiviral activity, in particular, having an inhibitory activity...
2017/0291890 HETEROCYCLE SUBSTITUTED AMINO-PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF
The present disclosure relates to heterocycle substituted amino-pyridine compounds. The present disclosure also relates to pharmaceutical compositions...
2017/0291889 PYRAZOLE DERIVATIVES AS SGC STIMULATORS
Compounds are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for...
2017/0291888 1,2,4-TRIAZINE-4-AMINE DERIVATIVES
According to the invention there is provided a compound of formula A1 which may be useful in the treatment of a condition or disorder ameliorated by the...
2017/0291887 PYRIMIDINES FOR TREATMENT OF BACTERIAL INFECTIONS
Filamenting temperature-sensitive mutant Z (FtsZ) protein plays a crucial role in the bacterial cell division machinery and is a validated drug target for...
2017/0291886 METHODS FOR TREATING PROTOZOAN INFECTIONS
The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of...
2017/0291885 METHOD FOR PREPARING ENAMIDE COMPOUND AND RUTHENIUM COMPLEX CATALYST USED THEREIN
Provided is a method for preparing an enamide compound, which includes reacting an organic azide compound having .alpha.-hydrogen and an anhydride by addition...
2017/0291884 HIGH-COVERAGE, LOW ODER MALODOR COUNTERACTANT COMPOUNDS AND METHODS OF USE
The present invention relates to novel compounds and their use as malodor counteractant materials.
2017/0291883 SALT OF DICARBOXYLIC ACID COMPOUND
It is an object of the present invention to provide a medicament for preventing or treating hyperphosphatemia. The solution is crystals, or hydrate thereof, of...
2017/0291882 Solid Forms of Mirabegron
Solid forms of Mirabegron, including forms APO-I, APO-II, and various salt forms, and processes for the preparation thereof, are provided.
2017/0291881 EFFICIENT AND SCALABLE SYNTHESIS OF 2-(1'H-INDOLE-3'-CARBONYL)-THIAZOLE-4-CARBOXYLIC ACID METHYL ESTER AND ...
Methods of synthesizing 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) and structural analogs thereof. The methods include...
2017/0291880 PROCESS FOR THE PREPARATION OF TOLTRAZURIL AND AN INTERMEDIATE USEFUL FOR ITS PREPARATION
Disclosed is a process for the preparation of toltrazuril of formula (I) via the intermediate ...
2017/0291879 Cancer Cell Growth Inhibitor, Anticancer Agent, and Method for Screening Same, as well as Novel Compound
A cancer cell proliferation inhibitor including at least one selected from compounds represented by Structural Formulae (1) to (8), wherein the cancer cell is...
2017/0291878 METHOD FOR PRODUCING OPTICALLY ACTIVE VALERIC ACID DERIVATIVE
A method for producing a compound (3), which comprises allowing a compound (1) to react with hydrogen gas in an inert solvent, in the presence of a specific...
2017/0291877 ANTIMICROBIAL IMIDAZOLIUM COMPOUNDS
The present invention relates to antimicrobial imidazolium compounds having the structure of Formula (I) wherein R is an optionally substituted aliphatic group...
2017/0291876 ASYMMETRICALLY CATALYZED SYNTHESIS METHOD OF NITROPYRAZOLE AMIDE COMPOUND
A synthesis method of .gamma.-nitropyrazole amide compound through asymmetrical catalyzing technique is provided, a nitroalkane and an ...
2017/0291875 QUINOLONES AS INHIBITORS OF CLASS IV BROMODOMAIN PROTEINS
The present invention provides compounds of formula (I) as described herein and pharmaceutically acceptable salts, hydrates and solvates thereof for use in...
2017/0291874 Process for the Manufacture of Idalopirdine via Hydrogenation of an Imine
The present invention relates to the preparation of N-(2-(6-fluoro-1H-indol-3-yl)-ethyl)-3-(2,2,3,3-tetrafluoropropoxy)-benzy- lamine (Compound I), INN-name...
2017/0291873 Beta-Mercaptoethanol Synthesis
A process includes reacting, in a reactor having a fixed bed containing a solid catalyst which contains a heterogeneous ion exchange resin, hydrogen sulfide...
2017/0291872 Mixed Decyl Mercaptans Compositions and Methods of Making Same
Compositions comprising branched C.sub.10 mercaptans selected from the group consisting of 5-methyl-1-mercapto-nonane, 3-propyl-1-mercapto-heptane,...
2017/0291871 2,2' -DIAMINOBIARYLS HAVING ONE PRIMARY AND ONE SECONDARY AMINE
Novel 2,2'-diaminobiaryls having one primary and one secondary amine and an electrochemical process for preparation thereof.
2017/0291870 SURFACTANT-CONTAINING AMIDE COMPOUND SOLUTION
The present invention relates to an amide compound solution comprising an amide compound and a surfactant. More specifically, the invention relates to an amide...
2017/0291869 EXHAUST GAS CLEANING IN A METHOD FOR CONTINUOUSLY PRODUCING DINITROTOLUENE
The invention relates to a method for producing dinitrotoluene, comprising the following steps: a) nitrating toluene with a mixture of nitric acid and sulfuric...
2017/0291868 Diesters for Personal Care Applications Derived from 1-Methylheptyl Alcohol
The invention includes a diester exhibiting improved hydrolytic stability that is an esterification product of a 1-methylheptyl alcohol and a dicarboxylic...
2017/0291867 Improved Process for Hydrogenation of Benzenepolycarboxylic Acids and Derivatives Thereof
A process for ring hydrogenation of a benzenepolycarboxylic acid or derivative thereof, includes contacting a feed stream comprising the acid or derivative...
2017/0291866 Production of Mixed Aldol Products from the Products of Hydroformylation Reactions
A method for producing mixed aldol products from the products of hydroformylation reactions. In one embodiment, the method comprises mixing hydroformylation...
2017/0291865 POLYFLUOROALKYL ALLYL COMPOUND AND METHOD FOR PRODUCING THE SAME
A polyfluoroalkyl allyl compound represented by the general formula: CF.sub.3(CF.sub.2).sub.n(CH.sub.2CF.sub.2).sub.a(CF.sub.2CF.sub.2).sub.b- ...
2017/0291864 Production of Isobutylene, Isoamylene, or Alkylates from Mixed Alkanes
A method includes brominating a butanes feed stream including i-butane in a bromination reactor to form a bromination effluent stream including t-butyl...
2017/0291863 METHOD FOR PRODUCING OLEFIN CONTAINING CHLORINE AND FLUORINE
A method for producing at least one olefin compound selected from the group consisting of a compound of formula (51) and a compound of formula (52), the method...
2017/0291862 METHOD FOR PRODUCING OLEFIN
A method for producing at least one olefin compound selected from the group consisting of a compound of formula (51), a compound of formula (52), a compound of...
2017/0291860 METHANE CONVERSION APPARATUS AND PROCESS USING A SUPERSONIC FLOW REACTOR
Apparatus and methods are provided for converting methane in a feed stream to acetylene. A hydrocarbon stream is introduced into a supersonic reactor and...
2017/0291859 METHOD FOR THE PRODUCTION OF BUTADIENE AND HYDROGEN FROM ETHANOL IN TWO LOW-WATER AND LOW-ENERGY-CONSUMPTION...
The invention concerns a process for the production of butadiene from an ethanol feed comprising at least 80% by weight of ethanol, comprising at least one...
2017/0291858 LIGHTWEIGHT ASSEMBLABLE APPLIANCE WITH PLIANT EXOSKELETAL SUPPORT RESPECTIVE KIT-OF-PARTS AND METHOD FOR...
An assemblable appliance and method of recycling organic waste into biogas and liquid fertilizer, implementing essentially anaerobic digestion processes, is...
2017/0291857 Fermented Soil Additive
A soil additive comprising a sugar ferment wherein said ferment contains signalling molecules comprising between about 1-50% of the organic matter present in...
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