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Patent # Description
2017/0327833 TAL-MEDIATED TRANSFER DNA INSERTION
The invention relates to methods for stably integrating a desired polynucleotide into a plant genome, comprising transforming plant material with a first...
2017/0327832 HAPLOID INDUCERS
The present invention relates to the provision of technical means such as nucleic acids which, after transcription or after expression in a plant, are suitable...
2017/0327831 HIGHLY EFFICIENT ETHANOL-FERMENTATIVE YEAST
An object of the present invention is to obtain a fermentative yeast having a highly efficient ethanol production without introducing a foreign gene. A further...
2017/0327830 ATTENUATED LIVE BACTERIA WITH INCREASED ACID RESISTANCE AND METHODS OF USE THEREOF
The present invention relates to inducing acid resistance in a bacterium and methods of increasing the acid resistance of an acid sensitive bacterium.
2017/0327829 Organic Compositions to Treat Beta-ENaC-Related Diseases
The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1...
2017/0327828 TREATMENT OF PAR4 RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO PAR4
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of PAR4, in particular, by targeting natural...
2017/0327827 ADIPOCYTE-SPECIFIC CONSTRUCTS AND METHODS FOR INHIBITING PLATELET-TYPE 12 LIPOXYGENASE EXPRESSION
The present invention is directed to constructs, compositions and methods for modulating platelet-type 12 lipoxygenase (12-LO) in adipose tissue in vivo....
2017/0327826 NEUTRAL NUCLEIC ACID LIGANDS
The invention generally relates to isolated nucleic acid ligands that are neutral under physiological conditions.
2017/0327825 DECOY OLIGONUCLEOTIDES FOR THE TREATMENT OF DISEASES
An isolated oligonucleotide comprising ribonucleotides is disclosed. The oligonucleotide comprises a nucleic acid sequence which encodes at least one copy of a...
2017/0327824 SELECTIVE ANTISENSE COMPOUNDS AND USES THEREOF
The present invention provides oligomeric compounds. Certain such oligomeric compounds are useful for hybridizing to a complementary nucleic acid, including...
2017/0327823 Selective Reactivation of Genes on the Inactive X Chromosome
Methods and compositions for selectively reactivating genes on the inactive X chromosome (Xi) in a locus-specific manner, e.g., genes associated with X-linked...
2017/0327822 RNA INTERFERENCE MEDIATING SMALL RNA MOLECULES
Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi)....
2017/0327821 OLIGONUCLEOTIDES FOR GENOMIC DNA EDITING
A method for making a change in an endogenous chromosomal DNA sequence of a mammalian cell, comprising steps of: (i) introducing into said cell an ...
2017/0327820 Compositions And Methods Of Nucleic Acid-Targeting Nucleic Acids
This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof.
2017/0327819 DE NOVO SYNTHESIZED GENE LIBRARIES
De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building...
2017/0327818 THERMOSTABLE REVERSE TRANSCRIPTASE
Embodiments of the disclosure concern methods and compositions related to generation and/or use of proofreading reverse transcriptases, including those that...
2017/0327817 SURFACE DISPLAY OF WHOLE ANTIBODIES IN EUKARYOTES
Methods for display of recombinant whole immunoglobulins or immunoglobulin libraries on the surface of eukaryote host cells, including yeast and filamentous...
2017/0327816 MOBILE DEVICE FOR ISOLATION OF NUCLEIC ACIDS
The invention relates to a mobile device system, comprising a hand-held device and a test kit for the mobile isolation of nucleic acids. The hand-held device...
2017/0327815 PROTEIN-BASED SAMPLE COLLECTION MATRICES AND DEVICES
Provided herein are methods and compositions to effectively isolate nucleic acids using protein-based sample collection matrices.
2017/0327814 DEVICE AND METHOD FOR INDUCING PLURIPOTENT CELLS USING ENERGY
The present invention relates to a device and a method for inducing pluripotent cells using energy and, more specifically, has an effect of inducing new type...
2017/0327813 3D Printable Hydrogel Materials
Hydrogel compositions including a polymer uniformly embedded with a loading agent are provided. Also provided are methods for extrusion printing hydrogel...
2017/0327812 MODIFIED BETA-LACTAMASES AND METHODS AND USES RELATED THERETO
The present invention relates to pharmaceuticals and modified beta-lactamases. Specifically, the invention relates to novel recombinant beta-lactamases and...
2017/0327811 PROCESS AND SYSTEM FOR OBTAINING BOTULINUM NEUROTOXIN
Rapid, animal protein free, chromatographic processes and systems for obtaining high potency, high yield botulinum neurotoxin for research, therapeutic and...
2017/0327810 FUSION PROTEINS AND METHODS FOR TREATING, PREVENTING OR AMELIORATING PAIN
A single chain polypeptide fusion protein, comprising: a non-cytotoxic protease capable of cleaving a protein of the exocytic fusion apparatus of a nociceptive...
2017/0327809 POLYPEPTIDES HAVING XYLANASE ACTIVITY WITH A HIGH CONVERSION RATE OF XYLOSE - CONTAINING POLYSACCHARIDES
The present application provides novel polypeptides having xylanase activity and the respective nucleic acid sequences encoding those polypeptides as well as...
2017/0327808 Polypeptides having Lysozyme Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having lysozyme activity and polynucleotides encoding the polypeptides. The invention also relates to...
2017/0327807 METHODS FOR RECOMBINANT EXPRESSION OF BETA-GLUCOSIDASE GENE
Provided is a method for recombinant expression of .beta.-glucosidase gene. Also provided is a recombinant expression vector comprising: (a) a coding sequence...
2017/0327806 Engineered CRISPR-Cas9 nucleases with Altered PAM Specificity
Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
2017/0327805 Using RNA-guided FokI Nucleases (RFNs) to Increase Specificity for RNA-Guided Genome Editing
Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
2017/0327804 Engineered CRISPR-Cas9 nucleases with Altered PAM Specificity
Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
2017/0327803 HCV NS3 RECOMBINANT ANTIGENS AND MUTANTS THEREOF FOR IMPROVED ANTIBODY DETECTION
The present disclosure relates to polypeptides, including fusions thereof, nucleic acids, vectors, host cells, immunodiagnostic reagents, kits, and...
2017/0327802 Anti-Inflammatory Peptides and Composition Comprising the Same
The present invention relates to a peptide with anti-inflammatory activity, wherein the peptide comprises any one amino acid sequence of SEQ ID NO: 1 to SEQ ID...
2017/0327801 RECOMBINANT POLYMERASES FOR IMPROVED SINGLE MOLECULE SEQUENCING
Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that...
2017/0327800 METHODS AND COMPOSITIONS FOR TREATING INEFFECTIVE ERYTHROPOIESIS
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including...
2017/0327799 Enhanced Production of Fatty Acid Derivatives
Genetically engineered cells and microorganisms are provided that produce fatty alcohols from the fatty acid biosynthetic pathway, as well as methods of their...
2017/0327798 MUTATED ENZYME HAVING DEHYDROGENASE ACTIVITY AND USE THEREOF
The object is to provide a novel enzyme exhibiting cholesterol dehydrogenase activity. Provided is a mutant enzyme having an amino acid sequence of a...
2017/0327797 RECOMBINANT HBV CCCDNA, THE METHOD TO GENERATE THEREOF AND THE USE THEREOF
The present invention relates to a recombinant HBV cccDNA comprising HBV genome or the fragment or variant thereof and a site-hybrid insert, a method to...
2017/0327796 INDUCED PLURIPOTENT STEM CELL AND METHOD FOR PRODUCING THE SAME
The disclosure provides an episome comprising OCT4, KLF4, SOX2, cMYC, NANOG, LIN28, and NRSA2. Also disclosed is a method for producing an induced pluripotent...
2017/0327795 Immune-compatible cells created by nuclease-mediated editing of genes encoding HLA
The present invention relates to a method for producing immune-compatible cells or a cell population which comprises a step of editing one or two alleles of...
2017/0327794 Method for Treating Diabetes and Other Glucose Regulation Disorders Using Stem Cells
Various embodiments of the invention provide methods of treating diabetes and other glucose regulation disorders. In one embodiment, the method comprises...
2017/0327793 DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS
The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present...
2017/0327792 STEM CELLS & DECELLULARIZED TISSUE MATRIX FROM CORD TISSUE
Methods and products obtained from the method for isolating and culturing mixed populations of stem cells, making decellularized tissue matrix, making...
2017/0327791 MUSCULAR DYSTROPHY THERAPEUTIC AGENT CONTAINING PLURIPOTENT STEM CELLS DERIVED FROM DENTAL PULP
Disclosed are a therapeutic agent for muscular dystrophy employing pluripotent stem cells obtained from dental pulp and a method for preparation thereof. The...
2017/0327790 METHOD OF PREPARING AUTOLOGOUS CELLS AND METHODS OF USE FOR THERAPY
A method for expanding mesenchymal cells derived from autologous bone marrow in autologous culture medium which can be used in a clinical setting, and a...
2017/0327789 Modulation of Dopamine Receptor to Promote Neural Cell Differentiation
A method of promoting neural stem cell differentiation is provided comprising exposing neural stem cells to a dopamine D.sub.4 receptor antagonist.
2017/0327788 COMPOSITION FOR COLLECTING AND PRESERVING PLACENTAL STEM CELLS AND METHODS OF USING THE COMPOSITION
The present invention provides improved compositions and methods for the collection of stem cells from an organ, e.g., placenta. The invention provides a stem...
2017/0327787 NEW UNDIFFERENTIATED STEM CELL REMOVAL AND MYOCARDIAL PURIFICATION AND REFINEMENT CULTURE MEDIUM
The present invention has as its object to find out new conditions that make it possible to induce cell death of non-cardiomyocytes or undifferentiated stem...
2017/0327786 Hypotaurine, GABA, Beta-Alanine, and Choline for Control of Waste Byproduct Accumulation in Mammalian Cell...
The present invention pertains to a cell culture medium comprising hypotaurine, GABA, and/or beta-alanine or the combination of choline and hypotaurine, GABA,...
2017/0327785 PROCESS FOR ENHANCING THE VIABLE COUNTS OF LACTIC ACID BACTERIA AND USEFUL COMPOSITIONS THEREOF
Disclosed herein is a composition containing turmeric starch for use as a prebiotic plant fiber. Also disclosed is a method to increase the viable counts of...
2017/0327784 ISOLATED STRAIN OF CLONOSTACHYS ROSEA FOR USE AS A BIOLOGICAL CONTROL AGENT
Described is an isolated strain of the fungus Colonostachys rosea termed BVT Cr-7 useful as a biological control agent for the treatment of plants. The...
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