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Patent # Description
2017/0355690 HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS
The present invention provides heterocyclic compounds, the stereoisomer thereof, the enantiomer thereof, or the pharmaceutically acceptable salt, which are...
2017/0355689 HEPATITIS C VIRUS INHIBITOR
The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical...
2017/0355688 Processes for the Preparation of Tasimelteon and Intermediates Thereof
The present invention provides processes for the preparation of Tasimelteon (1), as well as processes for the preparation of intermediates of Formulas (2), (3)...
2017/0355687 ANTIBACTERIAL BENZOTHIAZOLE DERIVATIVES
The invention relates to antibacterial compounds formula I ##STR00001## wherein R.sup.1 is the group M, whereby M is one of the groups M.sup.A and M.sup.B...
2017/0355686 NOVEL OXAZOLE COMPOUNDS AS BETA CATENIN MODULATORS AND USES THEREOF
Oxazole compounds according to formula I: ##STR00001## are provided as inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool...
2017/0355685 FXR (NR1H4) MODULATING COMPOUNDS
The present disclosure relates generally to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The disclosure further relates to the...
2017/0355684 CRYSTALLINE ISOXAZOLE HYDROXAMIC ACID COMPOUNDS
This invention pertains to a crystalline compound of Formula (A) as described herein and compositions containing this crystalline compound, as well as methods...
2017/0355683 QUINAZOLINE HETEROCYCLIC COMPOUND AS EGFR KINASE INHIBITOR AND PREPARATION AND APPLICATION THEREOF
The present invention relates to an N-substituted-phenyl-5-substituted-alkoxy-2,3-dihydro-[1,4]dioxane[2,3-f]- quinazolin-10-amine (I) or ...
2017/0355682 METHOD OF PREPARING A HIGH PURITY IMIDAZOLIUM SALT
The present invention encompasses a novel method for synthesizing highly pure salts of the general formula Q.sup.+A.sup.-, wherein the starting materials are...
2017/0355681 PROCESS FOR PURIFYING AN IONIC LIQUID
The invention relates to a process for purifying an ionic liquid comprising dialkylimidazolium ions by means of stripping, wherein water vapour is used at a...
2017/0355680 METHOD OF PREPARING A HIGH PURITY IMIDAZOLIUM SALT
The present invention encompasses a novel method for synthesizing highly pure salts of the general formula Q.sup.+A.sup.-, wherein Q.sup.+ is: ##STR00001## and...
2017/0355679 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES
The application relates to 2-amino-4-(substituted amino)phenyl carbamate derivatives, or pharmaceutically acceptable salts or solvates thereof, as KCNQ2/3...
2017/0355678 C-Met Modulators and Methods of Use
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation,...
2017/0355677 SYNTHESIS OF 2-CARBOXAMIDE CYCLOAMINO UREA DERIVATIVES
Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates...
2017/0355676 USE OF TETRAHYDROPYRIDINES IN THE TREATMENT OF SODIUM CHANNEL RELATED DISEASE AND DISORDERS
The present invention provides a method of treating one or more sodium channel related diseases or disorders in an individual, including related symptoms. The...
2017/0355675 SULFUR-CONTAINING COMPOUNDS TARGETING VESICULAR ACETYLCHOLINE TRANSPORTER
The present invention generally relates to various compounds that are useful as vesicular acetylcholine transporter (VAChT) ligands. The invention further...
2017/0355674 PROCESS FOR PRODUCING 2-(2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL)PROPANE-1,3-DIAMINE
A process for producing 2-(2,2,6,6-tetramethylpiperidin-4-yl)propane-1,3-diamine by A) reacting triacetonamine (TAA) and malononitrile to afford the...
2017/0355673 TRICYCLIC ATROPISOMER COMPOUNDS
Disclosed are compounds of Formula (I): or a salt thereof, wherein Q is: or; and X, R.sub.1a, R.sub.1b, R.sub.3, R.sub.4, and R.sub.5 are defined herein. Also...
2017/0355672 POLYFUNCTIONAL COMPOUNDS
The present invention relates to a an imide compound according to anyone of formulas Ia, Ib, Ic, or Ie wherein R1 is H or a C1-C20 optionally substituted...
2017/0355671 PERIPHERALLY SUBSTITUTED MONOCYCLIC BETA-LACTAMS
The invention provides monobactams that can be used as antibacterial agents or intermediates for the preparation of other useful compounds such as...
2017/0355670 PROCESS FOR THE PREPARATION OF 1-(2,6,6-TRIMETHYLCYCLOHEXYL)-ALKAN-3-OLS
The present invention relates to a process for the preparation of 1-(2,6,6-trimethylcyclohexylyalkan-3-ols, in particular ...
2017/0355669 COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS
The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the...
2017/0355668 METHODS FOR TREATING ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
The invention is directed to a method of treating attention-deficit/hyperactivity disorder (ADHD) in a subject, comprising administering a therapeutically...
2017/0355667 PROPYL CATIONIC PEPTIDE LIPIDS, SYNTHESIS METHOD THEREOF, AND APPLICATION THEREOF
A class of propyl cationic peptide lipids is propyl cationic peptide lipid compounds having a general formula structure as follows. After the propyl cationic...
2017/0355666 POLYMORPHS OF CDDO ETHYL ESTER AND USES THEREOF
The present invention relates to polymorphic forms of the compound of Formula I (i.e., ethyl 2-cyano-3,12-dioxokana-1,9(11)-dien-28-oate (CDDO ethyl ester))...
2017/0355665 (2S,4R)-5-(5'-CHLORO-2'-FLUOROBIPHENYL-4-YL)-4-(ETHOXYOXALYLAMINO)-2-HYDRO- XYMETHYL-2-METHYLPENTANOIC ACID
In one aspect, the invention relates to a compound of the structure: ##STR00001## or a pharmaceutically acceptable salt thereof, and a crystalline form of this...
2017/0355664 NEPRILYSIN INHIBITORS
In one aspect, the invention relates to compounds having the formula XII: ##STR00001## where R.sup.a, R.sup.b, R.sup.2, R.sup.7, and X are as defined in the ...
2017/0355663 NEURO-ATTENUATING KETAMINE AND NORKETAMINE COMPOUNDS, DERIVATIVES THEREOF, AND METHODS
The present invention is directed to novel neuro-attentuating norketamine (NANKET) compounds according to any one of formulas (I-shown below), (I-A) and...
2017/0355662 2-(3-(AMINOMETHYL)-3,5,5-TRIMETHYLCYCLOHEXYL)PROPANE-1,3-DIAMINE, A PROCESS FOR ITS PRODUCTION AND USE
A compound of the structural formula 1 ##STR00001## Also disclosed is a process for producing 2-(3-(aminomethyl)-3,5,5-trimethylcyclohexyl)propane-1,3-diamine by...
2017/0355661 2-(3,3,5-TRIMETHYLCYCLOHEXYL)PROPANE-1,3-DIAMINE, A PROCESS FOR ITS PRODUCTION AND USE
A diamine 2-(3,3,5-trimethylcyclohexyl)propane-1,3-diamine of formula 1 ##STR00001## and a process for producing ...
2017/0355660 MULTIFUNCTIONAL ACRYLIC ETHER-ESTER PRODUCTS MODIFIED WITH CARBOXYLIC ANHYDRIDE OR ITS POLYACID FORM, PROCESS...
The invention relates to a multifunctional acrylic product having a number-average functionality f of acrylate groups greater than 2.1, which is the product of...
2017/0355659 CARBONATE ESTER PURIFICATION METHOD, CARBONATE ESTER SOLUTION PRODUCTION METHOD, AND CARBONATE ESTER...
Provided is a carbonate ester purification apparatus including a treatment part for mixing a first solution containing a carbonate ester and an acidic...
2017/0355658 CO2-MEDIATED ETHERIFICATION OF BIO-BASED DIOLS
A method of etherifying glycols or other diols by employing renewable reagents is disclosed. In particular, the method involves contacting a diol with an...
2017/0355657 Device and process for producing undecylenic acid methyl ester using methyl ricinoleate as raw material
A device and a process for producing undecylenic acid methyl ester using methyl ricinoleate as raw material are provided. The device comprises a feed pump, a...
2017/0355656 HYDROFORMYLATION PROCESS
Catalytic metal loss when using a hydroformylation catalyst comprising an organophosphite ligand is ameliorated by adding CO to a strip gas vaporizer.
2017/0355655 PROCESS FOR LIQUID-LIQUID EXTRACTION OF A BLEND OF NON-UNIFORM OLIGOMERS AND POLYMERS
A process for liquid-liquid extraction of an oil-blend of non-uniform oligomeric and polymeric components comprising: (a) preselecting a desired molecular...
2017/0355654 HYDROCARBON GAS PROCESSING
A process and an apparatus are disclosed for a compact processing assembly to remove C.sub.5 and heavier hydrocarbon components from a hydrocarbon gas stream....
2017/0355653 HYDROCARBON PROCESSING
A process and an apparatus are disclosed for a compact processing assembly to fractionate lighter components from mixed hydrocarbon streams. The hydrocarbon...
2017/0355652 METHODS OF PREPARING OLIGOMERS OF AN OLEFIN
Methods of preparing oligomers of an olefin are provided. The methods can include providing a composition that includes an alkylaluminum compound, a chromium...
2017/0355651 OLIGOMERIZATION OF ETHENE IN SUPERCRITICAL MODE
The invention is concerned with the oligomerization of supercritical ethene. An essential aspect of the invention is that of mixing ethene with an inert medium...
2017/0355650 Process for Preparing Olefins by Dehydrating Alcohols with Less Side Effects Comprising Addition of Sulfur...
The present invention is a process for dehydrating an alcohol to prepare a corresponding olefin, comprising: (a) providing a composition (A) comprising at...
2017/0355649 ZEOLITIC CATALYTIC CONVERSION OF ALCOHOLS TO HYDROCARBON FRACTIONS WITH REDUCED GASEOUS HYDROCARBON CONTENT
A method for converting an alcohol to a hydrocarbon fraction reduced in gaseous hydrocarbon content, the method comprising: (i) contacting said alcohol with a...
2017/0355648 SYNTHESIS OF META-SUBSTITUTED [18F]-3-FLUORO-4-AMINOPYRIDINES BY DIRECT RADIOFLUORINATION OF PYRIDINE N-OXIDES
Disclosed herein are methods for the fluorination aromatic N-heterocyclic N-oxides that comprise at least one leaving group. The N-oxides may be reduced to the...
2017/0355647 REACTIVE MATERIALS
The invention relates to high density reactive materials, preferably materials with a high density and exothermic output There is provided a high density reactive...
2017/0355646 METHOD FOR PREPARING HYDRAULIC COMPOSITION
A hydraulic composition is prepared by mixing (A) an admixture aqueous solution containing a water-soluble salt which is a water-reducing agent or setting...
2017/0355645 HONEYCOMB STRUCTURE
The honeycomb structure body has a dense part at a part in axial direction including a center region of the inflow end face, the dense part having a change...
2017/0355644 METHOD OF PREPARING A MULTIMODAL CUBIC BORON NITRIDE POWDER
Multi-step milling processes to prepare cBN composite powder forms a first powder mixture by adding a binder and a first cBN component, mills the first powder...
2017/0355643 GLASS CERAMIC COMPOSITE ELECTROLYTE FOR LOW TEMPERATURE SOLID OXIDE FUEL CELL
The present disclosure provides a glass ceramic composite electrolyte comprising gadolinium doped ceria and glass composite with desired ionic conductivity in...
2017/0355642 MONO- AND BISALKYLENETRIALKOXYSILANE DISPERSANTS FOR HYDRAULIC BINDERS
The present invention relates to mono- and bisalkylenetrialkoxysilanes of the general formula (I), ##STR00001## in which: --Y-- is --O-- or...
2017/0355641 NOVEL HYDRAULIC BINDER AND HYDRAULIC COMPOSITION COMPRISING SAME
A hydraulic binder which includes a clinker with a specific shape, the clinker including as main phases, given as weight percentages relative to the total...
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