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Patent # Description
2017/0362336 Membrane Transporter NaPi2b (SCL34A2) Epitope for Antibody Therapy, Antibodies Directed Thereto, and Target for...
The present invention relates generally to the membrane transporter NaPi2b (SLC34A2) as a target for therapy, including immunotherapy, and particularly cancer...
2017/0362335 TEM-1 DIAGNOSTIC ANTIBODIES
Described herein are anybodies, and antigen-binding fragments thereof, that are specific for tumor endothelial marker 1 (TEM-1), related polynucleotides,...
2017/0362334 ANTIBODIES COMPRISING SITE-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, METHODS OF THEIR PREPARATION AND METHODS...
Provided herein are antibodies comprising non-natural amino acid residues at site-specific positions, compositions comprising the antibodies, methods of their...
2017/0362333 Antibodies Reactive with B7-H3, Immunologically Active Fragments Thereof and Uses Thereof
The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and...
2017/0362332 CD47 TARGETED THERAPIES FOR THE TREATMENT OF INFECTIOUS DISEASE
Methods are provided for treating a subject with for an intracellular pathogen infection, by administering an agent that reduces the binding of CD47 on a...
2017/0362331 CD6 ANTIBODY FOR TREATMENT OF T-CELL MEDIATED DISEASES OR DISORDERS
A method of treating a T-cell mediated disease in a subject by administering to the subject a therapeutically effective amount of an antibody or fragment...
2017/0362330 MACROPINOCYTOSING HUMAN ANTI-CD46 ANTIBODIES AND TARGETED CANCER THERAPEUTICS
In various embodiments human anti-CD46 antibodies that are internalizing and enter tumor cells via the macropinocytosis pathway are provided, as well as...
2017/0362329 HUMAN TNFRSF25 ANTIBODY
Antibodies and antigen binding fragments that bind specifically to TNFRSF25 are provided herein. Methods for using the antibodies and antigen binding fragments...
2017/0362328 METHOD OF TREATMENT OF PHILADELPHIA CHROMOSOME POSITIVE LEUKEMIA
The invention provides a method for the treatment of Ph+ leukemia in a patient comprising administering to the patient (i) a BCR-ABL tyrosine kinase inhibitor,...
2017/0362327 ANTI-TRKA ANTIBODIES WITH ENHANCED INHIBITORY PROPERTIES AND DERIVATIVES THEREOF FOR USE IN TREATING BONE...
The present invention relates to antibodies directed against TrkA receptor and their uses, including humanized anti-TrkA antibodies and methods of treatment...
2017/0362326 Compositions and Methods of Use for Therapeutic Low Density Lipoprotein-related protein 6 (LRP6) Antibodies
The present invention relates to antibodies targeting LRP6 and compositions and methods of use thereof.
2017/0362325 USE OF BLOCKING-REAGENTS FOR REDUCING UNSPECIFIC T CELL-ACTIVATION
The present invention relates to a blocking-reagent for use in reducing unspecific T cell activation in T cell engaging therapies. The present invention...
2017/0362324 HUMANIZED ANTI-ALPHA V BETA 5 ANTIBODIES AND USES THEREOF
Humanized antibodies and antibody fragments that bind to .alpha.v.beta.5 are disclosed. Also disclosed are methods of using the disclosed antibodies and...
2017/0362323 HETERODIMER PROTEIN COMPOSITION
According to the present invention, a heterodimer protein composition that is composed of a first polypeptide comprising an immunoglobulin heavy chain constant...
2017/0362322 NOVEL ANTI-B7H3 BINDING COMPOUNDS AND USES THEREOF
The invention is directed to novel antibody binding compounds specific for the human B7H3 and uses of such compounds for diagnostic and therapeutic purposes.
2017/0362321 ANTIBODIES AND IMMUNOCYTOKINES
The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines...
2017/0362320 CANCER THERAPY TARGETING INTERCELLULAR ADHESION MOLECULE 4 (ICAM4)
Methods for treating cancer, e.g., in conjunction with anti-cancer therapy, like immunotherapy, and for identifying candidate therapeutic agents, by targeting...
2017/0362319 POTENCY ASSAYS FOR ANTIBODY DRUG SUBSTANCE BINDING TO AN FC RECEPTOR
The invention relates to a method of characterizing an antibody, which method is suitable as a potency assay for batch release of a pharmaceutical composition...
2017/0362318 COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR HEMATOPOIETIC ORIGIN
The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those...
2017/0362317 USES OF ANTIBODIES TO INTERLEUKIN-6 IN CANCER TREATMENT
The present disclosure provides antibodies that bind to human interleukin-6 (IL6). The antibodies can modulate IL6 signaling and thus used in treatment or...
2017/0362316 Human Anti-IL-23 Antibodies, Compositions, Methods and Uses
A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making...
2017/0362315 Pan-ELR+ CXC CHEMOKINE ANTIBODIES
Antibodies are provided that specifically bind seven human ELR+ CXC chemokines. The antibodies of the invention are useful for treating various...
2017/0362314 Anti-CXCL12 Antibody Molecules and Their Uses
Anti-CXCL12 antibody molecules and their uses are disclosed, and in particular anti-CXCL12 antibody molecules that are capable of inhibiting a biological...
2017/0362313 USE OF BINDING MOLECULE SPECIFICALLY BINDING TO PRECURSOR OF BRAIN-DERIVED NEUROTROPHIC FACTOR
Disclosed herein is use of a binding molecule which specifically binds to a precursor of brain-derived neurotrophic factor (proBDNF). The binding molecule for...
2017/0362312 Sodium Pump Antibody Agonists And Methods Of Treating Heart Disease Using The Same
Antibodies that are agonists of sodium pump (Na.sup.+/K.sup.+ ATPase; NKA) activity are provided. In particular, antibodies that specifically bind epitopes on...
2017/0362311 METHODS AND COMPOSITIONS FOR REGULATING IRON HOMEOSTASIS BY MODULATION OF BMP-6
Modulation of iron homeostasis by regulating BMP-6 activity is provided. Methods of using BMP-6 and BMP-6 protein-specific reagents, such as antibodies, for...
2017/0362310 VHH BASED BINDING ANTIBODIES FOR ANTHRAX AND BOTULINUM TOXINS AND METHODS OF MAKING AND USING THEREFOR
Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent, methods, compositions and kits having...
2017/0362309 Nucleotide Sequences, Vectors and Host Cells
The present invention relates to fusion proteins comprising fragments from toxin A and/or toxin B of Clostridium difficile, wherein the polypeptide elicits...
2017/0362308 Immunogen adherence and method of making and using same
A microbial adherence inhibitor in the form of fowl egg antibodies is disclosed, along with the method of making it and methods of using it. The inhibitor...
2017/0362307 ENGINEERED MICROBE-TARGETING MOLECULES AND USES THEREOF
Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the...
2017/0362306 METHOD FOR PREPARING NOVEL ANTIBODY LIBRARY AND LIBRARY PREPARED THEREBY
The present invention relates to a method for preparing a novel antibody library and a library prepared thereby. The antibody library prepared according to the...
2017/0362305 SANDWICH ASSAY DESIGN FOR SMALL MOLECULES
Methods are disclosed of designing antibodies for a sandwich assay for a small molecule having a molecular weight of about 500 to about 2,000. The method...
2017/0362304 METHOD FOR MEASURING VISCOSITY OF PROTEIN SOLUTION
The inventors discovered that viscosity of a protein solution can be estimated by measuring the apparent particle size or apparent molecular weight by a small...
2017/0362303 NOVEL COMPOUNDS FOR THE TREATMENT OF CANCER
The technology provided herein relates to novel isolated polypeptides and peptides having a growth inhibitory effect on human cancer cells. Nucleic acid...
2017/0362302 Method and Pharmaceutical Composition for Use in the Treatment of Cancer
The present invention relates to a soluble peptide comprising the amino acids sequence: KRFYVVMWKK (SEQ ID NO: 1) or a function-conservative variant thereof...
2017/0362301 Cysteine Engineered Fibronectin Type III Domain Binding Molecules
Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared...
2017/0362300 OLIGOPEPTIDE-FREE CELL CULTURE MEDIA
The present invention relates to oligopeptide-free cell culture media comprising at least 0.5 mg/L of a polyamine and to methods for cultivating cells in said...
2017/0362299 Soluble Universal ADCC-Enhancing Synthetic Fusion Gene and Peptide Technology and Its Use Thereof
Novel synthetic biology-based ADCC technologies are provided that enhance or enable ADCC responses, for example, through a rationally-designed soluble...
2017/0362298 ENHANCED AFFINITY T CELL RECEPTORS AND METHODS FOR MAKING THE SAME
The present disclosure provides methods for generating enhanced affinity T cell receptors by agonist selection of hematopoietic progenitor cells expressing an...
2017/0362297 CHIMERIC ANTIGEN RECEPTORS AND METHODS OF USE THEREOF
The present invention provides chimeric antigen receptors, cells expressing same and methods of using same for treatment various disorders such as cancer.
2017/0362296 PEPTIDES BASED ON THE TRANSMEMBRANE DOMAIN OF A TOLL-LIKE RECEPTOR (TLR) FOR TREATMENT OF TLR-MEDIATED DISEASES
Peptides are provided that are capable of inhibiting cell activation mediated by a Toll-like receptor (TLR) selected from TLR 1, 2, 4 or 6, said peptide...
2017/0362295 USE OF ICOS-BASED CARS TO ENHANCE ANTITUMOR ACTIVITY AND CAR PERSISTENCE
The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a genetically modified Th17 cell...
2017/0362294 Methods for Protein and Peptide Reduction
Methods and systems are provided herein for on-line preparation of a sample for mass spectrometry. In accordance with various aspects of applicant's teachings,...
2017/0362293 FUSION POLYPEPTIDE CONTAINING GLP AND IMMUNOGLOBULIN HYBRID FC AND USE THEREOF
The present invention relates to a fusion polypeptide containing a glucagon-like peptide (GLP) and an immunoglobulin hybrid Fc, and more specifically, to a...
2017/0362291 Methods of Improving Yield in Recombinant Protein Production
Methods of enhancing production of cytokines such as IL-10 by, for example, optimizing refolding conditions, are described. The methods provide an efficient,...
2017/0362290 IL-17A-BINDING POLYPEPTIDES
The present disclosure relates to a class of engineered polypeptides having a binding affinity for interleukin-17A (IL-17A), and provides an IL-17A binding...
2017/0362289 SYNTHETIC FOLDABLE PROTEINS GENERATED FROM PEPTIDE SEGMENTS OF FOLDING NUCLEI OF REFERENCE PROTEINS
A method of making a synthetic foldable having a tertiary structure emulating the tertiary structure of a reference foldable protein is described. The method...
2017/0362288 COLON AND PANCREAS CANCER PEPTIDOMIMETICS
The invention relates to a peptidomimetic of an NPC-1 epitope on the MUC5AC protein which is differentially expressed in pancreatic and colorectal cancer, and...
2017/0362287 GPC3 EPITOPE PEPTIDES FOR TH1 CELLS AND VACCINES CONTAINING THE SAME
Isolated GPC3-derived epitope peptides having Th1 cell inducibility are disclosed herein. Such peptides can be recognized by MHC class II molecules and induce...
2017/0362286 NOVEL POTASSIUM CHANNEL BLOCKERS AND USE THEREOF IN THE TREATMENT OF AUTOIMMUNE DISEASES
Novel analogues of the sea anemone Stichodactyla helianthus toxin ShK, and their use as, for example, therapeutic agents for treating autoimmune diseases are...
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