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Patent # Description
2017/0362285 METHODS FOR TUNING CAROTENOID PRODUCTION LEVELS AND COMPOSITIONS IN RHODOSPORIDIUM AND RHODOTORULA GENERA
The present invention relates to the field of fungal biotechnology, more particularly to genetic engineering methods for the production of carotenoids in...
2017/0362284 Tuberculosis Compositions And Methods Of Treating Or Preventing Tuberculosis
The present disclosure provides fusion proteins comprising Mycobacterium tuberculosis (Mtb) antigens, nucleic acid molecules encoding the same, vectors...
2017/0362283 NISIN-BASED COMPOUNDS AND USE THEREOF IN THE TREATMENT OF BACTERIAL INFECTIONS
The invention relates to new antimicrobial compounds derived from nisin. In particular, the compounds are based on the unsubstituted nisin [1-12] structure,...
2017/0362282 ENGINEERED PROGRAMMABLE MOLECULAR SCAFFOLDS FROM POROUS PROTEIN CRYSTALS
The present disclosure provides compositions and methods for preparing engineered porous protein crystals comprising at least one guest molecule.
2017/0362281 MUTANT NQ-RHODOPSIN KR 2
The invention relates to mutant NQ-Rhodopsin having potassium pumping properties, nucleic acid constructs encoding same, expression vectors carrying the...
2017/0362280 HIV VACCINE FORMULATION
Immunogenic compositions containing a human immunodeficiency virus (HIV) gp140 protein, sorbitol, polysorbate 20, and histidine buffer are described. The...
2017/0362279 VLP WITH A FUSION PROTEIN
The disclosure relates to a fusion protein comprising a VP1 binding protein and an exogenous peptide, wherein the exogenous peptide comprises a cargo-securing...
2017/0362278 MAMMALIAN CELLS EXPRESSING CYTOMEGALOVIRUS ANTIGENS
This invention relates to cytomegalovirus (CMV) proteins suitable for vaccine uses. Provided herein are mammalian host cells, in particular CHO cells, in which...
2017/0362277 CYCLOSPORINE ANALOGUE MIXTURES AND THEIR USE AS IMMUNOMODULATING AGENTS
The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced...
2017/0362276 MU OPIOID RECEPTOR AGONIST ANALOGS OF THE ENDOMORPHINS
The invention relates to cyclic peptide agonists that bind to the mu (morphine) opioid receptor and their use in the treatment of acute and/or chronic pain....
2017/0362275 Growth Hormone Releasing Peptides
Disclosed are peptide and peptidomimetic compounds generally according to formula (I) that are useful as GHRP analogs: ...
2017/0362274 PEPTIDES ENHANCING NEURONAL OUTGROWTH AND APPLICATION THEREOF
The present invention relates to peptides enhancing neuronal outgrowth, particularly to peptides that enhance neurite outgrowth and their application.
2017/0362273 CONTROL OF COPOLYMER COMPOSITIONS
Methods of making copolymers are described.
2017/0362272 PROTEIN MANUFACTURE
The present invention provides a novel method for protein manufacture wherein the protein is expressed in a host cell, and in a more specific manner relates to...
2017/0362271 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described.
2017/0362270 MODIFIED OLIGONUCLEOTIDES AND METHODS FOR THEIR SYNTHESIS
Modified oligonucleotides that contain one or more of the phosphate groups substituted at phosphorus and methods for their synthesis are disclosed.
2017/0362269 Novel Neisseria Gonorrhoeae Therapeutic Based on CMP-Nonulosonate Sugars
N. gonorrhoeae has become resistant to almost every conventional antibiotic. Described herein is the use of CMP-nonulosonate analogues to counter gonococcal...
2017/0362268 STEVIOL GLYCOSIDE COMPOUNDS, COMPOSITIONS FOR ORAL INGESTION OR USE, AND METHOD FOR ENHANCING STEVIOL GLYCOSIDE...
Novel steviol glycoside compounds characterized by a first group of four glucopyranose residues attached via the number 13 carbon (C13) of the steviol moiety...
2017/0362267 NON-CALORIC SWEETENERS AND METHODS FOR SYNTHESIZING
Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside...
2017/0362266 Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions
The present application provides methods of functionalizing an organ or tissue of a mammal by administering a nutrient (e.g., peracetylated N-azido...
2017/0362265 METHODS FOR MODULAR SYNTHESIS OF N-GLYCANS AND ARRAYS THEREOF
The present disclosure relates to novel modular methods for generating a diversity of N-glycans of high mannose, hybrid and complex types. The present...
2017/0362264 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
Novel phosphorescent tetradentate platinum compounds of Formula I are provided. The complexes contain a dibenzo moiety, which allows for the creation of OLED...
2017/0362263 PHOSPHORUS LIGANDS AND METHODS OF USE
In one embodiment, the application discloses ligands, such as a ligand from a dihydrobenzo[1,3] oxaphosphole scaffold, and palladium complexes comprising the...
2017/0362262 A PROCESS FOR PREPARING HALOGENATED AZAINDOLE COMPOUNDS USING PYBROP
A process for preparing halogenated azaindole compounds makes use of a brominating agent PyBroP, together with a dehydrating agent BSA to enhance the...
2017/0362261 Tizoxanide Phosphate and Alkane Sulfonate and Pharmaceutical Applications Thereof
The invention relates to tizoxanide phosphate or alkane sulfonate compounds represented by Formula I, and pharmaceutically acceptable salts thereof, isomers...
2017/0362260 NEPRILYSIN INHIBITORS
In one aspect, the invention relates to compounds having the formula X: ##STR00001## where R.sup.a, R.sup.b, R.sup.2, R.sup.7, and X are as defined in the ...
2017/0362259 PROCESS AND INTERMEDIATES FOR MAKING TUBULYSIN ANALOGS
An improved process for making a compound B of the structure ##STR00001## wherein n, R.sup.1, R.sup.2, and R.sup.3 are as defined in the specification. Compound...
2017/0362258 SILICONE SURFACTANTS FOR EMULSION ASSAYS
System, including methods and compositions, for making and using emulsions that include a silicone oil and a silicone surfactant. The emulsions may include...
2017/0362257 MULTIFUNCTIONAL SUPERHYDROPHOBIC PARTICLES FOR CHEMICAL ADHESION AND BLOOMING
Provided herein is a multifunctional particle and methods of forming the same. The multifunctional particle includes a surface of the particle; a first moiety...
2017/0362256 Microwave Assisted Alcohol Condensation on Oxide Surfaces
A method for forming a modified surface comprising (1) on a substrate is provided wherein a reactive groups on the surface is condensed with alcohols, thiols,...
2017/0362255 LIGAND-EXCHANGEABLE NANOPARTICLES AND METHODS OF MAKING THE SAME
An aspect of the present disclosure is a nanocrystal that includes a nanocrystal core and a ligand coordinated to a surface of the nanocrystal core, where the...
2017/0362254 MELAMPOMAGNOLIDE B DIMERS
The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These...
2017/0362253 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The...
2017/0362252 Spirocyclic Heterocycle Compounds Useful as HIV Integrase Inhibitors
The present invention relates to Spirocyclic Heterocycle Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, B, X, R.sup.1,...
2017/0362251 PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY
The instant application relates to deazapurines, thienopyrimidines and furopyrimidines with zinc-binding moiety based derivatives and their use in the...
2017/0362250 SHIP1 MODULATORS AND METHODS RELATED THERETO
Compounds of formula (II): ##STR00001## wherein ##STR00002## R.sup.1, R.sup.2, R.sup.5 and R.sup.13 are described herein, or a stereoisomer, enantiomer or...
2017/0362249 NEW CCR2 RECEPTOR ANTAGONISTS AND USES THEREOF
The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and...
2017/0362248 C5-C6-OXACYCLIC FUSED IMINOPYRIMIDINONE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE
In its many embodiments, the present invention provides certain C5-C6-oxacyclic fused iminopyrimidinone compounds, including compounds Formula (I): or a...
2017/0362247 PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-alpha]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2- ...
The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-- ...
2017/0362246 INHIBITORS OF BRUTON'S TYROSINE KINASE
Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible...
2017/0362245 TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES AS LSD1 INHIBITORS
The present invention is directed to [1,2,4]triazolo[4,3-a]pyridine and [1,2,4]triazolo[4,3-a]pyrazine derivatives which are LSD1 inhibitors useful in the...
2017/0362244 PYRAZOLO[1,5-A]PYRIMIDINES FOR ANTIVIRAL TREATMENT
The invention provides compounds of Formula I or Formula II: ##STR00001## or a pharmaceutically acceptable salt or ester, thereof, as described herein. The...
2017/0362243 BIARYLETHER IMIDAZOPYRAZINE BTK INHIBITORS
The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to...
2017/0362242 BENZAMIDE IMIDAZOPYRAZINE BTK INHIBITORS
The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to...
2017/0362241 1-FUNCTIONALIZED DIBENZOFURANS AND DIBENZOTHIOPHENES FOR ORGANIC LIGHT EMITTING DIODES (OLEDS)
The present invention relates to compounds of formula(I), a process for their production and their use in electronic devices, especially electroluminescent...
2017/0362240 4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS
Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the...
2017/0362239 COMPOUNDS FOR TREATING CYSTIC FIBROSIS
The present invention relates to compounds of Formula (I) or pharmaceutically acceptable enantiomers, salts, solvates or prodrugs thereof. The invention...
2017/0362238 NANOMATERIAL COMPOSITIONS, SYNTHESIS, AND ASSEMBLY
Compositions or an assembly of a series of biomimetic compounds include chemical structures that mimic or structurally resemble a nucleic acid base pair....
2017/0362237 WATER SOLUBLE SALTS OF ALDOSE REDUCTASE INHIBITORS FOR TREATMENT OF DIABETIC COMPLICATIONS
The present invention relates to pharmaceutically acceptable water soluble salts of aldose reductase inhibitors, ...
2017/0362236 6,8-DISUBSTITUTED-9-(HETEROCYCLYL)PURINES, COMPOSITIONS CONTAINING THESE DERIVATIVES AND THEIR USE IN COSMETIC...
6,8-Disubstituted-9-(heterocyclyl)purines for use in pharmaceutical and cosmetic compositions and applications are provided. These ...
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