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Patent # Description
2018/0002741 METHOD OF DIAGNOSIS AND TREATING GASTROINTESTINAL AND NEUROLOGICAL DISEASES ASSOCIATED WITH SPECIES OF GENUS...
The invention includes a method of diagnosis and treating autism associated with an overgrowth of beta2-toxin-gene-positive Clostridium perfringens in the gut...
2018/0002740 TRANSCRIPTION FACTOR DECOYS, COMPOSITIONS AND METHODS
Compositions and methods for identifying and using cis-regulatory and decoy sequences are disclosed.
2018/0002738 HIGH MULTIPLEX PCR WITH MOLECULAR BARCODING
The present disclosure provides methods and kits for performing high multiplex PCR using molecular barcodes. The methods disclosed herein separately extend a...
2018/0002734 METHODS FOR MOLECULAR DETECTION
This invention relates to methods for molecular detection, particularly to methods utilizing target-specific molecular probes. In exemplary embodiments,...
2018/0002733 METHODS FOR INCREASING MANNOSE CONTENT OF RECOMBINANT PROTEINS
The present invention relates to methods of modulating the mannose content of recombinant proteins.
2018/0002732 FORMULATIONS FOR DRYING BACTERIAL CELL EXTRACTS
This invention provides for an improved method of stabilizing freeze dried bacterial extracts with a carbohydrate lyoprotectant such that the extracts can be...
2018/0002728 CULTURE CONDITIONS THAT ALLOW ZYMOMONAS MOBILIS TO ASSIMILATE N2 GAS AS A NITROGEN SOURCE DURING BIO-ETHANOL...
Chemically defined culture medium and culture conditions that allow bacteria to assimilate dinitrogen gas (N.sub.2) as a nitrogen source during bio-ethanol...
2018/0002727 PRODUCTION OF MEVALONATE, ISOPRENE, AND ISOPRENOIDS USING GENES ENCODING POLYPEPTIDES HAVING THIOLASE, HMG-COA...
The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in...
2018/0002724 AGENTS FOR IMPROVED DELIVERY OF NUCLEIC ACIDS TO EUKARYOTIC CELLS
New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in...
2018/0002723 RETARGETED HERPESVIRUS WITH A GLYCOPROTEIN H FUSION
The present invention relates to the field of disease therapy. More specifically, it relates to a retargeted herpesvirus having a heterologous polypeptide...
2018/0002721 Stable Production of Lentiviral Vectors
The present invention provides new stable packaging cell lines and producer cell lines as well as methods to obtain them, and a new method to produce...
2018/0002720 CELL FOR USE IN IMMUNOTHERAPY WHICH CONTAINS MODIFIED NUCLEIC ACID CONSTRUCT ENCODING WILMS TUMOR GENE PRODUCT...
A cell of the present invention contains a nucleic acid construct encoding a WT1 gene product or a fragment of the WT1 gene product. The nucleic acid construct...
2018/0002719 Vectors Conditionally Expressing Therapeutic Proteins, Host Cells Comprising the Vectors, and Uses Thereof
This invention relates to the field of therapeutics. Most specifically, the invention provides methods of generating conditionally expressing vectors for one...
2018/0002718 WISE/SOST NUCLEIC ACID SEQUENCES AND AMINO ACID SEQUENCES
The present invention relates to nucleic acid sequences and amino acid sequences which influence bone deposition, the Wnt pathway, ocular development, tooth...
2018/0002717 ENGINEERING PATHOGEN RESISTANCE IN PLANTS
Provided herein are compounds and methods for increasing disease resistance and/or root length in plants.
2018/0002714 BRASSICA NAPUS SEED SPECIFIC PROMOTERS IDENTIFIED BY MICROARRAY ANALYSIS
Provided are constructs and methods for expressing a transgene in plant cells and/or plant tissues using gene regulatory elements obtained from Brassica napus.
2018/0002712 Modified Gene Silencing
This invention relates to methods of controlling gene expression or gene suppression in eukaryotic cells. One aspect of this invention includes modifying the...
2018/0002709 RIBOSOME-MEDIATED INCORPORATION OF PEPTIDES AND PEPTIDOMIMETICS
Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and...
2018/0002708 NUCLEASE-MEDIATED DNA ASSEMBLY
Methods are provided herein for assembling at least two nucleic acids using a sequence specific nuclease agent (e.g., a gRNA-Cas complex) to create end...
2018/0002706 METHODS AND COMPOSITIONS FOR CLONING INTO LARGE VECTORS
Provided herein are methods of cloning into vectors.
2018/0002703 COMPOSITION FOR REDUCING CELLULAR SENESCENCE LEVEL INCLUDING ACTIVITY INHIBITOR INHIBITING DCUN1D3 ACTIVITY OR...
Provided is a composition and method for reducing a cellular senescence level by inhibiting the activity or expression of one or more of DCUN1D3 protein or...
2018/0002700 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DIABETIC COMPLICATIONS AND SCREENING METHOD FOR...
Disclosed are a pharmaceutical composition and a method for preventing or treating diabetic complications caused by vascular leakage, comprising a TGase2...
2018/0002699 COMPOSITIONS AND METHODS FOR REACTIVATING LATENT IMMUNODEFICIENCY VIRUS
The present disclosure provides compositions and methods for reactivating latent immunodeficiency virus and/or reducing transcription of HIV integrated into...
2018/0002698 C-REL-SPECIFIC SIRNA AND ITS USE FOR PREVENTING AND TREATING AUTOIMMUNE PSORIASIS
The present invention provides a c-Rel-specific siRNA and its use for preventing and treating autoimmune psoriasis. In particular, the c-Rel-specific siRNAs...
2018/0002696 TREATMENT OF SODIUM CHANNEL, VOLTAGE-GATED, ALPHA SUBUNIT (SCNA) RELATED DISEASES BY INHIBITION OF NATURAL...
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Sodium channel, voltage-gated, alpha subunit...
2018/0002694 REDUCING INTRON RETENTION
Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to...
2018/0002693 COMPOSITIONS AND METHODS
Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the oligomeric compounds are conjugated to N-Acetylgalactosamine.
2018/0002692 Sequence Specific and Organism Specific Antimicrobials and Related Materials and Methods
Described herein are RNA-based antisense therapeutics to target antibiotic resistant bacteria. The antisense therapeutics disclosed herein can be useful in...
2018/0002690 PLANT REGULATORY ELEMENTS AND USES THEREOF
The invention provides DNA molecules and constructs, and their nucleotide sequences, useful for modulating gene expression in plants, and for specifying...
2018/0002688 METHODS FOR TAGGING DNA-ENCODED LIBRARIES
The present invention relates to methods for producing encoded chemical entities. In particular, the oligonucleotides and methods can include encoded chemical...
2018/0002687 Methods for Enhancing Bacterial Cell Display of Proteins and Peptides
Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates...
2018/0002681 Engineered CRISPR-Cas9 nucleases with Altered PAM Specificity
Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
2018/0002680 NOVEL PHYTASES AND USES THEREOF
The present invention relates to variant phytase enzymes and their use thereof.
2018/0002678 Polypeptides Having Laccase Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having laccase activity and polynucleotides encoding the polypeptides and polynucleotides encoding the...
2018/0002675 HUMAN EBOLA VIRUS SPECIES AND COMPOSITIONS AND METHODS THEREOF
Compositions and methods including and related to the Ebola Bundibugyo virus (EboBun) are provided. Compositions are provided that are operable as immunogens...
2018/0002674 USE OF ADENOVIRUS AND NUCLEIC ACIDS CODING THEREFOR
This invention relates to the use of an adenovirus to treat cancer, for example. The adenovirus may be replication deficient in cells that lack Y box binding...
2018/0002673 COMPOUND FOR IDENTIFYING PLURIPOTENT CELLS
[Problem to be Solved] To provide a compound for removing pluripotent cells from a cell population potentially containing the pluripotent cells. [Solution] A...
2018/0002671 CHEMICAL APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing...
2018/0002669 EX VIVO PROLIFERATION OF EPITHELIAL CELLS
The technology relates in part to methods and compositions for ex vivo proliferation and expansion of epithelial cells.
2018/0002663 METHOD AND MATERIAL FOR SEPARATING LEUKOCYTES OR MONONUCLEAR CELLS
An object of the present invention is to provide a separation system and a separation material for efficiently separating white blood cells or mononuclear...
2018/0002662 PURIFICATION OF GERM STEM CELLS BY TARGETING MRP9
Provided herein are methods and compositions for the purification and detection of germ stem cells (e.g., oogonial stem cells) based on expression of MRP9.
2018/0002659 CELL CULTURING METHOD AND KIT
The present invention relates to a cell culturing method and kit. More specifically, it relates to a cell culturing method and kit using a support that is...
2018/0002658 HYPOTHERMIC 3D BIOPRINTING OF LIVING TISSUES SUPPORTED BY PERFUSABLE VASCULATURE
The present disclosure provides compositions and methods for producing hydrogel matrix constructs. Methods of using hydrogel matrix constructs for tissue...
2018/0002657 PROCESS FOR ENRICHING THE BIOMASS OF MICROALGAE OF THE THRAUSTOCHYTRIUM GENUS WITH DHA AND WITH ARG AND GLU...
The present invention relates to a process for enriching a biomass of microalgae of the Thraustochytrium genus with DHA and with arginine and glutamic acid...
2018/0002656 METHODS AND COMPOSITIONS FOR HIGH-EFFICIENCY PRODUCTION OF BIOFUEL AND/OR BIOMASS
Methods and composition related to genetically modified cells for producing intracellular biological products are provided. A method can include genetically...
2018/0002655 Bioreactor System for Cell Cultivation
The present invention relates to a novel bioreactor system for cell cultivation. More specifically, the invention relates to a compact bioreactor system which...
2018/0002653 Aseptically Connectable Sensor Patch
The invention discloses a first connection unit having a plurality of sensor surfaces and which is adapted to be asepetically connected to a second connection...
2018/0002652 APPARATUSES AND METHODS FOR ELECTROPORATION
Disclosed are apparatuses, systems, and methods for performing electroporation.
2018/0002651 METHOD OF TRANSFERRING LIQUID BETWEEN MULTIPLE VESSELS IN CELL CULTIVATION
A method of transferring a liquid between multiple containers in cell culture. A first container of multiple culture containers each having a port for...
2018/0002650 SHAKER CAPABLE OF BEING USED IN CARBON DIOXIDE INCUBATOR AND CELL SUSPENSION CULTURE METHOD
The present invention relates to a shaker capable of being used in a carbon dioxide incubator and a cell suspension culture method. The shaker comprises a...
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