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Patent # Description
2018/0044400 ISOLATED PEPTIDES DERlVED FROM THE B7 LlGAND DlMER INTERFACE AND USES THEREOF
Disclosed are peptides comprising amino acid residues of the dimer interface of human B7-1 and B7-2 and compositions and uses thereof.
2018/0044399 INHIBITORY CHIMERIC ANTIGEN RECEPTORS
The invention relates to an inhibitory chimeric antigen receptor (N-CAR) comprising an extracellular domain comprising an antigen binding domain, a...
2018/0044398 Specific A-beta Species-Binding Peptides for the Therapy and/or Diagnosis of Alzheimer's Dementia
The invention relates to peptides binding specifically to Abeta species for treating and/or diagnosing Alzheimer's disease.
2018/0044397 MINIMALLY-INVASIVE AND ACTIVITY-DEPENDENT CONTROL OF EXCITABLE CELLS
The present invention provides a method of bioluminescence-driven optogenetic control of excitable cells. The excitable cell expresses a light-gated ion...
2018/0044396 COMPOUNDS AND METHODS FOR MODULATING PHARMACOKINETICS
Methods and compositions are described for management of the pharmacokinetic properties of active agents, e.g., therapeutic moieties, by conjugating, fusing,...
2018/0044395 PROCESS FOR PREPARING RECOMBINANT INSULIN USING MICROFILTRATION
The use of two tandem microfiltration (MF) steps in a process for making recombinant insulin is described. The two MF steps in a single downstream purification...
2018/0044394 STABLE, PROTRACTED GLP-1/GLUCAGON RECEPTOR CO-AGONISTS FOR MEDICAL USE
The invention relates to novel stable and protracted GLP-1/glucagon receptor co-agonists, to the use of said peptides in therapy, to methods of treatment...
2018/0044393 OREXIN-B POLYPEPTIDES AND USES THEREOF
The present invention relates to Orexin-B polypeptides and uses thereof, in particular for the treatment of cancer. In particular, the polypeptide of the...
2018/0044392 CODON OPTIMIZED IL-15 AND IL-15R-ALPHA GENES FOR EXPRESSION IN MAMMALIAN CELLS
The present invention provides for nucleic acids improved for the expression of interleukin-15 (IL-15) in mammalian cells. The invention further provides for...
2018/0044391 FUSION PROTEINS COMPRISING A BINDING PROTEIN AND AN INTERLEUKIN-15 POLYPEPTIDE HAVING A REDUCED AFFINITY FOR...
The present invention relates to fusion proteins comprising a binding protein and an IL-15 polypeptide as well as uses thereof, pharmaceutical compositions...
2018/0044390 COMPOSITIONS AND METHODS FOR IMPROVING RESISTANCE TO BREAKAGE AND EGGSHELL STRENGTH
Described herein are FGF-23 epitope peptides, methods of producing antibodies in laying hens by injecting the peptides, and methods of improving resistance to...
2018/0044389 Compositions for Regulating Iron Homeostasis and Methods of Using Same
The present invention relates to hemojuvelin-IgG Fc domain fusion proteins, variants, derivatives, fragments and peptide mimetics derived therefrom and methods...
2018/0044388 OPSIN POLYPEPTIDES AND METHODS OF USE THEREOF
The present disclosure provides opsins, including variant opsins with increased activity and/or increased trafficking to the plasma membrane. The opsins are...
2018/0044387 SERUM AMYLOID P DERIVATIVES AND THEIR PREPARATION AND USE
One aspect of the present invention relates to the surprising discovery that modification of a glycan structure on a human SAP polypeptide can increase the...
2018/0044386 PEPTIDE
This invention provides a peptide consisting of (i) the amino acid sequence LSSTQAQQSY (SEQ ID NO: 1), (ii) the amino acid sequence LSSTQAQQSW (SEQ ID NO: 6),...
2018/0044385 METHODS AND COMPOSITIONS INVOLVING PROTEIN G VARIANTS
Methods and compositions are provided concerning polypeptides with modifications that increase its binding affinity for the Fab region of an antibody. Methods...
2018/0044384 METHODS AND COMPOSITIONS TO REDUCE PEANUT-INDUCED ANAPHYLAXIS
The present disclosure provides compositions comprising recombinant bacterial spores. The present disclosure is also directed to vaccine based compositions,...
2018/0044383 MONOMERIC NEAR-INFRARED FLUORESCENT PROTEINS ENGINEERED FROM BACTERIAL PHYTOCHROMES AND METHODS FOR MAKING SAME
Nucleic acid molecules encoding monomeric near-infrared fluorescent proteins, variants and derivatives thereof are provided, as well as proteins and peptides...
2018/0044382 Electron Spin Labeled Ice Binding Compounds Used For Carrying Paramagnetic Centers For Dynamic Nuclear Polarization
Spin-labeled ice binding compounds (IBCs) including ice binding proteins (IBPs) or antifreeze proteins (AFPs) and their analogs may carry paramagnetic centers...
2018/0044381 POLYSACCHARIDE DERIVATIVE HAVING MEMBRANE-PERMEABLE PEPTIDE CHAIN
A polysaccharide derivative has a partial structure represented by Formula (1) below. It is preferable that at least one of the amino acids that constitute...
2018/0044380 BETA-HAIRPIN PEPTIDOMIMETICS
Beta-hairpin peptidomimetics of the general formula (I), cyclo[P.sup.1-P.sup.2-P.sup.3-P.sup.4-P.sup.5-P.sup.6-P.sup.7-P.sup.8-P.s- ...
2018/0044379 CO-ASSEMBLY PEPTIDES, NANOSTRUCTURES, AND METHODS OF MAKING AND USING THE SAME
Provided herein are charge complementary peptides that can be optionally coupled to a cargo polypeptide that are capable of self-assembling under stimulating...
2018/0044378 PROCESSES FOR PREPARING PHARMACEUTICALLY RELEVANT PEPTIDES
The present technology provides methods of generating the peptides, and pharmaceutically acceptable salts of the peptides and intermediates thereof. In some...
2018/0044377 SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS
The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the...
2018/0044376 Method for Preparing Largazole Analogs and Uses Thereof
Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions...
2018/0044375 DEUTERATED EMRICASAN
This invention relates to novel 3-amido-4-oxo-5-phenoxypentanoic acids, and pharmaceutically acceptable salts thereof. This invention also provides...
2018/0044374 Separation Method
The invention relates to a method of isolating an immunoglobulin, comprising the steps of: a) providing a separation matrix comprising at least 15 mg/ml...
2018/0044373 FLUORINATED AND ALKYLATED BILE ACIDS
The present invention relates to fluorinated and alkylated bile acids.
2018/0044372 SINGLE-STRANDED DNA NANOSTRUCTURES
The present disclosure relates to nanostructures assembled from nucleic acid consisting of a single strand of DNA rationally-designed to self-assemble into a...
2018/0044371 Methods for Isolation, Identification, and Quantification of miRNAs
Method and compositions and kits for isolation, identification, and quantification of miRNAs and other small RNAs, including but not limited to, siRNAs, mRNAs,...
2018/0044370 METHOD FOR SOLUTION PHASE DETRITYLATION OF OLIGOMERIC COMPOUNDS
Provided herein are methods for removal of monomethoxytrityl groups from oligomeric compounds comprising terminally linked monomethoxytrityl protected amino...
2018/0044369 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such...
2018/0044368 GEMCITABINE DERIVATIVES
Compositions and methods in the field of medicine and chemistry are disclosed. Some of the disclosed embodiments are directed to nucleotide compounds,...
2018/0044367 NUCLEOSIDE PHOSPHORAMIDATES
Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA...
2018/0044366 NOVEL CRYSTALLINE FORMS OF AN ANTIVIRAL BENZIMIDAZOLE COMPOUND
The invention relates to crystalline forms of 5,6-dichloro-2-(isopropylamino)-1-.beta.-L-ribofuranosyl-1Hbenzimidazole, pharmaceutical compositions comprising...
2018/0044365 PROCESSES FOR PREPARING FLUOROKETOLIDES
Processes and intermediates for preparing fluoroketolide compounds are described herein.
2018/0044364 A METHOD OF SEPARATING RHAMNOLIPIDS FROM A FERMENTATION BROTH
A method of extracting at least one rhamnolipid compound from a rhamnolipid fermentation mixture, the method comprising the steps of: (a) admixing an inert...
2018/0044363 Methods and Systems for Post-Fermentation Lignin Recovery
Provided herein is process and system for the production of high-quality lignin by treating the post-fermentation solids. In one aspect, the present disclosure...
2018/0044362 PLATINUM PRODRUGS AND METHODS OF MAKING AND USING THEREOF
Disclosed herein are prodrugs of platinum containing anticancer agents such as cisplatin that contain an alkylating moiety. Upon administration, the prodrugs...
2018/0044361 PRODRUGS OF PYRIDONE AMIDES USEFUL AS MODULATORS OF SODIUM CHANNELS
The invention relates to prodrug compounds of formula I: ##STR00001## wherein R.sup.2, R.sup.3, R.sup.5, R.sup.7 and X are as defined herein. The invention also...
2018/0044360 DNA ALKYLATING AGENTS
Provided herein are compounds of formula I: wherein the variables are defined herein, processes of making them, and methods of treating cancer comprising...
2018/0044359 Method for Producing Acyloxysilanes, Acyloxysilanes Obtained Thereby, and Use of Same
An object of the invention is to provide a method for efficiently producing an acyloxysilane which is useful as a functional chemical, an acyloxysilane...
2018/0044358 METHOD FOR PRODUCING DIALKYLAMINOSILANE
In a method for synthesizing dialkylaminosilane from a reaction of dialkylamine with chlorosilane as the method for producing dialkylaminosilane, a large...
2018/0044357 PROCESS FOR THE GENERATION OF THIN INORGANIC FILMS
The present invention is in the field of processes for the generation of thin inorganic films on substrates. In particular the present invention relates to a...
2018/0044356 NOVEL CRYSTALLINE FORM OF A PROTEASOME INHIBITOR
The present disclosure relates to a novel crystalline form of a proteasome inhibitor, and to the processes for the preparation thereof. The novel crystalline...
2018/0044355 TRICYCLIC BENZOXABOROLE COMPOUNDS AND USES THEREOF
Compounds of Formula II, ##STR00001## wherein X is selected from chloro, fluoro, bromo and iodo, R.sup.1 and R.sup.2 are each independently selected from H,...
2018/0044354 Olefin Hydroboration
A process comprising contacting a) an alkene, b) a hydrogen-boron bond containing compound, c) an .alpha.-diimine metal salt complex comprising an...
2018/0044353 4-SUBSTITUTED BENZOXABOROLE COMPOUNDS AND USES THEREOF
Substituted benzoxaboroles whose structure comprises Formula (III), wherein R.sup.3 is selected from --CH.sub.3, --CH.sub.2CH.sub.3, --CH.sub.2.dbd.CH.sub.2,...
2018/0044352 Heterocyclic Hydroxamic Acids as Protein Deacetylase Inhibitors and Dual Protein Deacetylase-Protein Kinase...
The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including...
2018/0044351 METHODS OF PRODUCING COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY
A process for preparing a compound represented by formula (Y1) or (Y2) [wherein IV is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt...
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