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Patent # Description
2018/0050040 USE OF 4-(4-FLUORO-2-METHOXYPHENYL)-N--1,3,5-TRIAZIN-2-AMINE FOR TREATING LYMPHOMAS
The present invention relates to 4-(4-Fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-- 1,3,5-triazin-2-amine (compound A), more...
2018/0050039 INDUCTION OF TUMOR HYPOXIA FOR CANCER THERAPY
Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions...
2018/0050038 ERBB4 INHIBITORS AND METHODS OF USE THEREOF
Disclosed herein are methods of treating diseases that exhibit over-activation of the ERBB4 pathway, such as breast cancer and lung cancer. The method...
2018/0050037 ALK KINASE INHIBITOR AND ITS USE
A compound for treating a disease, in particular cancer like non-small cell lung cancer, exceptionally inhibits activity of oncogenic ALK kinase. Compositions,...
2018/0050036 CML THERAPEUTIC AGENTS WITH REDUCED DRUG-RESISTANCE AND SIDE-EFFECT COMPRISING 1,6-DISUBSTITUTED INDOLE COMPOUNDS
The present invention relates to a therapeutic agent for chronic myelogenous leukemia with reduced drug-resistance and side-effects containing a...
2018/0050035 ANTIFUNGAL TREATMENT OF ROSACEA
Methods of treating disorders with a combination of antifungals is provided. The methods include topically administering a combination of antifungal agents to...
2018/0050034 ANTIFUNGAL TREATMENT OF CROHN'S DISEASE
Methods of treating disorders with a combination of antifungals is provided. The methods include topically administering a combination of antifungal agents to...
2018/0050033 ANTIFUNGAL TREATMENT OF RHEUMATOID ARTHRITIS
Methods of treating disorders with a combination of antifungals is provided. The methods include topically administering a combination of antifungal agents to...
2018/0050032 TEMOZOLOMIDE POWDER FORMULATION
The present invention relates to a solid pharmaceutical composition of temozolomide that has good and consistent flowability as a powder and taste masking and...
2018/0050031 Treatment of Multiple Sclerosis With Combination of Laquinimod and Dimethyl Fumarate
This invention provides a method of treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome comprising administering...
2018/0050030 COMBINATION OF TASQUINIMOD OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND A PD-1 AND/OR PD-L1 INHIBITOR, FOR...
The present invention concerns a combination comprising tasquinimod, or a pharmaceutically acceptable salt thereof, and a PD-1 and/or PD-L1 inhibitor, for use...
2018/0050029 SELECTIVE CONNEXIN HEMICHANNELS BLOCKERS FOR THE TREATMENT OF EPILEPSY
The present invention provides connexin hemichannel blockers for the treatment of epilepsy. In particular, the present invention relates to organic compounds...
2018/0050028 COMBINATION DOSAGE FORM OF A MU OPIOID RECEPTOR ANTAGONIST AND AN OPIOID AGENT
The invention provides a solid composition of the peripheral mu opioid antagonist axelopran and a combination dosage form of the mu opioid antagonist axelopran...
2018/0050027 TREATMENT OF PEMPHIGUS
The present disclosure provides methods of treating with a BTK inhibitor a blistering disease, in particular pemphigus vulgaris or pemphigus folliaceous in a...
2018/0050026 METHODS FOR STABILIZING OXIDATIVELY UNSTABLE COMPOSITIONS
Ophthalmic compositions and methods of preparing such compositions are disclosed.
2018/0050025 PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS
This invention is directed to derivatives of piperidine-2,6-dione, or their organic or inorganic salts thereof, a methods of synthesis of these derivatives,...
2018/0050024 4-[2-(2-FLUOROPHENOXYMETHYL)PHENYL]PIPERIDINE COMPOUNDS
The invention relates to compounds of formula I: ##STR00001## where a, R.sup.1, and R.sup.3-6 are as defined in the specification, or a pharmaceutically...
2018/0050023 OXYBUTYNIN-XANOMELINE TRANSDERMAL THERAPEUTIC SYSTEM COMBINATIONS
Transdermal therapeutic system and method of using the same for safely treating hypocholinergic disorders of the central nervous system such as Alzheimer type...
2018/0050022 FACTOR XIa INHIBITORS
The present invention provides a compound of Formula I ##STR00001## and pharmaceutical compositions comprising one or more said compounds, and methods for using...
2018/0050021 Derivatives of 1-[(cyclopentyl or 2-pyrrolidinyl)carbonylaminomethyl]-4-(1,3-Thiazol-5-yl) benzene which ...
There is provided novel small molecule E3 ubiquitin ligase protein binding ligand compounds, having utility in PROteolysis Targeted Chimeras (PROTACs), as well...
2018/0050020 IFETROBAN TREATMENT OF PORTAL HYPERTENSION
The present invention is directed to methods of treating and/or ameliorating portal hypertension by administration of a therapeutically effective amount of...
2018/0050019 Melatonin for Preventing and Treating Radiation Vaginitis and Proctitis
Compositions comprising melatonin or derivatives thereof are provided for topical administration to the vaginal and/or rectal epithelium to protect against...
2018/0050018 PERIPHERAL-ANTICHOLINERGIC MUSCARINIC AGONIST COMBINATION
A combination of a non-selective, peripheral anticholinergic agent, and a muscarinic receptor agonist, optionally with an acetyl cholinesterase inhibitor, and...
2018/0050017 Pharmaceutical Solution of Asenapine for Sublingual or Buccal Use
A kit for treating psychosis by administering a pharmaceutically acceptable liquid composition of Asenapine to oral mucosa includes a formulation having...
2018/0050016 COMPOSITIONS AND METHODS TO TREAT NIEMANN-PICK DISEASE
The present disclosure is directed to compositions comprising bryostatin-1, and methods comprising administering a composition comprising bryostatin-1, to...
2018/0050015 PHARMACEUTICAL COMPOSITION CONTAINING SILYBIN AND VE
A pharmaceutical composition is prepared from the following raw materials (in parts by weight): silybin (8.75-60), phospholipid (15-65), a Pu'er tea extract...
2018/0050014 PHARMACEUTICAL COMBINATION COMPRISING METFORMIN AND DIHYDROQUERCETIN AND ITS USE FOR THE TREATMENT OF CANCER
Provided is a novel medicament capable of reducing the side effects of metformin or a pharmaceutically acceptable salt thereof and useful as an anti-malignant...
2018/0050013 LIPIDIC FURAN, PYRROLE, AND THIOPHENE COMPOUNDS FOR TREATMENT OF CANCER, NEUROLOGICAL DISORDERS, AND FIBROTIC...
Compounds, methods, and compositions are provided for the treatment of cancer, neurological disorders, and fibrotic disorders. Specifically, the invention...
2018/0050012 Method for Inhibiting Growth of Ovarian Cancer Cells
The present invention is directed to a method for inhibiting growth of ovarian cancer cells in a subject in need thereof, comprising administering to said...
2018/0050011 INFLAMMASOME ACTIVATION IN MYELODYSPLASTIC SYNDROMES
Disclosed are methods for treating a meylodysplastic syndrome (MDS) in a subject that involves administering to the subject a therapeutically effective amount...
2018/0050010 Doxepin Isomers And Isomeric Mixtures And Methods Of Using The Same To Treat Sleep Disorders
The invention relates to use of the cis- (Z) isomer or isomeric mixtures containing specified ratios of the cis- (Z) and trans- (E) isomers of doxepin,...
2018/0050009 METHODS AND COMPOSITIONS FOR THE TREATMENT OF WARTS
Embodiments are directed to compositions comprising greater than 40% w/w to about 70% w/w stabilized hydrogen peroxide. The composition may also include a...
2018/0050008 OXYBUTYNIN TRANSDERMAL THERAPEUTIC SYSTEM MUSCARINIC AGONIST COMBINATION
Pharmaceutical compositions and combinations containing a muscarinic receptor antagonist, such as oxybutynin in a transdermal therapeutic system, and a...
2018/0050007 METHOD FOR MANUFACTURING LONG CHAIN POLYUNSATURATED FATTY ACID-CONTAINING FAT
Oxidation stability is improved and a long chain polyunsaturated fatty acid-containing fat with a good flavor is obtained with a method for manufacturing a...
2018/0050006 PURIFIED COMPOSITIONS OF POLYUNSATURATED FATTY ACIDS, THEIR PREPARATION METHOD AND THEIR USE
The present invention refers to new purified compositions of long chain polyunsaturated fatty acids, or their salts or esters, characterized by being...
2018/0050005 Concentrated Solution of 17-Hydroxydocosahexaenoic Acid
A method of treating a mother having postpartum depression, comprising administering to the mother a composition comprising a plurality of mixed ...
2018/0050004 USES OF AND METHODS OF TREATMENT WITH CYSTATHIONINE
The present invention relates to uses of and methods of treatment with cystathionine. In one embodiment, cystathionine reduces the development of toxin-induced...
2018/0050003 Solid Solution Compositions and Use in Chronic Inflammation
The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a...
2018/0050002 Solid Solution Compositions and Use in Chronic Inflammation
The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a...
2018/0050001 METHODS OF TREATING DEVELOPMENTAL DISORDERS WITH BIGUANIDES
Methods of treating developmental disorders such as Angelman syndrome, Fragile X syndrome, Fragile X-associated tremor/ataxia syndrome (FXTAS), Autistic...
2018/0050000 CONTROLLED RELEASE ORAL PHARMACEUTICAL DOSAGE FORMS COMPRISING MGBG
Disclosed herein are controlled-release oral pharmaceutical dosage forms comprising MGBG, and their application for the improved treatment of diseases with...
2018/0049999 COMPOSITIONS AND METHODS OF TREATMENT OF BREAST DISORDERS AND ESTROGEN-RELATED DISORDERS
The present invention relates to pharmaceutical compositions comprising at least one therapeutic agent, a fatty acid mixture comprising at least one omega-3...
2018/0049998 Naphthoquinone Compounds and Methods for Preparing the Same
The present application provides vitamin K metabolite derivatives and methods for preparing vitamin K metabolites and metabolite derivatives.
2018/0049997 CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) INHIBITION IN THE TREATMENT OF CANCER
In one embodiment, the invention provides methods of treatment which use therapeutically effective amounts of Cholesteryl Ester Transfer Protein (CETP)...
2018/0049996 THERAPEUTIC AGENT FOR CHRONIC RESPIRATORY DISEASE AND COMPOSITION FOR INHIBITING CARDIAC FIBROSIS
A novel agent which is effective in the prevention or treatment of a chronic respiratory disease such as COPD, interstitial pneumonia and asthma is provided....
2018/0049995 HIF-2-ALPHA INHIBITOR POLYMORPHS
Chemical compounds that modulate HIF-2.alpha. activity, their polymorphs, pharmaceutical compositions, and methods of treatment of diseases and conditions...
2018/0049994 TOPICAL REGIONAL NEURO-AFFECTIVE THERAPY WITH CARYOPHYLLENE
A method of treating a disease state or condition in humans via topical brainstem afferent stimulation therapy via the administration of caryophyllene to the...
2018/0049993 Fibrous dosage form
At present, the most prevalent pharmaceutical dosage forms, the oral immediate-release tablets and capsules, are granular solids. The problem of such solids is...
2018/0049992 GLYCOSAMINOGLYCAN-COATED METALLIC NANOPARTICLES AND USES THEREOF
The present invention is a composition comprising a plurality of nanoparticles of at least one noble metal each coated with a plurality of linker molecules, at...
2018/0049991 Oligonucleotide Lipid Nanoparticle Compositions, Methods of Making and Methods of Using the Same
Methods for inhibiting oligonucleotide activity in vitro or in vivo to a cell that are formulated with at least one oligonucleotide encapsulated in a lipid...
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