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Patent # Description
2018/0057839 THERAPEUTIC COMPOSITIONS COMPRISING TRANSCRIPTION FACTORS AND METHODS OF MAKING AND USING THE SAME
The present invention relates to in vivo methods of delivering recombinant virions or viral vectors to a subject, including a human diagnosed with or suspected...
2018/0057838 SYNTHETIC TRANSCRIPTIONAL AND EPIGENETIC REGULATORS BASED ON ENGINEERED, ORTHOGONAL ZINC FINGER PROTEINS
Embodiments disclosed herein provide artificial expression systems comprising the zinc-finger containing transcription factors and engineered promoters to...
2018/0057837 DNA PLASMID, CODING HNP-1, OR HNP-2, OR HNP-3, BACTERIAL PRODUCER, ANALGESIC AGENT (VARIANTS)
The invention (embodiments) relates to the field of medicine, pharmacology, biotechnology, molecular biology, genetic engineering and can be used for...
2018/0057836 A NUCLEIC ACID CONSTRUCT FOR CONFERRING HERBICIDE TOLERANCE IN PLANTS
The present invention is drawn to a nucleic acid sequence which confers expression of a phosphinothricin acetyltransferase and a ...
2018/0057835 ISOLATED POLYNUCLEOTIDES AND POLYPEPTIDES, AND METHODS OF USING SAME FOR INCREASING PLANT YIELD AND/OR...
Provided are isolated polynucleotides, polypeptides encoded thereby, nucleic acid constructs comprising same, plant cells and plants comprising same and...
2018/0057834 PtDUF266 Gene Regulating Cell Wall Biosynthesis and Recalcitrance in Populus
This disclosure provides genetically modified plants having desirable levels of sugar release, cellulose content and reduction of recalcitrance; methods of...
2018/0057833 PLANT REGULATORY ELEMENTS AND USES THEREOF
The present invention provides novel DNA molecules and constructs, including their nucleotide sequences, useful for modulating gene expression in plants and...
2018/0057832 SOYBEAN U6 SMALL NUCLEAR RNA GENE PROMOTERS AND THEIR USE IN CONSTITUTIVE EXPRESSION OF SMALL RNA GENES IN PLANTS
The invention relates to gene expression regulatory sequences from soybean, specifically to promoters of U6 small nuclear RNA genes, and fragments thereof, and...
2018/0057831 Inducible flowering for fast generation times in maize and sorghum
A method of producing faster flowering times in corn and sorghum plants is presented herein. Corn and sorghum plants comprising a non-native flowering gene...
2018/0057830 WHEAT VARIETY A060013G1
A wheat variety designated A060013G1, the plants and seeds of wheat variety A060013G1, methods for producing a wheat plant produced by crossing the variety...
2018/0057829 WHEAT VARIETY W070287J1
A wheat variety designated W070287J1, the plants and seeds of wheat variety W070287J1, methods for producing a wheat plant produced by crossing the variety...
2018/0057828 WHEAT VARIETY W070474I1
A wheat variety designated W070474I1, the plants and seeds of wheat variety W070474I1, methods for producing a wheat plant produced by crossing the variety...
2018/0057827 WHEAT VARIETY W080366A1
A wheat variety designated W080366A1, the plants and seeds of wheat variety W080366A1, methods for producing a wheat plant produced by crossing the variety...
2018/0057826 WHEAT VARIETY W080148I1
A wheat variety designated W080148I1, the plants and seeds of wheat variety W080148I1, methods for producing a wheat plant produced by crossing the variety...
2018/0057825 WHEAT VARIETY W080329C1
A wheat variety designated W080329C1, the plants and seeds of wheat variety W080329C1, methods for producing a wheat plant produced by crossing the variety...
2018/0057824 GENETICALLY ENGINEERED VIBRIO SP. AND USES THEREOF
The present disclosure provides engineered Vibrio sp. organisms. The organisms can be engineered to have an altered Chromosome II so that the altered...
2018/0057823 Expression Vector
An expression vector for expressing a target polypeptide in a prokaryotic cell is provided. The vector comprises a promoter operably linked to a polynucleotide...
2018/0057822 Gold Optimized CAR T-cells
Control Devices are disclosed including RNA destabilizing elements (RDE), RNA control devices, and destabilizing elements (DE) combined with Chimeric Antigen...
2018/0057821 Compositions for Treating Pathological Calcification Conditions, and Methods Using Same
The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological...
2018/0057820 Compositions for Treating Pathological Calcification Conditions, and Methods Using Same
The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological...
2018/0057819 MOLECULAR TARGETS FOR THE PREVENTION AND/OR TREATMENT OF FIBROSIS, HYPERTROPHIC SCARS OR KELOIDS
The present invention relates to a therapeutic compound comprising: an agent that inhibits the activity of at least one gene selected from the group consisting...
2018/0057818 MIRNA MODULATORS OF THERMOGENESIS
Provided are novel methods and compositions for the modulation of thermogenesis. Such methods are particularly advantageous in that they allow for the...
2018/0057817 Particle-Nucleic Acid Conjugates and Therapeutic Uses Related Thereto
This disclosure relates to particles conjugated to therapeutic nucleic acids. In certain embodiments, the nucleic acid comprises a sequence that catalytically...
2018/0057816 METHODS AND COMPOSITIONS TO INHIBIT METASTASIS AND TO TREAT FIBROSIS AND TO ENHANCE WOUND HEALING
Methods and compositions are provided for inhibiting or treating metastasis based on discoveries regarding Kif19 and Cep192. Methods and compositions are...
2018/0057815 SIRNA SEQUENCE-INDEPENDENT MODIFICATION FORMATS FOR REDUCING OFF-TARGET PHENOTYPIC EFFECTS IN RNAI, AND...
Modification formats having modified nucleotides are provided for siRNA. Short interfering RNA having modification formats and modified nucleotides provided...
2018/0057814 COMPOSITIONS AND METHODS FOR INHIBITION OF NUCLEIC ACIDS FUNCTION
The invention relates generally to compositions and methods for inhibiting the function of target nucleic acids by sequence specific binding. The compositions...
2018/0057813 COMPOSITIONS AND METHODS FOR NUCLEIC ACID TRANSFER
Disclosed are methods for the enhancement of nucleic acid delivery systems. The methods may employ treatment with a compound and/or an RNAi molecule in...
2018/0057812 HEPCIDIN ANTAGONISTS FOR USE IN THE TREATMENT OF INFLAMMATION
The present invention relates to a hepcidin antagonist for use in the treatment of inflammatory diseases.
2018/0057811 SEQUENCE TAGS
Provided herein is a new class of nucleic acid tagging molecules which are essentially free of homopolymer stretches. The tagging molecules can tag a plurality...
2018/0057810 FUNCTIONAL SCREENING WITH OPTIMIZED FUNCTIONAL CRISPR-CAS SYSTEMS
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are...
2018/0057809 CARTRIDGE FOR PURIFICATION OF BIOLOGICAL SAMPLES
The present disclosure provides a cartridge for purifying biological samples. The cartridge comprises a first chamber configured to receive and hold biological...
2018/0057808 METHODS AND SYSTEMS FOR ISOLATING AND IDENTIFYING NUCLEIC ACID FROM A PLURALITY OF MICROORGANISMS AND VIRUSES
The disclosure relates to laboratory and bioinformatics methods for isolating, detecting, and characterizing microbes in biological samples using metagenomic...
2018/0057807 GENE MODIFICATION IN CLOSTRIDIUM FOR INCREASED ALCOHOL PRODUCTION
The present disclosure is directed to genetically engineered bacteria strains with enhanced biofuel-producing capabilities from cellulosic substrates. The...
2018/0057806 ENGINEERED SYNTHASE FOR PRODUCTION OF TRYPTOPHAN DERIVATIVES AND INTRANSIGENT SUBSTRATES
This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates...
2018/0057805 IONIC LIQUID-TOLERANT CELLULASE ENZYMES
The present invention provides ionic liquid-tolerant cellulases and method of producing and using such cellulases. The cellulases of the invention are useful...
2018/0057804 ENDOGLYCOSIDASE MUTANTS FOR GLYCOPROTEIN REMODELING AND METHODS OF USING IT
A mutant of EndoS2 includes one or more mutations in the sequence of a wild-type EndoS2 (SEQ ID NO: 1), wherein the one or more mutations are in a peptide...
2018/0057803 HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these...
2018/0057802 Method for Preparing Ascorbic Acid-2-phosphate Using a Recombinant Strain
The present invention provides a recombinant strain, construction method thereof and a method for producing acid phosphatase using the recombinant strain. In...
2018/0057801 RED-SHIFTED LUCIFERASE-LUCIFERIN PAIRS FOR ENHANCED BIOLUMINESCENCE
A bioluminescent protein is provided that includes a substituted luciferase polypeptide having amino acid substitutions at positions 21 and 166, and with one...
2018/0057800 CHLAMYDOMONAS VIOLAXANTHIN DE-EPOXIDASE ENZYME AND ITS USES
This disclosure provides Chlamydomonas violaxanthin de-epoxidase (CVDE) gene, polypeptides, and variants thereof as well as host cells that are genetically...
2018/0057799 STREPTOMYCES SP. STRAIN AND METHOD FOR PREPARING SULFIDE OXIDASE PREPARATION FROM THE SAME
The present invention discloses a Streptomyces sp. strain and a method for preparing a sulfide oxidase preparation from the same. This strain is a Streptomyces...
2018/0057798 PYRUVATE DEHYDROGENASE VARIANTS, A MICROORGANISM COMPRISING THE SAME AND A METHOD FOR PRODUCING L-AMINO ACID...
The present disclosure relates to a novel pyruvate dehydrogenase variant, a polynucleotide encoding the pyruvate dehydrogenase variant, a microorganism of the...
2018/0057797 METHODS FOR TREATING AN IMMUNE DISORDER-RELATED DISEASE BY REDUCING AUTOREACTIVITY IN A T CELL COMPARTMENT
The described invention provides a pharmaceutical composition comprising a therapeutic amount of an educated mononuclear cell product, a process for preparing...
2018/0057795 METHODS OF PRODUCING MODIFIED NATURAL KILLER CELLS AND METHODS OF USE
Disclosed herein are method of producing NK cells that include one or more heterologous nucleic acids. The methods include culturing a population of isolated...
2018/0057794 CYTOKINE RECEPTOR GENES AND THE USE THEREOF TO ENHANCE THERAPY
Cells, such a T-cells, are provided that comprise cytokine receptors having increased activity in response to their ligand. For example, cell can comprise IL-2...
2018/0057793 METHODS FOR ISOLATING AND PROLIFERATING AUTOLOGOUS CANCER ANTIGEN-SPECIFIC CD8+ T CELLS
Provided is a method for isolating and proliferating autologous cancer antigen-specific CD8.sup.+T cells, and more particularly, a method for selecting an...
2018/0057792 AUTOLOGOUS SOMATIC CELL THERAPY, METHOD OF CONTROLLABLE PREPARATION OF THERAPEUTIC COMPOSITION AND PROCEDURE OF...
A blood product containing peripheral blood mononuclear cells (PBMCs) in an amount of at least 4 million cells per milliliter and human chorionic gonadotropin...
2018/0057791 METHODS AND KITS FOR CELL ACTIVATION
Provided are methods and kits for activating T cells, the method comprising providing a population of T cells, adding a plurality of first agents, where the...
2018/0057790 Functional Myelination of Neurons
Hair follicle bulge region/LLP region CD34(+) MeSCs can be isolated from mammalian skin bearing hair follicles. These cells are multipotent and retain the...
2018/0057789 DIRECT CONVERSION OF CELLS TO CELLS OF OTHER LINEAGES
Methods, compositions and kits for producing functional neurons, astroctyes, oligodendrocytes and progenitor cells thereof are provided. These methods,...
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