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Patent # Description
2018/0057535 COMPOSITIONS FOR PREVENTING AND/OR TREATING AN INFECTION BY AN HIV-1 VIRUS
The present invention relates to an immunogenic composition comprising an antigenic peptide of formula (I) below: Nt-S-X1-X2-X3-K-X4-Ct (I) [SEQ ID N.degree....
2018/0057534 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CAST NEPHROPATHY AND RELATED CONDITIONS
Provided are novel peptides of Formula SEQ ID No. 1: TABLE-US-00001 (SEQ ID No. 1) ...
2018/0057533 PEPTIDES CAPABLE OF REACTIVATING p53 MUTANTS
The invention provides peptides that can reactivate p53 mutants efficiently and specifically, as well as methods that allow the identification, selection and...
2018/0057532 PEPTIDE HAVING EIGHT AMINO ACID SEQUENCES DERIVED FROM CAGE AND RETAINING ANTICANCER ACTIVITY AND ACTIVITY TO...
The present invention relates to a peptide having eight amino acid sequences derived from CAGE and retaining anticancer activity and activity to promote...
2018/0057531 MUC1-DERIVED PEPTIDE, AND PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF CANCER, IMMUNITY-INDUCING...
The present invention provides a peptide that includes eight or more consecutive amino acid residues of amino acid sequence of one of Sequence ID Nos. 1 to 12...
2018/0057530 CYCLIC PEPTIDE COMPOUND, AND PREPARATION AND USE THEREOF
The present invention relates to a compound represented by formula (I). The present invention also relates to the use of a compound represented by formula (I)...
2018/0057529 PRO-AMB REVERSE TURN RESTRICTED BIOACTIVE PEPTIDE ANALOGUES
The present invention discloses novel peptides acting as angiotensin II analogue for therapeutic applications. Said peptides can be used for treatment of...
2018/0057528 INDOLINE COMPOUNDS AS GRANZYME B INHIBITORS
Granzyme B inhibitor compounds, compositions that include the compounds, and methods for using the compounds. The compounds of the invention have advantageous...
2018/0057527 CARBAZOLE COMPOUND HAVING ANTI-VIRUS ACTIVITY
The present invention relates to a carbazole compound having anti-virus activity, and more particularly, to a novel compound selected from the group of...
2018/0057526 NEW DIFLUOROKETAMIDE DERIVATIVES
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8...
2018/0057525 SOLID PHASE PEPTIDE SYNTHESIS PROCESSES AND ASSOCIATED SYSTEMS
Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino...
2018/0057524 COMPOUNDS FROM INVASIVE SALVINIAS AND METHODS OF USING THE SAME
In some embodiments, the compositions and methods relate to compounds isolated from plants in the Salviniaceae family, pharmaceutical compositions comprising...
2018/0057523 PHILLYGENIN GLUCURONIC ACID DERIVATIVE AS WELL AS PREPARATION METHOD AND APPLICATION THEREOF
The present invention provides a novel phillygenin glucuronic acid derivative shown as a general formula (I). ##STR00001## wherein, R.sub.1.dbd.H,...
2018/0057522 NON-CALORIC SWEETENERS AND METHODS FOR SYNTHESIZING
Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside...
2018/0057521 NON-CALORIC SWEETENERS AND METHODS FOR SYNTHESIZING
Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside...
2018/0057520 NON-CALORIC SWEETENERS AND METHODS FOR SYNTHESIZING
Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside...
2018/0057519 NON-CALORIC SWEETENERS AND METHODS FOR SYNTHESIZING
Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M),...
2018/0057518 SYNTHETIC MEMBRANE ANCHORS
A construct of the structure F--S.sub.1-S.sub.2 where: F--S.sub.1 is an aminoalkylglycoside where F is ...
2018/0057517 Metal Tricarbonyl Complexes Comprising Substituted Iminodiactic Acid Ligands and Uses as Radioisotope Tracers
This disclosure relates to compositions comprising substituted iminodiacetic acid ligands and metal tricarbonyl complexes containing the ligands and...
2018/0057516 REAGENTS USEFUL FOR SYNTHESIZING RHODAMINE-LABELED OLIGONUCLEOTIDES
The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.
2018/0057515 HETEROCYCLIC COMPOUND AND ORGANIC SOLAR CELL COMPRISING SAME
The present specification relates to a heterocyclic compound and an organic solar cell including the same.
2018/0057514 SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS
The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system or method comprising or consisting...
2018/0057513 Transition Metal Complexes, Production and Use Thereof
Phosphasalen transition metal complexes are disclosed for use in alkene polymerization to produce polyolefins. The transition metal complexes are represented...
2018/0057512 ZWITTERIONIC ZINC(II) CARBOXYLATE COMPOUNDS AND THEIR USE
A method of preparing a crystalline zwitterionic zinc(II)-carboxylate compound includes the steps of preparing a mixture of zinc(II) ions and a first pyridyl...
2018/0057511 ORGANIC ANION LITHIUM IONIC COCRYSTAL COMPOUNDS AND COMPOSITIONS
A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and...
2018/0057510 Synthesis and Utility of New Capgroup Largazole Analogs
Analogs of largazole are described herein. Methods of treating cancer, blood disorders, autoimmune disease, and Alzheimer's Disease using largazole analogs and...
2018/0057509 ALKYLOXY SUBSTITUTED THIAZOLOQUINOLINES AND THIAZOLONAPHTHYRIDINES
Thiazoloquinolines and thiazolonaphthyridines with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds,...
2018/0057508 PYRIDO-1,3-OXAZINE-2,4-DIONE COMPOUNDS WITH FUNGICIDAL ACTIVITY
This disclosure relates to pyrido-1,3-oxazine-2,4-diones of Formula I and their use as fungicides. ##STR00001##
2018/0057507 INHIBITORS OF DUAL LEUCINE ZIPPER (DLK) KINASE FOR THE TREATMENT OF DISEASE
Disclosed herein are compounds which inhibit the kinase activity of dual leucine zipper (DLK) kinase (MAP3K12), pharmaceutical compositions, and methods of...
2018/0057506 FUSED DIHYDRO-4H-PYRAZOLO[5,1-C][1,4]OXAZINYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS
Disclosed are compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, wherein Ring B, A.sup.1, A.sup.2, R.sup.6, w and n1 are...
2018/0057505 BICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY
The compounds of formula I, wherein the variables are as defined herein, and pharmaceutically acceptable salts thereof are useful as inhibitors of the PAR-2...
2018/0057504 6-AMIDO DERIVATIVES OF 4,5A-EPOXYMORPHINANS FOR TREATMENT OF PAIN
Compounds of formula: ##STR00001## in which R.sup.4 is chosen from substituted phenyl, optionally substituted naphthylene, optionally substituted anthracene and...
2018/0057503 Pharmaceutically Acceptable Salts and Polymorphic Forms of Hydrocodone Benzoic Acid Enol Ester and Processes...
Compositions comprising hydrocodone benzoic acid enol ester to form novel prodrugs including hydrocodone benzoic acid enol ester salts, and various polymorphs....
2018/0057502 PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-alpha]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2- ...
The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-- ...
2018/0057501 FUSED TRICYCLIC PYRIDAZINONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS
The invention provides compounds of Formula (I): ##STR00001## as further described herein, as well as pharmaceutical compositions comprising such compounds, and...
2018/0057500 PYRAZOLE CARBOXAMIDE COMPOUNDS AND METHODS OF USE
Pyrazole carboxamide compounds of Formula I are provided, with various substituents, and including stereoisomers, tautomers, and pharmaceutically acceptable...
2018/0057499 PYRAZOLO[1,5-a]PYRIMIDINE COMPOUND
The compounds represented by formulas (I) to (XVIII) or pharmaceutically acceptable salts thereof. ##STR00001## ##STR00002## ##STR00003## ##STR00004## ...
2018/0057498 CDK INHIBITOR, EUTECTIC CRYSTAL OF MEK INHIBITOR, AND PREPARATION METHOD THEREFOR
The present disclosure relates to novel co-crystals of a CDK inhibitor and an MEK inhibitor and the preparation methods thereof. Specifically, the present...
2018/0057497 Pyrazolo[1,5-A][1,3,5]Triazine and Pyrazolo[1,5-A]Pyrimidine Derivatives as CDK Inhibitors
The present invention provides substituted pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives of formula (I), which are therapeutically...
2018/0057496 HETEROCYCLYL LINKED IMIDAZOPYRIDAZINE DERIVATIVES AS PI3KB INHIBITORS
The present invention relates to heterocyclyl linked imidazopyridazine derivatives of Formula (I) ##STR00001## wherein the variables have the meaning defined in...
2018/0057495 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS
The present invention relates to substituted xanthines of general formula ##STR00001## wherein R.sup.1 to R.sup.3 are as defined herein, the tautomers, the ...
2018/0057494 TRIAZOLOPYRAZINONE DERIVATIVE USEFUL AS A HUMAN PDE1 INHIBITOR
The present invention provides a compound of Formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, for use as a human PDE1 inhibitor.
2018/0057493 MORPHINAN DERIVATIVE
A morphinan derivative represented by the following general formula (I): ##STR00001## (wherein R.sup.1 represents hydrogen, C.sub.1-10 alkyl, cycloalkylalkyl ...
2018/0057492 SPECIFIC N AND P ACTIVE MATERIALS FOR ORGANIC PHOTOELECTRIC CONVERSION LAYERS IN ORGANIC PHOTODIODES
The field of the DISCLOSURE lies in active materials for organic image sensors. The present disclosure relates to naphtalene diimide-based molecules and...
2018/0057491 ISOQUINOLINE AMIDE AND ISOQUINOLINE AMIDE-SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS,...
Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic...
2018/0057490 BENZOMORPHOLINE AND BENZOMORPHOLINE-SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND...
Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic...
2018/0057489 1-Amino-triazolo(1,5-A)pyridine-substituted Urea Derivative and Uses Thereof
Provided herein is a compound, 1-(4-(3-amino-[1,2,3]triazolo[1,5-a]pyridin-4-yl)phenyl)-3-(3-chloropheny- l)urea, pharmaceutical compositions thereof and...
2018/0057488 COMPOSITIONS AND METHODS FOR INHIBITING KINASES
The present invention provides compounds for the prevention or treatment of cancer or a bacterial or viral infection. Additionally, the present invention...
2018/0057487 NOVEL GLUTAMINASE INHIBITORS
The present disclosure provides compounds of formula (I) to (III) as glutaminase inhibitors, methods of preparing them, pharmaceutical compositions containing...
2018/0057486 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The...
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